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Expression Of Fos Andjun Genes In Human Skeletal Muscle After Exercise

A. Puntschart, E. Wey, K. Jostarndt, M. Vogt, M. Wittwer, H. R. Widmer, H. Hoppeler, R. Billeter

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It is believed that the induction of the fos and jun gene family of transcription factors might be at the origin of genetic events leading to the differential regulation of muscle-specific genes. We have investigated the effect of a 30-min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families, including c- fos, fosB, fosBdel, fra-1, and fra-2 as well as c- jun, junB, and junD. While the fos family members were transiently upregulated 10- to 20-fold (an exception being fra-2), the induction of the jun family members was up to 3-fold only. The induction of c- fos could also be demonstrated at the protein level. Both c- fos and c- jun mRNAs were coinduced in muscle fiber nuclei. The induction was not restricted to a particular fiber type, as expected from established muscle fiber recruitment schemes, but followed a “patchy” pattern confined to certain regions of the muscle. The signals leading to the expression of these immediate early genes are therefore unclear.