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Transcriptomic Analysis Of The Venom Gland Of The Red-headed Krait (Bungarus Flaviceps) Using Expressed Sequence Tags

Ang Swee Siang, Robin Doley, F. Vonk, R. Kini
Published 2009 · Biology, Medicine

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BackgroundThe Red-headed krait (Bungarus flaviceps, Squamata: Serpentes: Elapidae) is a medically important venomous snake that inhabits South-East Asia. Although the venoms of most species of the snake genus Bungarus have been well characterized, a detailed compositional analysis of B. flaviceps is currently lacking.ResultsHere, we have sequenced 845 expressed sequence tags (ESTs) from the venom gland of a B. flaviceps. Of the transcripts, 74.8% were putative toxins; 20.6% were cellular; and 4.6% were unknown. The main venom protein families identified were three-finger toxins (3FTxs), Kunitz-type serine protease inhibitors (including chain B of β-bungarotoxin), phospholipase A2 (including chain A of β-bungarotoxin), natriuretic peptide (NP), CRISPs, and C-type lectin.ConclusionThe 3FTxs were found to be the major component of the venom (39%). We found eight groups of unique 3FTxs and most of them were different from the well-characterized 3FTxs. We found three groups of Kunitz-type serine protease inhibitors (SPIs); one group was comparable to the classical SPIs and the other two groups to chain B of β-bungarotoxins (with or without the extra cysteine) based on sequence identity. The latter group may be functional equivalents of dendrotoxins in Bungarus venoms. The natriuretic peptide (NP) found is the first NP for any Asian elapid, and distantly related to Australian elapid NPs. Our study identifies several unique toxins in B. flaviceps venom, which may help in understanding the evolution of venom toxins and the pathophysiological symptoms induced after envenomation.
This paper references
Molecular evolution and phylogeny of elapid snake venom threefinger toxins
BG Fry (2003)
10.1006/JMBI.1993.1107
Nicotinic acetylcholine receptor at 9 A resolution.
N. Unwin (1993)
10.1042/BJ20060302
Anticoagulant proteins from snake venoms: structure, function and mechanism.
R. Kini (2006)
10.1186/1471-2199-8-115
The venom gland transcriptome of the Desert Massasauga Rattlesnake (Sistrurus catenatus edwardsii): towards an understanding of venom composition among advanced snakes (Superfamily Colubroidea)
S. Pahari (2007)
10.1016/J.TOXICON.2005.11.009
Divergence of genes encoding B chains of β-bungarotoxins
Y. Cheng (2006)
10.1016/0014-5793(90)81426-O
Purification and characterization of a chymotrypsin Kunitz inhibitor type of polypeptide fro the venom of cobra (Naja naja naja)
J. Shafqat (1990)
10.3109/00016488309129574
Neuromuscular junctions of the posterior cricoarytenoid muscle in the cat.
T. Kanda (1983)
10.1021/BI00728A015
Complete amino acid sequence of a nonneurotoxic hemolytic protein from the venom of Haemachatus haemachates (African ringhals cobra).
L. Fryklund (1973)
10.1016/j.toxicon.2009.01.006
Transcriptome analysis of the Amazonian viper Bothrops atrox venom gland using expressed sequence tags (ESTs).
M. Neiva (2009)
10.1016/S0014-5793(00)01549-0
Molecular cloning, characterization and evolution of the gene encoding a new group of short‐chain α‐neurotoxins in an Australian elapid, Pseudonaja textilis
N. Gong (2000)
Phospholipase A 2structural review
RK Arni (1996)
10.1016/0006-8993(87)91043-2
Kappa-flavitoxin: isolation of a new neuronal nicotinic receptor antagonist that is structurally related to kappa-bungarotoxin
V. Chiappinelli (1987)
10.1042/BST0210456
Recognition of complex carbohydrates by Ca(2+)-dependent animal lectins.
K. Drickamer (1993)
Divergence of genes encoding B chains of beta-bungarotoxins.
Yun-Ching Cheng (2006)
10.1016/0006-291X(83)91675-3
The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties.
T. G. Flynn (1983)
m 1 - toxin isotoxins from the green mamba ( Dendroaspis angusticeps ) that selectively block m 1 muscarinic receptors
N Gong (2000)
10.1186/1471-2164-10-112
Transcriptomic basis for an antiserum against Micrurus corallinus (coral snake) venom
Luciana I Leão (2008)
10.1016/S0041-0101(01)00235-5
Isolation of the major lethal toxin in the venom of Bungarus flaviceps.
O. Khow (2002)
10.1016/J.TOXICON.2005.02.021
Structures and functions of snake venom CLPs (C-type lectin-like proteins) with anticoagulant-, procoagulant-, and platelet-modulating activities.
T. Morita (2005)
10.1042/0264-6021:3410733
Cloning of a galactose-binding lectin from the venom of Trimeresurus stejnegeri.
Q. Xu (1999)
10.1007/s00018-006-6315-0
Snake venom components and their applications in biomedicine
D. C. Koh (2006)
10.1023/A:1021660708187
Effects of Muscarinic Toxins MT1 and MT2 from Green Mamba on Different Muscarinic Cholinoceptors
A. Harvey (2004)
Structures and functions of snake venom CLPs (C-type lectinlike proteins) with anticoagulant-, procoagulant-, and plateletmodulating activities
T Morita (2005)
10.1093/jb/mvn174
Structural divergence of cysteine-rich secretory proteins in snake venoms.
Y. Matsunaga (2009)
10.1515/BC.2002.158
Muscarinic Toxin-Like Proteins from Taiwan Banded Krait (Bungarus multicinctus) Venom: Purification, Characterization and Gene Organization
Charling Chung (2002)
10.1098/RSTB.1994.0080
Molecular evolution of serine protease and its inhibitor with special reference to domain evolution.
T. Gojobori (1994)
10.1534/genetics.106.056515
Lachesis muta (Viperidae) cDNAs Reveal Diverging Pit Viper Molecules and Scaffolds Typical of Cobra (Elapidae) Venoms: Implications for Snake Toxin Repertoire Evolution
I. Junqueira-de-Azevedo (2006)
Structure-function relationships of postsynaptic neurotoxins from snake venoms
T. Endo (1991)
10.1016/0197-0186(92)90034-O
Purification and partial characterization of K+ channel blockers from the venom of Dendroaspis angusticeps
S. Chaki (1992)
10.1016/0006-291X(84)90250-X
Rat atrial natriuretic factor: isolation, structure and biological activities of four major peptides.
K. Misono (1984)
10.1016/S0041-0101(96)00110-9
Binding of native κ-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors
V. Chiappinelli (1996)
10.1046/J.1432-1327.1999.00800.X
Postsynaptic short-chain neurotoxins from Pseudonaja textilis. cDNA cloning, expression and protein characterization.
N. Gong (1999)
10.1016/0041-0101(93)90096-2
A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps).
H. Schweitz (1992)
10.1111/J.1432-1033.1990.TB15622.X
Primary structure and functional properties of cobra (Naja naja naja) venom Kunitz-type trypsin inhibitor.
J. Shafqat (1990)
10.1016/0024-3205(81)90370-2
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats.
A. D. de Bold (1981)
10.1016/S0378-1119(02)01080-6
A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs).
I. Junqueira-de-Azevedo (2002)
10.1186/1471-2148-8-196
Accelerated exchange of exon segments in Viperid three-finger toxin genes (Sistrurus catenatus edwardsii; Desert Massasauga)
Robin Doley (2008)
Effects of alpha-erabutoxin, alpha-bungarotoxin, alpha-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo.
F. Dajas-Bailador (1998)
10.1074/JBC.270.16.9362
Genetic Engineering of Snake Toxins
O. Trémeau (1995)
10.1016/S0014-5793(03)01039-1
Structurally conserved α‐neurotoxin genes encode functionally diverse proteins in the venom of Naja sputatrix 1
K. Jeyaseelan (2003)
10.1074/jbc.272.6.3502
Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom*
P. Marchot (1997)
10.1016/0041-0101(94)00161-Z
Binding of muscarinic toxins MTx1 and MTx2 from the venom of the green mamba Dendroaspis angusticeps to cloned human muscarinic cholinoceptors.
E. Kornisiuk (1995)
[A survey].
J. Charles (1974)
10.1126/SCIENCE.6419347
Purification and sequence analysis of bioactive atrial peptides (atriopeptins).
M. Currie (1984)
10.1073/pnas.74.12.5463
DNA sequencing with chain-terminating inhibitors.
F. Sanger (1977)
10.1016/J.BBAPAP.2004.11.006
Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization.
Yun-Ching Cheng (2005)
10.1021/BI026132H
Purification and cloning of toxins from elapid venoms that target cyclic nucleotide-gated ion channels.
Y. Yamazaki (2002)
10.1073/PNAS.73.1.178
beta-Bungarotoxin, a pre-synaptic toxin with enzymatic activity.
P. Strong (1976)
10.1007/978-1-4757-0022-0_1
Protein inhibitors of serine proteinases--mechanism and classification.
M. Laskowski (1986)
10.1021/BI971107A
Comparison of the hemolytic activity and solution structures of two snake venom cardiotoxin analogues which only differ in their N-terminal amino acid.
J. Jang (1997)
10.1016/S0041-0101(99)00141-5
m1-toxin isotoxins from the green mamba (Dendroaspis angusticeps) that selectively block m1 muscarinic receptors.
J. Carsi (2000)
10.1074/JBC.M111152200
Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (αβγδ) but a Poorly Reversible Antagonist of Neuronal α7 Nicotinic Acetylcholine Receptors*
S. Nirthanan (2002)
10.1016/J.GENE.2004.03.024
Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins.
I. Francischetti (2004)
10.1016/s0889-8529(18)30028-8
Natriuretic hormones.
E. Espiner (1995)
10.1016/0041-0101(65)90032-2
ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION.
C. Chang (1963)
10.1021/BI00135A004
Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins.
R. McDowell (1992)
10.2174/092986609789839304
Crystal structure of bucain, a three-fingered toxin from the venom of the Malayan krait (Bungarus candidus).
M. Murakami (2009)
10.1007/s00239-003-2461-2
Molecular Evolution and Phylogeny of Elapid Snake Venom Three-Finger Toxins
B. Fry (2003)
10.1016/S0003-9861(03)00028-6
Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins.
Y. Yamazaki (2003)
10.1067/MEM.2003.113
Diagnostic and prognostic usefulness of natriuretic peptides in emergency department patients with dyspnea.
S. Collins (2003)
10.1016/j.toxicon.2008.03.025
Genetic organization of Bungarus multicinctus protease inhibitor-like proteins.
L. Chang (2008)
Genetic engineering of snake toxins. Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis.
L. Pillet (1993)
10.1016/0167-4838(83)90189-9
The primary structure of Vipera ammodytes venom trypsin inhibitor I.
A. Ritonja (1983)
10.1080/15216549800204362
cDNA cloning and sequence analysis of six neurotoxin‐like proteins from Chinese continental banded krait
Y. Qian (1998)
Genus specific neutralization of Bungarus snake venoms by Thai Red Cross banded krait antivenom.
L. Chanhome (1999)
10.1016/S0041-0101(98)00154-8
Inhibition of mouse acetylcholinesterase by fasciculin: crystal structure of the complex and mutagenesis of fasciculin.
P. Marchot (1998)
10.1038/379537A0
Diet and snake venom evolution
Jennifer C. Daltry (1996)
10.1038/332078A0
A new natriuretic peptide in porcine brain
T. Sudoh (1988)
10.1021/BI00410A041
Amino acid sequence of kappa-flavitoxin: establishment of a new family of snake venom neurotoxins.
G. Grant (1988)
10.1006/BBRC.2001.4878
Purification and characterization of a chymotrypsin inhibitor from the venom of Ophiophagus hannah (King Cobra).
L. Chang (2001)
10.1016/J.TOXICON.2005.02.022
Snake venom C-type lectins interacting with platelet receptors. Structure-function relationships and effects on haemostasis.
Qiumin Lu (2005)
A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Reprinted from Life Sci. 28:89-94, 1981.
A. D. de Bold (2001)
10.1016/0041-0101(84)90003-5
Presynaptic effects of snake venom toxins which have phospholipase A2 activity (beta-bungarotoxin, taipoxin, crotoxin).
M. Su (1984)
10.1101/GR.3228405
From genome to "venome": molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins.
B. Fry (2005)
10.1016/0021-9673(94)01173-C
Resolution of isotoxins in the β-bungarotoxin family
C. Chu (1995)
10.1006/BBRC.1994.1166
Detection of C-type natriuretic peptide in human circulation and marked increase of plasma CNP level in septic shock patients.
N. Hama (1994)
10.1080/15569540600567438
SNAKE VENOM C-TYPE LECTINS INTERACTING WITH PLATELET RECEPTORS
Q. Lu (2007)
Snake venom alpha-neurotoxins and other 'three-finger' proteins.
V. Tsetlin (1999)
10.1016/J.TOXICON.2005.02.018
Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms.
R. Kini (2005)
10.1124/MOL.56.5.933
m2-toxin: A selective ligand for M2 muscarinic receptors.
J. Carsi (1999)
Resolution of isotoxins in the betabungarotoxin family
CC Chu (1995)
Potassium channel blockade by the B subunit of beta-bungarotoxin.
C. Benishin (1990)
10.1016/0014-5793(94)01235-0
On the site by which α‐dendrotoxin binds to voltage‐dependent potassium channels: Site‐directed mutagenesis reveals that the lysine triplet 28–30 is not essential for binding
J. M. Danse (1994)
10.1016/J.BBRC.2006.01.006
A catalog for transcripts in the venom gland of the Agkistrodon acutus: identification of the toxins potentially involved in coagulopathy.
Liu Qing-hua (2006)
10.1016/0041-0101(96)00036-0
Phospholipase A2--a structural review.
R. K. Arni (1996)
Protein inhibitors of serine proteinasesand classification
M Laskowski (1986)
10.1016/S0024-3205(97)00061-1
Workshop: the use of muscarinic toxins in the study of muscarinic receptors.
D. Jerusalinsky (1997)
10.1016/J.BBRC.2007.04.079
Dendroaspis Natriuretic Peptide Binds to the Natriuretic Peptide Clearance Receptor: Pharmacological Characterization and Therapeutic Implications: P205
D. Johns (2007)
[Molecular biology of the natriuretic peptide system].
Y. Ogawa (1992)
10.1007/s00018-009-0050-2
Protein complexes in snake venom
R. Doley (2009)
10.1016/S0041-0101(02)00388-4
Non-conventional toxins from Elapid venoms.
S. Nirthanan (2003)
10.1021/BI9802723
Flanking proline residues identify the L-type Ca2+ channel binding site of calciseptine and FS2.
R. Kini (1998)
m 1toxin isotoxins from the green mamba ( Dendroaspis angusticeps ) that selectively block m 1 muscarinic receptors
JM Carsi (2000)
10.1073/PNAS.92.12.5605
Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes.
K. Nakashima (1995)
10.1107/S1744309106005963
Purification, crystallization and preliminary X-ray structural studies of a 7.2 kDa cytotoxin isolated from the venom of Daboia russelli russelli of the Viperidae family.
S. R. Choudhury (2006)
10.1016/j.febslet.2006.07.010
Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome
A. T. C. Ching (2006)
Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins.
M. Ploug (1994)
10.1007/PL00006450
Accelerated Evolution and Molecular Surface of Venom Phospholipase A2 Enzymes
R. Kini (1999)
10.1016/S0041-0101(98)00148-2
Functional architectures of animal toxins: a clue to drug design?
A. Ménez (1998)
Transcriptomic analysis of the venom gland of the red-headed krait (Bungarus flaviceps) using expressed sequence tags
Siang (2010)
10.1152/PHYSREV.1990.70.3.665
Diverse biological actions of atrial natriuretic peptide.
B. Brenner (1990)
10.1016/0006-291X(90)92401-K
C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain.
T. Sudoh (1990)
10.1016/0014-5793(94)00674-1
Structure—function relationships in the receptor for urokinase‐type plasminogen activator Comparison to other members of the Ly‐6 family and snake venom α‐neurotoxins
M. Ploug (1994)
10.1016/S0197-0186(98)00033-3
Effects of α-erabutoxin, α-bungarotoxin, α-cobratoxin and fasciculin on the nicotine-evoked release of dopamine in the rat striatum in vivo
F. Dajas-Bailador (1998)
10.1016/J.TOXICON.2005.12.004
Molecular cloning of the major lethal toxins from two kraits (Bungarus flaviceps and Bungarus candidus).
R. Yanoshita (2006)
10.1042/BJ20041814
Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins.
P. Dubovskii (2005)
10.1016/J.TOXICON.2006.07.008
Bothrops jararaca venom gland transcriptome: analysis of the gene expression pattern.
Daniela A P Cidade (2006)
Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors.
V. Chiappinelli (1996)
10.2108/zsj.22.77
Involvement of Drinking and Intestinal Sodium Absorption in Hyponatremic Effect of Atrial Natriuretic Peptide in Seawater Eels
T. Tsukada (2005)
10.1007/BF00502565
Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps
A. Harvey (2004)
10.1146/ANNUREV.BI.49.070180.003113
Protein inhibitors of proteinases.
M. Laskowski (1980)
10.1093/OXFORDJOURNALS.JBCHEM.A131100
Snake venom proteinase inhibitors. III. Isolation of five polypeptide inhibitors from the venoms of Hemachatus haemachatus (Ringhal's corbra) and Naja nivea (Cape cobra) and the complete amino acid sequences of two of them.
Y. Hokama (1976)
10.1042/BJ1210609
Studies on ribonucleic acid synthesis in the venom glands of Vipera palaestinae (Ophidia, Reptilia).
D. Rotenberg (1971)
10.1016/0041-0101(64)90040-6
ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION.
Chang Cc (1963)
10.1107/S0907444902011022
Crystallization and preliminary X-ray analysis of bucain, a novel toxin from the Malayan krait Bungarus candidus.
L. Watanabe (2002)
10.1016/j.toxicon.2008.02.012
Cloning, characterization and phylogenetic analyses of members of three major venom families from a single specimen of Walterinnesia aegyptia.
Hsin-Yu Tsai (2008)
10.1111/j.1476-5381.1982.tb09281.x
PROTEASE INHIBITOR HOMOLOGUES FROM MAMBA VENOMS: FACILITATION OF ACETYLCHOLINE RELEASE AND INTERACTIONS WITH PREJUNCTIONAL BLOCKING TOXINS
A. Harvey (1982)
DNA sequencing with chainterminating inhibitors
F Sanger (1977)
10.1016/0163-7258(87)90002-7
Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms.
T. Endō (1987)
10.1046/J.1432-1327.1999.00623.X
Snake venom α‐neurotoxins and other ‘three‐finger’ proteins
V. Tsetlin (1999)
10.1007/BF01887150
cDNA sequence analysis and mutagenesis studies on the a chain of Β-bungarotoxin from Taiwan banded krait
L. Chang (1996)
10.1016/0163-7258(88)90111-8
Structure and pharmacology of elapid cytotoxins.
Mark Dufton (1988)
10.1021/BI963105G
Site-directed mutagenesis of dendrotoxin K reveals amino acids critical for its interaction with neuronal K+ channels.
L. Smith (1997)
10.1021/BI00017A022
NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom.
J. Albrand (1995)
10.1016/0167-4838(91)90051-Z
Studies on the subunit structure of textilotoxin, a potent presynaptic neurotoxin from the venom of the Australian common brown snake (Pseudonaja textilis). 2. The amino acid sequence and toxicity studies of subunit D.
J. Pearson (1991)
10.1016/0006-8993(83)90902-2
Kappa-Bungarotoxin: a probe for the neuronal nicotinic receptor in the avian ciliary ganglion
V. Chiappinelli (1983)
10.1186/1471-2164-7-152
Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags
Bing Zhang (2006)



This paper is referenced by
10.1186/2041-9139-2-19
Reptilian-transcriptome v1.0, a glimpse in the brain transcriptome of five divergent Sauropsida lineages and the phylogenetic position of turtles
Athanasia C. Tzika (2011)
10.1021/pr101248e
Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin.
D. Georgieva (2011)
10.1016/j.toxicon.2011.02.016
Cloning and sequence analysis of an Ophiophagus hannah cDNA encoding a precursor of two natriuretic peptide domains.
Weiwei Lei (2011)
10.1186/s12867-016-0059-7
Erratum to: Gene expression profiling of the venom gland from the Venezuelan mapanare (Bothrops colombiensis) using expressed sequence tags (ESTs)
M. Suntravat (2016)
10.1016/j.toxcx.2020.100039
Toxinology provides multidirectional and multidimensional opportunities: A personal perspective
R. Kini (2020)
Isolation and proteomics characterization of a novel muscarinic toxin from Bungarus candidus (Malayan Krait) crude venom
Muhamad Rusdi Ahmad Rusmili (2012)
10.1371/journal.pone.0142680
Global Transcriptome Analysis of the Tentacle of the Jellyfish Cyanea capillata Using Deep Sequencing and Expressed Sequence Tags: Insight into the Toxin- and Degenerative Disease-Related Transcripts
Guoyan Liu (2015)
10.1021/pr1008916
Identification of novel proteins from the venom of a cryptic snake Drysdalia coronoides by a combined transcriptomics and proteomics approach.
Shifali Tiwari Chatrath (2011)
10.5772/52380
Toxins from Venomous Animals: Gene Cloning, Protein Expression and Biotechnological Applications
M. F. Fernandes-Pedrosa (2013)
10.3390/toxins10090373
Proteomic Deep Mining the Venom of the Red-Headed Krait, Bungarus flaviceps
A. Chapeaurouge (2018)
Snake evolution and prospecting of snake venom
F. Vonk (2012)
10.2147/TCRM.S169581
Krait envenomation in Thailand
A. Tongpoo (2018)
10.1016/j.jprot.2014.08.001
Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms.
Muhamad Rusdi Ahmad Rusmili (2014)
10.1016/j.toxicon.2020.04.003
Venom gland transcriptome from Heloderma horridum horridum by high-throughput sequencing.
Gisela Jareth Lino-López (2020)
10.1002/jbt.22273
Expression and characterization of Flavikunin: A Kunitz‐type serine protease inhibitor identified in the venom gland cDNA library of Bungarus flaviceps
Simran Kaur (2019)
10.1016/j.phrs.2020.104687
Venom natriuretic peptides guide the design of heart failure therapeutics.
Sindhuja Sridharan (2020)
10.1186/1471-2164-15-1061
RNA-seq and high-definition mass spectrometry reveal the complex and divergent venoms of two rear-fanged colubrid snakes
James J. McGivern (2014)
10.3390/molecules24152778
Hypotensive Snake Venom Components—A Mini-Review
Orsolya Péterfi (2019)
10.3109/15563650.2010.533677
Life-threatening hyponatremia after krait bite envenoming – A new syndrome
J. Höjer (2010)
10.1016/j.toxicon.2010.07.010
Structure, function and evolution of three-finger toxins: mini proteins with multiple targets.
R. Kini (2010)
EFEITOS RENAIS E ALTERAÇÕES MORFOLÓGICAS CAUSADOS PELO PEPTÍDEO NATRIURÉTICO SINTÉTICO DO VENENO DE Crotalus durissus cascavella
João Alison De Moraes (2015)
10.1042/BJ20150281
Tail wags the dog: activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner.
S. Sridharan (2015)
10.1101/006031
Testing the Toxicofera: comparative reptile transcriptomics casts doubt on the single, early evolution of the reptile venom system
Adam D. Hargreaves (2014)
10.1016/j.jprot.2016.12.018
Proteomic analysis to unravel the complex venom proteome of eastern India Naja naja: Correlation of venom composition with its biochemical and pharmacological properties.
S. Dutta (2017)
10.1021/pr101091a
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).
Julián Fernández (2011)
Chapter 2 Toxins from Venomous Animals : Gene Cloning , Protein Expression and Biotechnological Applications
M. F. Fernandes-Pedrosa (2017)
10.1016/j.toxicon.2014.10.022
Venom gland transcriptomics for identifying, cataloging, and characterizing venom proteins in snakes.
Rajeev Kungur Brahma (2015)
10.1016/j.toxicon.2010.10.014
A novel natriuretic peptide from the cobra venom.
Y. Zhang (2011)
10.1016/j.jprot.2013.05.015
Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja).
S. A. Ali (2013)
10.1016/j.toxicon.2015.09.021
Discovery of toxin-encoding genes from the false viper Macropisthodon rudis, a rear-fanged snake, by transcriptome analysis of venom gland.
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