Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Forearm Metabolism In Obesity And Its Response To Intra-arterial Insulin. Characterization Of Insulin Resistance And Evidence For Adaptive Hyperinsulinism.

D. Rabinowitz, K. Zierler
Published 1962 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Obesity is considered ordinarily to be a consequence of overeating by an otherwise normal person, but the notion persists that there may be some underlying metabolic defect. The man of 70 kg, on becoming 20 per cent overweight, doubles his adipose organ mass (3). If obesity is viewed as a state of chronic substrate excess necessitating increase in fat storage of this magnitude, one might indeed predict that certain metabolic adjustments would occur, resulting in alterations in, but not implying a primary disturbance of, intermediary metabolism. Metabolism of obese subjects has been examined by measuring metabolic events in the forearm, which is predominantly skeletal muscle and adipose tissue, in the search for answers to the following questions. 1) What departures from normal take place in basal forearm metabolism of obese subjects and what light do these differences shed on adaptation to chronic substrate excess? 2) Is "simple" obesity related to maturity onset diabetes mellitus, in which obesity is common? Because resistance to exogenous insulin occurs in untreated maturity onset diabetes (4), response to intra-arterial -insulin was examined in simple obesity. From the observations it became clear that there are a number of similarities in metabo-
This paper references
The rate of production and degradation of cortisol in obesity ( abstract )
J. P. Eckert
The Treatment of Diabetes Mellitus, 8th ed
E. P. Joslin (1946)
10.1093/AJCN/8.5.712
The Obese Hyperglycemic Syndrome of Mice as an Example of "Metabolic" Obesity
J. Mayer (1960)
Effect of insulin on free fatty acid metabolism in the human forearm
D. Rabinowitz (1962)
10.1016/S0140-6736(61)90123-4
Insulin antagonism in the plasma of obese diabetic and prediabetics.
J. Vallance-owen (1961)
10.1172/JCI104452
Effect of insulin on carbohydrate metabolism and on potassium in the forearm of man.
R. Andres (1962)
10.1172/JCI104437
THEORY OF THE USE OF ARTERIOVENOUS CONCENTRATION DIFFERENCES FOR MEASURING METABOLISM IN STEADY AND NON-STEADY STATES.
K. Zierler (1961)
10.1016/S0140-6736(61)92838-0
Forearm metabolism in obesity and its response to intra-arterial insulin. Evidence for adaptive hyperinsulinism.
D. Rabinowitz (1961)
10.1001/JAMA.1939.02800010009002
A NEW INTERPRETATION OF HYPERGLYCEMIA IN OBESE MIDDLEAGED PERSONS
L. Newburgh (1939)
10.1172/JCI103324
The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm.
R. Andres (1956)
10.1172/JCI104453
Heterogeneity of forearm metabolism with special reference to free fatty acids.
M. Baltzan (1962)
10.1152/PHYSREV.1953.33.3.245
Body fat in adult man.
A. Keys (1953)
Spontaneous and insulin - induced resistance of peripheral tissues to insulin in diabetes
R. Andres (1958)
Dissociation of insulin action in the forearm of man ( abstract )
D. Rabinowitz (1962)
10.1172/JCI103259
A relation between non-esterified fatty acids in plasma and the metabolism of glucose.
V. Dole (1956)
Experimental Hypothalamic Hyperphagia in the Albino Rat *
J. Brobeck (1943)
10.2337/diab.12.3.197
Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay
J. Karam (1963)
10.1093/OXFORDJOURNALS.QJMED.A067659
SUGAR TOLERANCE IN OBESE SUBJECTS A REVIEW OF SIXTY-FIVE CASES
R. F. Ogilvie (1935)
10.1002/j.1550-8528.1996.tb00274.x
Immunoassay of endogenous plasma insulin in man.
R. Yalow (1960)
10.1002/PATH.1700370314
The islands of langerhans in 19 cases of obesity
R. Ogilvie (1933)
10.1172/JCI103475
Net potassium movement between resting muscle and plasma in man in the basal state and during the night.
R. Andres (1957)
10.1210/ENDO-18-1-75
GLUCOSE TOLERANCE STUDIES IN CHILDREN AND IN ADOLESCENTS
H. J. John (1934)
The obesity hyperglycemic syndrome of mice as an example of "metabolic' obesity. Amer
J Mayer (1960)
10.1210/JCEM-16-3-367
Studies on obesity. I. The insulin-glucose tolerance curve.
E. Arendt (1956)
10.1016/S0140-6736(00)61562-3
THE MECHANISM OF DIABETES MELLITUS
H. Himsworth (1939)



This paper is referenced by
Bedeutung einer Gewichtszunahme im normalen Gewichtsbereich für die Entwicklung der Insulinresistenz
Bianca Kallabis (2013)
10.1101/585372
Trans-Endothelial Insulin Transport is Impaired in Skeletal Muscle Capillaries of Obese Male Mice
I. M. Williams (2019)
10.1111/j.1532-5415.1989.tb06808.x
Effect of Habitual Physical Activity on Age‐Related Glucose Intolerance
J. Wang (1989)
10.1016/0002-9343(64)90063-4
NEWER APPROACHES TO THE STUDY OF OBESITY.
C. Waterhouse (1964)
10.2337/diab.14.6.341
Dynamics of Insulin Secretion in Hypoglycemia
R. Yalow (1965)
10.2337/diab.25.6.494
Nitrogen Metabolism and Insulin Requirements in Obese Diabetic Adults on a Protein-Sparing Modified Fast
B. Bistrian (1976)
10.1002/CPHY.CP050164
Metabolism of adipose tissue in experimental obesity
J. Mayer (2011)
10.1002/CPHY.CP050110
The development of adipose tissue
F. Wassermann (2011)
10.1172/JCI115476
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture.
C. Sztalryd (1991)
10.1016/0026-0495(90)90002-T
Obesity and insulin resistance in humans: a dose-response study.
R. Bonadonna (1990)
10.1016/S0025-7125(16)30696-4
Endocrine aspects of obesity.
A. Glass (1989)
10.1210/JCEM-51-4-739
Increased insulin resistance in obese, glucose-intolerant Southwestern American Indians: evidence for a defect not explained by obesity.
M. Nagulesparan (1980)
10.1002/CPHY.CP050113
Morphology of adipose tissue: a microscopic anatomy of fat
H. Sheldon (2011)
10.2337/diab.22.7.507
Relationship Between Fasting Plasma Insulin Level and Resistance to Insulin-Mediated Glucose Uptake in Normal and Diabetic Subjects
J. Olefsky (1973)
10.2337/db12-0271
Muscle Perfusion
E. Barrett (2012)
10.1016/0026-0495(66)90171-5
Carbohydrate-induced hypertriglyceridemia and glucose utilization in ischemic heart disease.
P. Nestel (1966)
10.1007/s00125-008-1148-z
Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women
T. McLaughlin (2008)
10.5555/URI:PII:0022214380901584
A defect in cell-mediated immune function in insulin-resistant diabetic and obese subjects.
O. Kolterman (1980)
Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man.
P. Barter (1972)
10.1016/S0140-6736(68)91660-7
Carcinoma of the colon and rectum.
E. Walrond (1968)
10.1016/0022-3999(67)90063-3
Obesity and depression.
E. V. Leckie (1967)
10.1016/S0300-595X(76)80030-8
Exercise in the treatment of obesity.
P. Björntorp (1976)
10.1002/CPHY.CP050154
The adipokinetic property of hypophyseal peptides and catecholamines: a problem in comparative endocrinology1
D. Rudman (2011)
10.1161/01.HYP.14.4.367
Insulin and Renal Sodium Retention in Obese Adolescents
A. Rocchini (1989)
10.2337/diacare.6.4.328
A Hypocaloric High-Protein Diet as Primary Therapy for Adults with Obesity-related Diabetes: Effective Long-Term Use in a Community Hospital
J. Fitz (1983)
10.1002/CPHY.CP050161
Psychogenic effects on lipid mobilization
Morton D. Bogdonoff (2011)
10.2337/diacare.19.12.1404
Separate Associations Between Visceral and Subcutaneous Adipose Tissue Distribution, Insulin and Glucose Levels in Obese Women
R. Ross (1996)
10.2337/db10-0766
Obesity and Insulin Resistance: An Ongoing Saga
S. Kim (2010)
10.2337/diab.18.11.759
The Interaction of Diabetes and Obesity on the Regulation of Fat Mobilization in Man
J. Bagdade (1969)
flow by positron emission tomography with H2 15O Regional measurement of canine skeletal muscle blood
José Guerrero (2013)
10.1002/CPHY.CP050152
Effect of dietary and endocrine factors on adipose tissue growth1
F. X. Hausberger (2011)
10.1093/AJCN/20.9.986
Weight gain, serum lipids, and vascular disease in diabetics.
W. Reinheimer (1967)
See more
Semantic Scholar Logo Some data provided by SemanticScholar