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Regional Cerebral Blood Flow In Chronic Hypertension. A Correlative Study.

F. Nobili, G. Rodriguez, S. Marenco, F. De Carli, M. Gambaro, C. Castello, R. Pontremoli, G. Rosadini
Published 1993 · Medicine

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BACKGROUND AND PURPOSE Cerebral hypoperfusion has occasionally been reported during essential hypertension. We explored regional cerebral blood flow in a large series of neurologically asymptomatic hypertensive patients to determine relations among cerebral blood flow, concomitant main vascular risk factors, and the most common signs of end-organ damage. METHODS Regional cerebral blood flow was measured by the 133Xe inhalation method in 101 hypertensive patients without clinically apparent central nervous system involvement, including 39 mild to moderate untreated and 62 mild to severe treated patients. RESULTS Compared with age- and sex-matched normal control subjects, cerebral blood flow was significantly reduced in untreated hypertensive patients (P < .01) and to a lesser extent in treated patients (P = .047). Both regional and global cerebral blood flow reductions were observed in approximately one third of patients in both groups. Analysis of variance failed to show significant correlations between cerebral blood flow and total cholesterol concentration, mean arterial blood pressure, duration of disease, or the presence of retinopathy or left ventricular hypertrophy. In the treated group, the quality of control of hypertension significantly influenced both global cerebral blood flow (P = .007) and cerebrovascular resistance (P < .0001). CONCLUSIONS Focal or diffuse cerebral hypoperfusion is present even in neurologically asymptomatic hypertensive patients, especially when untreated; good control of blood pressure may preserve cerebral perfusion and reduce cerebrovascular resistance. Regional cerebral blood flow examination represents a relatively simple and low-cost technique to explore the perfusional condition of the brain, one of the main target organs of hypertensive disease.
This paper references
An autopsy study of the incidence of lacunes in relation to age, hypertension, and arteriosclerosis.
K. Dozono (1991)
Cerebral blood flow and cerebrovascular reactivity in type I diabetes
G Rodriguez (1987)
Hypertensive disease and the cerebral circulation
S Strandgaard (1990)
133 - Xenon method , analysis of reproducibility : some of its physiological implications
UW Blauenstein (1975)
Cerebral blood flow and antihypertensive treatment with enalapril.
A. Frei (1986)
Regional Cerebral Blood Flow by 133Xenon Inhalation: Preliminary Evaluation of an Initial Slope Index in Patients with Unstable Flow Compartments
J. Risberg (1975)
Arterial hypertension injures brain capillaries. Definition of the lesions. Possible pathogenesis.
J. García (1981)
Developmental Course of Hypertension and Regional Cerebral Blood Flow in Stroke‐prone Spontaneously Hypertensive Rats
Y. Yamori (1977)
Efficacy of Nitrendipine in the Treatment of Elderly Hypertensive Subjects, and Its Effect on Cerebral Blood Flow
N. Pandita-Gunawardena (1989)
Regional cerebral blood flow in essential hypertension: data evaluation by a mapping system.
G. Rodriguez (1987)
Autoregulation of brain circulation in severe arterial hypertension.
S. Strandgaard (1973)
Regional cerebral blood flow estimated by xenon 133 inhalation
WD Obrist (1988)
A. Güell (1991)
Prospective analysis of long term control of mild hypertension on cerebral blood flow.
J. Meyer (1985)
Nuclear magnetic resonance image white matter lesions and risk factors for stroke in normal individuals.
H. Lechner (1988)
The blood flow, vascular resistance, and oxygen consumption of the brain in essential hypertension.
S. Kety (1948)
Hypertension in the elderly is associated with white matter lesions and cognitive decline
J. V. van Swieten (1991)
Evaluation of cerebral blood flow data in stroke patients using a mapping system.
G. Rosadini (1989)
Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.
I. Awad (1986)
Cerebral blood flow changes in benign aging and cerebrovascular disease
T. Shaw (1984)
White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors.
F. Fazekas (1988)
Antihypertensive therapy in the elderly. Effects on blood pressure and cerebral blood flow.
C. Ram (1987)
Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals.
R. Schmidt (1991)
Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.
K. Fujii (1990)
Vascular smooth muscle in hypertension.
A. Dominiczak (1989)
Hyperlipidemia is a risk factor for decreased cerebral perfusion and stroke.
J. Meyer (1987)
Hyperlipoproteine - mia in occlusive cerebrovascular disease
NT Mathew (1987)
Cerebral blood flow regulation in normotension and hypertension
HR Winn (1982)
Autoregulation of Cerebral Blood Flow in Hypertensive Patients: The Modifying Influence of Prolonged Antihypertensive Treatment on the Tolerance to Acute, Drug‐induced Hypotension
S. Strandgaard (1976)
Incidence of Silent Lacunar Lesion in Normal Adults and Its Relation to Cerebral Blood Flow and Risk Factors
S. Kobayashi (1991)
The effect of chronic propranolol therapy on regional cerebral blood flow in hypertensive patients.
M. Globus (1983)

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S. Birge (1997)
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Ischemia and lesion induced imbalances in cortical function
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