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Repair Capacity For UV Light–Induced DNA Damage Associated With Risk Of Nonmelanoma Skin Cancer And Tumor Progression

Li-e Wang, C. Li, S. Strom, L. Goldberg, A. Brewster, Z. Guo, Y. Qiao, G. Clayman, J. Lee, A. El-Naggar, V. Prieto, M. Duvic, S. Lippman, R. Weber, M. Kripke, Q. Wei
Published 2007 · Medicine

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Purpose: To examine the role of suboptimal DNA repair capacity (DRC) for UV light–induced DNA damage in the development of nonmelanoma skin cancer (NMSC) and tumor progression. Experimental Design: We conducted a hospital-based case-control study of 255 patients with newly diagnosed NMSC [146 with basal cell carcinoma (BCC) and 109 with squamous cell carcinoma (SCC)] and 333 cancer-free controls. We collected information on demographic variables and risk factors from questionnaires, tumor characteristics from medical records, and lymphocytic DRC phenotype by the host-cell reactivation assay. Multivariable logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95% CI). Results: Overall, there was a relative 16% reduction in DRC in NMSC patients compared with controls (P < 0.001 for BCC and for SCC, respectively). DRC below the controls' median value was associated with increased risk significantly for BCC (OR, 1.62; 95% CI, 1.07-2.45) but borderline for SCC (OR, 1.63; 95% CI, 0.95-2.79) after adjustment for age, sex, and other assay-related covariates. When the highest tertile of controls' DRC was used as the reference, the intermediate and low DRC were associated with a statistically significant trend for increasing risk for both BCC (Ptrend = 0.007) and SCC (Ptrend = 0.020). However, patients with aggressive or multiple SCC tended to have a higher DRC than those with nonaggressive or single SCC. Conclusions: Reduced DRC is an independent risk factor for BCC and single or nonaggressive SCC but not for multiple primaries, local aggressiveness, or recurrence of NMSC.
This paper references
DNA repair capacity as a risk factor for non‐melanocytic skin cancer—a molecular epidemiological study
J. Hall (1994)
XPD/ERCC2 polymorphisms and risk of head and neck cancer: a case-control analysis.
E. Sturgis (2000)
The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm.
K. Kraemer (1994)
DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population
Z. Hu (2005)
Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer.
Hyo-Sung Jeon (2003)
The relationship between skin cancers, solar radiation and ozone depletion.
J. Moan (1992)
An overview of skin cancers. Incidence and causation.
R. Marks (1995)
RepairofUVlight - induced DNA damage and risk of cutaneous malignant melanoma
MA Hedayati (2003)
Normal reactivation of plasmid DNA inactivated by UV irradiation by lymphocytes from individuals with hereditary dysplastic naevus syndrome
J. Hansson (1994)
Quantitative carcinogenesis in man: solar ultraviolet B dose dependence of skin cancer in Maryland watermen.
P. Strickland (1989)
DNA repair and nonmelanoma skin cancer in Puerto Rican populations.
J. Matta (2003)
DNA Repair Gene ERCC 1 and ERCC 2 / XPD Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck
E. Sturgis (2002)
Health effects from stratospheric ozone depletion and interactions with climate change.
F. D. de Gruijl (2003)
Association of nonmelanoma skin cancer and actinic keratosis with cumulative solar ultraviolet exposure in Maryland watermen
B. C. Vitasa (1990)
Epidemiology of human malignant skin tumors with special reference to natural and artificial ultraviolet radiation exposures.
J. M. Elwood (1989)
In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis.
Li-e Wang (2005)
Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma.
Q. Wei (2003)
The epidemiology of UV induced skin cancer.
B. Armstrong (2001)
XPD / ERCC 2 polymorphisms and risk of head and neck cancer : a case-control analysis
E. Sturgis (2000)
Mortality risk from squamous cell skin cancer.
G. Clayman (2005)
UV dose determines key characteristics of nonmelanoma skin cancer.
J. Ramos (2004)
DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck.
E. Sturgis (2002)
Epidemiology of human malignant skin tumors with special reference to natural and artificial ultraviolet radiation exposures.
E. Jm (1989)
DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum.
K. Kraemer (1984)
UV damage, DNA repair and skin carcinogenesis.
J. Cleaver (2002)
American Association for Cancer
Clin Cancer Res Li-E Wang (2007)
Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.
W. C. Athas (1991)
An overview of skin cancers
R. Marks (1995)
Repairof UV lightinduced DNA damage and risk of cutaneous malignant melanoma
Q Wei (2003)
Defective repair of gamma-ray induced DNA damage in xeroderma pigmentosum cells.
R. Setlow (1976)
Cancer Statistics, 2007
A. Jemal (2007)
DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
Q. Wei (1993)
Factors that influence the DNA repair capacity of normal and skin cancer-affected individuals.
M. D'errico (1999)
Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study.
Q. Wei (2000)

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The human health effects of ozone depletion and interactions with climate change.
M. Norval (2011)
DNA repair phenotype and cancer susceptibility—A mini review
C. Li (2009)
Association between polymorphisms in DNA repair gene XRCC1 and non-melanoma skin cancer risk: a meta-analysis
L. Wang (2017)
Transparent and flexible thin films of ZnO-polystyrene nanocomposite for UV-shielding applications
Yao Tu (2010)
XPG rs17655 G>C polymorphism associated with cancer risk: evidence from 60 studies
Jie Zhao (2018)
Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.
Zachary D. Nagel (2017)
Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis
Mei-ling Zhu (2012)
Development of Multiple-Lesion Basal Cell Carcinoma of the Skin: A Comprehensive Review
V. Bartoš (2019)
Nicotinamide for skin cancer chemoprevention
D. Damian (2017)
Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
E. L. Abel (2010)
Skin Cancer: New Markers for Better Prevention
R. Greinert (2009)
DNA Repair: From Genome Maintenance to Biomarker and Therapeutic Target
S. Jalal (2011)
Sex hormones and the risk of keratinocyte cancers among women in the United States: A population‐based case–control study
Lawrence F. Kuklinski (2016)
association between polymorphisms in Dna repair gene XRCC 1 and non-melanoma skin cancer risk : a meta-analysis
Lei Wang (2017)
Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility
Li-e Wang (2013)
Basal cell carcinoma of the skin: Topographic distribution and clinicopathological differences with regards to the extent of sunlight exposure
Bartoš Vladimír (2017)
Double-strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer from the New York site of the BCFR.
Nicola Machella (2008)
Deficient Nucleotide Excision Repair in Squamous Cell Carcinoma Cells
T. Dong (2016)
Association of XPF Levels and Genetic Polymorphism with Susceptibility to Ischemic Stroke
Y. Ma (2016)
Reduced DNA Repair Capacity for Removing Tobacco Carcinogen–Induced DNA Adducts Contributes to Risk of Head and Neck Cancer but not Tumor Characteristics
Li-e Wang (2010)
Polymorphisms of XPG/ERCC5 and risk of squamous cell carcinoma of the head and neck
H. Ma (2012)
Current World Literature
Differences in nucleotide excision repair capacity between newly diagnosed colorectal cancer patients and healthy controls.
J. Slyskova (2012)
HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma
Sheng-Yi Lin (2010)
High-Performance of Nanoparticles and Their Effects on The Mechanical, Thermal Stability and UV-Shielding Properties of PMMA Nanocomposites
Hesham M. Moustafa (2017)
Sunscreen Use Behaviour And Most Frequently Used Active Ingredients Among Beachgoers On Cancun, Mexico
G. Rodríguez-Fuentes (2010)
DNA repair capacity in peripheral lymphocytes predicts survival of patients with non-small-cell lung cancer treated with first-line platinum-based chemotherapy.
Li-e Wang (2011)
Solar Radiation and Human Health
G. Seckmeyer (2013)
Optical Design of Porous ZnO/TiO2 Films for Highly Transparent Glasses with Broadband Ultraviolet Protection
H. Song (2017)
Association between Single Nucleotide Polymorphisms in ERCC4 and Risk of Squamous Cell Carcinoma of the Head and Neck
H. Yu (2012)
Phenotyping for DNA repair capacity.
I. Decordier (2010)
Association between the XPG Asp1104His and XPF Arg415Gln Polymorphisms and Risk of Cancer: A Meta-Analysis
Xiao-Feng He (2014)
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