Online citations, reference lists, and bibliographies.
← Back to Search

Hydrogen Peroxide Produced Inside Mitochondria Takes Part In Cell-to-cell Transmission Of Apoptotic Signal

O. Pletjushkina, E. Fetisova, K. Lyamzaev, O. Ivanova, L. V. Domnina, M. Vyssokikh, A. Pustovidko, A. V. Alexeevski, D. A. Alexeevski, J. Vasiliev, M. Murphy, B. V. Chernyak, V. Skulachev
Published 2006 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
In monolayer of HeLa cells treated with tumor necrosis factor (TNF), apoptotic cells formed clusters indicating possible transmission of apoptotic signal via the culture media. To investigate this phenomenon, a simple method of enabling two cell cultures to interact has been employed. Two coverslips were placed side by side in a Petri dish, one coverslip covered with apoptogen-treated cells (the inducer) and another with non-treated cells (the recipient). TNF, staurosporine, or H2O2 treatment of the inducer cells is shown to initiate apoptosis on the recipient coverslip. This effect is increased by a catalase inhibitor aminotriazole and is arrested by addition of catalase or by pre-treatment of either the inducer or the recipient cells with nanomolar concentrations of mitochondria-targeted cationic antioxidant MitoQ (10-(6′-ubiquinolyl)decyltriphenylphosphonium), which specifically arrests H2O2-induced apoptosis. The action of MitoQ is abolished by an uncoupler preventing accumulation of MitoQ in mitochondria. It is concluded that reactive oxygen species (ROS) produced by mitochondria in the apoptotic cells initiate the release of H2O2 from these cells. The H2O2 released is employed as a long-distance cell suicide messenger. In processing of such a signal by the recipient cells, mitochondrial ROS production is also involved. It is suggested that the described phenomenon may be involved in expansion of the apoptotic region around a damaged part of the tissue during heart attack or stroke as well as in “organoptosis”, i.e. disappearance of organs during ontogenesis.
This paper references
10.1038/2221076A0
Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria
E. Liberman (1969)
10.1016/0005-2728(70)90153-2
Conversion of biomembrane-produced energy into electric form. I. Submitochondrial particles.
L. Grinius (1970)
10.1016/0005-2728(70)90156-8
Conversion of biomembrane-produced energy into electric form. IV. General discussion.
E. Liberman (1970)
Energetics of Biological Membranes [in Russian], Nauka, Moscow
V. P. Skulachev (1989)
Viruses hold the keys of death.
Wyllie Ah (1996)
10.1017/S0033583500005795
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants.
V. Skulachev (1996)
10.1023/A:1027344914565
Membrane-Linked Systems Preventing Superoxide Formation
V. Skulachev (1997)
10.1089/HUM.1998.9.16-2385
Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions.
R. Touraine (1998)
Possible role of reactive oxygen species in antiviral defense.
V. Skulachev (1998)
10.1016/S0891-5849(98)00296-2
Thyroxine enhancement and the role of reactive oxygen species in tadpole tail apoptosis.
A. Kashiwagi (1999)
10.1016/S0098-2997(99)00008-4
Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms.
V. Skulachev (1999)
10.1054/bjoc.2000.1433
Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis
F. Lyng (2000)
10.1084/JEM.192.7.1001
Reactive Oxygen Species (Ros-Induced) Ros Release: A New Phenomenon Accompanying Induction of the Mitochondrial Permeability Transition in Cardiac Myocytes
D. Zorov (2000)
10.1096/fj.99-0890com
Clustering of apoptotic cells via bystander killing by peroxides
K. Reznikov (2000)
Inhibition of angiogenesis and induction of apoptosis are involved in E1A-mediated bystander effect and tumor suppression.
R. Shao (2000)
Reactive oxygen and nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis.
G. Bauer (2000)
10.1073/PNAS.011417098
Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells.
E. Azzam (2001)
10.1038/35081184
Programmed cell death, mitochondria and the plant hypersensitive response
E. Lam (2001)
10.1517/14712598.1.5.753
Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction
M. Murphy (2001)
10.1038/sj.onc.1206053
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis
L. A. Shchepina (2002)
10.1093/JEXBOT/53.372.1367
The apoplastic oxidative burst in response to biotic stress in plants: a three-component system.
G. Bolwell (2002)
10.1073/pnas.182209699
Bystander effect produced by radiolabeled tumor cells in vivo
L. Xue (2002)
10.1111/j.1749-6632.2002.tb02098.x
Prevention of Mitochondrial Oxidative Damage Using Targeted Antioxidants
G. F. Kelso (2002)
10.1152/PHYSREV.00018.2001
Free radicals in the physiological control of cell function.
W. Dröge (2002)
10.1016/S0301-472X(03)00078-X
Low-dose radiation effects: experimental hematology and the changing paradigm.
C. Mothersill (2003)
Topics in Current Genetics. Model Systems in Ageing (Nystrom
V. P. Skulachev (2003)
10.1074/JBC.M310341200
Characterization of Superoxide-producing Sites in Isolated Brain Mitochondria*
A. Kudin (2004)
10.1096/fj.04-2882fje
Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
Meghna Waghray (2005)



This paper is referenced by
10.3390/cancers13030461
Hydrogen-Peroxide Synthesis and LDL-Uptake Controls Immunosuppressive Properties in Monocyte-Derived Dendritic Cells
Ann-Katrin Menzner (2021)
10.1080/10409238.2020.1828258
Riding the tiger – physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix
M. Brand (2020)
10.1016/j.bbamcr.2019.01.016
Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review.
David R Zhou (2019)
10.3390/genes9040175
Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?
G. Zsurka (2018)
10.3389/fphar.2018.00644
Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane
D. Yadav (2018)
10.1093/FQSAFE/FYY016
Pathogenic mechanisms and control strategies of Botrytis cinerea causing post-harvest decay in fruits and vegetables
Li Hua (2018)
10.1134/S0022093017030048
Gangliosides GM1 and GD1a normalize respiratory rates of rat brain mitochondria reduced by tert-butyl hydroperoxide
S. Korotkov (2017)
Characterisation of pathogenic pathways within the bone microenvironment of Gaucher disease which contribute to bone pathology and haematological malignancy
M. Reed (2017)
10.1016/j.bbacli.2017.06.002
Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium
P. Vishnyakova (2017)
10.1016/j.molp.2017.07.003
Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaliana.
Ayan Sadhukhan (2017)
10.1016/j.neuro.2016.05.022
Neural stem cells injured by oxidative stress can be rejuvenated by GV1001, a novel peptide, through scavenging free radicals and enhancing survival signals.
Hyunhee Park (2016)
10.1074/jbc.M116.727248
The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria*
A. Bhattacharjee (2016)
10.1134/S1819712416030144
Alpha-tocopherol prevents a dramatic oxidative stress-induced decline of the Bcl-2 concentration in cortical neurons
I. Zakharova (2016)
10.1080/10715762.2016.1193668
In vitro cell-based assays for evaluation of antioxidant potential of plant-derived products
L. C. Nascimento da Silva (2016)
Chapter 2 : Metabolic Stress Induced and ROS Mediated PCD in Xanthomonas
(2015)
10.3109/09553002.2014.911988
γ-Rays-generated ROS induce apoptosis via mitochondrial and cell cycle alteration in smooth muscle cells
S. Claro (2014)
10.1134/S1990519X14030043
Apoptosis and necrosis induced by ultraviolet radiation in the presence of autologous plasma
V. Artyukhov (2014)
10.1134/S0006297914100010
New data on programmed aging — slow phenoptosis
M. Skulachev (2014)
10.15407/FZ58.01.003
Cytochrome C as an amplifier of ROS release in mitochondria.
O. Akopova (2012)
10.1093/humupd/dmr043
Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss.
M. Dahl (2012)
Evaluation of Hydrogen Peroxide Induced Cardiotoxicity in Sixth Day Chick Embryo
Poonam Musale (2012)
10.3892/or.2012.1954
Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway.
L. Wang (2012)
10.1007/978-1-60761-956-7_27
Models of Mitochondrial Oxidative Stress
E. Cadenas (2011)
Age-Associated Alterations in the F344XBN Rat Heart and the Efficacy of Chronic Acetaminophen Ingestion as a Therapeutic Approach
Sunil K. Kakarla (2011)
10.1134/S1990519X11020039
DNA fragmentation of human lymphocytes in dynamics of development of apoptosis induced by action of UV radiation and reactive oxygen species
V. Artyukhov (2011)
10.1111/j.1574-6968.2010.02114.x
Metabolic stress-induced programmed cell death in Xanthomonas.
S. Wadhawan (2010)
10.1007/s00395-010-0094-3
Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat
Sunil K. Kakarla (2010)
Mechanisms of interaction of non-thermal plasma with living cells
S. Kalghatgi (2010)
10.1134/S1990519X09050125
Premature aging syndrome in ataxia telangiectasia patients
E. A. Polubotko (2009)
10.1134/S0006297909100071
Molecular mechanisms of transformation of SkQ mitotropic quinones and the search for new approaches to creation of selective free radical traps
S. A. Eremeyev (2009)
10.1007/s10863-009-9256-0
The mitochondrial kinase PINK1, stress response and Parkinson’s disease
M. Jendrach (2009)
10.1016/j.hrtlng.2007.05.011
Dopamine alleviation of diaphragm contractile dysfunction and reduction of deoxyribonucleic acid damage in rats.
J. Pierce (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar