Online citations, reference lists, and bibliographies.
← Back to Search

Fabrication And In Vitro Biological Evaluation Of Photopolymerisable Hydroxyapatite Hydrogel Composites For Bone Regeneration

J. Killion, Luke M. Geever, D. Devine, C. Higginbotham
Published 2014 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The aim of this study was to improve the bioactive and compressive properties of photopolymerisable polyethylene glycol hydrogels with the incorporation of hydroxyapatite at different loadings. The synthesis of pure hydroxyapatite was verified through Fourier transform infrared spectroscopy (FTIR) analysis by the complete reaction of all constituents. The formation of a bioactive layer of the hydrogel based composites was confirmed through the formation of carbonate hydroxyapatite after soaking the samples in simulated body fluid. The incorporation of hydroxyapatite into the system resulted in an increase in Young’s modulus from 4.36 to 12.73 MPa and an increase in the stress at limit value from 1.20 to 4.42 MPa. This was due to the hydroxyapatite absorbing the compressive load, the polymer matrix distributing the load, a reduction in swelling and the presence of physical crosslinking between both components. Drug dissolution testing showed that the release rate of a drug from the hydrogels was dependent on the molecular weight of the polymer and the type of drug used.
This paper references
10.1021/bm200027z
Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles.
A. Gaharwar (2011)
10.1016/J.CARBPOL.2006.06.033
Viscoelastic properties of dispersed chitosan/xanthan hydrogels
A. Martínez-Ruvalcaba (2007)
10.1007/s10853-012-6588-7
Modulating the mechanical properties of photopolymerised polyethylene glycol–polypropylene glycol hydrogels for bone regeneration
J. Killion (2012)
10.1016/J.MSEC.2009.03.010
Novel PVP/PVA hydrogels for articular cartilage replacement
Ruyin Ma (2009)
10.1016/S0142-9612(01)00243-5
Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures.
T. G. Chu (2002)
10.1007/s10856-010-4076-7
Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment
E. Andronescu (2010)
10.1016/J.BIOMATERIALS.2003.10.016
Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite.
R. Murugan (2004)
10.1177/0883911509341774
Injectable Poly(ethylene glycol) Dimethacrylate-based Hydrogels with Hydroxyapatite
Ziyou Zhou (2009)
10.1016/J.BIOMATERIALS.2006.01.017
How useful is SBF in predicting in vivo bone bioactivity?
T. Kokubo (2006)
10.1016/J.CERAMINT.2009.09.016
Synthesis, characterization and bioactivity investigation of bioglass/hydroxyapatite composite
R. Ravarian (2010)
10.1016/j.jconrel.2010.04.002
Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model.
B. Li (2010)
10.1016/J.EURPOLYMJ.2007.06.016
Degradation of covalently cross-linked carboxymethyl chitosan and its potential application for peripheral nerve regeneration
Guangyuan Lu (2007)
10.1016/S0142-9612(03)00340-5
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
10.1016/J.JMATPROTEC.2009.05.002
Polymeric microstructures induced by freeze-drying process: Comparative study of PS41-PAA(271) morphologies after impregnations in water and in an alkaline solution
M. Horgnies (2009)
10.1016/J.MSEC.2007.01.005
Hydrophilic poly (ethylene glycol) coating on PDLLA/BCP bone scaffold for drug delivery and cell culture
L. Zhang (2008)
10.1016/j.actbio.2011.08.019
The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics.
Chen Wang (2012)
10.1016/S0168-3659(99)00027-9
Poly(ethylene glycol)-containing hydrogels in drug delivery.
N. Peppas (1999)
10.1016/j.actbio.2011.07.023
Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles.
A. Gaharwar (2011)
10.1016/j.ijpharm.2011.06.015
Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate].
W. Wu (2011)
10.1016/j.actbio.2010.04.011
Synthesis, characterization and cytotoxicity of photo-crosslinked maleic chitosan-polyethylene glycol diacrylate hybrid hydrogels.
Chao Zhong (2010)
10.1016/j.biomaterials.2009.01.020
Injectable chitosan-based hydrogels for cartilage tissue engineering.
R. Jin (2009)
10.1016/J.MEMSCI.2005.09.040
Transport and structural characteristics of crosslinked poly(ethylene oxide) rubbers
H. Lin (2006)
10.1016/j.biomaterials.2008.09.037
The effect of photopolymerization on stem cells embedded in hydrogels.
N. E. Fedorovich (2009)
10.1016/j.jmbbm.2011.04.004
Mechanical properties and thermal behaviour of PEGDMA hydrogels for potential bone regeneration application.
J. Killion (2011)
10.1016/J.MSEB.2009.11.012
Study of nanobiomaterial hydroxyapatite in simulated body fluid: Formation and growth of apatite
Pradnya Chavan (2010)
10.1016/J.MSEC.2008.05.008
Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration
Cheng Xianmiao (2009)
10.1016/J.ACTBIO.2005.06.006
Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique.
C. M. Vaz (2005)
10.1016/J.MEMSCI.2009.05.043
Influence of phenoxy-terminated short-chain pendant groups on gas transport properties of cross-linked poly(ethylene oxide) copolymers
V. Kusuma (2009)
10.1007/BF03218754
Preparation of a porous chitosan/fibroin-hydroxyapatite composite matrix for tissue engineering
H. Kim (2007)
10.1016/j.bone.2010.10.171
Antibacterial activity of bone allografts: comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin.
C. Ketonis (2011)
10.1016/J.BBRC.2005.05.051
In vivo bone formation by human marrow stromal cells in biodegradable scaffolds that release dexamethasone and ascorbate-2-phosphate.
H. Kim (2005)
10.1016/j.actbio.2010.11.025
Gelatin functionalization with tyrosine derived moieties to increase the interaction with hydroxyapatite fillers.
A. Neffe (2011)
10.1016/J.MSEC.2010.09.009
In vitro study of the SBF and osteoblast-like cells on hydroxyapatite/chitosan–silica nanocomposite
Prapaporn Jongwattanapisan (2011)
10.1016/S0168-3659(02)00179-7
In vitro-in vivo characterization of gentamicin bone implants.
M. Baró (2002)
10.1016/j.jconrel.2009.06.012
Treatment of osteomyelitis and repair of bone defect by degradable bioactive borate glass releasing vancomycin.
Zongping Xie (2009)
10.1016/J.TCA.2012.05.016
Development of a thermogravimetric analysis (TGA) method for quantitative analysis of wood flour and polypropylene in wood plastic composites (WPC)
H. Jeske (2012)
10.1016/J.PROENG.2011.03.053
Design and Preparation of Synthetic Hydrogels Via Photopolymerisation for Biomedical Use as Wound Dressings
C. Witthayaprapakorn (2011)
10.1208/s12249-009-9308-0
Organic–Inorganic Composites for Bone Drug Delivery
C. Soundrapandian (2009)
10.1016/J.MOLSTRUC.2004.11.070
FTIR and XRD investigations on the thermal stability of hydroxyapatite during hot pressing and pressureless sintering processes
A. Rapacz-Kmita (2005)
10.1097/00003086-198304000-00009
Clinical experience with allograft implantation. The first ten years.
H. Mankin (1983)
10.1016/j.actbio.2011.09.008
Silicate bioceramics induce angiogenesis during bone regeneration.
Wanyin Zhai (2012)
10.1016/j.ijpharm.2009.01.008
The synthesis of novel pH-sensitive poly(vinyl alcohol) composite hydrogels using a freeze/thaw process for biomedical applications.
Michael J Mc Gann (2009)
10.1016/J.PROGPOLYMSCI.2011.05.003
Current research on the blends of natural and synthetic polymers as new biomaterials: Review
A. Sionkowska (2011)
10.1016/J.BIOMATERIALS.2003.11.022
Composite cell support membranes based on collagen and polycaprolactone for tissue engineering of skin.
N-T Dai (2004)
10.1016/J.MSEC.2008.07.004
Synthesis, characterization and in vitro bioactivity of sol-gel-derived SiO2-CaO-P2O5-MgO bioglass
A. Saboori (2009)
10.1002/jbm.b.31717
Characterization and cytocompatibility of biphasic calcium phosphate/polyamide 6 scaffolds for bone regeneration.
Juan Shen (2010)
10.1007/s00264-008-0700-2
Survival of massive allografts in segmental oncological bone defect reconstructions
P. Bullens (2008)
10.1016/J.CARBPOL.2009.09.015
Injectable hydrogels based on chitosan derivative/polyethylene glycol dimethacrylate/N,N-dimethylacrylamide as bone tissue engineering matrix
Guiping Ma (2010)



This paper is referenced by
10.1007/s10965-014-0538-9
Synthesis and photopolymerisation of maleic polyvinyl alcohol based hydrogels for bone tissue engineering
J. Killion (2014)
10.1088/1748-605X/ab2fa3
A tough and novel dual-response PAA/P(NiPAAM-co-PEGDMA) IPN hydrogels with ceramics by photopolymerization for consolidation of bone fragments following fracture.
G. G. de Lima (2019)
10.1088/1748-605X/aabb31
The effects of hydroxyapatite nanoparticles embedded in a MMP-sensitive photoclickable PEG hydrogel on encapsulated MC3T3-E1 pre-osteoblasts.
Maria Carles-Carner (2018)
10.1016/J.RADPHYSCHEM.2018.12.034
The influence of monomer/solvent feed ratio on POEGDMA thermoresponsive hydrogels: Radiation-induced synthesis, swelling properties and VPTT
E. Suljovrujic (2019)
10.1177/0885328219835995
Anti-inflammatory and antimicrobial activity of bioactive hydroxyapatite/silver nanocomposites
Juan J Martínez-Sanmiguel (2019)
10.1080/00914037.2014.886224
Evaluation of Novel Antibiotic-Eluting Thermoresponsive Chitosan-PDEAAm Based Wound Dressings
Jude I. Ngadaonye (2014)
10.1016/j.jmbbm.2019.07.003
Evaluation of the materials properties, stability and cell response of a range of PEGDMA hydrogels for tissue engineering applications.
G. Burke (2019)
10.1002/PC.24914
Photopolymerization for filling porous ceramic matrix: Improvement of mechanical properties and drug delivering behavior
M. Canillas (2018)
10.3233/BME-171641
Comparison of MSC properties in two different hydrogels. Impact of mechanical properties.
Hao Yu (2017)
Aptamer-functionalized Hydrogels for the Programmable Release of Growth Factors
Mark R. Battig (2014)
10.1016/B978-0-08-100741-9.00009-7
Injectable hydrogels as a delivery system for bone regeneration
Isabel Veloso Alves Pereira (2017)
10.1016/j.msec.2017.11.001
Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications.
D. Devine (2018)
10.3390/jfb6030708
Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications
S. Dorozhkin (2015)
10.1002/9783527699315.CH20
Biocomposites and Hybrid Biomaterials Based on CaPO4
S. Dorozhkin (2016)
10.1016/B978-0-12-803581-8.10134-1
2.11 Polymers of Biological Origin
S. S. Silva (2017)
10.2991/AME-16.2016.24
A Novel High Strength Porous Hydroxyapatite/Silk Fibroin Composite: Preparation and Characterization
Guo-Xuan Cao (2016)
10.1007/s10853-018-2713-6
Synthesis and characterization of hydrogels based on poly(2-hydroxyethyl methacrylate) for drug delivery under UV irradiation
Ş. Şenol (2018)
10.1002/jbm.a.37107
Effects of beta-tricalcium phosphate nanoparticles on theproperties of athermosensitive chitosan/collagen hydrogel and controlled release of quercetin.
Maytha Sareethammanuwat (2020)
10.1002/jbm.a.36683
In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes.
Isabel Pereira (2019)
10.1039/c9tb01976f
Functionalized calcium orthophosphates (CaPO4) and their biomedical applications.
S. Dorozhkin (2019)
10.1007/s00264-014-2402-2
Skeletal tissue regeneration: where can hydrogels play a role?
L. M. Moreira Teixeira (2014)
Semantic Scholar Logo Some data provided by SemanticScholar