← Back to Search
Comparative Studies Of Salinomycin-loaded Nanoparticles Prepared By Nanoprecipitation And Single Emulsion Method
Q. Wang, Puyuan Wu, Wei Ren, Kai Xin, Y. Yang, C. Xie, Chenchen Yang, Q. Liu, Lixia Yu, Xiqun Jiang, B. Liu, R. Li, L. Wang
Published 2014 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
To establish a satisfactory delivery system for the delivery of salinomycin (Sal), a novel, selective cancer stem cell inhibitor with prominent toxicity, gelatinase-responsive core-shell nanoparticles (NPs), were prepared by nanoprecipitation method (NR-NPs) and single emulsion method (SE-NPs). The gelatinase-responsive copolymer was prepared by carboxylation and double amination method. We studied the stability of NPs prepared by nanoprecipitation method with different proportions of F68 in aqueous phase to determine the best proportion used in our study. Then, the NPs were prepared by nanoprecipitation method with the best proportion of F68 and single emulsion method, and their physiochemical traits including morphology, particle size, zeta potential, drug loading content, stability, and in vitro release profiles were studied. The SE-NPs showed significant differences in particle size, drug loading content, stability, and in vitro release profiles compared to NR-NPs. The SE-NPs presented higher drug entrapment efficiency and superior stability than the NR-NPs. The drug release rate of SE-NPs was more sustainable than that of the NR-NPs, and in vivo experiment indicated that NPs could prominently reduce the toxicity of Sal. Our study demonstrates that the SE-NPs could be a satisfactory method for the preparation of gelatinase-responsive NPs for intelligent delivery of Sal.
This paper references
Eliminating drug resistant breast cancer stem-like cells with combination of simvastatin and gamma-tocotrienol.
Archana Gopalan (2013)
Comparative studies of salinomycin-loaded nanoparticles prepared by nanoprecipitation and single emulsion method
Salinomycin can effectively kill ALDH(high) stem-like cells on gastric cancer.
Qiao Ming Zhi (2011)
Reversion of pH-Induced Physiological Drug Resistance: A Novel Function of Copolymeric Nanoparticles
Rutian Li (2011)
Poly epsilon-caprolactone nanoparticles containing a poorly soluble pesticide: formulation and stability study.
A. L. Le Roy Boehm (2000)
An unaddressed issue of agricultural terrorism: a case study on feed security.
M. E. Kosal (2004)
Enhanced antitumor efficacy, biodistribution and penetration of docetaxel-loaded biodegradable nanoparticles.
Q. Liu (2012)
Preparation, drug release and cellular uptake of doxorubicin-loaded dextran-b-poly(ɛ-caprolactone) nanoparticles.
B. Li (2013)
Identification of new antimalarial drugs by linear discriminant analysis and topological virtual screening.
N. Mahmoudi (2006)
The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage.
Amr S. Abu Lila (2013)
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting.
K. Greish (2010)
Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting.
R. Aydın (2013)
Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species.
J. Zhou (2013)
Paclitaxel loaded carrier based biodegradable polymeric implants: Preparation and in vitro characterization.
J. G. Hiremath (2013)
Overcoming multidrug resistance of cancer cells by direct intranuclear drug delivery using TAT-conjugated mesoporous silica nanoparticles.
Limin Pan (2013)
Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis.
C. Eyler (2008)
Paclitaxel-loaded polymeric nanoparticles based on PCL-PEG-PCL: preparation, in vitro and in vivo evaluation.
L. Zhang (2011)
Preparation and evaluation of PEG-PCL nanoparticles for local tetradrine delivery.
Rutian Li (2009)
Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect.
H. Maeda (2009)
Intelligently Targeted Drug Delivery and Enhanced Antitumor Effect by Gelatinase-Responsive Nanoparticles
Rutian Li (2013)
Correction for Woodward et al., WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells
W. Woodward (2007)
Salinomycin toxicosis in horses.
M. Aleman (2007)
Nanoparticle therapeutics: an emerging treatment modality for cancer
M. Davis (2008)
Polymer-based nanocapsules for drug delivery.
C. E. Mora-Huertas (2010)
Simulation of transport and extravasation of nanoparticles in tumors which exhibit enhanced permeability and retention effect
Vishwa Priya Podduturi (2013)
Polymeric conjugates for drug delivery.
N. Larson (2012)
Molecular definition of breast tumor heterogeneity.
M. Shipitsin (2007)
Cancer stem cells: models and concepts.
P. Dalerba (2007)
Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy.
Shixian Lv (2013)
Gelatinase-stimuli strategy enhances the tumor delivery and therapeutic efficacy of docetaxel-loaded poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles
Q. Liu (2012)
Cancer, chitosan nanoparticles and catalytic nucleic acids.
M. Tan (2009)
Biodegradable nanoparticles for drug and gene delivery to cells and tissue.
J. Panyam (2003)
Association of reactive oxygen species levels and radioresistance in cancer stem cells
M. Diehn (2009)
Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells.
Guan-nan Zhang (2011)
Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties
V. Levina (2008)
New methods of drug delivery.
R. Langer (1990)
The eradication of breast cancer and cancer stem cells using octreotide modified paclitaxel active targeting micelles and salinomycin passive targeting micelles.
Yang Zhang (2012)
Biodegradable, polymeric nanoparticle delivery systems for cancer therapy.
Eric M. Pridgen (2007)
Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles.
Hong Jai Lee (2014)
Cancer, chitosan nanoparticles and catalytic nucleic acids
M. Tan (2009)
Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles.
Kyeongsoon Park (2007)
Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs.
Yuancai Dong (2004)
High Throughput Screening
W. P. Janzen (2016)
Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity.
Einat Cohen-Sela (2009)
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
P. Gupta (2009)
A case of human poisoning by salinomycin, an agricultural antibiotic.
Phillipa Story (2004)
Optimization of parameters for preparation of docetaxel-loaded PLGA nanoparticles by nanoprecipitation method
Wei Shi 施 伟 (2013)
Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects.
J.-L.C.M. Dorne (2013)
Nanoscale Research Letters
This paper is referenced by
Nanoparticles in Gastrooncology
André Jefremow (2020)
Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem cells
P. Mineo (2020)
Enhanced and Prolonged Antitumor Effect of Salinomycin-Loaded Gelatinase-Responsive Nanoparticles via Targeted Drug Delivery and Inhibition of Cervical Cancer Stem Cells
Q. Wang (2020)
The promotion of salinomycin delivery to hepatocellular carcinoma cells through EGFR and CD133 aptamers conjugation by PLGA nanoparticles.
Jianxin Jiang (2015)
Salinomycin nanocrystals for colorectal cancer treatment through inhibition of Wnt/β-catenin signaling.
Zhong-yuan Wang (2020)
FACTORS AFFECTING PREPARATION AND PROPERTIES OF NANOPARTICLES BY NANOPRECIPITATION METHOD
M. J. Ansari (2018)
Cationic functionalized biocompatible polylactide nanoparticles for slow release of proteins
Philippe C. Mesquita (2017)
CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel.
Eameema Muntimadugu (2016)
Efficacy of decitabine-loaded gelatinases-stimuli nanoparticles in overcoming cancer drug resistance is mediated via its enhanced demethylating activity to transcription factor AP-2 epsilon
Yi-Dong Hong (2017)
Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma
Jian-guo Wang (2020)
The application of nanoparticles in diagnosis and theranostics of gastric cancer.
Rutian Li (2017)
iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells.
Xiaoli Mao (2015)
Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics.
Feng-lei Wu (2015)
A comprehensive review of salinomycin derivatives as potent anticancer and anti-CSCs agents.
M. Antoszczak (2019)
Co-Eradication of Breast Cancer Cells and Cancer Stem Cells by Cross-Linked Multilamellar Liposomes Enhances Tumor Treatment.
Y. J. Kim (2015)