Online citations, reference lists, and bibliographies.

MicroRNA-299-3p/FOXP4 Axis Regulates The Proliferation And Migration Of Oral Squamous Cell Carcinoma

Yao-xiang Xu, Y. Liu, W. Xiao, J. Yue, Lingfa Xue, Qunli Guan, J. Deng, Jian Sun
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
MicroRNAs are noncoding RNAs of 21 to 23 nucleotides in length that play important roles in almost all biological pathways. The roles of microRNA-299-3p in the development and progression of oral squamous cell carcinoma remain unclear. Expression level of microRNA-299-3p in oral squamous cell carcinoma cell lines was analyzed. Then, the effects of microRNA-299-3p on oral squamous cell carcinoma cell proliferation and migration were investigated. Moreover, bioinformation algorithm and Western blot were conducted to explore whether forkhead box P4 was a direct target of miR-299-3p. We showed that microRNA-299-3p expression was significantly reduced in oral squamous cell carcinoma cell lines. Next, overexpression of microRNA-299-3p was found to inhibit oral squamous cell carcinoma cell proliferation and migration but promote apoptosis. In addition, forkhead box P4 was identified as a functional target of microRNA-299-3p. Our results provide a new perspective for the mechanisms underlying the progression of oral squamous cell carcinoma and a novel target for the treatment of oral squamous cell carcinoma.
This paper references
10.1111/cpr.12308
Up‐regulation of microRNA‐491‐5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma
Zhixun Yin (2017)
10.1016/j.biopha.2017.07.030
MicroRNA-299-3p suppresses proliferation and invasion by targeting VEGFA in human colon carcinoma.
Jia-yong Wang (2017)
10.1371/journal.pone.0042273
Foxp4 Is Dispensable for T Cell Development, but Required for Robust Recall Responses
Karla R. Wiehagen (2012)
10.1038/nrg2936
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
Eric Huntzinger (2011)
10.1016/j.biopha.2018.06.042
MiR-299-3p functions as a tumor suppressor via targeting Sirtuin 5 in hepatocellular carcinoma.
Shan Dang (2018)
10.1007/s10555-007-9082-y
Metastasis of squamous cell carcinoma of the oral tongue
D. Sano (2007)
10.1007/s13277-015-3498-8
FOXP4 modulates tumor growth and independently associates with miR-138 in non-small cell lung cancer cells
T. Yang (2015)
10.1038/nrc1840
Oncomirs — microRNAs with a role in cancer
A. Esquela-Kerscher (2006)
10.1158/0008-5472.CAN-16-0359
OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.
Alexander A. Svoronos (2016)
MicroRNA-338-3p inhibits cell proliferation in hepatocellular carcinoma by target forkhead box P4 (FOXP4).
G. Wang (2015)
10.1016/j.biopha.2018.06.151
Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling.
Xiaojie Li (2018)
10.1016/j.sjbs.2018.01.013
microRNA-1297 involves in the progression of oral squamous cell carcinoma through PTEN
Limin Liang (2018)
10.1016/j.oraloncology.2008.06.002
Global epidemiology of oral and oropharyngeal cancer.
S. Warnakulasuriya (2009)
10.1016/j.abb.2018.05.007
MicroRNA-299-3p regulates proliferation, migration and invasion of human ovarian cancer cells by modulating the expression of OCT4.
Ruiyan Zhao (2018)
10.1002/ijc.31638
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
10.1016/S0167-4781(03)00074-5
FoxP4, a novel forkhead transcription factor.
A. Teufel (2003)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar