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Protein Based Nanostructures For Drug Delivery

D. Verma, Neha Gulati, Shreya Kaul, S. Mukherjee, Upendra Nagaich
Published 2018 · Chemistry, Medicine

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The key role of protein based nanostructures has recently revolutionized the nanomedicine era. Protein nanoparticles have turned out to be the major grounds for the transformation of different properties of many conventional materials by virtue of their size and greater surface area which instigates them to be more reactive to some other molecules. Protein nanoparticles have better biocompatibilities and biodegradability and also have the possibilities for surface modifications. These nanostructures can be synthesized by using protein like albumin, gelatin, whey protein, gliadin, legumin, elastin, zein, soy protein, and milk protein. The techniques for their fabrication include emulsification, desolvation, complex coacervation, and electrospray. The characterization parameters of protein nanoparticles comprise particle size, particle morphology, surface charge, drug loading, determination of drug entrapment, and particle structure and in vitro drug release. A plethora of protein nanoparticles applications via different routes of administration are explored and reported by eminent researchers which are highlighted in the present review along with the patents granted for protein nanoparticles as drug delivery carriers.
This paper references
10.4103/2230-973X.82432
Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer
AV Jithan (2011)
10.1515/ntrev-2016-0009
Gelatin nanoparticles: a potential candidate for medical applications
Rehana Yasmin (2016)
Microencapsulation of cholecalciferol by coacervation
J. Sawicka (1990)
10.2174/187152006778699130
Recent developments in polymeric nanoparticle engineering and their applications in experimental and clinical oncology.
S. Moghimi (2006)
10.1186/1477-3155-2-3
Applications of nanoparticles in biology and medicine
OV Salata (2004)
10.1049/IP-NBT:20045004
Subtractive chromatography for purification and recovery of nano-bioproducts.
M. Jahanshahi (2005)
10.1021/jf205238x
Nanoparticles synthesized from soy protein: preparation, characterization, and application for nutraceutical encapsulation.
Zi Teng (2012)
A nanoparticle comprising rapamycin and albumin, as an anticancer agent
Нейл П. Дисэй (2008)
Dps fusion proteins for use in vaccines and diagnostics
Y. Ni (2016)
10.1371/journal.pone.0148848
Using Gelatin Nanoparticle Mediated Intranasal Delivery of Neuropeptide Substance P to Enhance Neuro-Recovery in Hemiparkinsonian Rats
Yingzheng Zhao (2016)
of Desgin nad formulation of protein based NPDDS, Informa Healthcare
Y Pathak (2009)
Arsenic compound solution and albumin nanoparticle and lyophilized preparation entrapping arsenic compound
L. Lou (2016)
A Brief Review on Polymeric Nanoparticles for Drug Delivery and Targeting
Y. Reddy (2015)
10.1186/s12951-015-0082-8
Albumin nanoparticles increase the anticancer efficacy of albendazole in ovarian cancer xenograft model
Lubna Noorani (2015)
Current Status of Drug Delivery Technologies and Future Directions
R. Verma (2001)
Potato Protein Nanoparticles
Y. D. Livney (2016)
10.1007/s11095-011-0641-0
Nose-to-Brain Transport Pathways of Wheat Germ Agglutinin Conjugated PEG-PLA Nanoparticles
Q. Liu (2011)
10.1002/JBM.A.31518
Immunogenicity of bioactive magnetic nanoparticles: natural and acquired antibodies.
O. Ziv (2008)
10.1208/s12249-012-9896-y
Nanosuspension Based In Situ Gelling Nasal Spray of Carvedilol: Development, In Vitro and In Vivo Characterization
N. Saindane (2012)
10.1016/j.biomaterials.2013.02.003
Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration.
Zhongyang Liu (2013)
10.3109/1061186X.2010.492522
Mannosylated gelatin nanoparticles bearing isoniazid for effective management of tuberculosis
G. Saraogi (2011)
10.4155/TDE.12.60
Nasal and buccal drug delivery: management forum conference.
J. Smart (2012)
10.1016/S0959-8049(97)85428-7
Antitumour activity of acid labile transferrin and albumin doxorubicin conjugates in in vitro and in vivo human tumour xenograft models
F. Kratz (1997)
10.18433/J3SW2T
Preparation and Physicochemical Characterization of Eudragit ® RL100 Nanosuspension with potential for Ocular Delivery of Sulfacetamide
B. Mandal (2010)
10.1155/2014/180549
Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy
Warangkana Lohcharoenkal (2014)
10.1016/j.neurobiolaging.2014.04.008
A mutation in Drosophila methuselah resists paraquat induced Parkinson-like phenotypes
A. Shukla (2014)
10.1002/PSSA.200824329
Gelatin nanoparticle fabrication and optimization of the particle size
M. Jahanshahi (2008)
10.1016/j.ijpharm.2009.10.004
Gelatin nanocarriers as potential vectors for effective management of tuberculosis.
G. Saraogi (2010)
10.1016/j.ijpharm.2009.12.052
Silk fibroin nanoparticles for cellular uptake and control release.
J. Kundu (2010)
10.1016/J.REACTFUNCTPOLYM.2010.10.002
Oral protein delivery: Current status and future prospect
K. Park (2011)
Nanoparticulated whey proteins
L.J.R. Bovetto (2011)
10.2967/jnumed.111.095224
Subregional Patterns of Preferential Striatal Dopamine Transporter Loss Differ in Parkinson Disease, Progressive Supranuclear Palsy, and Multiple-System Atrophy
M. Oh (2012)
10.1016/0142-9612(95)99639-4
Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle.
S. R. Jameela (1995)
Nanoparticles
J. Kreuter (1994)
10.3144/EXPRESSPOLYMLETT.2016.84
Polymeric nanoparticles: Recent development in synthesis and application
S. Mallakpour (2016)
Anticancer drug-loaded gliadin nanoparticles induce Journal of Pharmaceutics 17 apoptosis in breast cancer cells
M. Gulfam (2012)
10.2174/1389200211309010004
Models to predict intestinal absorption of therapeutic peptides and proteins.
Filipa Antunes (2013)
10.1016/J.ADDR.2006.01.003
Tight junction modulation and its relationship to drug delivery.
N. Salama (2006)
10.1038/nrd1067
Challenges for the oral delivery of macromolecules
M. Goldberg (2003)
10.4172/2157-7439.1000176
Albumin as a Delivery Carrier for Rheumatoid Arthritis
K. Ren (2013)
10.3390/nano6060116
Human Serum Albumin Nanoparticles for Use in Cancer Drug Delivery: Process Optimization and In Vitro Characterization
N. Lomis (2016)
10.1159/000384833
Immunochemistry and immunology of collagen and gelatin.
H. G. Schwick (1969)
10.1021/jf401859y
Soy protein nanoparticle aggregates as pickering stabilizers for oil-in-water emulsions.
F. Liu (2013)
Development of Zein-Pectin Nanoparticle as Drug carrier
T. DhanyaA (2012)
10.1517/17425247.2014.889678
Development of targeted 1,2-diacyl-sn-glycero-3-phospho-l-serine-coated gelatin nanoparticles loaded with amphotericin B for improved in vitro and in vivo effect in leishmaniasis
Renuka Khatik (2014)
Fabrication of Zein Nanoparticle-Biopolymer Complexes to Deliver Essential Oils in Aqueous Dispersions
Huaiqiong Chen (2014)
10.4155/TDE.12.40
Polymer-based oral peptide nanomedicines.
E. P. Herrero (2012)
Drug delivery and targeting.
R. Langer (1998)
10.15406/JNMR.2015.02.00018
Gelatin Nanoparticles as a Delivery System for Proteins
Reena Kaintura (2015)
10.1088/1468-6996/11/1/014104
Biopolymeric nanoparticles
S. Sundar (2010)
Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof
H.H.A. Salman (2013)
10.1164/RCCM.200504-613PP
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis.
S. Gelperina (2005)
Continuous flow production of gelatin nanoparticles
デン ブローク、セバスチャーン アントニウス マルティヌス ウォルサーウス ヴァン (2012)
10.1016/J.EJPB.2005.09.009
In vitro uptake of gelatin nanoparticles by murine dendritic cells and their intracellular localisation.
C. Coester (2006)
[Microencapsulization of cholecalciferol by coacervation].
J. Sawicka (1990)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1023/B:PHAR.0000026823.82950.ff
Nasal route and drug delivery systems
S. Türker (2004)
Human serum albumin nanoparticles for use in cancer drug delivery: process optimization and in vitro characterization,”Nanomaterials
N. Lomis (2016)
10.7939/R3J96097M
Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells.
S. Azarmi (2006)
Formulation of 5-fluorouracil Loaded Chitosan Nanoparticles By Emulsion Droplet Coalescence Method For Cancer Therapy
M. AntoShering (2011)
Fabrication and evaluation of gelatine nanoparticles for delivering of anti-cancer drug
Z. Babaei (2008)
10.2165/00063030-200519030-00003
Oral Delivery of Peptide Drugs
J. Hamman (2012)
Nanoparticle Carrier Systems based on Human Serum Albumin for Photodynamie Therapy
10.1063/1.2810116
An Introduction to Dynamic Light Scattering by Macromolecules
K. Schmitz (1990)
10.4314/TJPR.V5I1.14634
Nanoparticles - A Review
V. Mohanraj (2007)
Pharmacodynamic and pharmacokinetic characterization of poly ( ethylene glycol ) conjugation to met - enkephalin analog [ D - Pen 2 , D - Pen 5 ] - enkephalin ( DPDPE )
J. D. Huber (2001)
10.2147/IJN.S596
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
Formation of stable submicron peptide or protein particles by thin film freezing
K. P. Johnston (2015)
10.1016/J.MECHATRONICS.2004.04.005
A review of atomic force microscopy imaging systems: application to molecular metrology and biological sciences
N. Jalili (2004)
10.4314/AJB.V7I25.59701
Protein nanoparticle: A unique system as drug delivery vehicles
M. Jahanshahi (2008)
10.1080/02664760802382426
Optimization of parameters for the fabrication of gelatin nanoparticles by the Taguchi robust design method
M. Jahanshahi (2008)
10.1186/1743-8977-5-14
Optimized dispersion of nanoparticles for biological in vitro and in vivo studies
P. Bihari (2008)
10.1080/1061186021000066237
Adaptive Immune Responses of Legumin Nanoparticles
T. Mirshahi (2002)
10.5408/1089-9995-52.3.213
A Web Resource for the Study of Alkali Feldspars and Perthitic Textures Using Light Microscopy, Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy
Anne S. Argast (2004)
10.1021/acs.bioconjchem.6b00575
Size-Dependent Protein-Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona.
J. Piella (2017)
Novel functionalized polymers for nanoparticle formulations with anti cancer drugs
Sanyogitta Puri (2007)
Oral delivery of peptide drugs: barriers and developments.
J. Hamman (2005)
Pharmacodynamic and pharmacokinetic characterization of poly(ethylene glycol) conjugation to met-enkephalin analog [D-Pen2, D-Pen5]-enkephalin (DPDPE).
K. Witt (2001)
10.1039/C6RA09027C
Zein bio-nanoparticles: a novel green nanopolymer as a dispersive solid-phase extraction adsorbent for separating and determining trace amounts of azorubine in different foodstuffs
B. Zargar (2016)
10.1002/9780470027318.A1512
Photon Correlation Spectroscopy in Particle Sizing
W. Tscharnuter (2006)
10.1080/10611860903055470
Effect of physicochemical properties on intranasal nanoparticle transit into murine olfactory epithelium
Alpesh Mistry (2009)
10.1016/j.biomaterials.2014.10.059
Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine.
J. Huang (2015)
10.2174/0929866521666140807114240
Recent advances in protein and Peptide drug delivery: a special emphasis on polymeric nanoparticles.
Ashaben Patel (2014)
10.1517/17425247.2013.745509
Paracellular drug absorption enhancement through tight junction modulation
H. R. Lemmer (2013)
Fabrication and evaluation of gelatin nanoparticles for delivering of anti - cancer drug
Z. Babaei (2008)
10.1021/la300691n
Anticancer drug-loaded gliadin nanoparticles induce apoptosis in breast cancer cells.
Muhammad Gulfam (2012)
10.1201/B12778-8
Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases
D. Paturi (2012)
10.1111/j.1526-4610.2006.00603.x
Nasal Delivery of Antimigraine Drugs: Clinical Rationale and Evidence Base
A. Rapoport (2006)
Protein nanocarriers for topical delivery
O. P. Perumal (2016)
10.1016/j.juro.2010.11.091
Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy.
Z. Lu (2011)
10.1021/bm801033f
Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying.
Y. Wu (2009)
10.1155/2012/686108
Cationic Albumin Nanoparticles for Enhanced Drug Delivery to Treat Breast Cancer: Preparation and In Vitro Assessment
S. Abbasi (2012)
Preparation and Characterization of Poly(Lactic Acid) Nanoparticles for Pharmaceutical Use
S. Hirsjärvi (2008)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1208/pt050232
Anti-Helicobacter pylori effect of mucoadhesive nanoparticles bearing amoxicillin in experimental gerbils model
R. Umamaheshwari (2008)



This paper is referenced by
10.1016/j.ijbiomac.2020.05.262
Pullulan based stimuli responsive and sub cellular targeted nanoplatforms for biomedical application: Synthesis, nanoformulations and toxicological perspective.
Ruchira Raychaudhuri (2020)
10.1016/j.ijbiomac.2020.02.179
Protein nanocomposites: Special inferences to lysozyme based nanomaterials.
Sharanya Sarkar (2020)
10.1016/j.jconrel.2019.12.034
Receptor specific, stimuli responsive and subcellular targeted approaches for effective therapy of Alzheimer: Role of surface engineered nanocarriers.
Divya Gopalan (2019)
10.1016/j.carbpol.2019.115725
Carboxymethyl cellulose capsulated zein as pesticide nano-delivery system for improving adhesion and anti-UV properties.
L. Hao (2020)
10.1016/j.ijpharm.2020.119537
Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications.
Evangelos Georgilis (2020)
10.1016/j.semcancer.2019.08.014
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges.
D. Kashyap (2019)
10.1016/j.ijpharm.2020.119289
Protein-based nanoparticles for drug delivery purposes.
Ana L. Martínez-López (2020)
10.3389/fbioe.2020.00048
The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications
Divesha Essa (2020)
10.1016/j.phrs.2020.104685
Oral administration of protein nanoparticles: An emerging route to disease treatment.
S. Sadeghi (2020)
10.3390/pharmaceutics12100984
Optimization and Formulation of Nanostructured and Self-Assembled Caseinate Micelles for Enhanced Cytotoxic Effects of Paclitaxel on Breast Cancer Cells
F. Rehan (2020)
10.3390/cancers12020522
Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment
Vanessa T Chivere (2020)
10.20900/mo.20190021
Engineering Tumor-Targeting Nanoparticles as Vehicles for Precision Nanomedicine
Amber Gonda (2019)
10.1007/s12039-019-1671-0
Protein: a versatile biopolymer for the fabrication of smart materials for drug delivery
B. Singh (2019)
10.1016/j.jconrel.2019.05.035
Current state of the nanoscale delivery systems for temoporfin-based photodynamic therapy: Advanced delivery strategies.
I. Yakavets (2019)
10.3390/pharmaceutics12070604
Protein-Based Nanoparticles as Drug Delivery Systems
Seyoung Hong (2020)
10.3390/pharmaceutics12010065
Antitumor Features of Vegetal Protein-Based Nanotherapeutics
Silvia Voci (2020)
10.2174/1872211313666191024112137
Recent Patents Concerning the Use of Nanotechnology-Based Delivery 
Systems as Skin Penetration Enhancers
Bruna Medeiros-Neves (2019)
10.1080/14760584.2018.1541408
Universal influenza vaccines: from viruses to nanoparticles
Ye Wang (2018)
10.3390/cancers12102783
Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies
Qi-Yao Wei (2020)
10.1016/j.ijpharm.2020.119672
Updated but not outdated "Gliadin": A plant protein in advanced pharmaceutical nanotechnologies.
M. Mehanna (2020)
10.1039/d0na00478b
Biomedical nanomaterials for immunological applications: Ongoing research and clinical trials
Vincent Lenders (2020)
10.1016/j.jconrel.2020.03.040
Nucleic acid-based drug delivery strategies.
Xuyu Tan (2020)
10.1007/978-3-030-34544-0_11
Nano-Based Drug Delivery Tools for Personalized Nanomedicine
S. Parveen (2020)
10.1016/J.FOOSTR.2019.100113
Pickering emulsion stabilized by protein nanogel particles for delivery of curcumin: Effects of pH and ionic strength on curcumin retention
Andrea Araiza-Calahorra (2019)
10.1016/j.ijpharm.2019.03.011
Natural biodegradable polymers based nano‐formulations for drug delivery: A review
Archana George (2019)
10.1016/j.ijbiomac.2020.04.244
Nanoformulation of fibrinogen by thermal stabilization of its electrostatic complexes with hyaluronic acid.
E. Vlassi (2020)
10.1016/j.procbio.2019.09.032
Preparation of bovine hemoglobin surface molecularly imprinted cotton for selective protein recognition
P. Wang (2020)
10.1007/978-3-030-23906-0_6
Understanding Cancer Cell Behavior Through 3D Printed Bone Microenvironments
Yangyang Luo (2019)
10.1016/j.biotechadv.2020.107603
Nanostructured antimicrobial peptides: The last push towards clinics.
José Vicente Carratalá (2020)
10.1016/j.fshw.2020.04.009
Nanostructured food proteins as efficient systems for the encapsulation of bioactive compounds
Mehdi Mohammadian (2020)
10.22034/NMRJ.2020.01.004
Silver nanoparticles Synthesis by coffee residues extract and their antibacterial activity
Mahnaz Baghaienezhad (2020)
10.20517/cdr.2020.68
Albumin-based nanoparticles: a promising strategy to overcome cancer drug resistance
Islam A Hassanin (2020)
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