The Use Of Mesenchymal Stem Cells For Cartilage Repair And Regeneration: A Systematic Review
Andy Goldberg, Katrina Mitchell, Julian Soans, Louise U. Kim, Razi Zaidi
Published 2017 · Medicine
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BackgroundThe management of articular cartilage defects presents many clinical challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation techniques, such as microfracture, are the most frequently used method in clinical practice however the resulting mixed fibrocartilage tissue which is inferior to native hyaline cartilage. Other methods have shown promise but are far from perfect. There is an unmet need and growing interest in regenerative medicine and tissue engineering to improve the outcome for patients requiring cartilage repair. Many published reviews on cartilage repair only list human clinical trials, underestimating the wealth of basic sciences and animal studies that are precursors to future research. We therefore set out to perform a systematic review of the literature to assess the translation of stem cell therapy to explore what research had been carried out at each of the stages of translation from bench-top (in vitro), animal (pre-clinical) and human studies (clinical) and assemble an evidence-based cascade for the responsible introduction of stem cell therapy for cartilage defects.Main body of abstractThis review was conducted in accordance to PRISMA guidelines using CINHAL, MEDLINE, EMBASE, Scopus and Web of Knowledge databases from 1st January 1900 to 30th June 2015. In total, there were 2880 studies identified of which 252 studies were included for analysis (100 articles for in vitro studies, 111 studies for animal studies; and 31 studies for human studies). There was a huge variance in cell source in pre-clinical studies both of terms of animal used, location of harvest (fat, marrow, blood or synovium) and allogeneicity. The use of scaffolds, growth factors, number of cell passages and number of cells used was hugely heterogeneous.Short conclusionsThis review offers a comprehensive assessment of the evidence behind the translation of basic science to the clinical practice of cartilage repair. It has revealed a lack of connectivity between the in vitro, pre-clinical and human data and a patchwork quilt of synergistic evidence. Drivers for progress in this space are largely driven by patient demand, surgeon inquisition and a regulatory framework that is learning at the same pace as new developments take place.
This paper references
Behavior of Transplanted Bone Marrow-derived GFP Mesenchymal Cells in Osteochondral Defect as a Simulation of Autologous Transplantation
Y Oshima (2005)
Cell origin and differentiation in the repair of full-thickness defects of articular cartilage.
Frederic Shapiro (1993)
Effect of oxygen concentration, culture format and donor variability on in vitro chondrogenesis of human adipose tissue-derived stem cells.
Linda Pilgaard (2009)
Design and characterization of a tissue-engineered bilayer scaffold for osteochondral tissue repair.
Paolo Giannoni (2015)
Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure.
Chia-Hsin Lu (2014)
Integrated trilayered silk fibroin scaffold for osteochondral differentiation of adipose-derived stem cells.
Xiaoming Ding (2014)
Autologous Bone Marrow Stromal Cell Transplantation for Repair of Full-Thickness Articular Cartilage Defects in Human Patellae: Two Case Reports
Shigeyuki Wakitani (2004)
Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering.
Xuebin Chen (2013)
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
Yiyong Wei (2012)
Single-stage cartilage repair in the knee with microfracture covered with a resorbable polymer-based matrix and autologous bone marrow concentrate.
Davide Enea (2013)
Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report
Aad Alfons Maria Dhollander (2010)
Combination of transforming growth factor-beta2 and bone morphogenetic protein 7 enhances chondrogenesis from adipose tissue-derived mesenchymal stem cells.
Hye-Joung Kim (2009)
Integrating biologically inspired nanomaterials and table-top stereolithography for 3D printed biomimetic osteochondral scaffolds.
Nathan J. Castro (2015)
Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation versus mosaicplasty for symptomatic articular cartilage lesions of the knee.
George Bentley (2012)
Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model
Jun Young Chung (2013)
Repair of Chronic Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells in an Ovine Model
Matthias Zscharnack (2010)
Articular cartilage repair by genetically modified bone marrow aspirate in sheep
Alan Ivković (2010)
Embryonic Stem Cells Form Articular Cartilage, not Teratomas, in Osteochondral Defects of Rat Joints
Shigeyuki Wakitani (2004)
Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model
Susumu Araki (2015)
Translational research: from benchside to bedside.
Nikolaos C. Keramaris (2008)
Enhanced Early Tissue Regeneration after Matrix-Assisted Autologous Mesenchymal Stem Cell Transplantation in Full Thickness Chondral Defects in a Minipig Model
Martin Jung (2009)
In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta1 loaded fibrin-poly(lactidecaprolactone) nanoparticulate complex. Biomaterials
Y Jung (2009)
Journal of Orthopaedic Surgery and Research BioMed Central
BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hydrogel.
Young-Mee Park (2005)
The Influence of IL-10 and TNFα on Chondrogenesis of Human Mesenchymal Stromal Cells in Three-Dimensional Cultures
Michal Jagielski (2014)
Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation
Roberto Narcisi (2015)
Compare the effects of chondrogenesis by culture of human mesenchymal stem cells with various type of the chondroitin sulfate C.
Wei-Chuan Chen (2011)
Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
Paul D. Benya (1982)
Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis.
Ming Pei (2013)
Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: a randomized controlled trial.
Khay-Yong Saw (2013)
Chondrogenesis of Infrapatellar Fat Pad Derived Adipose Stem Cells in 3D Printed Chitosan Scaffold
Ken Ye (2014)
High-Impact Athletics After Knee Articular Cartilage Repair: A Prospective Evaluation of the Microfracture Technique
Bernard F. Morrey (2008)
Ann Acad Med Singapore. Accessed
TGF-β1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells
Jinku Kim (2015)
Bioinspired nanofibers support chondrogenesis for articular cartilage repair
Jeannine M Coburn (2012)
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series
Jaewoo Pak (2011)
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells: A Pilot Study
Lluís Orozco (2013)
Repair of cartilage defects in BMSCs via CDMP1 gene transfection.
G. Wu (2014)
Repair of articular cartilage defects with a novel injectable in situ forming material in a canine model.
Tatsuya Igarashi (2012)
Poly-l-Lactic Acid/Hydroxyapatite Electrospun Nanocomposites Induce Chondrogenic Differentiation of Human MSC
Cristiano Spadaccio (2009)
Generation of osteochondral tissue constructs with chondrogenically and osteogenically predifferentiated mesenchymal stem cells encapsulated in bilayered hydrogels.
Johnny Steven Lam (2014)
Chondrogenesis using mesenchymal stem cells and PCL scaffolds.
Hye-Joung Kim (2009)
Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications.
Elena Geta Popa (2015)
Human mesenchymal stem cells: Influence of oxygen pressure on proliferation and chondrogenic differentiation in fibrin glue in vitro.
Laura Baumgartner (2009)
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
Alessandro Liberati (2009)
Characterization of esterified hyaluronan-gelatin polymer composites suitable for chondrogenic differentiation of mesenchymal stem cells.
Peter Angele (2009)
Articular cartilage repair with autologous bone marrow mesenchymal cells.
Tomiya Matsumoto (2010)
Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2.
Yiyong Wei (2006)
Repair of full-thickness cartilage defects with cells of different origin in a rabbit model.
Hui Yan (2007)
Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix.
A A Worster (2001)
Arthroscopic abrasion arthroplasty historical and pathologic perspective: present status.
Lanny Leo Johnson (1986)
Experimental results of donor site filling for autologous osteochondral mosaicplasty.
Péter Feczkó (2003)
Cartilage tissue engineering by collagen matrix associated bone marrow derived mesenchymal stem cells.
Ronny M. Schulz (2008)
Mesenchymal stem cell-based therapy for cartilage repair: a review
Hideyuki Koga (2009)
Repair of the joint surface from subarticular tissue in the rabbit knee.
G. Meachim (1971)
Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix.
Nai-Chen Daniel Cheng (2009)
Effect of chondroitin sulphate C on the in vitro and in vivo chondrogenesis of mesenchymal stem cells in crosslinked type II collagen scaffolds.
Wei-Chuan Chen (2013)
Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bonemarrow stromal cells. Osteoarthritis Cartilage
R Kuroda (2007)
Human mesenchymal stem cells induced by growth differentiation factor 5: an improved self-assembly tissue engineering method for cartilage repair.
Beijiang Zhang (2011)
Articular Cartilage Repair With Magnetic Mesenchymal Stem Cells
Goki Kamei (2013)
Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology
Marie Maumus (2011)
Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits.
Zengjun Wang (2014)
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.
Geoffrey R. Erickson (2002)
A novel injectable scaffold for cartilage tissue engineering using adipose-derived adult stem cells.
Yiyong Wei (2008)
Intra-articular surgery for degenerative arthritis of the knee. A report of the work of the late K. H. Pridie.
John Nevil Insall (1967)
Preconditioning of mesenchymal stem cells with low-intensity ultrasound for cartilage formation in vivo.
Ji Hao Cui (2007)
Chondrogenic differentiation of mesenchymal progenitor cells encapsulated in ultrahigh-viscosity alginate.
Andre Friedrich Steinert (2003)
In vitro engineered cartilage constructs produced by press-coating biodegradable polymer with human mesenchymal stem cells.
Ulrich Noeth (2002)
Spongialization: a new treatment for diseased patellae.
R. Paul Ficat (1979)
Treatment of Focal Articular Cartilage Defects in the Knee
Robert A. Magnussen (2008)
Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
Janina Frisch (2014)
Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh.
Lei Cui (2009)
Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold.
Kota Uematsu (2005)
Repair of large osteochondral defects in a beagle model with a novel type I collagen/glycosaminoglycan-porous titanium biphasic scaffold.
Xin Duan (2013)
Synovial membrane-derived mesenchymal stem cells supported by platelet-rich plasma can repair osteochondral defects in a rabbit model.
Jae-Chul Lee (2013)
Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture.
Alexander T. Mehlhorn (2006)
Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit
Hideyuki Koga (2008)
Multipotent Stromal Cells Outperform Chondrocytes on Cartilage-Derived Matrix Scaffolds
K.E.M. Benders (2014)
Comparison of the efficacy of bone marrow mononuclear cells and bone mesenchymal stem cells in the treatment of osteoarthritis in a sheep model.
Fanglong Song (2014)
Cell sources for the regeneration of articular cartilage: the past, the horizon and the future.
Rachel A. Oldershaw (2012)
Tailoring adipose stem cell trophic factor production with differentiation medium components to regenerate chondral defects.
Christopher S. D. Lee (2013)
Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow.
G I Im (2001)
Xeno-free and shrinkage-free preparation of scaffold-free cartilage-like disc-shaped cell sheet using human bone marrow mesenchymal stem cells.
Yasushi Sato (2013)
Chitosan/poly(vinyl alcohol) hydrogel combined with Ad-hTGF-β1 transfected mesenchymal stem cells to repair rabbit articular cartilage defects
Bai-wen Qi (2013)
Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture.
C-Y Charles Huang (2004)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model
Hamoud Al Faqeh (2012)
Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit.
Brunella Grigolo (2009)
Osteochondral repair using porous poly(lactide-co-glycolide)/nano-hydroxyapatite hybrid scaffolds with undifferentiated mesenchymal stem cells in a rat model.
Deting Xue (2010)
Human adipose-derived stem cells contribute to chondrogenesis in coculture with human articular chondrocytes.
Florian Hildner (2009)
Large fresh osteochondral allografts of the knee: a systematic clinical and basic science review of the literature.
Francesca de Caro (2015)
In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel
Akiko Yokoyama (2005)
Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
Christopher J. Centeno (2008)
A Cell-free Scaffold-based Cartilage Repair Provides Improved Function Hyaline-like Repair at One year
Alberto Siclari (2012)
Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.
Lunli Gong (2014)
Human placenta-derived mesenchymal stem cells with silk fibroin biomaterial in the repair of articular cartilage defects.
Fang Li (2012)
Animal-origin osteochondral scaffold combined with bone marrow mesenchymal stem cells/chondrocytes for repair of composite osteochondral defects in rabbit knee joints
W Tan (2011)
Autologous chondrocyte implantation in the arthritic knee.
Tom Minas (2003)
In vivo outcomes of tissueengineered osteochondral grafts
BS Bal (2010)
Arthroscopic knee cartilage repair with covered microfracture and bone marrow concentrate.
Antonio Pompilio Gigante (2012)
A preliminary study comparing the use of allogenic chondrogenic pre-differentiated and undifferentiated mesenchymal stem cells for the repair of full thickness articular cartilage defects in rabbits.
Havva Dashtdar (2011)
Increased Failure Rate of Autologous Chondrocyte Implantation after Previous Treatment with Marrow Stimulation Techniques
Tom Minas (2009)
Directing chondrogenic differentiation of mesenchymal stem cells with a solid-supported chitosan thermogel for cartilage tissue engineering.
Hongjie Huang (2014)
Repair of an articular cartilage defect using adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid) and chitosan.
Kunxi Zhang (2013)
Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
Hideyuki Koga (2008)
Chondrogenesis of synovium-derived mesenchymal stem cells in gene-transferred co-culture system.
Rohan R. Varshney (2010)
Engineered Microtissues Formed by Schiff Base Crosslinking Restore the Chondrogenic Potential of Aged Mesenchymal Stem Cells.
Christopher Millan (2015)
Chondrogenesis and Integration of Mesenchymal Stem Cells Within an In Vitro Cartilage Defect Repair Model
Tatiana Vinardell (2009)
Cartilage repair using mesenchymal stem cell (MSC) sheet and MSCs-loaded bilayer PLGA scaffold in a rabbit model
Yiying Qi (2012)
Osteogenic protein-1 with transforming growth factor-β1: potent inducer of chondrogenesis of synovial mesenchymal stem cells in vitro
Chikara Miyamoto (2007)
Differentiation of transplanted mesenchymal stem cells in a large osteochondral defect in rabbit.
Masahiro Tatebe (2005)
Improved cartilage repair via in vitro pre-maturation of MSC-seeded hyaluronic acid hydrogels.
Isaac E. Erickson (2012)
Arthroscopic debridement of unicompartmental arthritis: fact or fiction?
Ahmad Badri (2014)
Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial
Aurelio Vega (2015)
Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis
Mitsuhiko Sato (2012)
Therapeutic Superiority for Cartilage Repair by CD271-Positive Marrow Stromal Cell Transplantation
Yutaka Mifune (2013)
Use of synovium-derived stromal cells and chitosan/collagen type I scaffolds for cartilage tissue engineering.
Zhongcheng Gong (2010)
Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: from open field autologous chondrocyte to bone-marrow-derived cells transplantation.
Sandro Giannini (2010)
Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases report.
Channarong Kasemkijwattana (2011)
Enhanced treatment of articular cartilage defect of the knee by intra-articular injection of Bcl-xL-engineered mesenchymal stem cells in rabbit model.
Bin Hu (2010)
Cartilage regeneration using mesenchymal stem cells and a PLGA-gelatin/chondroitin/hyaluronate hybrid scaffold.
Hongbin Fan (2006)
Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up.
Keng Lin Wong (2013)
Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model.
Ximin Guo (2004)
Chondrogenic differentiation of human adipose mesenchimal stem cells: influence of a biomimetic gelatin genipin crosslinked porous scaffold.
Stefano Focaroli (2014)
Role of abrasion arthroplasty and debridement in the management of osteoarthritis of the knee.
Bert Jm (1993)
Arthroscopic multiple osteochondral transplantation to the chondral defect in the knee associated with anterior cruciate ligament disruption.
Yoshitaka Matsusue (1993)
Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix.
Yang Liu (2006)
Long-Term Results of Cartilage Repair after Allogeneic Transplantation of Cartilaginous Aggregates Formed from Bone Marrow–Derived Cells for Large Osteochondral Defects in Rabbit Knees
Tomokazu Yoshioka (2013)
Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model.
Chin Tat Lim (2013)
The Chondrogenic Potential of Human Bone-Marrow-Derived Mesenchymal Progenitor Cells*
Jung U. Yoo (1998)
Chondrogenic differentiation of ATDC5 and hMSCs could be induced by a novel scaffold-tricalcium phosphate-collagen-hyaluronan without any exogenous growth factors in vitro.
Fangang Meng (2014)
Tissue engineering of articular cartilage with autologous cultured adipose tissue-derived stromal cells using atelocollagen honeycomb-shaped scaffold with a membrane sealing in rabbits.
Kazunori Masuoka (2006)
Marrow stromal cells embedded in alginate for repair of osteochondral defects.
David R. Diduch (2000)
BMSCs laden injectable amino-diethoxypropane modified alginate-chitosan hydrogel for hyaline cartilage reconstruction.
Wenbing Wan (2015)
Matrix-Associated Implantation of Predifferentiated Mesenchymal Stem Cells Versus Articular Chondrocytes
Bastian Marquaß (2011)
Osteochondral allografts: applications in treating articular cartilage defects in the knee.
Craig M Capeci (2013)
Chondrocyte transplantation: an experimental model in the rabbit
L Peterson (1984)
Multipotent Stromal Cells Derived From the Infrapatellar Fat Pad of the Knee
M. Quinn Wickham (2003)
Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells.
Conor Timothy Buckley (2010)
Repair of osteochondral defects in joints--how to achieve success.
George Bentley (2013)
The effects of staged intra-articular injection of cultured autologous mesenchymal stromal cells on the repair of damaged cartilage: a pilot study in caprine model
Hui Yin Nam (2013)
Cell Carriers as the Next Generation of Cell Therapy for Cartilage Repair
Mats Brittberg (2010)
J Equine Vet Sci
Transient exposure to TGF-β3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels.
Minwook Kim (2012)
The meaning of translational research and why it matters.
Steven H. Woolf (2008)
Effects of In Vitro Low Oxygen Tension Preconditioning of Adipose Stromal Cells on Their In Vivo Chondrogenic Potential: Application in Cartilage Tissue Repair
Sophie Portron (2013)
Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy.
Michael Ponticiello (2000)
Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma
Ichiro Sekiya (2004)
Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model
Sverre Løken (2008)
Variation of mesenchymal cells in polylactic acid scaffold in an osteochondral repair model.
Y Oshima (2009)
Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells.
Guangdong Zhou (2006)
The Pridie debridement operation for osteoarthritis of the knee.
John Nevil Insall (1974)
Programmed Application of Transforming Growth Factor β3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair.
Shouan Zhu (2014)
A novel, minimally-invasive technique of cartilage repair in the human knee using arthroscopic microfracture and injections of mesenchymal stem cells and hyaluronic acid--a prospective comparative study on safety and short-term efficacy.
Kevin B L Lee (2012)
Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs
Tomomasa Nakamura (2012)
Magnetic Resonance Imaging Appearance of Cartilage Repair in the Knee
Wendy E Brown (2004)
Informing future cartilage repair strategies: a comparative study of three different human cell types for cartilage tissue engineering
Sushmita Saha (2013)
Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in sodium alginate beads with or without hyaluronic acid
Dong-hwan Kim (2013)
Comparative Evaluation of Autologous Chondrocyte Implantation and Mosaicplasty: A Multicentered Randomized Clinical Trial
Beatrice Dozin (2005)
Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic acid after arthroscopic subchondral drilling: a report of 5 cases with histology.
Khay-Yong Saw (2011)
Stem cell therapy in a caprine model of osteoarthritis.
Joanne M. A. Murphy (2003)
Chondrogenesis of human bone marrow mesenchymal stem cells in fibrin-polyurethane composites.
Zhen Li (2009)
David J. Dandy (1986)
Marrow stimulation techniques.
Matthias R Steinwachs (2008)
Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: a patient-matched comparison.
Jerry I. Huang (2005)
Chondrogenesis of synoviumderived mesenchymal stem cells in genetransferred coculture system
RR Varshney (2010)
Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes.
Gun-Il Im (2011)
Enhanced Chondrogenesis of Adipose-Derived Stem Cells by the Controlled Release of Transforming Growth Factor-β1 from Hybrid Microspheres
Yisheng Han (2009)
The therapeutic effect of bone marrow-derived stem cell implantation after epiphyseal plate injury is abrogated by chondrogenic predifferentiation.
Rhima M. Coleman (2013)
Mesenchymal progenitor cells derived from chorionic villi of human placenta for cartilage tissue engineering.
Xiaohong Zhang (2006)
Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from high-density bone marrow-derived mesenchymal stem cells
Kohei Ishihara (2014)
Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects
Yi Zhang (2011)
Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppression.
Shufang Zhang (2013)
The microfracture technique for the treatment of articular cartilage lesions in the knee. A prospective cohort study.
Kai Mithoefer (2005)
Matrix-induced autologous mesenchymal stem cell implantation versus matrix-induced autologous chondrocyte implantation in the treatment of chondral defects of the knee: a 2-year randomized study
Isık Akgun (2014)
Mesenchymal stem cell chondrogenesis: composite growth factor-bioreactor synergism for human stem cell chondrogenesis.
Marios Petrou (2013)
Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects.
C. Wayne Mcilwraith (2011)
A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells
Daiki Murata (2015)
High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties.
Isaac E. Erickson (2012)
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.
Mats Brittberg (1994)
Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle.
Luis A. Solchaga (2002)
Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model.
Xinxin Shao (2006)
Multiphasic collagen fibre-PLA composites seeded with human mesenchymal stem cells for osteochondral defect repair: an in vitro study.
Andrea Heymer (2009)
Rat Cartilage Repair Using Nanophase PLGA/HA Composite and Mesenchymal Stem Cells
Huade Li (2009)
The osteochondral dilemma: review of current management and future trends.
Ken Ye (2014)
Electrospun nanofiber-based regeneration of cartilage enhanced by mesenchymal stem cells.
Abbas Shafiee (2011)
Fate of transplanted bone-marrow-derived mesenchymal cells during osteochondral repair using transgenic rats to simulate autologous transplantation.
Y Oshima (2004)
In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: influence of cell seeding density and collagen concentration.
T Y Hui (2008)
Effect of chondroitinase ABC on adhesion and behavior of synovial membrane-derived mesenchymal stem cells in rabbit partial-thickness chondral defects.
Jae-Chul Lee (2013)
In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel
横山 明子 (2007)
Repair of articular cartilage defects using mesenchymal stem cells.
Daniel Grande (1995)
Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model
Abir N Mokbel (2011)
Repair of osteochondral defects with adipose stem cells and a dual growth factor-releasing scaffold in rabbits.
Gun-Il Im (2010)
An in vitro study of collagen hydrogel to induce the chondrogenic differentiation of mesenchymal stem cells.
Li Zhang (2012)
Proliferation and chondrogenic differentiation of human adipose-derived mesenchymal stem cells in porous hyaluronic acid scaffold.
In-Soo Yoon (2011)
Articular cartilage: structure, injuries and review of management.
Abhijit M. Bhosale (2008)
Engineering of osteochondral tissue with bone marrow mesenchymal progenitor cells in a derivatized hyaluronan-gelatin composite sponge.
Peter Angele (1999)
a new one-step repair technique with Goldberg et al
R Buda (2017)
Chondrogenic phenotype of different cells encapsulated in κ-carrageenan hydrogels for cartilage regeneration strategies.
Elena Geta Popa (2012)
Arthroscopic debridement of the arthritic knee.
Baumgaertner Mr (1990)
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati (2009)
Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6.
Bradley T. Estes (2006)
Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using "bead-in-bead" polysaccharide capsules.
Jodie C. Babister (2008)
Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis or femoral fracture.
Felícito García-Álvarez (2011)
Articular cartilage regeneration with autologous marrow aspirate and hyaluronic Acid: an experimental study in a goat model.
Khay-Yong Saw (2009)
Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells.
Didier Hannouche (2007)
Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells.
Ryosuke Kuroda (2007)
Homing and efficacy of intra-articular injection of autologous mesenchymal stem cells in experimental chondral defects in dogs.
Abir N Mokbel (2011)
Comparative chondrogenesis of human cell sources in 3D scaffolds.
R. Seda Tıǧlı (2009)
Cell-based therapy in the repair of osteochondral defects: a novel use for adipose tissue.
Suresh Nathan (2003)
Mosaicplasty associated with gene enhanced tissue engineering for the treatment of acute osteochondral defects in a goat model
Jun Sun (2008)
Tissue-engineered cartilage and bone using stem cells from human infrapatellar fat pads.
Jason L. Dragoo (2003)
Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate
Jeroen Leijten (2014)
Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis.
Mohsen Emadedin (2012)
Study of human acellular amniotic membrane loading bone marrow mesenchymal stem cells in repair of articular cartilage defect in rabbits.
P-F Liu (2014)
Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes
Alberto Gobbi (2004)
Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage.
Masashi Nawata (2005)
Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres.
Yisheng Han (2010)
Bone Marrow Aspiration Concentrate and Platelet Rich Plasma for Osteochondral Repair in a Porcine Osteochondral Defect Model
Marcel Betsch (2013)
Second-Look Arthroscopic Evaluation of Cartilage Lesions After Mesenchymal Stem Cell Implantation in Osteoarthritic Knees
Yong Gon Koh (2014)
Influence of different growth factors on chondrogenic differentiation of adipose-derived stem cells in polyurethane-fibrin composites.
Katrin Froelich (2012)
The evaluation of a biphasic osteochondral implant coupled with an electrospun membrane in a large animal model.
Saey Tuan Barnabas Ho (2010)
Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee
Justus Gille (2010)
Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration.
Xuetao Xie (2012)
In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes.
Wei Wang (2010)
A Modified Aggregate Culture for Chondrogenesis of Human Adipose-Derived Stem Cells Genetically Modified with Growth and Differentiation Factor 5
Xinlin Yang (2013)
In situ chondrogenic differentiation of human adipose tissue-derived stem cells in a TGF-beta1 loaded fibrin-poly(lactide-caprolactone) nanoparticulate complex.
Youngmee Jung (2009)
Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells.
Elena López-Ruíz (2013)
The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT Task Force on total joint replacement.
Laure Gossec (2011)
Long-Term Follow-up of Intra-articular Injection of Autologous Mesenchymal Stem Cells in Patients with Knee, Ankle, or Hip Osteoarthritis.
Mohsen Emadedin (2015)
Intraarticular Administration of Dexamethasone after Mesenchymal Stem Cells Implantation Does Not Improve Significantly the Treatment of Preestablished Full-Thickness Chondral Defect in a Rabbit Model
Maximiliano Espinosa (2013)
Autologous bone marrow stromal cell transplantation for repair of fullthickness articular cartilage defects in human patellae: two case reports
S Wakitani (2004)
Autologous chondrocyte implantation.
Myron Spector (2001)
Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration
Shiro Suzuki (2012)
Articular cartilage tissue engineering based on a mechano-active scaffold made of poly(L-lactide-co-epsilon-caprolactone): In vivo performance in adult rabbits.
Jun Xie (2010)
Synovium-derived mesenchymal stem cells encapsulated in a novel injectable gel can repair osteochondral defects in a rabbit model.
Jae-chul Lee (2012)
Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin
Giuseppe Musumeci (2011)
Arthrosc J Arthrosc Relat Surg
Dj Dandy (1986)
Mesenchymal Stem Cell-Based Repair of Articular Cartilage with Polyglycolic Acid-Hydroxyapatite Biphasic Scaffold
Xiao-bo Zhou (2008)
Augmentation of degenerated human cartilage in vitro using magnetically labeled mesenchymal stem cells and an external magnetic device.
Takaaki Kobayashi (2009)
Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis.
Yong-Gon Koh (2012)
Adult bone marrow stem cells in cartilage therapy.
Andri Mt Lubis (2012)
Matrix-Assisted Autologous Chondrocyte Transplantation for the Repair of Cartilage Defects of the Knee
Elizaveta Kon (2009)
Treatment of osteochondral lesions of the talus: a systematic review
Maartje Zengerink (2009)
In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering.
Jennifer S. Wayne (2005)
Regulation of adiposederived adult stem cells differentiating into chondrocytes with the use of rhBMP2
Y Wei (2006)
Autologous chondrocyte implantation in the arthritic knee. Orthopedics
T. Minas (2016)
Marrow stimulation techniques. Injury
MR Steinwachs (2008)
Stem cell therapy for human cartilage defects: a systematic review. Osteoarthritis Cartilage
P Pastides (2013)
Transitory improvement of articular cartilage characteristics after implantation of polylactide:polyglycolic acid (PLGA) scaffolds seeded with autologous mesenchymal stromal cells in a sheep model of critical-sized chondral defect
Marta Caminal (2014)
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells.
K Gelse (2003)
Arthroscopic management of the degenerative knee.
D. J. Ogilvie-Harris (1991)
Arthroscopic subchondral bone plate microfracture technique augments healing of large chondral defects in the radial carpal bone and medial femoral condyle of horses.
David Frisbie (1999)
Two- to 9-Year Outcome After Autologous Chondrocyte Transplantation of the Knee
Lamar Peterson (2000)
Treatment of Chondral Lesions in Advanced Osteochondritis Dissecans: A Comparative Study of the Efficacy of Chondrocytes, Mesenchymal Stem Cells, Periosteal Graft, and Mosaicplasty (Osteochondral Autograft) in Animal Models
James Hoi Po Hui (2004)
Repair of large animal partial-thickness cartilage defects through intraarticular injection of matrix-rejuvenated synovium-derived stem cells.
Ming Pei (2013)
Arthroscopic Transplantation of Synovial Stem Cells Improves Clinical Outcomes in Knees With Cartilage Defects
Ichiro Sekiya (2015)
Injectable mesenchymal stem cell therapy for large cartilage defects--a porcine model.
Kevin B L Lee (2007)
Cartilage Regeneration of Adipose-Derived Stem Cells in a Hybrid Scaffold from Fibrin-Modified PLGA
Yiyong Wei (2009)
Porous gelatin-chondroitin-hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-beta1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair.
Hongbin Fan (2006)
Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee.
Mikiko Kayakabe (2006)
Repair of osteochondral defects with a construct of mesenchymal stem cells and a polydioxanone/poly(vinyl alcohol) scaffold.
Woong-Kyo Jeong (2008)
The classification and treatment of acute articular cartilage lesions.
Robert B. Dzioba (1988)
Management of Articular Cartilage Defects of the Knee
Lauren H. Redler (2012)
A novel MSC-seeded triphasic construct for the repair of osteochondral defects.
Bastian Marquaß (2010)
Enhanced early tissue regeneration after matrixassisted autologous mesenchymal
Synovial membranederived mesenchymal stem cells supported by platelet-rich plasma can repair osteochondral defects in a rabbit model. Arthroscopy
J-C Lee (2013)
The Clinical Use of Human Culture–Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects
Amgad M. Haleem (2010)
Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study.
William Bartlett (2005)
Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients.
Fereydoun Davatchi (2011)
Autologous Bone Marrow–Derived Mesenchymal Stem Cells Versus Autologous Chondrocyte Implantation An Observational Cohort Study
Hossein Nejadnik (2010)
Preliminary Results with Abrasion Arthroplasty in the Osteoarthritic Knee
Marc J. Friedman (1984)
Treatment of Bilateral Medial Femoral Condyle Articular Cartilage Fissures in a Horse Using Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells
Leah F. Raheja (2011)
Human induced pluripotent stem cells derived from fetal neural stem cells successfully undergo directed differentiation into cartilage.
Sergey Medvedev (2011)
Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model.
Markus M Wilke (2007)
Chondrogenesis of human mesenchymal stem cells encapsulated in a hydrogel construct: neocartilage formation in animal models as both mice and rabbits.
Ji sun Park (2009)
Effect of serum and growth factors on chondrogenic differentiation of synovium-derived stromal cells.
Sahnghoon Lee (2009)
Long-term results of cartilage repair after allogeneic transplantation of cartilaginous aggregates formed from bone marrow-derived cells for large osteochondral defects in rabbit knees. Cartilage
T Yoshioka (2013)
Repair of chronic osteochondral defects in the rat. A bone marrow-stimulating procedure enhanced by cultured allogenic bone marrow mesenchymal stromal cells.
Makoto Nishimori (2006)
The influence of transforming growth factor beta1 on mesenchymal cell repair of full-thickness cartilage defects.
Carsten Perka (2000)
Co-Culture of Mesenchymal Stem Cells with Mature Chondrocytes: Producing Cartilage Construct for Application in Cartilage Regeneration
Mohamadreza Baghaban Eslaminejad (2009)
Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up.
J. Richard Steadman (2003)
In vivo cartilage repair using adipose-derived stem cell-loaded decellularized cartilage ECM scaffolds.
Hongjun Kang (2014)
Cartilage healing after microfracture in osteoarthritic knees.
Dae Kyung Bae (2006)
Arthroscopic debridement of the arthritic knee.
Michael R. Baumgaertner (1990)
Repair of osteochondral defects in the minipig model by OPF hydrogel loaded with adipose-derived mesenchymal stem cells.
Laura de Girolamo (2015)
Repair of osteochondral defects by mosaicplasty and allogeneic BMSCs transplantation.
Xin Ma (2015)
Combination of bone marrow concentrate and PGA scaffolds enhance bone marrow stimulation in rabbit articular cartilage repair
Qinghua Zhao (2012)
Improved chondrogenesis and engineered cartilage formation from TGF-β3-expressing adipose-derived stem cells cultured in the rotating-shaft bioreactor.
Chia-Hsin Lu (2012)
Driving cartilage formation in high-density human adipose-derived stem cell aggregate and sheet constructs without exogenous growth factor delivery.
Phuong N Dang (2014)
Combined Effects of Connective Tissue Growth Factor-Modified Bone Marrow-Derived Mesenchymal Stem Cells and NaOH-Treated PLGA Scaffolds on the Repair of Articular Cartilage Defect in Rabbits
Songsong Zhu (2014)
Autologous bone-marrow mesenchymal cell induced chondrogenesis: Single-stage arthroscopic cartilage repair
Asode Ananthram Shetty (2014)
Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the Treatment of Large Patellofemoral Chondral Lesions
Alberto Gobbi (2015)
Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees.
Shigeyuki Wakitani (2002)
Ex vivo cartilage defect model for the evaluation of cartilage regeneration using mesenchymal stem cells.
Ryosuke Iwai (2011)
Chondrogenic differentiation of mesenchymal stem cells for repairing articular cartilage
T Li (2009)
Adapted chondrogenic differentiation of human mesenchymal stem cells via controlled release of TGF-β1 from poly(ethylene oxide)-terephtalate/poly(butylene terepthalate) multiblock scaffolds.
Ana Rey-Rico (2015)
Mesenchymal stem cell implantation in osteoarthritic knees: is fibrin glue effective as a scaffold
YS Kim (2015)
Embryonic stem cells form articular cartilage, not teratomas, in osteochondral defects of rat
S Wakitani (2004)
Comparison between loose fragment chondrocytes and condyle fibrochondrocytes in cellular proliferation and redifferentiation
Naoki Takata (2011)
Hyaluronic acid and autologous synovial fluid induce chondrogenic differentiation of equine mesenchymal stem cells: a preliminary study.
Aldemar Andres Hegewald (2004)
Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial.
Chris Hyunchul Jo (2014)
Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds.
Huajia Diao (2009)
Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model.
Chih-Hung Chang (2011)
One-step Bone Marrow-derived Cell Transplantation in Talar Osteochondral Lesions
Sandro Giannini (2009)
Bipolar fresh osteochondral allografting of the tibiotalar joint.
William D. Bugbee (2013)
Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.
Lisa A Fortier (2010)
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds.
Christoffer K. Abrahamsson (2010)
Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression.
Eric G. Meyer (2010)
Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow.
Rie Katayama (2004)
A controlled trial of arthroscopic surgery for osteoarthritis of the knee
N Engl (2005)
Hypoxic culture of bone marrow-derived mesenchymal stromal stem cells differentially enhances in vitro chondrogenesis within cell-seeded collagen and hyaluronic acid porous scaffolds
Troy D. Bornes (2015)
Genipin-crosslinked cartilage-derived matrix as a scaffold for human adipose-derived stem cell chondrogenesis.
Nai-Chen Daniel Cheng (2013)
Arthroscopic implantation of a matrix to cover large chondral defect during microfracture.
Thore Zantop (2009)
Chondrogenesis of human bone marrow mesenchymal stromal cells in highly porous alginate-foams supplemented with chondroitin sulfate.
Zhao Huang (2015)
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
Shigeyuki Wakitani (1994)
Role of abrasion arthroplasty and debridement in the management of osteoarthritis of the knee.
Jack M. Bert (1993)
Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration.
Jennifer J. Wood (2006)
Regenerative and technological section enhanced chondrogenesis of adipose-derived stem cells by the controlled release of transforming growth factor-NL 1 from hybrid microspheres
Y Han (2009)
J Biosci Bioeng
Re: The osteochondral dilemma: review of current management and future trends.
Warren Matthew Rozen (2014)
Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC)
Taro Kusano (2011)
Histologic analysis of tissue after failed cartilage repair procedures.
Stefan Nehrer (1999)
Healing full-thickness cartilage defects using adipose-derived stem cells.
Jason L. Dragoo (2007)
Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair.
Tong Ming Liu (2011)
Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam.
Edward J. Caterson (2001)
Chondrogenesis of human bone marrow-derived mesenchymal stem cells is modulated by complex mechanical stimulation and adenoviral-mediated overexpression of bone morphogenetic protein 2.
Alexander J. Neumann (2013)
Construction of tissue-engineered osteochondral composites and repair of large joint defects in rabbit.
Tianzheng Deng (2014)
Enhanced migration of human bone marrow stromal cells in modified collagen hydrogels
Daniel Günther (2013)
GFOGER-modified MMP-sensitive polyethylene glycol hydrogels induce chondrogenic differentiation of human mesenchymal stem cells.
Rami Mhanna (2014)
Osteochondral Lesions of the Knee: A New One-Step Repair Technique with Bone-Marrow-Derived Cells
Bernard F. Morrey (2011)
In vivo outcomes of tissue-engineered osteochondral grafts.
B Sonny Bal (2010)
Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells
Gang Feng (2008)
Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation
Sarindr Bhumiratana (2014)
Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model.
Rebecca L. Dahlin (2014)
Chondral Delamination of the Knee in Soccer Players
Andrew Stewart Levy (1996)
Reconstruction of cartilage with clonal mesenchymal stem cell-acellular dermal matrix in cartilage defect model in nonhuman primates.
Anlun Ma (2013)
Induced Pluripotent Stem Cells
Kazutoshi Takahashi (2011)
Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue
Jerry I. Huang (2005)
The restoration of full-thickness cartilage defects with mesenchymal stem cells (MSCs) loaded and cross-linked bilayer collagen scaffolds on rabbit model
Yiying Qi (2011)
Role of arthroscopy in osteoarthritis of the knee.
James A. Rand (1991)
Autologous osteochondral mosaicplasty grafting.
Lajos Bartha (2006)
Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees.
Shigeyuki Wakitani (2007)
The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.
Paul Hero Ousema (2012)
Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acidhydroxyapatite biphasic scaffold
XZ Zhou (2008)
Reconstruct large osteochondral defects of the knee with hIGF-1 gene enhanced Mosaicplasty.
Ping Leng (2012)
Stem cell therapy for human cartilage defects: a systematic review.
Philip S Pastides (2013)
Treatment Outcomes of Alginate-Embedded Allogenic Mesenchymal Stem Cells Versus Autologous Chondrocytes for the Repair of Focal Articular Cartilage Defects in a Rabbit Model
Liang Xin Tay (2012)
In vitro release and expansion of mesenchymal stem cells by a hyaluronic acid scaffold used in combination with bone marrow.
Marco Spoliti (2012)
IGF-1 and BMP-2 Induces Differentiation of Adipose-Derived Mesenchymal Stem Cells into Chondrocytes-Like Cells
Chunhou An (2009)
This paper is referenced by
An Approach to Derive Bone Marrow Mesenchymal Stem Cells with Therapeutic Significance
Kavitha Balaji (2020)
Experimental Study on Cell-free Approach for Articular Cartilage Treatment
Gözde Dursun (2019)
SUMO modified bone marrow mesenchymal stem cells promoted the repair of articular cartilage in rats.
Ying Liu (2019)
Autologous liquid platelet rich fibrin: A novel drug delivery system.
Richard J. Miron (2018)
Point-of-care treatment of focal cartilage defects with selected chondrogenic mesenchymal stromal cells-An in vitro proof-of-concept study.
Oliver Petters (2018)
Advances in perinatal stem cells research: a precious cell source for clinical applications.
Bahareh Abbaspanah (2018)
Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
Laetitia Keller (2019)
Tackling the Concept of Symbiotic Implantable Medical Devices with Nanobiotechnologies.
Jean-Pierre Alcaraz (2018)
Large Animal Models for Osteochondral Regeneration.
Isabel Rosa Dias (2018)
Magnetic Resonance Cartigram Sequencing in the Setting of Autologous Orthopedic Immunobiologics
Austin Yeargan (2020)
Regenerative Medicine Applications of Mesenchymal Stem Cells.
Samaneh Hosseini (2018)
Bifunctional Labeling of Rabbit Mesenchymal Stem Cells for MR Imaging and Fluorescence Microscopy
Markus T Berninger (2019)
Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair
Marco Viganò (2018)
Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study
Laura de Girolamo (2019)
Neuroimmune modulation of pain and regenerative pain medicine.
Thomas Edward Buchheit (2020)
Sphingosine‐1‐phosphate mediates the therapeutic effects of bone marrow mesenchymal stem cell‐derived microvesicles on articular cartilage defect
Chuan Xiang (2018)
Advances in stem cell therapy for cartilage regeneration in osteoarthritis.
Leire Iturriaga (2018)
Tissue-derived scaffolds and cells for articular cartilage tissue engineering: characteristics, applications and progress
Xuejian Liu (2017)
State of art and limitations in genetic engineering to induce stable chondrogenic phenotype.
Valeria Graceffa (2018)
Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading.
Jorge Oliver-De La Cruz (2019)
Rogue stem cell clinics
I R Murray (2020)
Human mesenchymal stem cell therapy for cartilage repair: Review on isolation, expansion, and constructs.
Alan Tin Lun Lam (2020)
Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells
Alessandro Pirosa (2019)
Comparing atmospheric and hypoxic cultured mesenchymal stem cell transcriptome: implication for stem cell therapies targeting intervertebral discs
Christian Elabd (2018)
Adjuvant Therapies in the Treatment of Pre-Arthritic Hip Disease
Johnny Huard (2020)
Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins
Robert Mitchell (2019)
Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.
Xin-xin Zhao (2018)
Facilitated recruitment of mesenchymal stromal cells by bone marrow concentrate and platelet rich plasma
Hannah Holmes (2018)
Office-Based Mesenchymal Stem Cell Therapy for the Treatment of Musculoskeletal Disease: A Systematic Review of Recent Human Studies.
Luke Law (2018)
Combating Osteoarthritis through Stem Cell Therapies by Rejuvenating Cartilage: A Review
Navneet Kumar Dubey (2018)
Hypoxic Preconditioning Enhances Bone Marrow-Derived Mesenchymal Stem Cell Survival in a Low Oxygen and Nutrient-Limited 3D Microenvironment.
Sun H Peck (2019)
Protective Effects of Membrane-Free Stem Cell Extract from H2O2-Induced Inflammation Responses in Human Periodontal Ligament Fibroblasts
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