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Cluster Headache And Herpes Simplex: An Association?
Published 1985 · Medicine
(6) It is also incorrect to state that our evaluation was based almost entirely on diary cards. Patients were seen regularly, and the information from the diary cards was used only as an additional source of information. (7) While it is true that confirmation of virological diagnosis was obtained in only one centre and although we would have preferred to have had virological confirmation in all cases, we believe that an experienced consultant dermatologist can recognise herpes labialis without undue difficulty. Difficulty in diagnosis is more likely to occur in immunocompromised patients, since lesions often present atypically and are slow to heal. We did not include such patients in our trial. Finally, we would agree with Dr Raborn's last point-that "the jury is still out." We were disappointed to find that acyclovir did not appear to be beneficial among patients in our series. However, in view of the fact that others have had more encouraging results, we ourselves suggested that "further large scale, double blind, placebo controlled parallel trials should be carried out."