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Poly(ethylene) Glycol–capped Silver And Magnetic Nanoparticles: Synthesis, Characterization, And Comparison Of Bactericidal And Cytotoxic Effects
A. Mandal, S. Sekar, N. Chandrasekaran, A. Mukherjee, T. Sastry
Published 2013 · Materials Science, Medicine
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Silver and magnetic (Fe3O4) nanoparticles have attracted wide attention as novel antimicrobial agents due to their unique chemical and physical properties. In order to study the comparative effects on antibacterial and animal cytotoxicity, Staphylococcus aureus and NIH 3T3 fibroblasts were used, respectively. Both nanoparticles were synthesized via a novel matrix-mediated method using poly(ethylene) glycol. Formation of silver nanoparticles was confirmed by fluorescence and ultraviolet–visible spectroscopic techniques. The poly(ethylene) glycol–coated silver and Fe3O4 nanoparticles were characterized by scanning electron microscope, transmission electron microscope, zeta potential, particle size analysis, Fourier-transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopy. The antimicrobial results indicate that both poly(ethylene) glycol–coated silver and Fe3O4 nanoparticles inhibited S. aureus growth at the concentrations of 5 and 10 µg/mL at all time points without showing any significant cytotoxicity on NIH 3T3 fibroblasts. The particle size of both the poly(ethylene) glycol–coated silver and Fe3O4 nanoparticles dominated in the range 10–15 nm, obtained by particle size analyzer. The poly(ethylene) glycol coating on the particles showed less aggregation of nanoparticles, as observed by scanning electron microscope and transmission electron microscope. The overall obtained results indicated that these two nanoparticles were stable and could be used to develop a magnetized antimicrobial scaffolds for biomedical applications.
This paper references
Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster.
M. Ahamed (2010)
Evaluation of biofilm production and prevalence of the icaD gene in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains isolated from patients with nosocomial infections and carriers.
M. Grinholc (2007)
Bacterial heavy metal resistance: new surprises.
S. Silver (1996)
The changing epidemiology of Staphylococcus aureus?
H. Chambers (2001)
Synthesis and characterization of Ag/PVA nanocomposite by chemical reduction method
P. Khanna (2005)
Characterization of enhanced antibacterial effects of novel silver nanoparticles
S. Shrivastava (2007)
“Celbenin” - resistant Staphylococci
R. Knox (1961)
Silver nanoparticles as a new generation of antimicrobials.
M. Rai (2009)
Nanomaterials Show Signs of Toxicity
R. Service (2003)
Green synthesis of silver nanoparticles using Capsicum annuum L
S Li (2007)
Synthesis of amino-group functionalized superparamagnetic iron oxide nanoparticles and applications as biomedical labeling probes
M. Ma (2011)
Staphylococcus aureus adhesion to titanium oxide surfaces coated with non-functionalized and peptide-functionalized poly(L-lysine)-grafted-poly(ethylene glycol) copolymers.
L. Harris (2004)
Evaluation of antibacterial activity of silver nanoparticles against MSSA and MRSA on isolates from skin infections
M. Ansari (2011)
Preparation of a biocompatible magnetic film from an aqueous ferrofluid
C. Albornoz (2006)
Synthesis of colloids based on gold nanoparticles dispersed in castor oil
E. D. Silva (2008)
Bactericidal effect of iron oxide nanoparticles on Staphylococcus aureus
N. Tran (2010)
Effect of Surfactants and Polymers on Stability and Antibacterial Activity of Silver Nanoparticles (NPs)
L. Kvítek (2008)
Multi-functional polymeric nanoparticles for tumour-targeted drug delivery
Lilian E van Vlerken (2006)
SYNTHESIS AND CHARACTERIZATION OF MAGNETIC NANO SIZED FE3O4/MNO2 COMPOSITE PARTICLES
Z. Shu (2009)
Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles.
S. Sun (2004)
Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles.
P. Wunderbaldinger (2002)
Nanoparticles – known and unknown health risks
P. Hoet (2004)
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
M. Kohanski (2007)
In vitro cytotoxicity of nanoparticles in mammalian germline stem cells.
L. Braydich-Stolle (2005)
Characterization of the Degradation of Polylactic Acid Polymer in a Solid Substrate Environment
M. Agarwal (1998)
Some biomedical applications of ferrofluids
J. Roger (1999)
Magnetic nanoparticles and their applications in medicine.
E. Duguet (2006)
One-step, solid-state reaction to the synthesis of copper oxide nanorods in the presence of a suitable surfactant
Wenzhong Wang (2001)
Synthesis and characterization of magnetic nanosized Fe 3 O 4 /MnO 2 composite particles
Z. Shu (2009)
Antibacterial effect of silver nanoparticles on Staphylococcus aureus
Wen-ru Li (2010)
Preparation and characterization of magnetic nanoparticles coated with polyethylene glycol
L. M. Hoa (2009)
Green synthesis of silver nanoparticles using Capsicum annuum L . extract
Y Shen (2007)
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.
Y. Zhang (2002)
Synthesis, characterization and comparison of antimicrobial activity of PEG/TritonX-100 capped silver nanoparticles on collagen scaffold.
A. Mandal (2012)
One-step synthesis of monodisperse silver nanoparticles beneath vitamin E Langmuir monolayers.
L. Zhang (2006)
Germanium and silver resistance, accumulation, and toxicity in microorganisms.
R. Slawson (1992)
Investigation of antibacterial properties silver nanoparticles prepared via green method
K. Shameli (2012)
Effect of polyvinyl pyrrolidone molecular weights on the formation of nanosized silver colloids
K. Chou (2004)
Iron and oxidative stress in bacteria.
D. Touati (2000)
Biofunctional Magnetic Nanoparticles for Protein Separation and Pathogen Detection
Hongwei Gu (2006)
Green synthesis of silver nanoparticles using Capsicum annuum L. extract
Shikuo Li (2007)
Tuning the Grain Size and Particle Size of Superparamagnetic Fe3O4 Microparticles
S. Xuan (2009)
Synthesis and antimicrobial effects of silver nanoparticles produced by chemical reduction method
S. Kheybari (2010)
DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells.
M. Ahamed (2008)
Magnetic field induced synthesis and self-assembly of super paramagnetic particles in a protein matrix.
A. Sinha (2005)
Effect of iron oxide and gold nanoparticles on bacterial growth leading towards biological application
S. Chatterjee (2011)
Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials.
M. C. Hudson (1999)
Phase separation in poly(ethylene glycol)/poly(lactic acid) blends
H. Younes (1988)
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
T. Mosmann (1983)
Surface-modified magnetite nanoparticles for hyperthermia: Preparation, characterization, and cytotoxicity studies
D. Kim (2006)
Cytotoxicity of Uncoated and Polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles
M. Mahmoudi (2009)
Characterization of nanostructured magnetite thin films produced by sol–gel processing
A. E. Eken (2009)
Exchange-coupled magnetic nanoparticles for efficient heat induction.
Jae-Hyun Lee (2011)
Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells
J. Xie (2007)
The role of poly(ethylene glycol) in the formation of silver nanoparticles.
Chengcai Luo (2005)
Biomimetic synthesis of superparamagnetic iron oxide particles in proteins
A. Sinha (2003)
Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy
H. Mansur (2004)
The formation of copper oxide nanorods in the presence of various surfactant micelles
N. Fathima (2008)
Silver/poly (lactic acid) nanocomposites: preparation, characterization, and antibacterial activity
K. Shameli (2010)
Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance.
K. Hiramatsu (2001)
Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
P. V. AshaRani (2009)
M. Jevons (1961)
Effect and intracellular uptake of pure magnetic Fe3O4 nanoparticles in the cells and organs of lung and liver.
Shi-yuan Liu (2009)
The bactericidal effect of silver nanoparticles
K. Piksová (2010)
Bactericidal effect of photodynamic inactivation against methicillin-resistant and methicillin-susceptible Staphylococcus aureus is strain-dependent.
M. Grinholc (2008)
Synthesis and antibacterial activity of silver nanoparticles with different sizes
G. Martínez-Castañón (2008)
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A. Mandal (2014)
Effect of Ternary Additives on the Evolution of Structure Formation in Aqueous PEO-PPO-PEO Micelles
A. Thompson (2018)
Controlled Release Characteristics of Aqueous PEO‐PPO‐PEO Micelles With Added Malachite Green, Erythrosin, and Cisplatin Determined by UV–Visible Spectroscopy
A. Thompson (2018)
Fabrication of collagen scaffolds impregnated with sago starch capped silver nanoparticles suitable for biomedical applications and their physicochemical studies.
A. Mandal (2014)
Bacterial magnetic particles improve testes-mediated transgene efficiency in mice
C. Wang (2017)
Supported Silver Nanoparticle and Near-Interface Solution Dynamics in a Deep Eutectic Solvent
Joshua A. Hammons (2016)
Synthesis, characterization and evaluation of collagen scaffolds crosslinked with aminosilane functionalized silver nanoparticles: in vitro and in vivo studies.
A. Mandal (2015)
Biosynthesis of silver nanoparticles and their versatile antimicrobial properties
S. Some (2018)
Synthesis and characterization of chemically modified collagen based nanobiocomposite containing silver nanorods incorporated with ciprofloxacin
S. Sekar (2014)
Polyethylene glycol-coated zinc oxide nanoparticle: an efficient nanoweapon to fight against herpes simplex virus type 1.
A. Tavakoli (2018)
Green synthesis of silver nanoparticles using leaf extract of Acalypha hispida and its application in blood compatibility.
P. Selvakumar (2018)
Unique properties of silver and copper silica-based nanocomposites as antimicrobial agents
J. Peszke (2017)
Studies on interaction of green silver nanoparticles with whole bacteria by surface characterization techniques.
Anike P V Ferreyra Maillard (2019)
Vibrational spectroscopic investigation on interaction of sago starch capped silver nanoparticles with collagen: a comparative physicochemical study using FT-IR and FT-Raman techniques
A. Mandal (2015)
Production of silica nanoparticles bound fabrics and evaluation of its antibacterial/ultraviolet protection properties
Senthil Rethinam (2018)
Fate of engineered nanoparticles: Implications in the environment
A. D. Dwivedi (2015)
Surface Characterization of Silver and Fe 3O4 Nanoparticles Incorporated into Collagen‐based Scaffolds as Biomaterials for Tissue Regeneration: State‐of‐the‐Art and Future Perspectives
A. Mandal (2016)