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Effects Of Apolipoprotein E Genotype On Outcome After Ischaemic Stroke, Intracerebral Haemorrhage And Subarachnoid Haemorrhage

N. A. Martínez-González, C. Sudlow
Published 2006 · Medicine

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Background: Rodent models of acute ischaemic stroke and head injury suggest that apolipoprotein E (APOE) genotype influences neuronal repair, regeneration and survival after brain injury. Possession of an APOE ε4 allele is associated with poor outcome after head injury in clinical studies. APOE might therefore influence outcome after acute stroke in humans. Objective and methods: To comprehensively search, identify, assess and carry out meta-analyses of studies reporting on the association between APOE and the combined outcome of death or dependency, or death alone, several months after ischaemic stroke, intracerebral haemorrhage (ICH) or subarachnoid haemorrhage (SAH). Results: Main analyses included data from nine studies on 2262 patients (1453 with ischaemic stroke, 199 with ICH and 610 with SAH). Overall, ε4+ genotypes were not significantly associated with risk of death or dependency several months after stroke. However, there was significant heterogeneity between studies, and between the three pathological types of stroke. ε4+ genotypes were associated with increased death or dependency after SAH (relative risk (RR) 1.40, 95% confidence interval (CI) 1.06 to 1.84), with a trend towards a similar association with ICH (RR 1.38, 95% CI 0.99 to 1.92), but not with ischaemic stroke (RR 0.98, 95% CI 0.85 to 1.12). Results were similar for death alone. Conclusions: APOE may differentially affect outcome after the three main pathological types of stroke. Further, large studies are needed to confirm or refute these findings, and to assess the possibility of an interaction between the effects of APOE and age.
This paper references
10.1212/WNL.29.3.313
Microangiopathy of the brain and retina
John O. Susac (1979)
10.1126/SCIENCE.3283935
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
R. Mahley (1988)
10.1016/0306-4522(93)90456-P
Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats
J. Poirier (1993)
10.1016/0166-2236(94)90156-2
Apolipoprotein E in animal models of CNS injury and in alzheimer's disease
J. Poirier (1994)
Susac’s syndrome: the triad of microangiopathy of the brain and retina with hearing loss in young women
JO Susac (1994)
10.1016/S0140-6736(95)91411-0
ApoE genotype and survival from intracerebral haemorrhage
M. Alberts (1995)
Susac's syndrome: improvement with combined antiplatelet and calcium antagonist therapy.
B. Wildemann (1996)
The apolipoprotein E epsilon4 allele and outcome in cerebrovascular disease.
M. O. MCarron (1998)
10.1161/01.STR.29.9.1882
The Apolipoprotein E ε4 Allele and Outcome in Cerebrovascular Disease
M. McCarron (1998)
10.1136/bmj.316.7124.61
meta-analysis bias in location and selection of studies
M. Egger (1998)
10.1080/02688699908540619
Surgical intervention, biopsy and APOE genotype in cerebral amyloid angiopathy-related haemorrhage.
M. McCarron (1999)
10.1212/WNL.53.9.2176
Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes
M. McCarron (1999)
10.1007/978-3-7091-6391-7_15
Apolipoprotein E and the response of the brain to injury.
D. Graham (1999)
10.1016/S0197-4580(00)00097-X
The role of apolipoprotein E in Alzheimer’s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models
K. Horsburgh (2000)
10.1001/ARCHNEUR.57.10.1480
Prospective study of apolipoprotein E genotype and functional outcome following ischemic stroke.
M. McCarron (2000)
10.1034/j.1600-0404.2000.90308a.x
Apolipoprotein E polymorphism in cerebrovascular disease
A. Catto (2000)
10.1093/BRAIN/123.9.1784
Genetics and ischaemic stroke.
A. Hassan (2000)
10.1046/j.1365-2362.2001.00851.x
Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population
M. Macleod (2001)
10.1111/J.1442-2034.2001.98-13.X
APOLIPOPROTEIN E GENOTYPE AND OUTCOME IN ANEURYSMAL SUBARACHNOID HAEMORRHAGE
C. Leung (2001)
10.1161/01.STR.32.5.1181
Association of Apolipoprotein E Polymorphism With Outcome After Aneurysmal Subarachnoid Hemorrhage: A Preliminary Study
T. Niskakangas (2001)
10.1002/ana.1058
Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke
J. Broderick (2001)
10.1097/00008506-200110000-00019
The influence of apolipoprotein E genotype on outcome after spontaneous subarachnoid hemorrhage: a preliminary study.
D. Warner (2001)
10.1212/WNL.57.6.1097
Apolipoprotein E genotype, coagulation, and survival following acute stroke
C. Weir (2001)
Association of apolipoprotein E polymorphism with outcome after aneurysmal subarachnoid haemorrhage : a preliminary study
LT Dunn (2001)
10.1161/HS0202.102326
Apolipoprotein E Genotype and Outcome in Aneurysmal Subarachnoid Hemorrhage
C. Leung (2002)
10.1097/01.WCB.0000033200.58646.B3
Apolipoprotein E Polymorphism and Acute Ischemic Stroke: A Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging Study
Y. Liu (2002)
10.1093/AJE/155.6.487
Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review.
J. Eichner (2002)
Apolipoprotein E polymorphism and acute ischaemic stroke : a diffusion - and perfusion - weighted magnetic resonance imaging study
Y Liu (2002)
10.1016/S0003-9993(03)00043-1
Association between apolipoprotein E4 and rehabilitation outcome in hospitalized ischemic stroke patients.
I. Treger (2003)
10.1016/S0090-3019(03)00323-9
Apolipoprotein e ϵ4 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage
Jie Tang (2003)
10.1034/j.1600-0404.2003.01365.x
Effect of apolipoprotein E genotype on in‐hospital mortality following intracerebral haemorrhage
M. McCarron (2003)
Association between apolipoprotein E 4 and rehabilitation outcome in hospitalized ischaemic stroke patients
I Treger (2003)
Apolipoprotein E epsilon 4 and the risk of unfavorable outcome after aneurysmal subarachnoid haemorrhage
Y Zhao (2003)
10.1001/ARCHNEUR.61.11.1652
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
J. Casas (2004)
10.1016/J.MRI.2004.08.006
Susac syndrome: serial diffusion-weighted MR imaging.
M. S. Xu (2004)
10.1034/j.1600-0404.2003.00206.x
Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage
P. G. Morris (2004)
10.1007/s11910-004-0078-5
Not so accidental outcomes following cerebrovascular accidents
J. Meschia (2004)
10.1007/s00415-005-0661-y
Genes and outcome after aneurysmal subarachnoid haemorrhage
Y. Ruigrok (2005)
The association between APOE epsilon4, age and outcome after head injury: a prospective cohort study.
G. Teasdale (2005)
10.1097/01.ccx.0000155354.78617.91
Genetic influences on outcome following acute neurological insults
Ryan J. Waters (2005)
10.1093/BRAIN/AWH595
The association between APOE ε4, age and outcome after head injury : a prospective cohort study
G. Teasdale (2005)
10.1212/01.WNL.0000156523.77347.B4
APOE influences vasospasm and cognition of noncomatose patients with subarachnoid hemorrhage
L. Lanterna (2005)
10.1161/01.STR.0000199065.12908.62
Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls.
C. Sudlow (2006)
10.1097/01.wco.0000200545.37539.4e
Cerebral small vessel diseases: manifestations in young women
E. Ringelstein (2006)



This paper is referenced by
10.1016/j.archger.2021.104418
Sex differences in the association between the APOEε4 allele and hearing impairment: A longitudinal memory clinic study.
C. Kim (2021)
10.1097/EJA.0000000000001250
Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins
U. Dokkedal (2020)
10.3233/JAD-200747
APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid
M. Berger (2020)
10.1101/2020.06.30.20143578
APOE4 Copy Number-Dependent Proteomic changes in the Cerebrospinal Fluid
M. Berger (2020)
10.1097/AUD.0000000000000788
The Apolipoprotein Allele and Sensorineural Hearing Loss in Older Community-Dwelling Adults in Australia
J. Sarant (2019)
10.1212/WNL.0000000000008459
APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome
Cecilia Lagging (2019)
10.1007/s10072-019-04024-w
Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases
N. Math (2019)
10.1016/j.cortex.2018.03.025
APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
M. C. O'Donoghue (2018)
10.4037/aacnacc2018566
Genetics and Genomics of Acute Neurologic Disorders
M. Maserati (2018)
10.1016/j.bbr.2016.08.029
Factors affecting post-stroke motor recovery: Implications on neurotherapy after brain injury
A. Alawieh (2018)
enetic Influences on Neural Plasticity
Pearson-Fuhrhop (2018)
Development and assessment of in vitro simulation approaches to intracerebral haemorrhage
Apostolos Zarros (2017)
10.1055/s-0037-1607990
Aneurysmal Subarachnoid Hemorrhage: Strategies for Preventing Vasospasm in the Intensive Care Unit.
M. Diringer (2017)
10.1002/acn3.399
Apolipoprotein E mimetic peptide, CN‐105, improves outcomes in ischemic stroke
T. Tu (2017)
10.1016/j.jstrokecerebrovasdis.2017.07.028
Downregulation of Apolipoprotein-E and Apolipoprotein-J in Moyamoya Disease-A Proteome Analysis of Cerebrospinal Fluid.
D. Kashiwazaki (2017)
10.1016/j.mgene.2016.06.003
Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis
S. Arati (2016)
10.3389/fneur.2016.00069
BDNF Genotype Interacts with Motor Function to Influence Rehabilitation Responsiveness Poststroke
C. T. Shiner (2016)
10.4236/WJCD.2015.52006
Low Ankle Brachial Index in Acute Ischemic Stroke: Does ApoE Gene Polymorphism Have a Role?
S. El-Jaafary (2015)
10.1002/pbc.24768
Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy?
R. Caselli (2014)
10.3389/fnagi.2014.00154
The potential applications of Apolipoprotein E in personalized medicine
S. Villeneuve (2014)
10.1586/14737175.2014.915740
Understanding the cause of sporadic Alzheimer’s disease
H. Zetterberg (2014)
The effects of macronutrient composition of the larval diet on life history traits and pigmentation in Drosophila virilis
M. Rodrigues (2014)
10.1371/journal.pone.0114156
Genetic Variation at the BDNF Locus: Evidence for Association with Long-Term Outcome after Ischemic Stroke
T. Stanne (2014)
10.1016/j.pediatrneurol.2012.09.016
Genetic risk factors for perinatal arterial ischemic stroke.
A. Gelfand (2013)
10.1016/j.neurobiolaging.2013.05.009
Effects of APOE ɛ4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment
Hee Jin Kim (2013)
10.1111/j.1468-1331.2011.03615.x
Correlation between genetic polymorphisms and stroke recovery: Analysis of the GAIN Americas and GAIN International Studies
S. Cramer (2012)
10.4103/0028-3886.93581
Genetics of intracerebral hemorrhage: Insights from candidate gene approaches.
Bao-qiong Liu (2012)
10.1080/13803395.2011.642849
Neurocognitive correlates of nocturnal oxygen desaturation in a memory clinic population
K. Yamout (2012)
10.3892/mmr.2012.961
Correlation between ischemia-modified albumin and lipid levels in patients with acute cerebrovascular disease.
K. Han (2012)
10.1016/j.neurobiolaging.2012.04.001
Gene dose of apolipoprotein E and age-related hearing loss
C. Kurniawan (2012)
10.1001/archgenpsychiatry.2011.1893
Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults.
Lisa Nichols (2012)
10.1007/7854_2011_176
The role of diffusion tensor imaging in the study of cognitive aging.
O. Carmichael (2012)
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