Online citations, reference lists, and bibliographies.
← Back to Search

Direct Effect Of CNS On Insulin Hypersecretion In Obese Zucker Rats: Involvement Of Vagus Nerve.

H. C. Lee, D. Curry, J. Stern
Published 1989 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
It is hypothesized that the vagus nerve makes a major contribution to pancreatic insulin hypersecretion in the genetically obese rat (fa/fa) via direct pancreatic innervation. An in situ brain-pancreas perfusion model with intact pancreatic central nervous system (CNS) innervation was used in these studies. The dynamics of insulin secretion in response to a 40-min glucose stimulus (200 mg/dl) was investigated in CNS intact (INT), bilateral cervical vagotomized (VGX), and CNS functionally ablated (ABL) 11- to 12-wk-old homozygous lean (Fa/Fa) and obese (fa/fa) female Zucker rats. The overall pattern of insulin secretory dynamics from obese and lean rats was similar. However, insulin released during the entire 40-min perfusion period by pancreata from obese rats was significantly greater than in lean rats. In lean rats, there was no significant difference in insulin secretion from pancreata of CNS-INT, VGX, and ABL rats. In obese rats, CNS-INT pancreata secreted almost twice as much insulin as pancreata from obese ABL rats and four times as much insulin as CNS-INT lean rats. This demonstrates that hypersecretion of insulin in obese Zucker rats is comprised of a significant direct CNS component. Although vagotomy had little effect on CNS-INT lean rats, it reversed the CNS component of hypersecretion present in CNS-INT obese rats. Because insulin secretion in CNS-INT obese rats was lowered by vagotomy to that equivalent to values of CNS-ABL obese rats, this demonstrates a significant contribution by the parasympathetic nervous system to the hyperinsulinemia seen in the Zucker obese rat that is attributed to direct parasympathetic innervation of the pancreas.
This paper references
10.1016/B978-0-12-027310-2.50012-8
Central nervous system regulation of insulin secretion.
F. Rohner-Jeanrenaud (1983)
10.1055/S-0028-1093529
Insulin and glucagon: plasma levels and pancreatic release in the genetically obese Zucker rat.
G. Bryce (1977)
10.3181/00379727-139-36078
Insulin Resistance and Pancreatic Insulin Release in the Genetically Obese Zucker Rat 1
J. Stern (1972)
10.1016/0026-0495(88)90152-7
Pancreatic hypersensitivity to glucose by young obese Zucker rats (fa/fa).
A. Kuffert (1988)
10.1016/0006-8993(81)90865-9
Defective catecholamine metabolism in peripheral organs of genetically obese zucker rats
B. Levin (1981)
10.1210/ENDO-101-1-203
Magnesium modulation of glucose-induced insulin secretion by the perfused rat pancreas.
D. Curry (1977)
10.1152/AJPLEGACY.1973.225.2.481
Direct enhancement of insulin secretion by vagal stimulation of the isolated pancreas.
R. Bergman (1973)
10.1210/ENDO-83-4-651
Stimulation of insulin secretion by parasympathomimetic agents.
A. Kaneto (1968)
10.1152/PHYSREV.1974.54.3.596
Neural control of the endocrine pancreas.
S. C. Woods (1974)
10.1210/endo-90-5-1320
Insulin and obesity in the Zucker genetically obese rat "fatty".
L. Zucker (1972)
Changes in the islets of langerhans in the obese Zucker rat.
L. Li (1977)
10.2337/diab.16.7.443
Effect of Vagotomy and Vagal Stimulation on Insulin Secretion
L. Frohman (1967)
10.1159/000145071
Study on the innervation of the pancreas of the rat.
I. Kamel (1979)
10.1210/ENDO-116-2-830
Involvement of the cholinergic system in insulin and glucagon oversecretion of genetic preobesity.
F. Rohner-Jeanrenaud (1985)
10.1210/ENDO-121-1-241
Synthesis-secretion coupling of insulin: effect of aging.
Curry Dl (1987)
10.1210/JCEM-33-5-732
Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays.
B. Desbuquois (1971)
10.1093/JN/114.8.1438
Effect of manganese deficiency on insulin secretion and carbohydrate homeostasis in rats.
Deborah L. Baly (1984)
10.1210/EDRV-2-4-471
Pancreatic neuroendocrinology: peripheral neural mechanisms in the regulation of the Islets of Langerhans.
R. E. Miller (1981)
10.1210/ENDO-80-3-530
Effects of stimulation of the vagus nerve on insulin secretion.
A. Kaneto (1967)
10.1016/0026-0495(85)90100-3
Dynamics of insulin hypersecretion by obese Zucker rats.
D. Curry (1985)
10.1210/ENDO-112-3-904
Increases in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve.
E. Ionescu (1983)



This paper is referenced by
10.1007/BF01818893
Insulin resistance and autonomic function in traumatic lower limb amputees
E. Peles (2005)
University of Groningen Overfeeding , autonomic regulation and metabolic consequences
A. Scheurink (2017)
10.1023/A:1021819318484
Autonomic Dysfunction of the β-Cell and the Pathogenesis of Obesity
R. Lustig (2004)
10.1007/978-1-60327-139-4_5
The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology
R. H. Lustig (2007)
10.1007/BF00120496
Overfeeding, autonomic regulation and metabolic consequences
A. Scheurink (2004)
10.1002/J.1550-8528.1993.TB00015.X
Tonic sympathetic nervous system inhibition of insulin secretion is diminished in obese Zucker rats.
H. C. Lee (1993)
10.1111/j.1365-2362.1994.tb01089.x
Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?
S. Dryden (1994)
10.1002/J.1550-8528.1995.TB00491.X
Energy homeostasis, autonomic activity and obesity.
A. Scheurink (1995)
10.3181/00379727-197-43238
Neural Regulation of Glucose-Stimulated Insulin Secretion in Younger and Older Fischer 344 Rats
D. Curry (1991)
10.1210/JC.2003-032094
Prolonged mild hyperglycemia induces vagally mediated compensatory increase in C-Peptide secretion in humans.
K. Teff (2004)
10.1002/9780813820637.ch5
Is insulin resistance a disorder of the brain?
U. Das (2011)
10.1038/sj.ijo.0800523
Cholinergic enhancement by pyridostigmine increases the insulin response to glucose load in obese patients but not in normal subjects
G Del Rio (1997)
10.1152/ajpendo.00565.2012
Intraportal GLP-1 stimulates insulin secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways.
M. Nishizawa (2013)
10.2337/diab.40.11.1423
Altered Neuropeptide Y Concentrations in Specific Hypothalamic Regions of Obese (fa/fa) Zucker Rats: Possible Relationship to Obesity and Neuroendocrine Disturbances
P. McKibbin (1991)
10.1007/978-3-319-15126-7_28
Taurine supplementation regulates pancreatic islet function in response to potentiating agents in leptin-deficient obese mice.
J. Santos-Silva (2015)
10.1080/10408440701215100
Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes
T. Wang (2007)
10.1111/j.1365-2362.1991.tb01417.x
Effects of muscarinic blockade on insulin secretion and on glucose‐induced thermogenesis in lean and obese human subjects
D. Schneeberger (1991)
10.1016/S0306-4522(97)00121-8
Role of hypothalamic neuropeptide Y neurons in the defective thermogenic response to acute cold exposure in fatty Zucker rats
C. Bing (1997)
10.4162/nrp.2008.2.4.240
Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats
Jeongsu Nam (2008)
10.1093/jn/121.7.1081
High Sucrose Diet and Exercise: Effects on Insulin-Receptor Function of 12- and 24-mo-old Sprague-Dawley Rats
K. C. Eiffert (1991)
10.1210/EDRV.22.5.0440
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function.
P. Gilon (2001)
10.3181/00379727-207-43793
Dietary Macronutrient Composition Influences Tissue Trace Element Accumulation in Diabetic Sprague-Dawley Rats
M. Oster (1994)
10.1016/0300-483X(93)90096-B
Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects.
M. Oster (1993)
10.1002/DMR.5610080302
Animal models of non-insulin-dependent diabetes.
E. Shafrir (1992)
10.1515/JPEM.2006.19.2.129
Dexamphetamine Use for Management of Obesity and Hypersomnolence Following Hypothalamic Injury
D. Ismail (2006)
10.1111/j.1365-2826.2007.01607.x
Reduced Expression of the KATP Channel Subunit, Kir6.2, is Associated with Decreased Expression of Neuropeptide Y and Agouti‐Related Protein in the Hypothalami of Zucker Diabetic Fatty Rats
A. Gyte (2007)
10.2337/diacare.13.6.655
Physiology and Pathophysiology of Insulin Secretion
H. Rasmussen (1990)
10.1016/j.physbeh.2017.03.036
Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans
S. Kullmann (2017)
10.1007/BF03347965
Effects of cholinergic blockade by pirenzepine on insulin and glucose response to oral and intravenous glucose and to arginine load in obesity
M. Maccario (1997)
10.1210/ENDO-128-6-2739
Hypersecretion of islet amyloid polypeptide from pancreatic islets of ventromedial hypothalamic-lesioned rats and obese Zucker rats.
Y. Tokuyama (1991)
10.1038/sj.ijo.0802558
Persistence of abnormal neural responses to a meal in postobese individuals
A. Delparigi (2004)
10.1016/B978-141604090-3.50024-7
CHAPTER 19 – Disorders of Energy Balance
R. Lustig (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar