Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Changes Of Exhaled Nitric Oxide During Steroid Treatment Of Childhood Asthma

J. Beck-Ripp, M. Griese, S. Arenz, C. Koering, B. Pasqualoni, P. Bufler
Published 2002 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Exhaled nitric oxide (eNO) is elevated in several inflammatory airway diseases and is significantly reduced by anti-inflammatory treatment with inhaled steroids. The aim of this randomized, open clinical trial was to evaluate eNO in relation to conventional lung function parameters at rest and after exercise during sequential changes of inhaled steroids in children with persistent asthma. The study consisted of a 4 week run-in period, a 4 week washout phase and a randomized treatment period during which only one group was treated again with inhaled budesonide. After run-in, eNO was reduced to normal values, and rose again during washout. In the patients randomized to steroid treatment, eNO was again decreased, whereas it remained unchanged in the untreated patients. Forced expiratory volume in one second and forced vital capacity at rest and after exercise improved significantly after run-in, but showed no difference after randomization. However there was a strong correlation of eNO with patient compliance. Exhaled nitric oxide was able to differentiate between children briefly treated with or without steroids, the conventional lung-function variables however could not. In practice exhaled nitric oxide may thus be a valuable parameter to monitor adherence to steroids, but less suitable to describe physiologically relevant impairments of lung function.
This paper references
Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children.
G. Piacentini (1999)
Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma
E. V. van Rensen (1999)
Kü hl P. Airway nitric oxide in asthmatic children and patients with cystic fibrosis
J Dö Tsch (1996)
Exhaled nitric oxide and exercise-induced bronchoconstriction in asthmatic children.
M. Scollo (2000)
Airway nitric oxide in asthmatic children and patients with cystic fibrosis.
J. Dötsch (1996)
Comparison of exhaled nitric oxide to spirometry during emergency treatment of asthma exacerbations with glucocorticoids in children.
M. Lanz (1999)
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force.
S. Kharitonov (1997)
National Asthma Education Program Expert Panel report: guidelines for the diagnosis and management of asthma.
S. Fitzgerald (1992)
Exhaled nitric oxide, serum ECP and airway responsiveness in mild asthmatic children.
G. Piacentini (2000)
Induction of nitric oxide synthetase in asthma
Q Hamid (1993)
National Asthma Education Program.
C. Lenfant (1990)
Standardization of spirometry – 1994 update
A Zapletal (1995)
Exhaled and nasal nitric oxide measurements : recommendations
S. Kharitonov (1997)
Corticosteroids decrease exhaled nitric oxide in children with acute asthma.
E. Baraldi (1997)
Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma.
S. Lim (1999)
Lung Function in Children and Adolescents
Adm (1988)
Induction of nitric oxide synthase in asthma
Q. Hamid (1993)
Characteristics of flow dependency of nitric oxide in exhaled air in children with cystic fibrosis and asthma.
J. Beck (1999)
Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.
D. Yates (1995)
Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.
S. Kharitonov (1996)
Increased nitric oxide in exhaled air of asthmatic patients
S. Kharitonov (1994)
Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-native patients with asthma
LJ Dupont (1998)
Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma
A. Jatakanon (1999)
Asthma severity, recommended changes of inhaled therapy and exhaled nitric oxide in children: a prospective, blinded trial.
M. Griese (2000)
The National Asthma Education Program. Expert panel report guidelines for the diagnosis and management of asthma. National Heart, Lung, and Blood Institute.
A. L. Sheffer (1993)
Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with mild asthma.
L. Dupont (1998)
Nitric oxide synthases: Roles, tolls, and controls
C. Nathan (1994)
Standardization of Spirometry, 1994 Update. American Thoracic Society.
C. Irvin (1995)
Exhaled nitric oxide measurements in normal and asthmatic children
C. A. Byrnes (1997)
Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids.
J. Sont (1996)
Nitric oxide and airway disease.
P. Barnes (1995)
An Analytic Approximation to the Distribution of Lilliefors's Test Statistic for Normality
G. Dallal (1986)
Budesonide treatment of moderate and severe asthma in children: a dose-response study.
S. Pedersen (1995)
Orally exhaled nitric oxide levels are related to the degree of blood eosinophilia in atopic children with mild-intermittent asthma.
M. Silvestri (1999)

This paper is referenced by
Mesure du NO exhalé et monitoring de l’asthme
L. Têtu (2007)
Inhaled corticosteroid adherence in paediatric patients: the PACMAN cohort study
E. Koster (2011)
Measurement of offline exhaled nitric oxide in a study of community exposure to air pollution.
J. Koenig (2003)
Towards better treatment of childhood asthma: inflammometry with exhaled nitric oxide
M. Pijnenburg (2006)
Study of the beneficial role of exhaled nitric oxide in combination with GINA guidelines for titration of inhaled corticosteroids in children with asthma.
Hang Dinh-Thi-Dieu (2020)
Changes in Type 2 Biomarkers After Anti-IL5 Treatment in Patients With Severe Eosinophilic Asthma
Jae-Hyuk Jang (2020)
Charles Darwin University Clinical utility of exhaled nitric oxide fraction in the management of asthma and COPD
S. Turner (2019)
The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management
Z. Wang (2017)
Peanut allergy and allergic airways inflammation
J. Hughes (2010)
Characterisation of gene expression in the airway epithelium of children with asthma
C. Lane (2007)
Clinical Utility Of The Exhaled Nitric Oxide (NO) Measurement With Portable Devices In The Management Of Allergic Airway Inflammation And Asthma
S. Duong-Quy (2019)
An elevated bronchodilator response predicts large airway inflammation in mild asthma
James L. Puckett (2010)
Two variants of occupational asthma separable by exhaled breath nitric oxide level.
V. Moore (2010)
Study of the role of exhaled nitric oxide (NO) in predicting controlled or uncontrolled asthma in asthmatic children
Xuan Ngo-Minh (2020)
Title Utility of serum periostin in combination with exhaled nitricoxide in the management of asthma
T. Nagasaki (2019)
Air pollution and childhood asthma: recent advances and future directions
M. Patel (2009)
Towards better treatment outcomes in childhood asthma
E. Koster (2007)
Formoterol as needed with or without budesonide in patients with intermittent asthma and raised NO levels in exhaled air: a SOMA study
T. Haahtela (2006)
Exhaled Nitric Oxide Decreases in Association with Attendance at an Asthma Summer Camp
D. Kaminsky (2008)
Exhaled NO: forward, backward, or sideways?
D. Taylor (2007)
FeNO as aMarker of Airways Inflammation : The Possible Implications in Childhood AsthmaManagement
Marcello Verini (2014)
Demonstrating Bioequivalence of Locally Acting Orally Inhaled Drug Products (OIPs): Workshop Summary Report.
W. Adams (2010)
Suivi de l’enfant asthmatique : définition et outils de mesure
J. Blic (2008)
Exhaled nitric oxide in healthy nonatopic school‐age children: Determinants and height‐adjusted reference values
L. P. Malmberg (2006)
Fractional exhaled nitric oxide measurement: Comparison between the Sunvou-CA2122 analyzer and the NIOX VERO analyzer.
Tingxuan Huang (2019)
Current evidence and future research needs for FeNO measurement in respiratory diseases.
L. Bjermer (2014)
Something Old, Something New Spirometry and Exhaled Nitric Acid as Biomarkers of Airflow Obstruction
Maureen George (2012)
Fractional Exhaled Nitric Oxide: Indications and Interpretation
Young-Jee Kim (2015)
Exhaled Nitric Oxide in the Management of Respiratory Disorders
History, technical and regulatory aspects of exhaled nitric oxide.
P. Silkoff (2008)
Sputum Tests and Exhaled NO in the Diagnosis and Monitoring of Asthma
M. Zitt (2009)
The beneficial role of FeNO in association with GINA guidelines for titration of inhaled corticosteroids in adult asthma: A randomized study.
Tung Truong-Thanh (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar