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Effects Of Growth Hormone Substitution Therapy On Cognitive Functioning In Growth Hormone Deficient Patients: A Functional MRI Study

L. Arwert, D. Veltman, J. B. Deijen, P. V. van Dam, M. Drent
Published 2006 · Psychology, Medicine

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Patients with childhood-onset growth hormone (GH) deficiency (GHD) show impairments in mood and cognitive functioning which may resolve following GH substitution. Brain functional magnetic resonance imaging (fMRI) during performance of a memory task was used to assess the cerebral activity of such patients. Thirteen childhood-onset GHD patients (mean age 27.3 ± 6.9 years) were included in a double-blind, placebo-controlled study. The effects of 6 months of GH replacement or placebo therapy were studied using neuropsychological tests and fMRI. One patient was excluded from the study due to noncompliance with the protocol. Six months of GH substitution in these GHD patients resulted in improved memory functioning, both for long-term and working memory. fMRI showed activations during the working memory task in prefrontal, parietal, motor, and occipital cortices, as well as in the right thalamus and anterior cingulate cortex. Decreased activation in the ventrolateral prefrontal cortex was observed after GH treatment as compared with placebo treatment, indicating decreased effort and more efficient recruitment of the neural system involved. It can be concluded that GH treatment for 6 months improved the long-term as well as the working memory in patients with GHD, and this was associated with decreased brain activation in the ventrolateral prefrontal cortex. GH substitution in GHD patients is beneficial for cognitive functioning, the effects of which can be visualized by means of neuroimaging.
This paper references
10.1210/JC.2002-020632
Testosterone treatment enhances regional brain perfusion in hypogonadal men.
N. Azad (2003)
The PC/S Vienna Test System: Test Management Program, Mödling 1992. 21 Letz R: NES2 User's Manual, version 4.6
G Schufried (1993)
10.1093/BRAIN/124.5.849
Frontal lobes and human memory: insights from functional neuroimaging.
P. Fletcher (2001)
NES2 User’s Manual, version 4.6
R Letz (1993)
10.1530/ACTA.0.1230185
Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency.
M. Degerblad (1990)
10.1006/nimg.2001.0887
Effects of Estrogen on Patterns of Brain Activity at Rest and during Cognitive Activity: A Review of Neuroimaging Studies
P. Maki (2001)
10.1159/000126813
Treatment of growth hormone-deficient adults with recombinant human growth hormone increases the concentration of growth hormone in the cerebrospinal fluid and affects neurotransmitters.
J. Johansson (1995)
10.1016/j.neuroimage.2003.05.001
Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex
N. Wee (2003)
10.1210/JCEM.83.9.5112
Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency.
H. B. Baum (1998)
10.1006/nimg.2001.1037
Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate
C. Genovese (2002)
10.1159/000090123
Growth Hormone Deficiency and Memory Functioning in Adults Visualized by Functional Magnetic Resonance Imaging
L. Arwert (2005)
10.1016/0140-6736(93)92975-Y
Effect of growth hormone on brain neurotransmitters
P. Burman (1993)
10.1046/j.1365-2265.1996.617439.x
Growth hormone treatment affects brain neurotransmitters and thyroxine
P. Burman (1996)
10.1016/0306-4530(95)00050-X
Cognitive impairments and mood disturbances in growth hormone deficient men
J. B. Deijen (1996)
10.1016/S1053-8119(03)00167-8
Conflict monitoring in the human anterior cingulate cortex during selective attention to global and local object features
D. Weissman (2003)
10.1159/000084872
Memory Performance and the Growth Hormone/Insulin-Like Growth Factor Axis in Elderly: A Positron Emission Tomography Study
L. Arwert (2005)
10.1016/J.GHIR.2004.11.004
The influence of growth hormone (GH) substitution on patient-reported outcomes and cognitive functions in GH-deficient patients: a meta-analysis.
L. Arwert (2005)
10.1016/0006-8993(89)91678-8
Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
A. Adem (1989)
10.1590/S0004-282X1999000200003
Impact of recombinant human growth hormone (RH-GH) treatment on psychiatric, neuropsychological and clinical profiles of GH deficient adults. A placebo-controlled trial.
C. Soares (1999)
10.1016/j.neulet.2003.09.028
Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients
M. Lijffijt (2003)
10.1016/S0306-4530(97)00092-9
Cognitive changes during growth hormone replacement in adult men
J. B. Deijen (1998)
Growth hormone treatment affects brain neurotransmitters and thyroxine [see comment].
P. Burman (1996)
Growth hormone (GH) deficiency and memory functioning in adults visualized by fMRI
LI Arwert (2005)
10.1016/j.yhbeh.2004.11.015
Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men
L. Arwert (2005)
10.1159/000184582
Growth hormone treatment in adults with childhood onset growth hormone deficiency: effects on psychological capabilities.
A. Sartorio (1995)
10.1016/S1053-8119(02)00049-6
Maintenance versus manipulation in verbal working memory revisited: an fMRI study
D. Veltman (2003)
10.1016/J.EJPHAR.2004.02.047
Insulin-like growth factor-I, cognition and brain aging.
P. V. van Dam (2004)
10.1207/S15327752JPA4703_14
A shortened version of the Profile of Mood States.
S. Shacham (1983)
10.1016/S0006-3223(00)00227-4
Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance
D. Manoach (2000)
10.1016/S0306-4530(03)00151-3
The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism
H. Oertel (2004)
10.1006/frne.2000.0200
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
F. Nyberg (2000)
10.1093/SCHBUL/8.2.310
Cognitive and emotional functioning in hypopituitary short-statured children.
D. Abbott (1982)
10.1006/nimg.2000.0645
Specific versus Nonspecific Brain Activity in a Parametric N-Back Task
J. Jansma (2000)
10.1016/j.psyneuen.2004.10.002
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate
P. V. Dam (2005)
10.1016/j.schres.2003.08.010
Spatial working memory among middle-aged and older patients with schizophrenia and volunteers using fMRI
S. Kindermann (2004)
10.1016/0306-4530(86)90020-X
Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study
O. Almqvist (1986)
Adaptation of Two Standardized International Test Batteries for Use in The Netherlands for Detection of Exposure to Neurotoxic Compounds
Hh Emmen (1988)



This paper is referenced by
10.1016/B978-0-444-59602-4.00024-1
Long-term effects of treatment of pituitary adenomas.
A. Pereira (2014)
10.1111/j.1365-2362.2005.1479_8.x
Hormones and aging
V. Zjačić-Rotkvić (2010)
10.1677/JOE-08-0495
Peripheral administration of GH induces cell proliferation in the brain of adult hypophysectomized rats.
N. Åberg (2009)
10.1016/j.yhbeh.2017.04.001
Spatial learning and memory in male mice with altered growth hormone action
A. Basu (2017)
10.1111/j.1651-2227.2009.01679.x
Late effects of early growth hormone treatment in Down syndrome
Å. Myrelid (2010)
10.1007/s12020-015-0736-1
Neuropsychological functioning in acromegaly: towards identification of modifiable factors to improve long-term care after remission
A. M. Pereira (2015)
10.1210/er.2013-1067
Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances.
K. Alatzoglou (2014)
10.1097/MED.0b013e3282ffd97d
Adult-onset growth hormone deficiency: causes, complications and treatment options
N. Mathioudakis (2008)
10.1016/j.psyneuen.2018.12.229
Differences in the functional connectivity density of the brain between individuals with growth hormone deficiency and idiopathic short stature
Yu-min Hu (2019)
10.1097/mci.0b013e32831550ad
Adult-onset growth hormone deficiency: causes, complications and treatment options
N. Mathioudakis (2008)
10.1016/j.ecl.2013.05.003
The impact of traumatic brain injury on pituitary function.
Nina K Sundaram (2013)
10.5498/wjp.v10.i9.212
Delirium, insulin-like growth factor I, growth hormone in older inpatients
D. Adamis (2020)
10.1016/j.brainres.2020.147081
Morphological changes of the cerebral cortex between children with isolated growth hormone deficiency and idiopathic short stature
Zhonghe Zhang (2020)
Growth hormone in the brain
Erika Brolin (2017)
10.3390/REPORTS1010002
Cognitive Evolution of a Patient Who Suffered a Subarachnoid Haemorrhage Eight Years Ago, after Being Treated with Growth Hormone, Melatonin and Neurorehabilitation
A. Quintana (2018)
10.1089/rej.2010.1053
Improving effects of long-term growth hormone treatment on monoaminergic neurotransmission and related behavioral tests in aged rats.
S. Esteban (2010)
A role for growth hormone in neurorestoration and neurogenic processes in the brain
P. Pathipati (2010)
10.25112/RCO.V1I0.140
TRATAMENTO COM HORMÔNIO DO CRESCIMENTO: BAIXA ESTATURA VERSUS ENVELHECIMENTO
A. Hoppen (2010)
Cognition in the adult with childhood-onset growth hormone deficiency
I. C. V. Nieuwpoort (2008)
10.1530/EJE-18-0018
MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?
Reetobrata Basu (2018)
10.1002/9781118559406.CH27
Complications of Pituitary Disease
L. Grasso (2013)
10.1677/JOE-09-0323
Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
E. Nieves-Martinez (2010)
10.1007/978-1-4419-0345-7_28
Pediatric Applications of fMRI
N. Altman (2011)
10.1007/s00247-015-3365-1
Pediatric applications of functional magnetic resonance imaging
N. Altman (2015)
10.1016/B978-0-12-803592-4.00083-3
4.17 – Health-Related Quality of Life and Behavior in Patients with Both Pituitary and Hypothalamic Diseases
I. Crespo (2017)
10.1007/s11102-019-00957-9
Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae
D. Pavlović (2019)
10.1093/gerona/gls118
Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1.
F. Deák (2012)
Cognitive decline with age: Role of striatal cholinergic system and growth hormone
E. Nieves-Martinez (2010)
10.1038/nrendo.2013.78
Growth hormone and cognitive function
F. Nyberg (2013)
10.1186/s12979-019-0171-x
Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women
Svetlana Di Benedetto (2019)
10.1016/j.tem.2011.01.004
Visualizing hormone actions in the brain
G. Brabant (2011)
10.4137/CMED.S38201
Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?
J. Devesa (2016)
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