Bleomycin Loaded Magnetic Chitosan Nanoparticles As Multifunctional Nanocarriers
Doga Kavaz, Sedat Odabas, Eylem Güven, Murat Demirbilek, Emir Baki Denkbaş
Published 2010 · Chemistry
Download PDFAnalyze on Scholarcy
Iron oxide (Fe3O4) containing magnetic chitosan nanoparticles were prepared with Concanavalin-A and Bleomycin as multifunctional nanocarriers for the targeted cancer therapy by co-precipitation techniques. The chemical structures of nanoparticles were analyzed by FTIR and the magnetic properties of the nanoparticles were evaluated by electron spin resonance technique and vibrational scanning mangnetometer measurements. The in vitro release profiles of Bleomycin were investigated and chitosan nanoparticles characteristics were optimized for subsequent in vivo applications. The magnetic chitosan nanoparticles are biocompatible-based MTT assays. The therapeutic potential of these nanoparticles are being investigated for in vivo applications.
This paper references
Chitin and Chitosan
Shigehiro Hirano (2002)
A REVIEW OF CHITIN AND CHITOSAN APPLICATIONS
Ravi Kumar M.N.V. (2000)
In Vivo Angiogenic Gene Silencing Using Chitosan Nanoparticles in Ovarian Carcinoma
A. K. Sood (2009)
A review of chitin and chitosan applications
Majeti N V Ravi Kumar (2000)
Synthesis of Magnetite Nanoparticles by Precipitation with Forced Mixing
Yihua Zhu (1999)
Magnetic Fluid Hyperthermia, In: Haneli
A. Jordan (1997)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
Ajay Kumar Gupta (2005)
Preparation and properties of magnetic Fe3O4–chitosan nanoparticles
Gui-yin Li (2008)
Preparation and Characterization of Biochemically Modified Polymeric Carriers for Cancer Therapy, Thesis, Hacettepe University
E. Ozturk (2007)
Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies
Donghyun Kim (2006)
World Cancer Report
Bernard W. Stewart (2003)
Magnetically loaded poly(methyl methacrylate-co-acrylic acid) nano particles
Ferena Sayar (2006)
Drug Delivery and Transport to Solid Tumors
Seong Hoon Jang (2004)
Theragnostic imaging for radiation oncology: dose-painting by numbers.
Søren M Bentzen (2005)
Perspectives on: Chitosan Drug Delivery Systems Based on their Geometries
Emir Baki Denkbaş (2006)
The Cancer Handbook, London: Nature Publishing Group
M. R. Alison (2003)
Development and characterisation of chitosan nanoparticles for siRNA delivery.
Haliza Katas (2006)
Effects of Copper-Cyclam and CopperCyclam/Polymer Complexes on HeLa Cells
M. Demirbilek (2008)
Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity.
M Paula M Marques (2002)
Magnetic Fluid Hyperthermia (MFH)
Andreas Jordan (1997)
CHITIN AND CHITOSAN: PROPERTIES AND APPLICATIONS
Marguerite Rinaudo (2006)
Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going?
Giorgio Parmiani (2002)
siRNA delivery technologies for mammalian systems
David B. Rozema (2003)
Preparat|on and Propert|es of Magnet|c Fe3O4-Ch|tosan Nanopart|cles
G. Li (2008)
ESMO Handbook of Advanced Cancer Care
Raphael Catane (2006)
Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs.
A. Aigner (2006)
Preparation and characterization of (3-aminopropyl)triethoxysilane-coated magnetite nanoparticles
Mitsuyo Yamaura (2004)
Concanavalin A-induced inhibition of abrin and ricin activity parallels with a decrease of the number of toxin-binding uptake-elution cycles.
Costante Delfini (1982)
Delivery of molecular and cellular medicine to solid tumors.
Rakesh K. Jain (2001)
New trends in cancer for the 21st century
Antonio Llombart-Bosch (2003)
Chitosan microspheres and sponges: Preparation and characterization
Emir Baki Denkbaş (2000)
Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol
Heath R. Pardoe (2001)
The Biology of Cancer
Robert A Weinberg (1957)
Delivery of molecular and cellular medicine to solid tumors.
Rakesh K. Jain (1997)
PVP magnetic nanospheres: biocompatibility, in vitro and in vivo bleomycin release.
Ding Guo-wei (2007)
Natural polymers for gene delivery and tissue engineering.
Jiyoung M Dang (2006)
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Tobias Neuberger (2005)
This paper is referenced by
Microwave assisted synthesis and characterization of sodium alginate-graft-poly(N,N'-dimethylacrylamide).
Alper Akın (2016)
Thermal potentiation of chemotherapy by magnetic nanoparticles Magnetic nanoparticles
Madeline Torres-Lugo (2010)
In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells.
Patrícia Figueiredo (2017)
Synthesis, characterization, antimicrobial and antimetastatic activity of silver nanoparticles synthesized from Ficus ingens leaf
Doga Kavaz (2018)
Synthesis, characterization, cytotoxicity and DNA binding studies of Fe3O4@SiO2 nanoparticles coated by an antiviral drug lamivudine
Nahid Shahabadi (2018)
Nano-radiogold-decorated composite bioparticles.
Agata Wójtowicz (2019)
Chitosan Based Nanoparticles towards Biomedical Applications
Khairujjaman Laskar (2017)
Nano-Sized Polymeric Drug Carrier Systems
Cornelia Vasile (2014)
Polymer-coated magnetic nanoparticles and modified polymer nanofibers for the efficient capture of Mycobacterium tuberculosis (Mtb)
Marica Smit (2018)
Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHX) based nanoparticles for targeted cancer therapy.
Ebru Kilicay (2011)
Fabrication of Fe3O4 nanoparticles coated by extracted shrimp peels chitosan as sustainable adsorbents for removal of chromium contaminates from wastewater: The design of experiment
Seied Mahdi Pourmortazavi (2019)
Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line
Öznur Akbal (2017)
Pembuatan Nanopartikel Kitosan-Fe3O4 secara Ko-Presipitasi Ex-Situ Menggunakan Tripolyphosphate/Sulfat sebagai Crosslinker dan Karakterisasinya Menggunakan XRD
Ika Oktavia Wulandari (2016)
Osteoblast activity on anodized titania nanotubes: effect of simulated body fluid soaking time.
Cem Bayram (2012)
Use of a chitosan–cadmium polymer as a redox hybridization indicator for CaMV35S promoter gene detection
Qingxiang Wang (2012)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
Thermal potentiation of chemotherapy by magnetic nanoparticles.
Madeline Torres-Lugo (2013)
Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases.
Ibrahim M A ElSherbiny (2017)
Colloidal stability and “in vitro” antitumor targeting ability of lipid nanocapsules coated by folate–chitosan conjugates
Azahara Rata-Aguilar (2012)
GABA and 5-HT chitosan nanoparticles enhanced liver cell proliferation and neuronal survival in partially hepatectomised rats: GABAB and 5-HT2A receptors functional
Joy Shilpa (2013)
Effects of Mechanotransduction on Stem Cell Behavior
Bahar Bilgen (2016)
Effect of N/P ratios on physicochemical stability, cellular association, and gene silencing efficiency for trimethyl chitosan/small interfering RNA complexes
Xing Liu (2013)
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery.
Gozde Unsoy (2014)
pH-responsive microspheres encapsulated with iron oxide nanoaggregates for gastrointestinal delivery
Young Ju Son (2012)
Marine microbes as a valuable resource for brand new industrial biocatalysts
Azadeh Beygmoradi (2017)
Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity
Confidence Onyebuchi (2019)
Rapid anti-tumor effects of gelatin sponge/nano-β-TCP construct on SKOV-3 human ovarian cancer cells in vitro
Xing Ma (2011)
Investigation on Conjugation Capacity of New Chitosan Carriers Based on Conjugated Model Toward Enzyme Delivery
Solmaz Zakhire (2014)
Industrial applications of marine carbohydrates.
Prasad N Sudha (2014)
IN SITU SYNTHESIS and CHARACTERIZATION OF CHITOSAN COATED IRON OXIDE NANOPARTICLES and LOADING OF DOXORUBICIN
Gozde Unsoy (2012)
A molecular zipping/unzipping nano-vehicles sensitive to tumor extracellular pH
Jung Ok Lee (2014)
Magnetically based nanocarriers in drug delivery
Emir Baki Denkbaş (2016)See more