Online citations, reference lists, and bibliographies.
← Back to Search

High Prevalence Of Occult Papillary Thyroid Carcinoma In A Surgical Series For Benign Thyroid Disease

M. Pelizzo, A. Piotto, D. Rubello, D. Casara, A. Fassina, B. Busnardo
Published 1990 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
In a surgical series of 277 consecutive patients operated on the thyroid for benign diseases, a high prevalence rate (10.5%) of occult papillary carcinoma was found by means of an accurate histologic examination. Indications for surgery were euthyroid multinodular goiter in 25 patients, autonomously hyperfunctioning adenoma in 2 and Graves’ disease in 2 patients. Neoplastic foci were unilaterally found in 25 cases but multifocally in 6 and bilaterally in 4 cases: the diameters ranged from 2-10 mm. After operation (14 subtotal and 15 total thyroidectomies), all patients received TSH-suppressive doses of T4. At a mean follow-up of 5.6 years, neither local recurrences nor lymph node or distant metastases had occurred; no patient died of the tumor. In keeping with other surgical and autopsy series, the prevalence of occult thyroid carcinoma in a normal population is calculated to be about 5-10%, whereas it is known that the prevalence of clinically evident thyroid cancer is only 0.05%. This means that only 1-2% of occult carcinomas may evolve in an overt tumor during life. In view of such an epidemiologic difference and the favorable course of our patients, although the mean follow-up is rather short, we suggest that lobectomy plus T4 treatment may be considered an adequate therapeutic approach in patients with occult papillary thyroid carcinoma.
This paper references
Occult papillary thyroid carcinoma
L Bondeson (1984)
Metastatic occult follicular thyroid carcinoma.
T. Boehm (1976)
Occult thyroid carcinoma at autopsy in Malmö, Sweden
L. Bondeson (1981)
Occult papillary thyroid carcinoma in the young and the aged
L. Bondeson (1984)
Thyroid gland morphology in young adults: normal subjects versus those with prior low-dose neck irradiation in childhood.
G. A. Hanson (1983)
Occult thyroid carcinoma in olmsted county, minnesota: Prevalence at autopsy compared with that in hiroshima and nagasaki. Japan
R. J. Sampson (1974)
Nodular thyroid disease. Evaluation and management.
M. Rojeski (1985)
Clinical and radio-diagnostic aspects in the evaluation of thyroid nodules with respect to thyroid cancer.
E. Krenning (1988)
Malignant cold thyroid nodules in hyperthyroidism
D. Livadas (1976)
, Ljungberg 0 . : Occult papillary thyroid carcinoma in the young and aged
L. Bondeson (1984)
Papillary thyroid carcinoma: factors influencing prognosis and current therapy.
E. Mazzaferri (1987)
Gross and microscopic findings in clinically normal thyroid glands.
J. Mortensen (1955)
Occult papillary carcinoma of the thyroid in children and young adults: A systemic autopsy study in Finland
Kaarle O. Franssila (1986)
Ljungberg 0 . : Occult thyroid carcinoma at autopsy in Malmo , Sweden
L. Bondeson (1981)
Some observations on the incidence 257 of thyroid cancer
P. Mustacchi (1986)
The incidence of thyroid cancer and the problem of malignancy in nodular goiter
J. E. Sokal (1960)
The reliability of malignant thyroid tumor diagnosis in the Swedish Cancer Registry. Review of 200 cases.
L. E. Holm (1980)
Thyroid cancer. In: Thyroid
M. Tubiana (1982)
Some observations on the incidence of thyroid cancer in the United States.
S. Cutler (1956)
TSH levels and TSH response to TRH as a guide to the replacement treatment of patients with thyroid carcinoma.
B. Busnardo (1976)

This paper is referenced by
Treatment for Microcarcinoma of the Thyroid—Clinical Experience
N. Küçük (2007)
Micropapillary thyroid cancer: should we aspirate all nodules regardless of size?
K. Burman (2006)
Anatomy and Pathology of the Thyroid and Parathyroid Glands
L. Loevner (2011)
Thyroid biopsies: fine-needle aspiration biopsy versus spring-activated core biopsy needle in 102 patients.
S. F. Quinn (1994)
Thyroid nodules: pathogenesis, diagnosis and treatment.
C. Meier (2000)
Papillary thyroid microcarcinomas: a comparative study of the characteristics and risk factors at presentation in two cancer registries.
P. Malandrino (2013)
Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience
M. Pelizzo (2004)
Observing micopapillary thyroid cancers.
D. Ross (2014)
Controversies in papillary microcarcinoma of the thyroid
M. Piersanti (2003)
High prevalence of carcinoma in ultrasonography-guided fine needle aspiration cytology of thyroid nodules.
Dong-lim Kim (2008)
Incidental thyroid carcinoma (ITC): a retrospective study in a series of 737 patients treated for benign disease.
R. Gelmini (2010)
Simultaneous Occurrence of Papillary Intrafollicular and Microcarcinomas with Bilateral Medullary Microcarcinoma of the Thyroid in a Patient with Multiple Endocrine Neoplasia Type 2A: Report of a Case
M. Kösem (2002)
Papillary microcarcinoma of the thyroid gland
M. Bramley (1996)
Pathologic Diagnosis of Thyroid Cancer
Xiaoyin “Sara” Jiang (2017)
"Occult" papillary carcinoma of the thyroid: a questionable entity.
B. Salvadori (1993)
Frequency of Thyroid Carcinoma in a Recent Series of 539 Consecutive Thyroidectomies for Multinodular Goiter
M. Pelizzo (1997)
Differential expression of IGFBP-5 and two human ESTs in thyroid glands with goiter, adenoma and papillary or follicular carcinomas.
B. Stolf (2003)
Cross-sectional imaging
Syed Ajaz (2011)
Management of a solitary thyroid nodule.
E. Mazzaferri (1993)
Effets tardifs de la radiothrapie externe sur la glande thyrode
A. Monnier (1997)
Fine-needle aspiration biopsy of the thyroid: comparison between thyroid palpation and ultrasonography.
M. Deandrea (2002)
Active surveillance for patients with very low‐risk thyroid cancer
S. Lohia (2020)
Advances in the management of patients with thyroid disease.
H. Dworkin (1995)
Highly aggressive behaviour of occult papillary thyroid carcinoma.
T. Hefer (1995)
Clinical features and therapeutic implication of papillary thyroid microcarcinoma.
K. Pazaitou-Panayiotou (2007)
Thyroid papillary microcarcinoma: a descriptive and meta-analysis study.
E. Roti (2008)
Thyroid Papillary Microcarcinoma
L. A. Perez (2001)
Insidious Rare Thyroid Microcarcinoma (Black Ink)
E. Trapanese (2017)
Clinical and histological characteristics of papillary thyroid microcarcinoma: results of a retrospective study in 243 patients.
E. Roti (2006)
Small carcinomas of the thyroid. A long-term follow-up of 867 patients.
S. Noguchi (1996)
Papillary thyroid microcarcinoma: a surgical perspective.
G. Sakorafas (2005)
Incidence of thyroid carcinoma in multinodular goitre: retrospective analysis in a medical college hospital
Praveen Kumar Kundapur (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar