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Biodegradable Multi-liposomal Containers
A. Efimova, A. Sybachin, S. N. Chvalun, A. I. Kulebyakina, E. V. Kozlova, A. Yaroslavov
Published 2015 · Chemistry
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The method of preparing biodegradable multi-liposomal containers via modification of anionic liposomes with a cationic polymer and subsequent adsorption of the obtained liposome-polymer cationic complex on the surfaces of negatively charged polylactide micelles with grafted polyoxyethylene chains is described. Liposomes preserve their integrity in a ternary micelle-polycation-liposome complex, a circumstance that allows the complex to be used as a multi-liposomal container for encapsulation of bioactive compounds.
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