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Indole Alkaloids From Marine Sources As Potential Leads Against Infectious Diseases

Paulo H. B. França, Daniel P. Barbosa, Daniel L. da Silva, Êurica A. N. Ribeiro, Antônio E. G. Santana, Bárbara V. O. Santos, José M. Barbosa-Filho, Jullyana S. S. Quintans, Rosana S. S. Barreto, Lucindo J. Quintans-Júnior, João X. de Araújo-Júnior

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Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.