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Preoperative Computed Tomography–Determined Sarcopenia And Postoperative Outcome After Surgery For Non-Small Cell Lung Cancer

E. Kim, H. Lee, K. Kim, J. Lee, Y. Kim, W-J Choi, J. Kim
Published 2018 · Medicine

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Background: Sarcopenia, reduced skeletal muscle mass, is associated with frailty, injuries, and mortality. The purpose of this study was to evaluate the impact of computed tomography–determined sarcopenia on surgical complications and outcomes after resection of non-small cell lung cancer. Methods: For a total 272 non-small cell lung cancer patients that underwent surgery between 2011 and 2016, cross-sectional area of muscle at the third lumbar vertebra (L3) was retrospectively measured using preoperative chest computed tomography images. Sarcopenia was defined as an L3 muscle index of <55 cm2/m2 for men and of <39 cm2/m2 for women. Clinical characteristics, postoperative complications, disease-free survival, and overall survival of patients with or without sarcopenia were compared. Results: A total of 60.3% (n = 164) were male, and mean patient age was 62.9 ± 9.6 years. The prevalence of sarcopenia was 22.4% for all study subjects, 32.9% for men, and 6.5% for women. No significant difference was observed between patients with or without sarcopenia in terms of intensive care unit or hospital stay (p = 0.502 and p = 0.378, respectively), and the presence of sarcopenia was not associated with postoperative complications. Furthermore, no significant difference was observed between the 3-year disease-free survival rate (74.3% vs 66.7%, p = 0.639) or 3-year overall survival rate (83.9% vs 87.7%, p = 0.563) of patients with or without sarcopenia. Conclusion: Sarcopenia as determined by preoperative computed tomography does not appear to have a negative impact on surgical outcome or overall survival for resected non-small cell lung cancer patients.
This paper references
Prognostic significance of CTdetermined sarcopenia in patients with small-cell lung cancer
EY Kim (2015)
Pre-operative Assessment of Muscle Mass to Predict Surgical Complications and Prognosis in Patients With Endometrial Cancer
L. M. Kuroki (2014)
Nutritional status of patients undergoing lung cancer
RT Jagoe (2001)
A Clinical Prediction Rule for Pulmonary Complications After Thoracic Surgery for Primary Lung Cancer
D. Amar (2010)
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies
Who Expert Consultation (2004)
Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment
C. Prado (2009)
Sarcopenia negatively impacts short-term outcomes in patients undergoing hepatic resection for colorectal liver metastasis.
P. Peng (2011)
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care.
M. Mourtzakis (2008)
Nutritional status of patients undergoing lung cancer operations.
R. Jagoe (2001)
Acute respiratory distress syndrome: the Berlin Definition.
V. M. Ranieri (2012)
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image.
Wei Shen (2004)
Prediction of major cardiovascular events after lung resection using a modified scoring system.
M. Ferguson (2014)
Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index.
L. Martin (2013)
Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?
C. Prado (2013)
Impact of Sarcopenia on Outcomes Following Resection of Pancreatic Adenocarcinoma
Peter Peng (2012)
Definition and classification of cancer cachexia: an international consensus.
K. Fearon (2011)
Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery
J. Lieffers (2012)
Sarcopenia as a Prognostic Biomarker of Advanced Urothelial Carcinoma
H. Fukushima (2015)
The assessment and impact of sarcopenia in lung cancer: a systematic literature review
J. Collins (2014)
Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma
N. Harimoto (2013)
Development of a Prediction Rule for Estimating Postoperative Pulmonary Complications
Byeong-Ho Jeong (2014)
Pulmonary complications following lung resection: a comprehensive analysis of incidence and possible risk factors.
F. Stéphan (2000)
Cancer statistics, 2016
Rebecca L. Siegel Mph (2016)
Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies.
C. Nishida (2004)
Prognostic Significance of CT-Determined Sarcopenia in Patients with Small-Cell Lung Cancer
E. Kim (2015)
Sarcopenia as a Prognostic Index of Nutritional Status in Concurrent Cirrhosis and Hepatocellular Carcinoma
J. Meza-Junco (2013)
Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis.
V. Baracos (2010)
Cancer statistics, 2016
R. Siegel (2016)
Cancer statistics
N. Dubrawsky (1989)
Body composition and outcome in patients undergoing resection of colorectal liver metastases
M. G. van Vledder (2012)

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