Adipose-derived Stem Cells For Regenerative Medicine.
Jeffrey M Gimble, Adam J. Katz, Bruce A Bunnell
Published 2007 · Biology, Medicine
Download PDFAnalyze on Scholarcy
The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.
This paper references
Heterotopic Ossification: Two Rare Forms and What They Can Teach Us
Frederick S. Kaplan (1994)
A Porcine Model for Adipose Tissue-Derived Endothelial Cell Transplantation
Cheryl L. Young (1992)
Novel Autologous Cell Therapy in Ischemic Limb Disease Through Growth Factor Secretion by Cultured Adipose Tissue-derived Stromal Cells: P198
Hironori Nakagami (2005)
Adipose tissue angiogenesis.
Gary J. Hausman (2004)
Stromal progenitor cells present within liposuction and reduction abdominoplasty fat for autologous transfer to aged skin.
Mitchell E Stashower (1999)
Secreted proteins and genes in fetal and neonatal pig adipose tissue and stromal-vascular cells.
Gary J. Hausman (2006)
Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus.
Mauro Krampera (2006)
Myogenic Differentiation by Human Processed Lipoaspirate Cells
Hiroshi Mizuno (2002)
Quantitative proteomic analysis of the secretory proteins from rat adipose cells using a 2D liquid chromatography-MS/MS approach.
Xiaoli Chen (2005)
Metabolism of isolated fat cells. II. The similar effects of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on glucose and amino acid metabolism.
Martin Rodbell (1966)
Stem cell therapy for neurologic disorders: therapeutic potential of adipose-derived stem cells.
Kristine M. Safford (2005)
Endothelial cell transplantation into the corpus cavernosum: moving towards cell-based gene therapy.
Hunter Wessells (1999)
Adipose tissue development in the fetal pig examined using monoclonal antibodies.
Jackson T. Wright (1990)
Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous.
Anindita Sen (2001)
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny.
Hugo Castro-Malaspina (1980)
Functional tissue engineering: the role of biomechanics.
David Lee Butler (2000)
Paternally inherited inactivating mutations of the GNAS1 gene in progressive osseous heteroplasia.
Eileen M Shore (2002)
Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk (2001)
Adipose tissuederived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy
MJ Oedayrajsingh-Varma (2006)
Collagenase lot selection and purification for adipose tissue digestion.
Stuart K. Williams (1995)
Regulation of adipocyte development.
Peter Cornelius (1994)
Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-β-dependent mechanism
Eun Su Jeon (2006)
Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro.
Qing Zeng (2007)
Influences of Centrifugation on Cells and Tissues in Liposuction Aspirates: Optimized Centrifugation for Lipotransfer and Cell Isolation
Masakazu Kurita (2008)
Transdifferentiation of preadipose cells into smooth muscle-like cells: role of aortic carboxypeptidase-like protein.
Anissa Abderrahim-Ferkoune (2004)
Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo.
Ying Cao (2005)
Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue.
Reza Izadpanah (2006)
into three mesenchymal lineages
JK Fraser (2007)
A novel device for the simple and efficient refinement of liposuctioned tissue.
Adam J. Katz (2001)
Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells.
Bénédicte Puissant (2005)
Human subcutaneous adipose cells support complete differentiation but not self-renewal of hematopoietic progenitors.
Jill Corre (2006)
Proteomic Profiling of Bone Marrow Mesenchymal Stem Cells upon Transforming Growth Factor β1 Stimulation*
Daojing Wang (2004)
Human microvessel endothelial cell isolation and vascular graft sodding in the operating room.
Stuart K. Williams (1989)
Human adipose tissue endothelial cells promote preadipocyte proliferation.
Louise J. Hutley (2001)
Fat tissue: an underappreciated source of stem cells for biotechnology.
J. Keith Fraser (2006)
Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells
Kristine M. Safford (2004)
Monoclonal antibodies against cell surface antigens expressed during porcine adipocyte differentiation.
Jackson T. Wright (1990)
Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF and IGF-1 in response to TNF by a p38 mitogen acivated protein kinase dependent mechanism
M Wang (2006)
Emerging approaches to the tissue engineering of fat.
Adam J. Katz (1999)
Adipose tissue-derived cells: from physiology to regenerative medicine.
Louis Casteilla (2006)
Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells.
Jamie Case (2005)
Cardiomyocyte-mediated contact programs human mesenchymal stem cells to express cardiogenic phenotype.
Sunil Rangappa (2003)
Adipose-Derived Stem and Progenitor Cells as Fillers in Plastic and Reconstructive Surgery
Timothy A. Moseley (2006)
Human pluripotent and progenitor cells display cell surface cluster differentiation markers CD10, CD13, CD56, and MHC class-I.
Henry E. Young (1999)
Human adipose tissue as a source of Flk-1+ cells: new method of differentiation and expansion.
Ofelia M Martínez-Estrada (2005)
Coculture of endothelial cells and mature adipocytes actively promotes immature preadipocyte development in vitro.
Shigehisa Aoki (2003)
A phase II trial with rosiglitazone in liposarcoma patients
Guy Debrock (2003)
A proteomic analysis during serial subculture and osteogenic differentiation of human mesenchymal stem cell.
Hyun Jin Sun (2006)
Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction.
Gregory S. Jack (2005)
Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1.
P J Simmons (1991)
The metabolism of isolated fat cells. IV. Regulation of release of protein by lipolytic hormones and insulin.
Martin Rodbell (1966)
Adipose-derived stem cells for the regeneration of damaged tissues
Anna M. Parker (2006)
Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis.
Y D Halvorsen (2001)
In vitro differentiation of human processed lipoaspirate cells into early neural progenitors.
Peter H Ashjian (2003)
[Human adipose derived stem cells suppress lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli].
Lei Cui (2005)
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
George D. Demetri (1999)
Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6.
Bradley T. Estes (2006)
The genetic basis of progressive osseous heteroplasia.
Harald W Jueppner (2002)
Mitochondrial transfer between cells can rescue aerobic respiration
Jeffrey L. Spees (2006)
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Jalees Rehman (2004)
Genomic imprinting and dermatological disease.
G W M Millington (2006)
Serial MRI assessment of human adipose - derived stem cells ( HASCS ) in a murine model of reperfused myocardial infarction
Metabolism of isolated fat cells. 3. The similar inhibitory action of phospholipase C (Clostridium perfringens alpha toxin) and of insulin on lipolysis stimulated by lipolytic hormones and theophylline.
Martin Rodbell (1966)
Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.
Anja Winter (2003)
Liposuction-derived human fat used for vascular graft sodding contains endothelial cells and not mesothelial cells as the major cell type.
Stuart K. Williams (1994)
Medical consequences of obesity.
George A Bray (2004)
Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy.
Hironori Nakagami (2006)
Molecular regulation of adipogenesis.
Evan D Rosen (2000)
Characterization of 75:25 poly(l-lactide-co-epsilon-caprolactone) thin films for the endoluminal delivery of adipose-derived stem cells to abdominal aortic aneurysms.
Chris A Burks (2006)
Human adipose tissue is a source of multipotent stem cells.
Patricia A. Zuk (2002)
Differentiation potential of adipose derived adult stem (ADAS) cells.
Jeffrey M Gimble (2003)
Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction
Yoshinori Miyahara (2006)
Multipotent Stromal Cells Derived From the Infrapatellar Fat Pad of the Knee
M. Quinn Wickham (2003)
Multilineage potential of adult human mesenchymal stem cells.
Mark F. Pittenger (1999)
GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis.
G L Yeh (2000)
Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells.
Coralie Sengenès (2005)
Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation
Wen-Chi Christina Lee (2007)
Differentiation of human adipocyte precursors in a chemically defined serum-free medium.
S. Deslex (1987)
Plasticity of human adipose stem cells toward endothelial cells and cardiomyocytes
J. Keith Fraser (2006)
Regulation of alpha-smooth muscle actin protein expression in adipose-derived stem cells.
Wen-Chi Christina Lee (2006)
Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells.
Y D Halvorsen (2001)
Classification of human liposarcoma and lipoma using ex vivo proton NMR spectroscopy.
Keith K. Millis (1999)
Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells.
Jerry I. Huang (2002)
Down-regulation of aortic carboxypeptidase-like protein during the early phase of 3T3-L1 adipogenesis.
Annemarie Gagnon (2002)
Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo.
Min Jeong Seo (2005)
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells.
Raquel Taléns-Visconti (2006)
Body Contouring by Lipolysis: A 5‐Year Experience with over 3000 Cases
Yves Gérard Illouz (1983)
Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives
Valérie Planat-Benard (2004)
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.
Amelia M. Bartholomew (2002)
Search for the preadipocyte progenitor cell.
Gary J. Hausman (2006)
The Central Melanocortin System and Energy Homeostasis
Roger D. Cone (1999)
Human adipose-derived stem cells display myogenic potential and perturbed function in hypoxic conditions.
Jee-hyung Lee (2006)
Isolation and characterization of cells from rat adipose tissue developing into adipocytes.
Per Björntorp (1978)
Cardiac progenitor cells in brown adipose tissue repaired damaged myocardium.
Yoshihiro Yamada (2006)
The immunophenotype of human adipose derived cells: temporal changes in stromal- and stem cell-associated markers
JB Mitchell (2006)
From heterogeneity to plasticity in adipose tissues: site-specific differences.
Bénédicte Prunet-Marcassus (2006)
Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells.
Katharina Timper (2006)
Biochemical assessment of cellular damage after adipocyte harvest.
Janice F. Lalikos (1997)
Differentiation of adipocyte precursor cells from obese and nonobese adult women and from different adipose tissue sites.
Hans Hauner (1988)
Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O.
A. Strawford (2004)
Adipose tissue regeneration following lipectomy.
Irving M. Faust (1977)
Differentiation of human adipose tissue stem cells using extracts of rat cardiomyocytes.
Kristine G Gaustad (2004)
Secretome of Primary Cultures of Human Adipose-derived Stem Cells
Sanjin Zvonic (2007)
Proteomic Analysis of Primary Cultures of Human Adipose-derived Stem Cells
James P DeLany (2005)
Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages.
Tong Ming Liu (2006)
VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes.
Yao-hua Song (2007)
Cell surface and transcriptional characterization of human adipose-derived adherent stromal (hADAS) cells.
Adam J. Katz (2005)
Progressive osseous heteroplasia resulting from a new mutation in the GNAS1 gene.
I Chan (2004)
Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.
Hans Hauner (1989)
Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects.
Vanessa van Harmelen (2004)
Deficiency of the alpha-subunit of the stimulatory G protein and severe extraskeletal ossification.
M C Eddy (2000)
Improvement of Postnatal Neovascularization by Human Adipose Tissue–Derived Stem Cells
Alexandra Miranville (2004)
Spontaneous Cardiomyocyte Differentiation From Adipose Tissue Stroma Cells
Valérie Planat-Bénard (2004)
Cytological and enzymological characterization of adult human adipocyte precursors in culture.
R L Van (1976)
Regulation of Adipose Cell Development In Utero
Richard J. Martin (1998)
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.
Geoffrey R. Erickson (2002)
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Peter Tontonoz (1997)
Functional characterization of human mesenchymal stem cellderived adipocytes
M Ryden (2003)
Osteogenic Induction in Hereditary Disorders of Heterotopic Ossification
Eileen M Shore (2000)
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA
Richard A. Neese (2002)
Identification of Extracellular and Intracellular Signaling Components of the Mammary Adipose Tissue and Its Interstitial Fluid in High Risk Breast Cancer Patients
J. E. Celis (2005)
Extended passaging, but not aldehyde dehydrogenase activity, increases the chondrogenic potential of human adipose-derived adult stem cells.
Bradley T. Estes (2006)
Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects
Vanessa van Harmelen (2003)
Yield of human adipose-derived adult stem cells from liposuction aspirates.
Louise B Aust (2004)
Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis
Dai Fukumura (2003)
Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.
Joseph T. Crossno (2006)
Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors.
Gail E. Kilroy (2007)
Human Adipose Tissue-Derived Mesenchymal Stem Cells Improve Postnatal Neovascularization in a Mouse Model of Hindlimb Ischemia
Mi Hyang Moon (2006)
Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure.
Maikel J. Oedayrajsingh-Varma (2006)
Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates.
Kotaro Yoshimura (2006)
Identi - fication of common pathways mediating differentiation of bone marrow - and adipose tissue - derived human mesenchymal
Adipose tissue-derived therapeutics
Jeffrey M Gimble (2003)
Regional Anatomic and Age Effects on Cell Function of Human Adipose-Derived Stem Cells
Bret M. Schipper (2008)
Neurogenic differentiation of murine and human adipose-derived stromal cells.
Kristine M. Safford (2002)
Surface protein characterization of human adipose tissue-derived stromal cells.
Stan Gronthos (2001)
A Proteomic Approach for Identification of Secreted Proteins during the Differentiation of 3T3-L1 Preadipocytes to Adipocytes*
Irina Kratchmarova (2002)
Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage.
Raquel Taléns-Visconti (2007)
The immunogenicity of human adipose-derived cells: temporal changes in vitro.
Kevin R. Mcintosh (2006)
Adipose-derived stromal cells—their utility and potential in bone formation
Y D Halvorsen (2000)
Functional studies of mesenchymal stem cells derived from adult human adipose tissue.
Andrea Dicker (2005)
Human adipose-derived adult stem cells produce osteoid in vivo.
Kevin C Hicok (2004)
Spontaneous human adult stem cell transformation.
Daniel González Rubio (2005)
Expression of cardiomyocytic markers on adipose tissue-derived cells in a murine model of acute myocardial injury.
Brian M. Strem (2005)
Neurogenesis of Rhesus adipose stromal cells
Soo Kyung Kang (2004)
Viability of fat obtained by syringe suction lipectomy: effects of local anesthesia with lidocaine
John Moore (2004)
Proteome analysis of adipogenesis.
Gavin I. Welsh (2004)
Development of adipose tissues.
Joseph O. Nnodim (1987)
The metabolism of isolated fat cells
Martin Rodbell (1965)
This paper is referenced by
Vasopressin-induced Ca(2+) signals in human adipose-derived stem cells.
Tran Doan Ngoc Tran (2016)
Insight on stem cell preconditioning and instructive biomaterials to enhance cell adhesion, retention, and engraftment for tissue repair.
Muhammad Shafiq (2016)
Fat grafting for breast cancer patients: From basic science to clinical studies.
Rosella Gennari (2016)
Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells.
António M de Soure (2016)
Changing innovation into a registered product: From concept to regulatory approval.
Linda Rhodes (2018)
Adipose tissue-derived stem cells: characterization and potential for cardiovascular repair.
Rosalinda Madonna (2009)
Comparative Profiling of mRNA and microRNA Expression in Human Mesenchymal Stem Cells Derived from Adult Adipose and Lipoma Tissues
Li-Pin Kao (2009)
Isolation and Flow Cytometric Analysis of the Stromal Vascular Fraction Isolated from Mouse Adipose Tissue.
Annie C Bowles (2018)
High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow
Ken Watanabe (2018)
Therapeutic Potential of Adipose Stem Cells.
Rachel A. Sabol (2018)
Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
Alina Mieczkowska (2018)
Adipose tissue-derived stem cells and their application in bone and cartilage tissue engineering.
Tommaso Rada (2009)
Stem Cells : Sources , Therapies and the Dental Professional
Fiona M. Collins (2007)
A Mechatronic Microinjection Platform for Gene Delivery to Planarian
Michael Lee (2018)
[Adipose-derived stromal cells: history, isolation, immunomodulatory properties and clinical perspectives].
Nicolas Bertheuil (2015)
microRNA-145 Mediates the Inhibitory Effect of Adipose Tissue-Derived Stromal Cells on Prostate Cancer.
Kiyoshi Takahara (2016)
Stromal vascular fraction: A regenerative reality? Part 1: Current concepts and review of the literature.
Andrew T Nguyen (2016)
Effect of adipose derived stem cells on ovariectomised Wistar rats
Anitha Oommen (2015)
Engineered synthetic microenvironments for human pluripotent stem cells: applications for neuronal regeneration
Aaron L. Carlson (2013)
Making Sense of Stem Cells and Fat Grafting in Plastic Surgery: The Hype, Evidence, and Evolving U.S. Food and Drug Administration Regulations
Rod J. Rohrich (2019)
Designing and constructing a prototype standalone bioreactor using 3D printing and finite element analysis: A tool to define osteogenic differentiation in a 3D mechanical environment
Sigurður Rúnar Rúnarsson (2019)
Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence
Berardo Di Matteo (2019)
Human Adipose-Derived Stem Cells as Future Tools in Tissue Regeneration: Osteogenic Differentiation and Cell-Scaffold Interaction
L. A. De Girolamo (2008)
Autotransplantation of the Adipose Tissue-Derived Mesenchymal Stromal Cells in Therapy of Venous Stasis Ulcers
Leszek Masłowski (2020)
The Effect of Conditioned Media of Stem Cells Derived from Lipoma and Adipose Tissue on Macrophages’ Response and Wound Healing in Indirect Co-culture System In Vitro
Sanja Stojanovic (2019)
Dose-dependent cytotoxicity induced by pristine graphene oxide nanosheets for potential bone tissue regeneration.
Xi-liu Zhang (2019)
Use of stem cells as alternative methods to animal experimentation in predictive toxicology.
Tae-Won Kim (2019)
Knockout of E2F1 Inhibits Adipose Stem Cell Proliferation and Differentiation in Fat Transplantation by Repressing Peroxisome Proliferator-Activated Receptor Gamma Expression.
Changchun Yang (2020)
Isolation and Characterization of Adipose-Derived Stromal Cells
Fiona A. van Vollenstee (2016)
Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications
Gabriele Togliatto (2016)
Adipose Stem Cells: From Bench to Bedside
Giuseppe Andrea Ferraro (2016)
Human adipose stem cells: properties and use in clinical applications
Laura Mäkinen (2015)See more