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Time-dependent Effect Of Intensity Of Smoking And Of Occupational Exposure To Asbestos On The Risk Of Lung Cancer: Results From The ICARE Case–control Study

Emilie Lévêque, A. Lacourt, D. Luce, M. Sylvestre, P. Guénel, I. Stücker, K. Leffondré
Published 2018 · Medicine

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Objective To estimate the impact of intensity of both smoking and occupational exposure to asbestos on the risk of lung cancer throughout the whole exposure history. Methods Data on 2026 male cases and 2610 male controls came from the French ICARE (Investigation of occupational and environmental causes of respiratory cancers) population-based, case–control study. Lifetime smoking history and occupational history were collected from standardised questionnaires and face-to-face interviews. Occupational exposure to asbestos was assessed using a job exposure matrix. The effects of annual average daily intensity of smoking (reported average number of cigarettes smoked per day) and asbestos exposure (estimated average daily air concentration of asbestos fibres at work) were estimated using a flexible weighted cumulative index of exposure in logistic regression models. Results Intensity of smoking in the 10 years preceding diagnosis had a much stronger association with the risk of lung cancer than more distant intensity. By contrast, intensity of asbestos exposure that occurred more than 40 years before diagnosis had a stronger association with the risk of lung cancer than more recent intensity, even if intensity in the 10 years preceding diagnosis also had a significant effect. Conclusion Our results illustrate the dynamic of the effect of intensity of both smoking and occupational exposure to asbestos on the risk of lung cancer. They confirm that the timing of exposure plays an important role, and suggest that standard analytical methods assuming equal weights of intensity over the whole exposure history may be questionable.
This paper references
Low-dose exposure to asbestos and lung cancer: dose-response relations and interaction with smoking in a population-based case-referent study in Stockholm, Sweden.
P. Gustavsson (2002)
The Effect of Age at Smoking Initiation on Lung Cancer Risk
K. Hegmann (1993)
A flexible modeling approach to estimating the component effects of smoking behavior on lung cancer.
B. Rachet (2004)
Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: a flexible method applied to cigarette smoking and lung cancer in the SYNERGY Study.
Jelle Vlaanderen (2014)
Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature
Lene Snabe Nielsen (2014)
rP, et al. the effect of age at smoking initiation on lung cancer risk
Hegmann Kt (1993)
Serum Cotinine Level as Predictor of Lung Cancer Risk
P. Boffetta (2006)
Occupational exposure assessment in case–control studies: opportunities for improvement
K. Teschke (2002)
cigarette Smoking and lung cancer: Modeling total exposure and intensity. Cancer Epidemiology Biomarkers & Prevention 2006;15:517–23
JH 34lubin (2006)
Using tensor product splines in modeling exposure-time-response relationships: application to the Colorado Plateau Uranium Miners cohort.
K. Berhane (2008)
Flexible modeling of the cumulative effects of time-dependent exposures on the hazard.
M. Sylvestre (2009)
Quantifying the mediating effects of smoking and occupational exposures in the relation between education and lung cancer: the ICARE study
G. Menvielle (2016)
Matgéné: a program to develop job-exposure matrices in the general population in France.
J. Févotte (2011)
Follow-up study of chrysotile textile workers: cohort mortality and exposure-response
M. Hein (2007)
Flexible modeling of the cumulative effects of time-dependent exposures on the hazard.
M. Hauptmann (2011)
Exposure–response relationship between chrysotile exposure and mortality from lung cancer and asbestosis
Q. Deng (2011)
Hierarchical latency models for dose-time-response associations.
D. Richardson (2011)
Modeling smoking history: a comparison of different approaches.
K. Leffondré (2002)
Cancer incidence within a cohort occupationally exposed to asbestos: a study of dose–response relationships
B. Clin (2011)
Analysis of exposure-time-response relationships using a spline weight function.
M. Hauptmann (2000)
Multistage Carcinogenesis and Lung Cancer Mortality in Three Cohorts
W. Hazelton (2005)
Regression Models for the Effects of Exposure Rate and Cumulative Exposure
D. Richardson (2012)
Exposure–Response Analyses of Asbestos and Lung Cancer Subtypes in a Pooled Analysis of Case–Control Studies
A. Olsson (2017)
Keaney rP, et al. the effect of age at smoking initiation on lung cancer risk
Hegmann Kt (1993)
Accounting for outcome misclassification in estimates of the effect of occupational asbestos exposure on lung cancer death.
J. Edwards (2014)
Cigarette Smoking and Lung Cancer: Modeling Total Exposure and Intensity
J. Lubin (2006)
Lung cancer mortality in North Carolina and South Carolina chrysotile asbestos textile workers
L. Elliott (2012)
Lagging exposure information in cumulative exposure-response analyses.
D. Richardson (2011)
Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France
D. Luce (2011)
Lung cancer mortality and fibre exposures among North Carolina asbestos textile workers
D. Loomis (2009)
Levelling-off of the risk of lung and bladder cancer in heavy smokers: an analysis based on multicentric case-control studies and a metabolic interpretation.
P. Vineis (2000)
Modelling smoking history using a comprehensive smoking index: application to lung cancer.
K. Leffondré (2006)
Dose-time-response association between occupational asbestos exposure and pleural mesothelioma
A. Lacourt (2017)
The exposure-time-response relationship between occupational asbestos exposure and lung cancer in two German case-control studies.
M. Hauptmann (2002)
The use of sliding time windows for the exploratory analysis of temporal effects of smoking histories on lung cancer risk.
M. Hauptmann (2000)
The effect of smoking on the risk of lung cancer mortality for asbestos workers in Great Britain (1971-2005).
G. Frost (2011)
Temporal patterns of occupational asbestos exposure and risk of pleural mesothelioma
A. Lacourt (2011)
Performance of odds ratios obtained with a job-exposure matrix and individual exposure assessment with special reference to misclassification errors.
J. Bouyer (1995)
ec, Seidman H. latency of asbestos disease among insulation workers in the United States and canada
Selikoff iJ (1980)
Asbestos, asbestosis, pleural plaques and lung cancer.
G. Hillerdal (1997)
Dynamic aspects of exposure history-do they matter?
R. Vermeulen (2012)
Heavy smoking and lung cancer: Are women at higher risk? Result of the ICARE study
A. Papadopoulos (2014)
Harding aH. the effect of smoking on the risk of lung cancer mortality for asbestos workers in great Britain
Latency of asbestos disease among insulation workers in the United States and Canada
I. Selikoff (1980)
Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults
D. Kang (2013)
Absence of multiplicative interactions between occupational lung carcinogens and tobacco smoking: a systematic review involving asbestos, crystalline silica and diesel engine exhaust emissions
Mohamad El Zoghbi (2017)

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