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The Fixation Of Radioactive Digitoxin By Isolated Hearts

A. SJOERDSMA, C. S. FISCHER

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The nature of digitoxin fixation in isolated hearts was studied with C 14 labelled digitoxin. Fixation was greatest in the early stages of perfusion. The amount of drug fixed was measured directly. A considerable percentage of the digitoxin in cardiac muscle was changed to other substances. These substances are more firmly bound to the heart than digitoxin.