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Nitric Oxide Pathways And Evidence-Based Perturbations In Acute Pancreatitis

M. DiMagno
Published 2007 · Medicine

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Nitric oxide (NO) is a gaseous neurotransmitter, a vasodilator and paracrine regulator. In the pancreas, NO regulates normal pancreatic exocrine secretion, endocrine pancreatic insulin secretion and pancreatic microvascular blood flow. NO has multiple species and is produced de novo by 3 NO synthase enzymes. Endothelial NO synthase reduces the severity of the initial phase of experimental acute pancreatitis (AP). Cigarette smoking and chronic alcohol use disrupt normal NO pathways and are associated with pancreatitis and pancreatic cancer. The aims of this minireview are to describe normal intrapancreatic NO pathways, perturbations during experimental AP and due to epidemiological factors associated with pancreatic pathology, and the clinical implications of NO on AP.
This paper references
10.1016/0306-3623(94)90109-0
The action of amyl nitrite and isosorbide dinitrate on the contractility of sphincter of Oddi of guinea-pigs.
F. Göçer (1994)
10.1016/0016-5085(95)90150-7
Nitric oxide modulates pancreatic basal secretion and response to cerulein in the rat: effects in acute pancreatitis.
X. Molero (1995)
10.1136/gut.52.2.270
Increased nitric oxide excretion in patients with severe acute pancreatitis: evidence of an endotoxin mediated inflammatory response?
S. Rahman (2003)
10.1067/MGE.2003.29
Transdermal glyceryl trinitrate for prevention of post-ERCP pancreatitis: A randomized double-blind trial.
M. Moretó (2003)
Nordback I: Prospective randomized trial of the effect of nifedipine on pancreatic irritation after endoscopic retrograde cholangiopancreatography
J Sand (1993)
10.1016/0092-8674(93)90615-W
Targeted disruption of the neuronal nitric oxide synthase gene
P. Huang (1993)
10.1136/gut.2004.039263
Cigarette smoking accelerates progression of alcoholic chronic pancreatitis
P. Maisonneuve (2005)
10.1001/JAMA.286.2.169
Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis.
A. Lowenfels (2001)
10.1097/00024382-200205000-00013
Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
S. Cuzzocrea (2001)
10.1124/DMD.104.001891
TIME-DEPENDENT INHIBITION AND TETRAHYDROBIOPTERIN DEPLETION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE CAUSED BY CIGARETTES
E. Lowe (2005)
10.1097/00006676-199401000-00006
Effect of Alcohol and Smoking on Pancreatic Lithogenesis in the Course of Chronic Pancreatitis
G. Cavallini (1994)
10.1016/J.GIE.2005.11.060
A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis.
A. Kaffes (2006)
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
T. Lomis (1995)
[Medical management of acute pancreatitis and complications].
Y. Kim (2005)
10.1161/01.RES.86.2.E36
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase.
T. Heitzer (2000)
10.1073/PNAS.93.23.13176
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.
E. Shesely (1996)
10.1016/S0016-5107(04)02013-9
Does prophylactic pancreatic stent placement reduce the risk of post-ERCP acute pancreatitis? A meta-analysis of controlled trials.
P. Singh (2004)
10.1097/00006676-200310000-00012
Depletion of Serum L-arginine in Patients with Acute Pancreatitis
P. Sandstrom (2003)
10.1046/J.0007-1323.2001.01842.X
Prospective randomized double‐blind placebo‐controlled trial of glyceryl trinitrate in endoscopic retrograde cholangiopancreatography‐induced pancreatitis
S. Sudhindran (2001)
Secretagogue-Stimulated Pancreatic Secretion is Differentially Regulated by Constitutive Nitric Oxide Synthase Isoforms in Mice
M. DiMagno (2003)
Impact of etiology on the painful early stage of chronic pancreatitis : a long-term prospective study
B. Mullhaupt (2005)
10.1152/ajpgi.1999.277.4.G745
Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice.
H. Mashimo (1999)
10.1152/AJPGI.00368.2003
Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.
M. DiMagno (2004)
10.1136/gut.42.4.507
Effects of botulinum toxin A on the sphincter of Oddi: an in vivo and in vitro study
J. A. Sand (1998)
10.1055/S-2005-858733
Impact of etiology on the painful early stage of chronic pancreatitis: a long-term prospective study.
B. Müllhaupt (2005)
10.1097/00006676-200010000-00009
Cigarette Smoke Enhances Ethanol-Induced Pancreatic Injury
W. Hartwig (2000)
10.1097/00006676-200008000-00002
Cigarette Smoking Increases the Risk of Pancreatic Calcification in Late-Onset But Not Early-Onset Idiopathic Chronic Pancreatitis
M. Imoto (2000)
10.1159/000201021
Prospective randomized trial of the effect of nifedipine on pancreatic irritation after endoscopic retrograde cholangiopancreatography.
J. A. Sand (1993)
10.1152/ajpgi.1999.276.2.G315
Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation.
M. Grisham (1999)
10.1006/JSRE.2002.6464
Pancreatic capillary blood flow in an improved model of necrotizing pancreatitis in the rat.
J. Schmidt (2002)
Splanchnic and pancreatic tissue perfusion in experimental acute pancreatitis.
P. Kinnala (2002)
10.1159/000090318
Pharmacological Prevention and Treatment of Acute Pancreatitis: Where Are We Now?
P. Lankisch (2006)
10.1097/00006676-200107000-00013
Susceptibility to Cerulein-Induced Pancreatitis in Inducible Nitric Oxide Synthase-Deficient Mice
B. Qui (2001)
10.1152/AJPHEART.2001.281.5.H1863
Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption.
H. Sun (2001)
10.1111/j.1572-0241.2004.04143.x
Smoking, Coffee, and Pancreatitis
C. Morton (2004)
10.1080/gas.37.7.845.849
Pancreas Splanchnic and Pancreatic Tissue Perfusion in Experimental Acute Pancreatitis
P. Kinnala (2002)
10.1007/s10620-006-9125-1
Pathogenic Role of Endothelial Nitric Oxide Synthase (eNOS/NOS-III) in Cerulein-Induced Rat Acute Pancreatitis
Y. Sugiyama (2006)
10.1016/S0016-5107(02)70178-8
Nifedipine for prevention of post-ERCP pancreatitis: a prospective, double-blind randomized study.
F. Prat (2002)
10.3109/00365529409094868
Nitric oxide contributes to multiorgan oxidative stress in acute experimental pancreatitis.
A. Dąbrowski (1994)
10.1136/gut.37.3.434
Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis.
H. Weidenbach (1995)
10.1016/S0039-6060(97)90178-1
Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis.
J. Werner (1997)
10.1073/PNAS.92.23.10688
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
V. Laubach (1995)
10.1016/S0016-5085(19)31778-0
Simultaneous measurement of basal pancreatic, gastric acid secretion, plasma gastrin, and secretin during smoking.
S. Murthy (1977)
10.4065/76.3.242
The effect of small amounts of alcohol on the clinical course of chronic pancreatitis.
M. Lankisch (2001)
10.1097/00024382-200106001-00224
Inducible Nitric Oxide Synthase-Deficient Mice Exhibit Resistance to the Acute Pancreatitis Induced by Cerulein
S. Cuzzocrea (2002)
10.1007/0-306-46825-5_55
Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase.
D. Kline (2000)
10.1159/000198221
Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption.
J. P. Durbec (1978)
10.1152/AJPGI.00525.2003
Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice.
M. DiMagno (2004)
10.1097/01.mpa.0000175180.70539.b6
Certain Background Factors Exhibit an Association With an Increased Risk for Pancreatic Calcification Among Japanese Male Alcoholics
Y. Nakamura (2005)
10.1152/ajpgi.1999.276.2.G315
I. Physiological chemistry of nitric oxide and its metabolites: implications in inflammation.
M. Grisham (1999)
10.1136/gut.26.2.194
Effect of glyceryl trinitrate on the sphincter of Oddi motility and baseline pressure.
M. Staritz (1985)
10.1161/01.ATV.16.4.546
Smoking impairs the activity of endothelial nitric oxide synthase in saphenous vein.
D. Higman (1996)
10.1159/000076021
Efficacy of Serum Nitric Oxide Level Estimation in Assessing the Severity of Necrotizing Pancreatitis
S. Mettu (2003)
10.1097/00006676-199603000-00004
Cigarette Smoking: An Independent Risk Factor in Alcoholic Pancreatitis
G. Talamini (1996)



This paper is referenced by
10.1097/MPA.0000000000000062
From Nitric Oxide to Hyperbaric Oxygen: Invisible and Subtle but Nonnegligible Gaseous Signaling Molecules in Acute Pancreatitis
G. Wang (2014)
10.1111/j.1939-1676.2012.00949.x
Pathophysiology of acute pancreatitis: potential application from experimental models and human medicine to dogs.
C. Mansfield (2012)
10.4172/2155-9929.1000257
Pathophysiology of Oxidative Stress and Antioxidant Therapy in Acute Pancreatitis
S. Meher (2015)
10.1097/MPA.0b013e31817f76d8
Cardiovascular Homeostasis in Hypotension Associated With Initial Stages of Severe Acute Pancreatitis
M. García (2008)
10.4172/JCSB.1000083
Computer Aided Drug Designing Using Phytochemicals- Bacoside A3 and Myricetin and Nitric Oxide Donors-S-Nitroso N-Acetylpenicillamine and Nitroglycerin as a Potential Treatment of Pancreatic Cancer
N. Desai (2012)
Computer Aided Drug Designing Using Phytochemicals-Bacoside A 3 and Myricetin and Nitric Oxide Donors-S-Nitroso-N-Acetylpenicillamine and Nitroglycerin as a Potential Treatment of Pancreatic Cancer
Nilima S. Desai (2012)
10.4292/wjgpt.v1.i1.9
Cardiocirculatory pathophysiological mechanisms in severe acute pancreatitis.
M. García (2010)
10.1111/j.1440-1746.2009.05902.x
Effect of baicalin and octreotide on the expression levels of P‐selectin protein in multiple organs of rats with severe acute pancreatitis
X. Zhang (2009)
10.15171/mejdd.2018.131
Effect of Aggressive Fluid Therapy on Outcomes after Endoscopic Retrograde Cholangiopancreatography: A Randomized Controlled Clinical Trial
Ramin Ghaderi (2019)
10.1097/01.EHX.0000396877.23400.14
Histological and immunohistochemical study of the effect of orlistat on the exocrine pancreas of adult female albino rat
Reda H. Elbakary (2011)
10.1016/j.pan.2015.09.002
How does cigarette smoking cause acute pancreatitis?
S. Barreto (2016)
10.1159/000178886
Expression of Nitric Oxide Synthase Isoforms and Nitric Oxide Production in Acute Pancreatitis and Associated Lung Injury
A. Ang (2008)
Cellular Mechanisms of L-arginine induced experimental acute Pancreatitis
O. Masood (2010)
New directions in diagnosis and treatment of canine acute pancreatitis
Caroline Mansfield (2011)
10.2174/138161209789058075
Cross-talk between oxidative stress and pro-inflammatory cytokines in acute pancreatitis: a key role for protein phosphatases.
J. Escobar (2009)
10.1016/j.cgh.2008.11.020
Alcohol use and cigarette smoking as risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis.
Anthony T Debenedet (2009)
10.1007/s00441-020-03211-y
Animal models to study the role of pulmonary intravascular macrophages in spontaneous and induced acute pancreatitis
V. Vrolyk (2020)
10.1016/j.redox.2015.01.014
Redox signaling in acute pancreatitis
S. Pérez (2015)
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