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Enrofloxacin Shifts Intestinal Microbiota And Metabolic Profiling And Hinders Recovery From Salmonella Enterica Subsp. Enterica Serovar Typhimurium Infection In Neonatal Chickens

Boheng Ma, Xueran Mei, Changwei Lei, Cui Li, Yufeng Gao, Linghan Kong, Xiwen Zhai, Hongning Wang

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In this study, we examined the effects of S. Typhimurium infection and enrofloxacin treatment on the microbiota and metabolite synthesis in chicken cecum, in order to identify target metabolites that may promote S. Typhimurium colonization and aggravate inflammation and to evaluate the important microbiota that may be associated with these metabolites. Our findings may facilitate the use of antibiotics to prevent S. Typhimurium infection.