Online citations, reference lists, and bibliographies.

A Review On Annona Squamosa L.: Phytochemicals And Biological Activities.

Chengyao Ma, Yayun Chen, Jianwei Chen, X. Li, Y. Chen
Published 2017 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Annona squamosa L. (Annonaceae) is a fruit tree with a long history of traditional uses. A. squamosa is an evergreen plant mainly located in tropical and subtropical regions. Srikayas, the fruits of A. squamosa, are extensively used to prepare candies, ice creams and beverages. A wide range of ethno-medicinal uses has been related to different portions of A. squamosa, such as tonic, apophlegmatisant, cool medicine, abortient and heart sedative. Numerous research projects on A. squamosa have found that it has anticancer, anti-oxidant, antidiabetic, antihypertensive, hepatoprotective, antiparasitic, antimalarial, insecticidal, microbicidel and molluscicidal activities. Phytochemistry investigations on A. squamosa have considered annonaceous acetogenins (ACGs), diterpenes (DITs), alkaloids (ALKs) and cyclopeptides (CPs) as the main constituents. Until 2016, 33 DITs, 19 ALKs, 88 ACGs and 13 CPs from this species were reported. On the basis of the multiple researches on A. squamosa, this review strives to integrate available information on its phytochemicals, folklore uses and bioactivities, hoping to promote a better understanding of its medicinal values.
This paper references
New bioactive annonaceous acetogenins from the bark of {\it Annona squamosa}, and the use of countercurrent chromatography for their isolation
D. C. Hopp (1997)
10.1016/J.CROPRO.2009.09.003
Effects of crude seed extracts of Annona atemoya and Annona squamosa L. against the cabbage looper, Trichoplusia ni in the laboratory and greenhouse
R. Seffrin (2010)
10.4268/CJCMM20121414
[Constituents from the bark of Annona squamosa and their anti-tumor activity].
Lirui Sun (2012)
10.1016/S0169-4758(99)01622-1
Chemotherapy for falciparum malaria: the armoury, the problems and the prospects.
P. Winstanley (2000)
10.1016/j.foodchem.2013.11.100
Anti-inflammatory cyclopeptides from exocarps of sugar-apples.
Ping Wu (2014)
10.1007/s13593-013-0180-7
Agroecological practices for sustainable agriculture. A review
A. Wezel (2013)
10.1021/np50118a021
(-)-Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug-resistance phenotype with cultured cells.
M. You (1995)
10.1016/j.jep.2012.05.019
Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds.
Y. Chen (2012)
10.1002/ptr.2650080611
Toxicity testing of organic solvent extracts from Annona squamosa: Effects on rabbit eyes and ear skin
N. Sookvanichsilp (1994)
10.1016/S0968-0896(98)00018-2
Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa.
D. C. Hopp (1998)
Oil-bearing plants of Zaire. III. Botanical families providing oils of relatively high unsaturation.
C. Kabele Ngiefu (1976)
10.1021/JF072594W
New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities.
Y. Yang (2008)
10.1039/B500186M
Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action.
A. Bermejo (2005)
10.1016/B978-0-12-375688-6.10052-0
Beneficial Aspects of Custard Apple (Annona squamosa L.) Seeds
Jianwei Chen (2011)
The hepatoprotective effect of alcoholic extract of Annona squamosa leaves on experimentally induced liver injury in Swiss albino mice.
Dominic S. C. Raj (2009)
10.1271/bbb1961.53.2719
Isolation and Structure of Neoannonin, a Novel Insecticidal Compound from the Seeds of Annona squamosa
K. Kawazu (1989)
10.1007/s00436-011-2671-2
Acaricidal, insecticidal, and larvicidal efficacy of fruit peel aqueous extract of Annona squamosa and its compounds against blood-feeding parasites
G. Madhumitha (2011)
Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats.
M. Kaleem (2006)
[Blocking actions of l-stephanine, xylopine and 7 other tetrahydroisoquinoline alkaloids on alpha adrenoceptors].
G. Q. Liu (1989)
10.1111/JFPP.12219
Phenolic Composition and Antioxidant Capacity of Wine Prepared from Custard Apple (Annona squamosa L.) Fruits
Umesh B. Jagtap (2015)
10.1016/S0031-9422(97)00917-5
Natural acetogenins from annonaceae, synthesis and mechanisms of action
M. C. Zafra-Polo (1998)
10.1016/S0031-9422(00)98511-X
Alkaloids from leaves of Annona squamosa
P. K. Bhaumik (1979)
10.1016/0031-9422(72)85042-8
Aporphine alkaloids of annona squamosa
D. S. Bhakuni (1972)
10.1007/s11655-014-1845-z
Anticancer effect of total annonaceous acetogenins on hepatocarcinoma
Run-mei Yang (2014)
10.1523/JNEUROSCI.1644-07.2007
Annonacin, a Natural Mitochondrial Complex I Inhibitor, Causes Tau Pathology in Cultured Neurons
M. Escobar-Khondiker (2007)
10.1016/S0031-9422(96)00829-1
Cyclopeptide from the seeds of Annona squamosa
L. Chao-ming (1997)
Antitumour activity of Annona squamosa seed extracts is through the generation of free radicals and induction of apoptosis.
B. V. Pardhasaradhi (2004)
10.1590/S0037-86822011000500007
Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil.
Nadja Soares Vila-Nova (2011)
10.1111/j.1744-7348.1940.tb07497.x
THE INSECTICIDAL PROPERTIES OF CERTAIN SPECIES OF ANNONA AND OF AN INDIAN STRAIN OF MUNDULEA SERICEA (“SUPLI”)
F. Tattersfield (1940)
10.1142/S0192415X16500762
A Chinese Herbal Decoction, Shaoyao-Gancao Tang, Exerts Analgesic Effect by Down-Regulating the TRPV1 Channel in a Rat Model of Arthritic Pain.
Feng Sui (2016)
10.1021/np200708q
Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa.
Y. Chen (2011)
10.1016/S0031-9422(02)00351-5
Squamocin-O(1) and squamocin-O(2), new adjacent bis-tetrahydrofuran acetogenins from the seeds of Annona squamosa.
H. Araya (2002)
10.1016/j.phytol.2008.11.006
Annonaceous acetogenins: Precursors from the seeds of Annona squamosa
Idensi Bajin ba Ndob (2009)
10.1016/S0140-6736(12)60034-8
Global malaria mortality between 1980 and 2010: a systematic analysis
C. Murray (2012)
10.1016/J.BMCL.2006.06.008
Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.
H. Morita (2006)
Pharmageddon: is it too late to tackle growing resistance to anti-infectives?
H. Adcock (2002)
10.3390/molecules180910465
Biological Activities and Phytochemicals of Swietenia macrophylla King
Soheil Zorofchian Moghadamtousi (2013)
Evaluation of mosquitocidal activity of Annona squamosa leaves against filarial vector mosquito, Culex quinquefasciatus Say.
A. Jaswanth (2002)
10.1039/C5MD00481K
Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature?
J. Glaser (2016)
10.1007/BF02703704
Differential cytotoxic effects ofAnnona squamosa seed extracts on human tumour cell lines: Role of reactive oxygen species and glutathione
B. Pardhasaradhi (2007)
Antioxidant activity of different parts from Annona squamosa, and Catunaregam nilotica methanolic extract.
A. Mariod (2012)
10.1080/14786419.2015.1055490
Four cytotoxic annonaceous acetogenins from the seeds of Annona squamosa
Y. Miao (2016)
10.1016/J.FITOTE.2005.04.002
Antimicrobial and cytotoxic constituents from the seeds of Annona squamosa.
M. Mukhlesur Rahman (2005)
10.1002/BIOF.5520310307
Antidiabetic and antioxidative effects of Annona squamosa leaves are possibly mediated through quercetin‐3‐O‐glucoside
S. Panda (2007)
10.1021/JM9700169
Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.
N. Oberlies (1997)
10.1142/S0192415X15500019
Traditional Chinese medicine formulas for irritable bowel syndrome: from ancient wisdoms to scientific understandings.
Hai-tao Xiao (2015)
10.1300/J044V08N01_04
Molluscicidal Activity of the Custard Apple (Annona squamosa L.) Alone and in Combination with Other Plant Derived Molluscicides
Amrita Singh (2001)
10.1016/S0140-6736(98)10166-6
Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study
D. Caparros-Lefebvre (1999)
Antimalarial alkaloids isolated from Annona squamosa
T R Johns (2011)
Acute and sub-acute toxicological evaluation of aqueous and ethanol fractions of Annona squamosa root a traditional medicinal herb
C. Ronald Darwin (2011)
10.1002/PS.414
Antimicrobial and pesticidal activity of partially purified flavonoids of Annona squamosa.
Hemlata M. Kotkar (2002)
10.1055/S-0032-1320684
Annonaceous acetogenins as environmental neurotoxins: Human exposure from edible Annona fruits
N. Bonneau (2012)
10.1016/0031-9422(95)00836-5
Acetogenins from Annonaceae, inhibitors of mitochondrial complex I.
M. C. Zafra-Polo (1996)
10.1016/j.jpba.2008.09.055
Supercritical fluid CO2 extraction and simultaneous determination of eight annonaceous acetogenins in Annona genus plant seeds by HPLC-DAD method.
Haijun Yang (2009)
10.1080/13880200490505438
Oral Antidiabetic Activity of Annona squamosa Leaf Alcohol Extract in NIDDM Rats
A. Shirwaikar (2004)
10.1021/np960416j
Identification of ent-16 beta, 17-dihydroxykauran-19-oic acid as an anti-HIV principle and isolation of the new diterpenoids annosquamosins A and B from Annona squamosa.
Y. Wu (1996)
Antioxidant activity of custard apple (Annona squamosa) peel and seed extracts
M. Seema (2008)
[Low Polar Constituents from Annona squamosa Fruit Pericarp].
Ya-yun Chen (2015)
10.1016/J.PHYTOL.2011.08.015
Monotetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa
Y. Chen (2012)
10.1016/j.phymed.2009.05.016
Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark.
M. Chavan (2010)
10.1080/10412905.2005.9698894
Composition of the Leaf Oil of Annona squamosa L. from the North Indian Plains
S. Garg (2005)
10.1016/S0024-3205(01)01209-7
Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction.
H. Chih (2001)
10.5962/bhl.title.137025
Indian Medicinal Plants
K. R. Kirtikar (2005)
Murihexocin C from the Leaves of Annona squamosa Linn. Induces Apoptosis in Human Colon Carcinoma Col 2 Cell Line
A. R. Mazahery (2009)
10.1080/10286020802682916
Two new cytotoxic acetogenins from Annona squamosa
Hai-Jun Yang (2009)
10.1080/10412905.2014.982876
Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
Cassio S Meira (2015)
10.1016/J.IJCAS.2013.08.005
New compound 6,7-dimethoxy-2-methylisoquinolinium from Indian medicinal plant Annona squamosa L.
Jayendra (2013)
10.1055/S-2005-871234
An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions.
Shang-Hsin Yeh (2005)
10.1080/14786410500138823
Major volatile constituents of Annona squamosa L. bark
M. Chavan (2006)
10.1016/j.bmcl.2015.10.090
Protective effects of 5,7,4'-trihydroxy-6,3'dimethoxy-flavone 5-O-α-l-rhamnopyranoside, isolated from Annona squamosa leaves in thyrotoxicosis and in hepatic lipid peroxidation in rats.
Sunanda Panda (2015)
10.3923/PJBS.2003.1593.1596
Toxicological Evaluation of Annotemoyin-1 Isolated from Annona squmosa Linn. on Long Evan?s Rats
M. S. Parvin (2003)
10.1016/j.fct.2013.05.028
Antitumor activity and toxicity relationship of annonaceous acetogenins.
Y. Chen (2013)
10.1016/S0378-8741(98)00129-9
Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell.
A. El Tahir (1999)
In: Fruits of warm climates
J. Morton (1987)
10.1006/JFCA.2000.0968
Chemical characterization of the fruit of Annona squamosa L. occurring in the amazon
E. Andrade (2001)
10.1021/np800191t
Paw paw and cancer: annonaceous acetogenins from discovery to commercial products.
J. McLaughlin (2008)
The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model.
Rasha Y M Ibrahim (2015)
10.1007/s00436-011-2457-6
Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India
C. Kamaraj (2011)
10.1142/S0192415X16500774
Rhamnella gilgitica Attenuates Inflammatory Responses in LPS-Induced Murine Macrophages and Complete Freund's Adjuvant-Induced Arthritis Rats.
Shan Huang (2016)
Dictionary of Indian medicinal plants
A. Husain (1992)
10.1111/j.1742-481X.2011.00924.x
Efficacy of Annona squamosa on wound healing in streptozotocin‐induced diabetic rats
T. Ponrasu (2012)
10.1128/CMR.12.4.564
Plant Products as Antimicrobial Agents
M. M. Cowan (1999)
10.1016/j.bmcl.2015.12.091
Alkenes with antioxidative activities from Murraya koenigii (L.) Spreng.
Qin-Ge Ma (2016)
10.1152/physrev.1979.59.3.527
Hydroperoxide metabolism in mammalian organs.
B. Chance (1979)
10.1079/IJT200416
Toxicity and antifeedant activity of crude seed extracts of Annona squamosa (Annonaceae) against lepidopteran pests and natural enemies
J. A. Leatemia (2004)
10.1007/s10600-010-9538-0
Annonaceous acetogenins from the seeds of Annona squamosa
X. Li (2010)
10.1016/j.expneurol.2009.08.004
Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies
M. Höllerhage (2009)
Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats.
M. Kaleem (2008)
10.3390/molecules14093621
Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
N. Kojima (2009)
10.1016/S0009-2797(99)00120-9
Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.
J. Tormo (1999)
Annona squamosa Linn: cytotoxic activity found in leaf extract against human tumor cell lines.
De-Shen Wang (2014)
Larvicidal and chemosterilant activity of Annona squamosa alkaloids against Anopheles stephensi.
R. C. Saxena (1993)
10.1021/jf203017f
Nematicidal and antifungal activities of annonaceous acetogenins from Annona squamosa against various plant pathogens.
Quang Le Dang (2011)
10.1016/j.jfda.2015.04.012
Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves.
Narasimharaju Kalidindi (2015)
10.1016/j.fitote.2011.09.019
N-Methyl-6, 7-dimethoxyisoquinolone in Annona squamosa twigs is the major immune modifier to elicit polarized Th1 immune response in BALB/c mice.
V. K. Soni (2012)
10.1021/np0704957
Mono-tetrahydrofuran annonaceous acetogenins from Annona squamosa as cytotoxic agents and calcium ion chelators.
C. Liaw (2008)
10.1016/J.JEP.2003.12.017
Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats.
A. Shirwaikar (2004)
10.1021/NP980406D
Annonaceous acetogenins: recent progress.
F. Alali (1999)
10.1002/HLCA.201200249
Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L.
Chang-xin Zhou (2013)
10.1142/S0192415X15500500
Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties.
Yi-Min Li (2015)
10.1080/14786419.2015.1022775
Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.)
Priyabrata Das (2016)
10.1078/0944-7113-00008
Molluscicidal properties of some species of Annona.
A. F. dos Santos (2001)
Hepatoprotective activity of Annona squamosa Linn. on experimental animal model
T. M. Saleem (2008)
10.1021/NP020191E
New ent-kaurane diterpenoids with anti-platelet aggregation activity from Annona squamosa.
Y. Yang (2002)
10.3390/ijms160715625
Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities
Soheil Zorofchian Moghadamtousi (2015)
10.1007/s10787-010-0061-5
Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark
Machindra Jayram Chavan (2010)
A New Cytotoxic Acetogenin from the Seeds of Annona squamosa
HaiHuiXIE (2003)
10.1016/S1071-5754(96)90047-9
Wound Fluids and the Pathogenesis of Chronic Wounds
A. Wysocki (1996)
10.1155/2014/124352
Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats
Thangavel Ponrasu (2014)
[Chemical constituents from the seeds of Annona squamosa].
J. Yu (2005)
10.1006/JMBI.1999.3383
Plant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif.
D. Craik (1999)
10.3329/JBS.V14I0.453
INSECTICIDAL ACTIVITY OF ANNONA SQUAMOSA L. SEED EXTRACTS AGAINST THE RED FLOUR BEETLE, TRIBOLIUM CASTANEUM (HERBST)
M. Khalequzzaman (2007)
10.1016/j.jep.2008.03.008
In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models.
R. Gupta (2008)
10.1016/j.bmcl.2014.12.088
Structure-activity relationships of diverse ACGs against multidrug resistant human lung cancer cell line A549/Taxol.
Fei Yuan (2015)
In vitro antioxidant studies of Annona squamosa Linn. leaves.
A. Shirwaikar (2004)
10.1016/j.fitote.2011.02.005
Anti-ulcer constituents of Annona squamosa twigs.
Dinesh Kumar Yadav (2011)
10.1016/S0040-4020(99)00372-5
Cyclosquamosins A – G, cyclic peptides from the seeds of Annona squamosa
H. Morita (1999)
10.1142/S0192415X14500025
Phytochemistry and biology of Loranthus parasiticus Merr, a commonly used herbal medicine.
Soheil Zorofchian Moghadamtousi (2014)
10.1142/S0192415X15500056
Apocynum venetum leaf attenuates myocardial ischemia/reperfusion injury by inhibiting oxidative stress.
Wenqing Wang (2015)



This paper is referenced by
10.1016/j.jep.2019.112187
Forest fevers: traditional treatment of malaria in the southern lowlands of Laos.
E. Elliott (2019)
10.1080/16878507.2020.1719329
Ex-vivo transdermal delivery of Annona squamosa entrapped in niosomes by electroporation
Amr A. Abd-Elghany (2020)
10.1080/15538362.2019.1621236
Molecular Approaches for the Improvement of Under-Researched Tropical Fruit Trees: Jackfruit, Guava, and Custard Apple
Vishwas Anant Bapat (2019)
10.1016/S1875-5364(19)30032-9
Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa.
Cheng-yao Ma (2019)
Study of chemical composition and larvicidal efficacy of secondary metabolites from aromatic phytoextracts against dengue vector: Aedes aegypti (Linn) (Diptera: Culicidae)
Mamta Goyal (2019)
10.32539/bsm.v3i4.102
The Anticancer Activity of Srikaya Leaves Fraction (Annona squamosa L.): An In Vitro Study
Makbruri Amin (2019)
10.1007/s00044-019-02425-2
Nitro derivatives and other compounds from sugar apple (Annona squamosa L.) leaves exhibit soluble epoxide hydrolase inhibitory activity
Hong Xu Li (2019)
10.1111/jocd.13223
Annona squamosa L. leaves inhibit alpha‐melanocyte‐stimulating hormone (α‐MSH) stimulated melanogenesis via p38 signaling pathway in B16F10 melanoma cells
Gyeong-A Ko (2019)
10.1007/978-981-13-7248-3_28
Fruits of Indian Subcontinent and Their Health Benefits
Jiwan S. Sidhu (2020)
10.1016/J.MSEC.2019.109756
Antibiotic potentiation and anti-cancer competence through bio-mediated ZnO nanoparticles.
Lakshmi Kalyani Ruddaraju (2019)
10.1007/978-3-030-31885-7_12
Annona squamosa: Phytochemical Constituents, Bioactive Compounds, Traditional and Medicinal Uses
Rasheeda Hamid Abdalla Ahmed (2019)
10.3390/molecules25030510
Bioactives from Agri-Food Wastes: Present Insights and Future Challenges
Sana Ben-Othman (2020)
10.29161/PT.v7.i1.2019.5
A Review on: Phytochemical and Pharmacological Study of Annona Squamosa
Diksha A Narwade (2019)
10.1016/j.jpba.2018.10.037
Non‐targeted metabolomic analysis on multidrug resistance hepatocellular carcinoma cell and reversal effect of annonaceous acetogenins
Chengyao Ma (2019)
Semantic Scholar Logo Some data provided by SemanticScholar