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Insulin-like Growth Factor I Mediates Selective Anabolic Effects Of Parathyroid Hormone In Bone Cultures.
E. Canalis, M. Centrella, W. Burch, T. McCarthy
Published 1989 · Medicine
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PTH was studied for its effects on bone formation in cultured rat calvariae. 0.01-10 nM PTH stimulated [3H]thymidine incorporation into DNA by up to 4.8-fold. Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into collagen, transient (24 h) treatment enhanced [3H]proline incorporation into collagen 24-48 h after the hormone was removed. The collagen stimulated by PTH was type I and the effect was observed in the periosteum-free bone and was not blocked by hydroxyurea. Furthermore, treatment with 1-100 nM PTH for 24 h increased insulin-like growth factor (IGF) I concentrations by two to fourfold, and an IGF I antibody prevented the PTH stimulation of collagen synthesis, but not its mitogenic effect. In conclusion, continuous treatment with PTH inhibits calvarial collagen, whereas transient treatment stimulates collagen synthesis, and the stimulatory effect is mediated by local production of IGF I.
This paper references
Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.
E. Canalis (1980)
Bone Cells: Biochemical and Biological Studies after Enzymatic Isolation
W. A. Peck (1964)
Parathyroid hormone stimulates the proliferation of cells derived from human bone.
B. Macdonald (1986)
Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.
W. Russell (1984)
The hormonal and local regulation of bone formation.
E. Canalis (1983)
Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.
M. Centrella (1985)
Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.
G. Wong (1975)
Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.
G. Howard (1981)
The estimation of two collagens from human dermis by interrupted gel electrophoresis.
B. Sykes (1976)
An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.
W. Kiess (1987)
The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts.
B. Peterkofsky (1972)
Growth factors and the regulation of bone remodeling.
E. Canalis (1988)
Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.
M. Centrella (1987)
Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats.
J. Hock (1988)
The type II insulin-like growth factor receptor does not mediate deoxyribonucleic acid synthesis in human fibroblasts.
R. Furlanetto (1987)
CHAPTER 5 – Parathyroid Physiology and the Skeleton
J. A. Parsons (1976)
Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.
M. Centrella (1988)
Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I.
M. Ernst (1988)
Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin.
J. Dietrich (1976)
Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.
D. Slovik (1981)
Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae.
E. Canalis (1988)
Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration.
C. Tam (1982)
Insulin-like growth factor I has independent effects on bone matrix formation and cell replication.
J. Hock (1988)
Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.
B. Peterkofsky (1971)
DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bones.
J. Lorenzo (1983)
BONE RESORPTION IN TISSUE CULTURE. FACTORS INFLUENCING THE RESPONSE TO PARATHYROID HORMONE.
L. Raisz (1965)
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Somatomedin-C, physical fitness, and bone density.
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J. Antonsen (1996)
Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts*
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Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
N. Ogata (2000)
IGFs: function and clinical importance 2 The regulation of osteoblast function by hormones and cytokines with special reference to insulin‐like growth factors and their binding proteins
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Actions of Parathyroid Hormone
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Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo.
F. Pirih (2005)
Characterization, regulation, and function of specific cell membrane receptors for insulin‐like growth factor I on bone endothelial cells
G. Fiorelli (1994)
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The influence of culture conditions on extracellular matrix proteins synthesized by osteoblasts derived from rabbit bone marrow.
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