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Neurocognitive Costs And Benefits Of Psychotropic Medications In Older Adults
J. Brooks, J. Hoblyn
Published 2007 · Psychology, Medicine
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Time to take this seriously.
Psychotropic medications are widely used in older adults and may cause neurocognitive deficits. Older adults are at increased risk of developing adverse effects because of age-related pharmacodynamic and pharmacokinetic changes. This article provides a comprehensive review of the undesirable, and at times beneficial, effects of psychotropic medications. The review covers a wide range of medications that impair executive function, memory, and attention, as well as a much smaller group of medications that lead to improved neurocognitive function. Some of the most commonly used psychotropic medications in older adults, namely, antidepressants, sedatives, and hypnotics, are among the drugs that most consistently lead to cognitive impairments. Medications with anticholinergic properties almost invariably lead to neurocognitive dysfunction, despite symptom improvement. The neurocognitive costs and benefits of psychiatric medications should be considered in the context of disease treatment in older adults. (J Geriatr Psychiatry Neurol 2007;20:199—214)
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Antidepressant Suppression of Non-REM Sleep Spindles and REM Sleep Impairs Hippocampus-Dependent Learning While Augmenting Striatum-Dependent Learning
Alain Watts (2012)
Discontinuity in the Transition from Pediatric to Adult Health Care for Patients with Attention–Deficit/Hyperactivity Disorder
C. B. Montano (2012)
Contributions of Environment, Comorbidity, and Stage of Dementia to the Onset of Walking and Eating Disability in Long‐Term Care Residents
S. Slaughter (2012)
Short-term study on the effects of rosemary on cognitive function in an elderly population.
A. Pengelly (2012)
Pre- and Post- GPi DBS Neuropsychological Profiles in a Case of X-Linked Dystonia-Parkinsonism
N. Kemmotsu (2011)
Psychotropic medication discussions in older adults’ primary care office visits: So much to do, so little time
SangNam Ahn (2011)
Antidepressant suppression of REM and spindle sleep impairs hippocampus-dependent learning and memory but fosters striatal-dependent strategies
Alain Watts (2011)
Benzodiazepines and Adequacy of Initial Antidepressant Treatment for Depression
P. Pfeiffer (2011)
Prevalence and predictors of cognitive dysfunction in opioid-treated patients with cancer: a multinational study.
G. Kurita (2011)
Roles for pharmacists in improving the quality use of psychotropic medicines in residential aged care facilities
J. Westbury (2011)
Potentially inappropriate medication use in older adults with mild cognitive impairment.
Andrea Weston (2010)See more