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Biodistribution Of60Co–Co/Graphitic-Shell NanocrystalsIn Vivo

Li Zhan, Qi Wei, Geng Yanxia, Xu Junzheng, Wu Wangsuo

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The magnetic nano-materials, Co/graphitic carbon- (GC-) shell nanocrystals, were madeviachemicalvapour deposition (CVD) method, and their biodistribution and excretion in mice were studied by using postintravenously (i.v.) injecting with60Co–Co/GC nanocrystals. The results showed that about 5% of Co was embedded into graphitic carbon to form multilayer Co/GC nanocrystals and the size of the particle was ~20 nm, the thickness of the nanocrystal cover layer was ~4 nm, and the core size of Co was ~14 nm. Most of the nanocrystals were accumulated in lung, liver, and spleen after 6, 12, 18, and 24 h afteri.v.with60Co–Co/GC nanocrystals. The nanoparticles were cleared rapidly from blood and closed to lower level in 10 min after injection. The60Co–Co/GC nanocrystals were eliminated slowly from body in 24 h after injection, ~6.09% of60Co–Co/GC nanocrystals were excreted by urine, ~1.85% by feces in 24 h, and the total excretion was less than 10%.