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Stent Design Properties And Deployment Ratio Influence Indexes Of Wall Shear Stress: A Three-dimensional Computational Fluid Dynamics Investigation Within A Normal Artery.

John F. LaDisa, Lars E. Olson, Ismail Guler, Douglas A. Hettrick, Said H. Audi, Judy R. Kersten, David C. Warltier, Paul S. Pagel
Published 2004 · Chemistry, Medicine
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Restenosis limits the effectiveness of stents, but the mechanisms responsible for this phenomenon remain incompletely described. Stent geometry and expansion during deployment produce alterations in vascular anatomy that may adversely affect wall shear stress (WSS) and correlate with neointimal hyperplasia. These considerations have been neglected in previous computational fluid dynamics models of stent hemodynamics. Thus we tested the hypothesis that deployment diameter and stent strut properties (e.g., number, width, and thickness) influence indexes of WSS predicted with three-dimensional computational fluid dynamics. Simulations were based on canine coronary artery diameter measurements. Stent-to-artery ratios of 1.1 or 1.2:1 were modeled, and computational vessels containing four or eight struts of two widths (0.197 or 0.329 mm) and two thicknesses (0.096 or 0.056 mm) subjected to an inlet velocity of 0.105 m/s were examined. WSS and spatial WSS gradients were calculated and expressed as a percentage of the stent and vessel area. Reducing strut thickness caused regions subjected to low WSS (<5 dyn/cm(2)) to decrease by approximately 87%. Increasing the number of struts produced a 2.75-fold increase in exposure to low WSS. Reducing strut width also caused a modest increase in the area of the vessel experiencing low WSS. Use of a 1.2:1 deployment ratio increased exposure to low WSS by 12-fold compared with stents implanted in a 1.1:1 stent-to-vessel ratio. Thinner struts caused a modest reduction in the area of the vessel subjected to elevated WSS gradients, but values were similar for the other simulations. The results suggest that stent designs that reduce strut number and thickness are less likely to subject the vessel to distributions of WSS associated with neointimal hyperplasia.
This paper references
A focal stress gradient-dependent mass transfer mechanism for atherogenesis in branching arteries.
M Lei (1996)
The effect of proximal artery flow on the hemodynamics at the distal anastomosis of a vascular bypass graft: computational study.
S M Kute (2001)
Coronary artery stretch versus deep injury in the development of in-stent neointima
Julian Gunn (2002)
Acute changes in aortic wall mechanical properties after stent placement in rabbits.
Hélène Vernhet (2000)
Shear stress downregulation of platelet-derived growth factor receptor-beta and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration.
Renato Palumbo (2000)
Stent design: implications for restenosis.
McLean Dr (2002)
A comparison of balloon-expandible-stent implantation with balloon angioplasty in patients with coronary heart disease
P Serruys (1994)
Control of the shape of a thrombus-neointima-like structure by blood shear stress.
Shu Q. Liu (2002)
Does stent design affect probability of restenosis? A randomized trial comparing Multilink stents with GFX stents.
Yuji Yoshitomi (2001)
Role of blood shear stress in the regulation of vascular smooth muscle cell migration
Shu Q. Liu (2001)
Stent endothelialization. Time course, impact of local catheter delivery, feasibility of recombinant protein administration, and response to cytokine expedition.
Éric Van Belle (1997)
Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics.
Ender A. Finol (2001)
A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators.
David L Fischman (1994)
Geometric design improvements for femoral graft-artery junctions mitigating restenosis.
M Lei (1996)
Shear stress gradients remodel endothelial monolayers in vitro via a cell proliferation-migration-loss cycle.
Yanik Tardy (1997)
Spatial and temporal variations of wall shear stress within an end-to-side arterial anastomosis model.
Maheswar Ojha (1993)
Hemodynamic parameters and early intimal thickening in branching blood vessels.
Clement Kleinstreuer (2001)
Flow through internal elastic lamina affects shear stress on smooth muscle cells (3D simulations).
Shigeru Tada (2002)
Stent and artery geometry determine intimal thickening independent of arterial injury.
Joseph M. Garasic (2000)
Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation: Positive Correlation between Plaque Location and Low and Oscillating Shear Stress
David N. Ku (1985)
Stent Implantation Alters Coronary Artery Hemodynamics and Wall Shear Stress During Maximal Vasodilation.
John F. LaDisa (2002)
Influence of topography on endothelialization of stents: clues for new designs.
Clayton D. Simon (2000)
Pattern Formation of Vascular Smooth Muscle Cells Subject to Nonuniform Fluid Shear Stress: Role of Platelet-Derived Growth Factor β-Receptor and Src
Shu Q. Liu (2003)
Three-Dimensional Computational Fluid Dynamics Modeling of Alterations in Coronary Wall Shear Stress Produced by Stent Implantation
John F. LaDisa (2004)
Hemodynamic shear stress and its role in atherosclerosis.
Adel M. Malek (1999)
Computational fluid dynamics and stent design.
Andreas O. Frank (2002)
Introduction to fluid mechanics
Robert Were Fox (1985)
Experimental and Computational Flow Evaluation of Coronary Stents
Joel L. Berry (2000)
Experimental study of laminar blood flow through an artery treated by a stent implantation: characterisation of intra-stent wall shear stress.
Nicolas Bénard (2003)
Impact of the cross-sectional geometry of the post-deployment coronary stent on in-stent neointimal hyperplasia: an intravascular ultrasound study.
Takashige Murata (2002)
Tissue proliferation within and surrounding Palmaz-Schatz stents is dependent on the aggressiveness of stent implantation technique.
Rainer Hoffmann (1999)
A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group.
P. W. Serruys (1994)
David N. Ku (1997)
Long-term endothelial dysfunction is more pronounced after stenting than after balloon angioplasty in porcine coronary arteries.
Heleen M. M. van Beusekom (1998)
Connecting signaling and cell cycle progression in growth factor-stimulated cells
Steven Michael Jones (2000)
Coronary stent symmetry and vascular injury determine experimental restenosis
Christian Schulz (2000)
Effect of Endothelial Shear Stress on the Progression of Coronary Artery Disease, Vascular Remodeling, and In-Stent Restenosis in Humans: In Vivo 6-Month Follow-Up Study
Peter Stone (2003)
Patterns and mechanisms of in-stent restenosis. A serial intravascular ultrasound study.
Rainer Hoffmann (1996)
Hemodynamics and wall mechanics of a compliance matching stent: in vitro and in vivo analysis.
Joel L. Berry (2002)
ACC Expert Consensus document on coronary artery stents. Document of the American College of Cardiology.
David R. Holmes (1998)
Endovascular stent design dictates experimental restenosis and thrombosis.
C Rogers (1995)
Balloon-artery interactions during stent placement: a finite element analysis approach to pressure, compliance, and stent design as contributors to vascular injury.
C Rogers (1999)
Vascular smooth muscle growth: autocrine growth mechanisms.
Bradford C. Berk (2001)
Pattern formation of vascular smooth muscle cells subject to nonuniform fluid shear stress: mediation by gradient of cell density.
Shu Q. Liu (2003)
Factors Influencing Blood Flow Patterns in the Human Right Coronary Artery
Jerry G. Myers (2004)
Open-cell design stents in congenital heart disease: a comparison of IntraStent vs. Palmaz stents.
Jacqueline N Kreutzer (2002)
Effects of vascular stent surface area and hemodynamics on intimal thickening.
V S Newman (1996)
Restenosis after coronary placement of various stent types.
Adnan Kastrati (2001)
Fluid wall shear stress measurements in a model of the human abdominal aorta: oscillatory behavior and relationship to atherosclerosis.
James E. Moore (1994)
Pathology of acute and chronic coronary stenting in humans.
Andrew Farb (1999)
Vascular endothelium responds to fluid shear stress gradients.
Natacha Depaola (1992)
Shear stress downregulation of platelet-derived growth factor receptor- and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration. Circulation
R Palumbo (2000)

This paper is referenced by
Microfocal X-ray computed tomography post-processing operations for optimizing reconstruction volumes of stented arteries during 3D computational fluid dynamics modeling
John F. LaDisa (2005)
models3D computational fluid dynamics implantation alters wall shear stress evaluated with Circumferential vascular deformation after stent
David C. Warltier (2015)
The Influence of Stent Geometry on Haemodynamics and Endothelialisation
Luke Boldock (2017)
Papel de la tensión de cizallamiento en la enfermedad aterosclerótica y la reestenosis tras implantación de stent coronario
Rosaire Mongrain (2006)
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Laura Ellwein (2011)
Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations
Susann Beier (2015)
The evolution of an ideal stent design and its impact on the aortic endothelium during and after percutaneous replacement
Gideon V Praveen Kumar (2010)
Nonaortic Stents and Stent-Grafts
Benjamin J. Pearce (2010)
Simulation based planning of surgical interventions in pediatric cardiology.
Alison L. Marsden (2013)
Eluting combination drugs from stents.
Rajesh Thipparaboina (2013)
Hemodynamics of Aortas with Multiple Overlapping Endografts: A New Design Consideration
Han Song Li (2017)
Three-dimensional numerical simulation of blood flow in two coronary stent
Franco Gori (2015)
Measurement and modeling of coronary blood flow.
Matthew Sinclair (2015)
A Numerical Methodology to Fully Elucidate the Altered Wall Shear Stress in a Stented Coronary Artery
ERGAL (2019)
Bioabsorbable stenting in peripheral artery disease.
George Galyfos (2015)
Etude numérique et expérimentale du transfert de masse, par advection et diffusion en écoulement pulsé, sur des stents actifs.
Fatiha Chabi (2016)
Flow Velocity, Fluid Dynamics and Vascular Pathophysiology
Rao Gundu Hr (2016)
Haemodynamic effects of incomplete stent apposition in curved coronary arteries.
Winson X Chen (2017)
Influence of strut cross-section of stents on local hemodynamics in stented arteries
Yongfei Jiang (2016)
Stent Design for Compensating Wall Shear Stress via Computational Modeling and Fluid Dynamics
Chun-Ming Chang (2016)
Flow in the Vascular System Post Stent Implantation: Examining the Near-Stent Flow Physics
Chekema Prince (2012)
Three-dimensional numerical simulation of a failed coronary stent implant at different degrees of residual stenosis. Part I: Fluid dynamics and shear stress on the vascular wall
Ivan Di Venuta (2017)
Finite element analysis of balloon-expandable coronary stent deployment: influence of angioplasty balloon configuration.
David Moral Martín (2013)
Impact of Stent Design on In-Stent Stenosis in a Rabbit Iliac Artery Model
Christof M. Sommer (2009)
Stents for intracranial wide-necked aneurysms: more than mechanical protection
Isabel Wanke (2008)
The role of shear stress in the pathogenesis of atherosclerosis
Kristopher S. Cunningham (2005)
Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear stress: analysis of a curved coronary artery using 3D computational fluid dynamics modeling
John F. LaDisa (2006)
Three-Dimensional CFD Analysis of the Hemodynamic Effect of Different Stent-to-Artery Deployment Ratios
Azadeh Lotfi (2014)
Optimization of Drug-Eluting Stents
Franz Bozsak (2013)
Local hemodynamic changes caused by main branch stent implantation and subsequent virtual side branch balloon angioplasty in a representative coronary bifurcation.
Andrew Robert Williams (2010)
Laminar and Transitional Flow disturbances in Diseased and Stented Arteries
Satyaprakash Karri (2009)
[The role of haemodynamic factors in the development of in-stent restenosis].
Jarosław P. Wasilewski (2012)
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