Online citations, reference lists, and bibliographies.

Safe Temperature Range For Intraoperative And Early Postoperative Continuous Hyperthermic Intraperitoneal Perfusion In A Swine Model Of Experimental Distal Gastrectomy With Billroth II Reconstruction

Sheng Li, Yong-lei Zhang, Jia-yuan Sun, Ya-wei Hua, Pei-Hong Wu
Published 2013 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BackgroundThe current study sought to investigate the safety of intraoperative and early postoperative continuous hyperthermic intraperitoneal perfusion (IEPCHIP) at different temperatures in a swine model of experimental distal gastrectomy with Billroth II reconstruction.MethodsThirty pigs were randomly divided into 5 groups. Two groups were used as the control groups (groups A1 and A2), and 3 groups were used as the perfusion groups (groups B, C and D). Pigs in group A1 received distal gastrectomy with Billroth II reconstruction only. Pigs in groups A2, B, C and D received the same surgery as group A1, followed by IEPCHIP at 37 ± 0.5°C, 42.5 ± 0.5°C, 43.5 ± 0.5°C or 44.5 ± 0.5°C, respectively. The perfusion time was assessed for each pig in group A2 as well as in the perfusion groups, and the perfusions were performed twice for each group. The first perfusion was conducted intraoperatively, and the second perfusion was initiated 1 day after surgery. Data concerning vital signs and hepatic and renal function were collected. Parameters concerning anastomotic healing, the pathology of the anastomotic tissue and abdominal adhesion were compared.ResultsThe vital signs and hepatic and renal functions of the pigs in groups A1, A2, B and C were not significantly affected by this procedure. In contrast, the vital signs and hepatic and renal functions of the pigs in group D were significantly affected. Compared to the pigs in groups A1, A2 or B, the anastomotic bursting pressure, breaking strength and hydroxyproline content in group C and D pigs were significantly lower. No significant differences were observed in these parameters between groups A1, A2 and B. Abdominal adhesion was more severe in group D pigs. Collagen deposition in group A1, A2 and B pigs was dense in the anastomosis, and inflammatory cell infiltration was observed in group D.ConclusionsIEPCHIP at 42.5 ± 0.5°C was safe and caused minimal impairments. However, anastomotic healing was affected by perfusion at 43.5 ± 0.5°C and 44.5 ± 0.5°C, and abdominal adhesion was most severe in the group D animals, which were perfused at 44.5 ± 0.5°C.
This paper references
10.3322/canjclin.49.1.33
Global cancer statistics.
Donald Maxwell Parkin (1999)
10.1200/JCO.2004.10.012
Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study.
Olivier Glehen (2004)
10.1016/j.suronc.2010.09.002
Treatment of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: state of the art and future developments.
Franco Roviello (2011)
10.1245/s10434-012-2579-9
Quality of Life in Patients after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is It Worth the Risk?
Nikolaos Tsilimparis (2012)
10.1245/s10434-006-9185-7
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement
Jesús Esquivel (2006)
181 Page 9 of 10 http://www.translational-medicine.com/content
Li (2013)
10.1200/JCO.2009.24.8500
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer: a panacea or just an obstacle course for the patient?
Vijay P. Khatri (2010)
[Clinical application of perioperative continuous hyperthermic peritoneal perfusion chemotherapy for gastric cancer].
Hai-jun Deng (2009)
10.1684/BDC.2009.0927
Chimiohyperthermie intrapéritonéale : évaluation, prévention et gestion des risques professionnels au bloc opératoire
Laura Simón (2009)
10.1245/s10434-010-0937-z
Which Method to Deliver Hyperthermic Intraperitoneal Chemotherapy with Oxaliplatin? An Experimental Comparison of Open and Closed Techniques
P Ortega-Deballon (2010)
10.1002/jso.20013
Toxicity of cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy.
Vic J. Verwaal (2004)
10.1159/000011847
Heated Intraoperative Intraperitoneal Mitomycin C and Early Postoperative Intraperitoneal 5-Fluorouracil: Pharmacokinetic Studies
Pierre Jacquet (1998)
10.1186/1471-2407-5-31
The optimal starting time of postoperative intraperitoneal mitomycin-C therapy with preserved intestinal wound healing
Ali Uzunkoy (2004)
10.1684/bdc.2009.0927
[Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC): evaluation, prevention and policies to avoid occupational exposure for operating room personnel].
Lorna Simon (2009)
10.1097/SLA.0b013e3182436c28
Multidimensional Analysis of the Learning Curve for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Surface Malignancies
Shigeki Kusamura (2012)
Global cancer statistics. CA Cancer J Clin
A Jemal (2011)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology.
Jesús Esquivel (2007)
In vitro efficacy of carboplatin and hyperthermia in a murine retinoblastoma cell line.
Timothy G. Murray (1997)
10.3109/15376516.2010.550016
Heat stress-induced hepatotoxicity and its prevention by resveratrol in rats
Asima Das (2011)
10.3748/WJG.14.1159
Current status and future strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for peritoneal carcinomatosis.
Hassan-Alaa-Hammed Al-Shammaa (2008)
10.1007/978-3-540-30760-0_2
The natural history of free cancer cells in the peritoneal cavity.
Yutaka Yonemura (2007)
10.3109/07357907.2012.654871
Peritoneal Carcinomatosis: Cytoreductive Surgery and HIPEC–-Overview and Basics
Björn L.D.M. Brücher (2012)
10.1002/jso.21051
Drugs, carrier solutions and temperature in hyperthermic intraperitoneal chemotherapy.
Shigeki Kusamura (2008)
10.1002/cncr.21708
Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion: analysis of morbidity and mortality in 209 peritoneal surface malignancies treated with closed abdomen technique.
Shigeki Kusamura (2006)
Survival Benefit at Considerable Morbidity and Mortality
(2013)
10.1245/s10434-007-9551-0
Incidence of Postoperative Pancreatic Fistula and Hyperamylasemia after Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy
Shigeki Kusamura (2007)
10.1245/s10434-013-3053-z
Outcomes of Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients Older Than 70 Years; Survival Benefit at Considerable Morbidity and Mortality
Konstantinos I. Votanopoulos (2013)
10.1016/S0039-6060(96)80145-0
Effects of intraoperative chemohyperthermia in patients with gastric cancer with peritoneal dissemination.
Yutaka Yonemura (1996)
10.1245/s10434-011-1984-9
Intraoperative versus Early Postoperative Intraperitoneal Chemotherapy after Cytoreduction for Colorectal Peritoneal Carcinomatosis: an Experimental Study
Yvonne L. B. Klaver (2011)
10.1002/cncr.25356
Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1,290 patients.
Olivier Glehen (2010)
10.1080/00015458.2003.11679430
Influence of Neo-Adjuvant Chemotherapy with 5-Fluorouracil on Colonic Anastomotic Healing: Experimental Study in Rats
Mohamed El-Malt (2003)
10.1245/s10434-010-1028-x
In vivo Toxicity and Bioavailability of Taxol® and a Paclitaxel/β-Cyclodextrin Formulation in a Rat Model During HIPEC
Wim Bouquet (2010)
10.1097/PPO.0b013e3181a58d95
Pharmacokinetics and Pharmacodynamics of Perioperative Cancer Chemotherapy in Peritoneal Surface Malignancy
Kurt van der Speeten (2009)
10.1245/s10434-008-0070-4
The Effects of Adjuvant Experimental Radioimmunotherapy and Hyperthermic Intraperitoneal Chemotherapy on Intestinal and Abdominal Healing after Cytoreductive Surgery for Peritoneal Carcinomatosis in the Rat
Frits Aarts (2008)
10.1097/SLA.0b013e3182197102
Hyperthermia and Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis: An Experimental Study
Yvonne L. B. Klaver (2011)
Safe temperature range for intraoperative and early postoperative continuous hyperthermic intraperitoneal perfusion in a swine model of experimental distal gastrectomy with Billroth II reconstruction
Li (2013)
Cytoreductive surgery followed by intra peritoneal hyperthermic perfusion in the treatment of peritoneal surface malignancies: morbidity and mortality with closed abdomen technique.
Shigeki Kusamura (2003)
10.1245/s10434-007-9487-4
A Systematic Review and Meta-analysis of the Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Gastric Cancer
Tristan D. Yan (2007)
10.1186/1479-5876-9-53
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study
Li Tang (2011)
10.1371/journal.pone.0002428
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy
Scott J. Dylla (2008)
10.1016/j.jss.2010.10.001
Effects of platelet-rich plasma on intestinal anastomotic healing in rats: PRP concentration is a key factor.
Ryushiro Yamaguchi (2012)
10.1016/j.ejso.2005.08.009
Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei--a report of 103 procedures.
Robert M. Smeenk (2006)
Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multiinstitutional study
O Glehen (2010)
10.1016/j.ygyno.2009.01.016
Incidence of intestinal obstruction following intraperitoneal chemotherapy for ovarian tubal and peritoneal malignancies.
Siobhan M. Kehoe (2009)
10.1007/978-1-4613-1247-5_6
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
10.1245/s10434-011-1631-5
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial
Xiaojun Yang (2011)
10.1245/s10434-010-1039-7
Peritoneal Carcinomatosis from Gastric Cancer: A Multi-Institutional Study of 159 Patients Treated by Cytoreductive Surgery Combined with Perioperative Intraperitoneal Chemotherapy
Olivier Glehen (2010)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar