Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effect Of Insulin On Utilization And Production Of Circulating Glucose.

J. Wall, R. Steele, R. C. De Bodo, N. Altszuler
Published 1957 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
C 14 glucose was adminisered continuously to unanesthetized normal dogs by intravenous infusion following a priming dose at a rate which maintained the specific activity of the circulating glucose at a nearly constant level. Glucagon-free insulin was then administered intravenously in varying doses. Samples of blood were collected at intervals throughout the experiment and more frequently just subsequent to insulin injection. The glucose concentration of the circulating blood and the specific activity of this glucose, when considered together, allow calculations to be made of a ) the outflow of glucose toward the tissue cells, and b ) the inflow of glucose from the liver during the period after insulin injection. By this means it was shown that increased glucose uptake by the tissues is much more important than decreased delivery of glucose by the liver in bringing about insulin-induced hypoglycemia. It was also shown that recovery from hypoglycemia is brought about by increased glucose delivery by the liver and not by a decrease in tissue uptake of glucose below the preinsulin level. Alternative methods of calculation of absolute values for glucose inflow and outflow during periods of changing blood glucose concentrations are discussed and evaluated.



This paper is referenced by
10.1152/AJPENDO.1994.266.3.E438
Role of glucagon in the metabolic response to stress hormone infusion in the conscious dog.
O. McGuinness (1994)
EVIDENCE FORA DIRECT IMMEDIATE EFFECT OF INSULIN ON THE BALANCE OF GLUCOSE ACROSS THE LIVER
B. Combes (2013)
10.1210/JCEM.86.8.7720
Sexual dimorphism in counterregulatory responses to hypoglycemia after antecedent exercise.
P. Galassetti (2001)
10.1152/AJPENDO.00566.2001
Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs.
S. Cardin (2002)
10.1152/AJPENDO.00059.2003
Glucagon's actions are modified by the combination of epinephrine and gluconeogenic precursor infusion.
S. Gustavson (2003)
10.1016/0002-9343(59)90226-8
On the nature of the metabolic defect(s) in diabetes.
J. Field (1959)
10.1152/ajpendo.1997.273.4.E674
Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog.
O. McGuinness (1997)
10.2337/db05-1359
Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation
R. McCrimmon (2006)
10.1016/0739-7240(86)90018-4
Effect of spontaneous hyperadrenocorticism on endogenous production and utilization of glucose in the dog
M. Peterson (1986)
10.1007/978-1-4684-5499-4_9
Effect of Exercise on Fuel Utilization and Insulin Requirements
M. P. Mclane (1988)
10.1016/S0083-6729(08)60511-7
The metabolic effects of growth hormone and their physiological significance.
R. C. De Bodo (1957)
10.1210/JCEM-58-6-973
The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes.
R. Bergenstal (1984)
10.1152/AJPENDO.1979.236.3.E263
Importance of hypoglycemia-induced glucose production during isolated glucagon deficiency.
A. Cherrington (1979)
10.1172/JCI109174
Effect of glucagon on glucose production during insulin deficiency in the dog.
A. Cherrington (1978)
10.1177/28.8.6255031
Polypeptide hormone receptors in vivo: demonstration of insulin binding to adrenal gland and gastrointestinal epithelium by quantitative radioautography.
J. Bergeron (1980)
10.1007/BF00275744
Role of glucagon suppression on gluconeogenesis during insulin treatment of the conscious diabetic dog
R. W. Stevenson (2004)
10.1152/AJPENDO.1993.264.5.E748
Effects of hyperinsulinemia on the subsequent hormonal response to hypoglycemia in conscious dogs.
S. Davis (1993)
10.1210/en.2010-0890
Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia.
Jonathan P. German (2011)
10.1152/AJPENDO.00244.2005
Effect of differing antecedent hypoglycemia on counterregulatory responses to exercise in type 1 diabetes.
P. Galassetti (2006)
10.2337/diab.36.3.382
Similar Dose Responsiveness of Hepatic Glycogenolysis and Gluconeogenesis to Glucagon In Vivo
R. W. Stevenson (1987)
10.2337/diab.9.5.356
Comparison of Plasma Insulin Levels Following Administration of Tolbutamide and Glucose
R. Yalow (1960)
10.2337/diab.22.7.537
Effect of Arginine on Glucose Turnover and Plasma Free Fatty Acids in Normal Dogs
A. Cherrington (1973)
10.2337/db09-0318
Application of Isotopic Techniques Using Constant Specific Activity or Enrichment to the Study of Carbohydrate Metabolism
A. Vella (2009)
10.1152/AJPENDO.00311.2004
Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes.
Deanna L Aftab Guy (2005)
10.1210/JC.2002-020757
Effect of gender on counterregulatory responses to euglycemic exercise in type 1 diabetes.
P. Galassetti (2002)
10.1152/AJPENDO.00340.2007
Antecedent short-term central nervous system administration of estrogen and progesterone alters counterregulatory responses to hypoglycemia in conscious male rats.
D. Sandoval (2007)
10.1016/0026-0495(90)90303-T
Chronic hyperinsulinemia decreases insulin action but not insulin sensitivity.
O. McGuinness (1990)
10.1172/JCI112847
Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog.
B. Adkins (1987)
10.1016/0003-2697(85)90210-6
Simultaneous determination of glucose turnover, alanine turnover, and gluconeogenesis in human using a double stable-isotope-labeled tracer infusion and gas chromatography-mass spectrometry analysis.
A. Martineau (1985)
10.2337/diab.31.10.917
Evidence for an Intrahepatic Contribution to the Waning Effect of Glucagon on Glucose Production in the Conscious Dog
A. Cherrington (1982)
10.2337/DIABETES.53.3.679
The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats.
D. Sandoval (2004)
10.2337/db09-0382
Effects of Differing Antecedent Increases of Plasma Cortisol on Counterregulatory Responses During Subsequent Exercise in Type 1 Diabetes
S. Bao (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar