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Modulation Of Laryngeal Responses To Superior Laryngeal Nerve Stimulation By Volitional Swallowing In Awake Humans.

J. Barkmeier, S. Bielamowicz, N. Takeda, C. Ludlow
Published 2000 · Medicine, Psychology

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Laryngeal sensori-motor closure reflexes are important for the protection of the airway and prevent the entry of foreign substances into the trachea and lungs. The purpose of this study was to determine how such reflexes might be modulated during volitional swallowing in awake humans, when persons are at risk of entry of food or liquids into the airway. The frequency and the amplitude of laryngeal adductor responses evoked by electrical stimulation of the internal branch of the superior laryngeal nerve (ISLN) were studied during different phases of volitional swallowing. Subjects swallowed water on command while electrical stimuli were presented to the ISLN at various intervals from 500 ms to 5 s following the command. Laryngeal adductor responses to unilateral ISLN stimulation were recorded bilaterally in the thyroarytenoid muscles using hooked wire electrodes. Early ipsilateral R1 responses occurred at 17 ms, and later bilateral R2 began around 65 ms. The muscle responses to stimuli occurring during expiration without swallowing were quantified as control trials. Responses to stimulation presented before swallowing, during the swallow, within 3 s after swallowing, and between 3 and 5 s after a swallow were measured. The frequency and amplitude of three responses (ipsilateral R1 and bilateral R2) relative to the control responses were compared across the different phases relative to the occurrence of swallowing. Results demonstrated that a reduction occurred in both the frequency and amplitude of the later bilateral R2 laryngeal responses to electrical stimulation for up to 3 s after swallowing (P = 0.005). The amplitude and frequency of ipsilateral R1 laryngeal responses, however, did not show a significant main effect following the swallow (P = 0.28), although there was a significant time by measure interaction (P = 0.006) related to reduced R1 response amplitude up to 3 s after swallowing (P = 0.021). Therefore, the more rapid and shorter unilateral R1 responses continued to provide some, albeit reduced, laryngeal protective functions after swallowing, whereas the later bilateral R2 responses were suppressed both in occurrence and amplitude for up to 3 s after swallowing. The results suggest that R2 laryngeal adductor responses are suppressed following swallowing when residues may remain in the laryngeal vestibule putting persons at increased risk for the entry of foreign substances into the airway.
This paper references
10.1007/PL00009594
Temporal and Durational Patterns Associating Respiration and Swallowing
Matthew S. Klahn (1999)
10.1016/S0194-5998(97)70025-1
Effects of stimulus intensity on laryngeal long latency responses in awake humans.
T. Yamashita (1997)
Expression of Foslike immunoreactivity in the laryngeal reflex pathway of the cat ’ s lower brainstem
Y. TANAKA (1996)
Dysphagia in movement disorders.
J. Logemann (1988)
Crossing inptus of the superior laryngeal nerve afferents top medullary swallowingrelated neurons in the cat
T. SUGIMOTO (1972)
10.1152/JN.1999.82.3.1529
Features of cortically evoked swallowing in the awake primate (Macaca fascicularis).
R. Martin (1999)
10.1016/S0006-8993(99)01151-8
Effects of functional disruption of lateral pericentral cerebral cortex on primate swallowing
N. Narita (1999)
10.1183/09031936.95.08071193
Neurophysiology of the cough reflex.
J. Widdicombe (1995)
10.11501/3131258
Characteristics of laryngeal receptors analyzed by presynaptic recording from the cat medulla oblongata(ネコ延髄内記録による喉頭粘膜知覚受容器特性の解析)
江崎秀夫 (1997)
10.1016/0006-8993(73)90217-5
Excitatory and inhibitory inputs to single neurones in the solitary tract nucleus and adjacent reticular formation.
B. Sessle (1973)
10.1152/JAPPL.1996.81.4.1707
Coordination of breathing and swallowing: effects of bolus consistency and presentation in normal adults.
H. Preiksaitis (1996)
10.3950/JIBIINKOKA.93.938
[Reflex control on laryngeal functions--vibration effect of the laryngeal mucosa on recurrent laryngeal nerve reflexes].
A. Mochida (1990)
10.1152/JN.1997.78.3.1516
Functional properties of neurons in the primate tongue primary motor cortex during swallowing.
R. Martin (1997)
10.1016/0003-9993(94)90393-X
Laryngeal movement, oropharyngeal pressure, and submental muscle contraction during swallowing.
J. L. Schultz (1994)
10.1159/000118856
Brainstem organization of the swallowing network.
A. Jean (1984)
The swallowing side effects of botulinum toxin type A injection in spasmodic dysphonia.
D. Buchholz (1997)
Expression of Fos-like immunoreactivity in the laryngeal reflex pathway of the cat's lower brainstem
Y Tanaka (1996)
10.1152/AJPREGU.1992.263.3.R624
Coordination of respiration and swallowing: effect of bolus volume in normal adults.
H. Preiksaitis (1992)
10.1016/S1052-3057(96)80018-8
Lesion site in unilateral stroke patients with dysphagia.
B. Jacobson (1996)
10.1152/JAPPL.1988.65.3.1007
Afferent neural pathways in cough and reflex bronchoconstriction.
J. Karlsson (1988)
10.1016/0003-9969(72)90045-3
Periodontal and facial influences on the laryngeal input to the brain stem of the cat.
B. Sessle (1972)
10.1016/S0194-5998(99)70285-8
Behaviors of Bulbar Respiratory Interneurons during Fictive Swallowing and Vomiting
K. Nakazawa (1999)
Crossing inptus of the superior laryngeal nerve afferents top medullary swallowingrelated neurons in the cat
Sugimoto (1998)
10.1044/JSHR.1202.362
Use of hooked-wire electrodes for electromyography of the intrinsic laryngeal muscles.
M. Hirano (1969)
10.1113/jphysiol.1987.sp016625
Quantitative analysis of laryngeal mechanosensitivity in the cat and rabbit.
P. Davis (1987)
10.1177/000348949910800615
Laryngeal Long Latency Response Conditioning in Abductor Spasmodic Dysphonia
Frederic W.-B. Deleyiannis (1999)
10.1177/000348949510401203
Abnormalities in Long Latency Responses to Superior Laryngeal Nerve Stimulation in Adductor Spasmodic Dysphonia
C. Ludlow (1995)
10.1017/S0022215100129196
Expression of Fos-protein activated by tactile stimulation on the laryngeal vestibulum in the cat's lower brain stem.
Y. Tanaka (1995)
10.1016/S0166-2236(97)01212-5
Gut feelings about recovery after stroke: the organization and reorganization of human swallowing motor cortex
S. Hamdy (1998)
10.1016/S0168-0102(98)00004-2
Crossing inputs of the superior laryngeal nerve afferents to medullary swallowing-related neurons in the cat
Toshihiko Sugimoto (1998)
10.1038/nm1196-1217
The cortical topography of human swallowing musculature in health and disease
S. Hamdy (1996)
10.1152/AJPGI.1992.262.2.G338
Closure mechanisms of laryngeal vestibule during swallow.
J. Logemann (1992)
10.1152/JAPPL.1999.86.5.1663
Electromyographic activity from human laryngeal, pharyngeal, and submental muscles during swallowing.
A. Perlman (1999)
Mechanism of cough and its regulation.
Widdicombe Jg (1980)
10.1016/0165-1838(84)90017-1
Control of the central swallowing program by inputs from the peripheral receptors. A review.
A. Jean (1984)
10.1002/ANA.410190310
Swallowing and speech production in Parkinson's disease
J. Robbins (1986)
10.1177/000348949210100204
Characteristics of Late Responses to Superior Laryngeal Nerve Stimulation in Humans
C. Ludlow (1992)
10.1001/ARCHOTOL.1976.00780120048004
Laryngeal reflexes in cat, dog, and man.
C. Sasaki (1976)
10.1016/0006-8993(73)90218-7
Presynaptic excitability changes induced in single laryngeal primary afferent fibres.
B. Sessle (1973)
10.1152/JAPPL.1994.76.2.714
Coordination between respiration and swallowing: respiratory phase relationships and temporal integration.
B. J. Martin (1994)
10.1016/S0140-6736(97)02068-0
Explaining oropharyngeal dysphagia after unilateral hemispheric stroke
S. Hamdy (1997)
10.1097/00001756-199806010-00022
Medullary swallowing‐related neurons in the anesthetized cat
T. Umezaki (1998)
10.1523/JNEUROSCI.17-23-09340.1997
Differential Brainstem Fos-Like Immunoreactivity after Laryngeal-Induced Coughing and Its Reduction by Codeine
C. Gestreau (1997)
Dysphagia in movement disorders.
Logemann Ja (1988)
10.1001/ARCHNEUR.1991.00530230078026
Dysphagia following brain-stem stroke. Clinical correlates and outcome.
J. Horner (1991)
10.1044/JSHR.3204.749
Electrical activity from the superior pharyngeal constrictor during reflexive and nonreflexive tasks.
A. L. Perlman (1989)



This paper is referenced by
10.1179/016164107X171555
Electric stimulation approaches to the restoration and rehabilitation of swallowing: a review
C. Steele (2007)
10.1097/WNP.0000000000000187
Laryngeal Reflexes: Physiology, Technique, and Clinical Use
C. Ludlow (2015)
10.1007/978-1-4614-4466-4
Craniofacial Muscles
L. McLoon (2013)
10.1121/1.3575593
Laryngeal electromyographic responses to perturbations in voice pitch auditory feedback.
H. Liu (2011)
10.1152/JN.00064.2004
Neuronal activation in the medulla oblongata during selective elicitation of the laryngeal adductor response.
R. Ambalavanar (2004)
10.1007/s00455-019-09980-1
Relationship Between Laryngeal Sensation, Length of Intubation, and Aspiration in Patients with Acute Respiratory Failure
James C. Borders (2019)
10.1007/s00455-010-9301-5
Sensory Input Pathways and Mechanisms in Swallowing: A Review
C. Steele (2010)
10.1007/978-1-4614-4466-4_10
Motor Control and Biomechanics of Laryngeal and Pharyngeal Muscles
C. Ludlow (2012)
10.1016/S1349-0079(07)80030-2
Relation between Bolus Size and Hyoid Movement during Normal Ingestion in Humans
Miwako Honma (2007)
10.1016/j.exger.2012.07.008
Effects of aging and levodopa on the laryngeal adductor reflex in rats
Xin Feng (2012)
10.1152/JAPPLPHYSIOL.00417.2002
Mucosal afferents mediate laryngeal adductor responses in the cat.
R. Andreatta (2002)
10.1152/JN.00595.2001
Selective suppression of late laryngeal adductor responses by N-methyl-D-aspartate receptor blockade in the cat.
R. Ambalavanar (2002)
10.1177/000348941112001110
Neuronal Mechanisms Underlying the Laryngeal Adductor Reflex
Qi-Jian Sun (2011)
10.1007/s00221-008-1529-z
Reflexive and volitional voice fundamental frequency responses to an anticipated feedback pitch error
T. Burnett (2008)
10.1177/0003489419901145
Inter- and Intra-Rater Reliability of Laryngeal Sensation Testing with the Touch Method During Flexible Endoscopic Evaluations of Swallowing
James C Borders (2020)
10.1016/S1632-3475(15)72752-9
Fisiología de la deglución normal
Franck Marmouset (2015)
10.1016/j.resp.2019.103351
Reflex swallowing elicited by electrical stimulation in obstructive sleep apnea patients: a preliminary study
Mohammed T. Mousa (2019)
Tele-rehabilitacioåln en la disfagia orofariålngea: un nuevo paradigma para tratar y empoderar a nuestros pacientes
H. B. Ambrós (2015)
10.2399/ana.15.005
Reflex influences on oropharyngeal swallowing
Cumhur Ertekin (2015)
10.1016/S0034-5687(00)00205-X
Central nervous pathways and control of the airways.
D. Jordan (2001)
10.1007/s00455-020-10126-x
The Effect of Cranial Nerve Stimulation on Swallowing: A Systematic Review
Michelle Florie (2020)
10.1007/978-3-211-33079-1_40
Neuroprostheses for management of dysphagia resulting from cerebrovascular disorders.
D. Tyler (2007)
Role of the Internal Superior Laryngeal Nerve in the Motor Responses of Vocal Cords and the Related Voice Acoustic Changes
Sadegh Seifpanahi (2016)
10.1007/s00455-009-9232-1
A Mouse Model of Pharyngeal Dysphagia in Amyotrophic Lateral Sclerosis
T. Lever (2009)
10.1007/s00405-017-4619-3
Effects of transcutaneous electrical stimulation on vocal folds adduction
Sadegh Seifpanahi (2017)
10.1007/978-1-4614-3794-9_56
Electrical Stimulation Treatment
C. Ludlow (2013)
10.1007/s00455-010-9319-8
Voluntary Versus Spontaneous Swallowing in Man
C. Ertekin (2010)
10.1016/j.resp.2005.04.015
Central nervous system control of the laryngeal muscles in humans
C. Ludlow (2005)
10.14814/phy2.12752
Orosensory contributions to dysphagia: a link between perception of sweet and sour taste and pharyngeal delay time
B. Pauloski (2016)
10.1002/lary.27249
Unearthing a consistent bilateral R1 component of the laryngeal adductor reflex in awake humans
M. Téllez (2018)
Title : Electrical stimulation approaches to the restoration and rehabilitation of swallowing : A review . Running Title : Electrical stimulation of swallowing
C. Steele (2008)
10.1002/lary.28642
The Internal Superior Laryngeal Nerve in Humans: Evidence for Pure Sensory Function.
Laura F Santoso (2020)
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