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Interleukin 11 Reduces Apoptosis In UVB-Irradiated Mouse Skin

I. Scordi, M. Nassiri, A. Hanly, V. Vincek
Published 1999 · Biology, Medicine

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Background: UVB radiation, the major cause of skin cancer, causes apoptosis in the skin, characterized by the appearance of ‘sunburn cells’. Interleukin 11 (IL-11) has been shown to protect cells in the gastrointestinal system from chemotherapy and radiation-induced death. Objective: To determine whether exogenous IL-11 has any effect on the UVB-induced apoptosis of cutaneous tissues. Methods: Mice were injected with IL-11 or vehicle control prior to irradiation, and TUNEL assays were performed on paraffin-embedded tissue sections at various times after irradiation. Results: Exogenous IL-11 protects epidermal keratinocytes, epithelial cells of the hair follicles inflammatory cells and fibroblasts in the dermis from UVB-induced apoptotic death. Conclusion: These findings suggest that IL-11 may play a role in the general homeostasis of the skin.
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