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Insulin-like Growth Factor I Mediates Selective Anabolic Effects Of Parathyroid Hormone In Bone Cultures.

E. Canalis, M. Centrella, W. Burch, T. McCarthy
Published 1989 · Medicine

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PTH was studied for its effects on bone formation in cultured rat calvariae. 0.01-10 nM PTH stimulated [3H]thymidine incorporation into DNA by up to 4.8-fold. Although continuous treatment with PTH for 24-72 h inhibited [3H]proline incorporation into collagen, transient (24 h) treatment enhanced [3H]proline incorporation into collagen 24-48 h after the hormone was removed. The collagen stimulated by PTH was type I and the effect was observed in the periosteum-free bone and was not blocked by hydroxyurea. Furthermore, treatment with 1-100 nM PTH for 24 h increased insulin-like growth factor (IGF) I concentrations by two to fourfold, and an IGF I antibody prevented the PTH stimulation of collagen synthesis, but not its mitogenic effect. In conclusion, continuous treatment with PTH inhibits calvarial collagen, whereas transient treatment stimulates collagen synthesis, and the stimulatory effect is mediated by local production of IGF I.
This paper references
10.1172/JCI109908
Effect of insulinlike growth factor I on DNA and protein synthesis in cultured rat calvaria.
E. Canalis (1980)
10.1126/science.146.3650.1476
Bone Cells: Biochemical and Biological Studies after Enzymatic Isolation
W. A. Peck (1964)
10.1210/ENDO-118-6-2445
Parathyroid hormone stimulates the proliferation of cells derived from human bone.
B. Macdonald (1986)
10.1073/PNAS.81.8.2389
Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.
W. Russell (1984)
10.1210/EDRV-4-1-62
The hormonal and local regulation of bone formation.
E. Canalis (1983)
10.1073/PNAS.82.21.7335
Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.
M. Centrella (1985)
10.1073/PNAS.72.8.3167
Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.
G. Wong (1975)
10.1073/PNAS.78.5.3204
Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.
G. Howard (1981)
10.1016/S0006-291X(76)80180-5
The estimation of two collagens from human dermis by interrupted gel electrophoresis.
B. Sykes (1976)
10.1016/s0021-9258(18)45269-6
An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.
W. Kiess (1987)
10.1016/0003-9861(72)90221-4
The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts.
B. Peterkofsky (1972)
10.1172/JCI113318
Growth factors and the regulation of bone remodeling.
E. Canalis (1988)
10.1016/s0021-9258(18)61587-x
Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.
M. Centrella (1987)
10.1210/ENDO-122-6-2899
Human parathyroid hormone-(1-34) increases bone mass in ovariectomized and orchidectomized rats.
J. Hock (1988)
10.1210/JCEM-64-6-1142
The type II insulin-like growth factor receptor does not mediate deoxyribonucleic acid synthesis in human fibroblasts.
R. Furlanetto (1987)
10.1016/B978-0-12-119204-4.50012-0
CHAPTER 5 – Parathyroid Physiology and the Skeleton
J. A. Parsons (1976)
10.1073/PNAS.85.16.5889
Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.
M. Centrella (1988)
10.1016/0006-291X(88)90570-0
Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I.
M. Ernst (1988)
10.1210/ENDO-98-4-943
Hormonal control of bone collagen synthesis in vitro: effects of parathyroid hormone and calcitonin.
J. Dietrich (1976)
10.1172/JCI110372
Short-term effects of synthetic human parathyroid hormone-(1--34) administration on bone mineral metabolism in osteoporotic patients.
D. Slovik (1981)
10.1210/ENDO-122-1-22
Isolation and characterization of insulin-like growth factor I (somatomedin-C) from cultures of fetal rat calvariae.
E. Canalis (1988)
10.1210/ENDO-110-2-506
Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration.
C. Tam (1982)
10.1210/ENDO-122-1-254
Insulin-like growth factor I has independent effects on bone matrix formation and cell replication.
J. Hock (1988)
10.1021/BI00782A009
Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.
B. Peterkofsky (1971)
10.1172/JCI111156
DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bones.
J. Lorenzo (1983)
10.1172/JCI105117
BONE RESORPTION IN TISSUE CULTURE. FACTORS INFLUENCING THE RESPONSE TO PARATHYROID HORMONE.
L. Raisz (1965)



This paper is referenced by
10.1016/B978-0-12-373884-4.00049-5
Cellular Actions of Parathyroid Hormone
S. Kousteni (2008)
10.1016/B978-012370544-0.50020-3
Cytokines and bone remodeling
G. Mundy (1991)
10.1007/978-3-540-35687-5_3
Biologische und physiologische Grundlagen
G. Schmidmaier (2006)
10.1007/978-1-59259-278-4_25
Parathyroid Hormone as a Therapy for Osteoporosis
M. Rubin (2003)
10.12701/YUJM.2008.25.1.19
The Diagnosis and Treatment of Osteoporosis
J. Moon (2008)
10.1007/s12011-012-9593-4
Effects of Silicon on Osteoblast Activity and Bone Mineralization of MC3T3-E1 Cells
E. Kim (2012)
10.1002/JBMR.5650091221
Bone morphogenetic protein 2 increases insulin‐like growth factor I and II transcripts and polypeptide levels in bone cell cultures
E. Canalis (1994)
Neonatal Nutrition and Metabolism
P. Thureen (1991)
10.1016/S0765-1597(05)80083-8
Particularités du métabolisme phosphocalcique chez le cheval
J. Barlet (1993)
10.1002/JCP.1041490216
Insulin‐Like growth factor binding protein (IGFBP) inhibits igf action on human osteosarcoma cells
P. Campbell (1991)
10.1074/JBC.M009973200
Regulated Nuclear-Cytoplasmic Localization of CCAAT/ Enhancer-binding Protein δ in Osteoblasts*
J. Billiard (2001)
10.1210/ENDO-128-2-1006
Parathyroid hormone and parathyroid hormone-related peptide stimulate insulin-like growth factor-binding protein secretion by rat osteoblast-like cells through a adenosine 3',5'-monophosphate-dependent mechanism.
O. Tørring (1991)
10.1210/JCEM-70-3-718
Somatomedin-C, physical fitness, and bone density.
P. J. Kelly (1990)
10.1002/jcp.25369
Role of PTHrP(1‐34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis
J. Fischer (2016)
10.21767/2380-7245.100169
Calcification of Soft Tissues in a Family, Case Report and Review of Pseudohypoparathyroidism
Mohammad Reza Navaeifar (2017)
10.1002/jcb.22322
Growth factor control of bone mass
E. Canalis (2009)
10.1111/j.1525-139X.1996.tb00680.x
Renal Osteodystrophy: Past and Present
J. Antonsen (1996)
10.1074/JBC.271.36.21835
Identification of the cAMP Response Element That Controls Transcriptional Activation of the Insulin-like Growth Factor-I Gene by Prostaglandin E2 in Osteoblasts*
M. J. Thomas (1996)
10.1172/JCI9017
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
N. Ogata (2000)
10.1111/j.1365-2796.1993.tb01011.x
IGFs: function and clinical importance 2 The regulation of osteoblast function by hormones and cytokines with special reference to insulin‐like growth factors and their binding proteins
C. Schmid (1993)
10.1677/JOE-10-0045
The effect of GH and IGF1 on linear growth and skeletal development and their modulation by SOCS proteins.
S. Ahmed (2010)
10.1359/jbmr.2000.15.2.188
Insulin‐Like Growth Factor I Production Is Essential for Anabolic Effects of Thyroid Hormone in Osteoblasts
B. K. Huang (2000)
10.1016/B978-012098652-1.50129-3
Actions of Parathyroid Hormone
J. Hock (2002)
10.1016/J.BBRC.2005.04.132
Parathyroid hormone induces the NR4A family of nuclear orphan receptors in vivo.
F. Pirih (2005)
10.1002/JBMR.5650090307
Characterization, regulation, and function of specific cell membrane receptors for insulin‐like growth factor I on bone endothelial cells
G. Fiorelli (1994)
10.1210/clinem/dgz054
Effects of Pegvisomant and Pasireotide LAR on vertebral fractures in acromegaly resistant to First-Generation SRLs.
S. Chiloiro (2019)
10.2147/CIA.S3372
Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatment
C. Gagnon (2008)
10.1002/JBM.10252
The influence of culture conditions on extracellular matrix proteins synthesized by osteoblasts derived from rabbit bone marrow.
F. Cornet (2002)
10.1359/jbmr.2001.16.7.1300
Continuous Parathyroid Hormone and Estrogen Administration Increases Vertebral Cancellous Bone Volume and Cortical Width in the Estrogen‐Deficient Rat
H. Zhou (2001)
10.1007/s007740050090
The response of bone to unloading
D. Bikle (1999)
10.7150/ijbs.14077
Fibroblast Growth Factor Receptor 3 Deficiency Does Not Impair the Osteoanabolic Action of Parathyroid Hormone on Mice
Y. Xie (2016)
10.1007/s000110050288
IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis
J. Martel-Pelletier (1998)
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