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Cancer-associated Fibroblasts: An Emerging Target Of Anti-cancer Immunotherapy

T. Liu, Chencheng Han, S. Wang, Panqi Fang, Zhifei Ma, Lin Xu, R. Yin
Published 2019 · Medicine

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Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide physical support for tumor cells but also play a key role in promoting and retarding tumorigenesis in a context-dependent manner. CAFs have also been involved in the modulation of many components of the immune system, and recent studies have revealed their roles in immune evasion and poor responses to cancer immunotherapy. In this review, we describe our current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct immune cell types. More importantly, we highlight potential therapeutic strategies that target CAFs to unleash the immune system against the tumor.
This paper references
10.1007/s00262-015-1742-0
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
Hideyuki Takahashi (2015)
10.1038/82763
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
P. Chomarat (2000)
10.1016/j.ccell.2017.10.005
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
V. Kumar (2017)
10.1158/0008-5472.CAN-13-0062
Docetaxel conjugate nanoparticles that target α-smooth muscle actin-expressing stromal cells suppress breast cancer metastasis.
M. Murakami (2013)
10.1158/0008-5472.CAN-18-1750
An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells.
Joshua D. Freedman (2018)
10.1080/2162402X.2014.1001232
Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment
L. Danelli (2015)
10.1126/science.1195300
Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α
Matthew Kraman (2010)
Transforming growth factor - beta signaling in
E Batlle
10.1038/onc.2016.273
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells
Y. Deng (2017)
10.1038/nature09707
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
W. Tan (2011)
10.1016/j.cell.2005.02.034
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
A. Orimo (2005)
Epigenetic silencing of microRNA-149 in cancer-associated Liu et al
P Li (2019)
10.1016/j.cell.2011.11.025
EMT and Dissemination Precede Pancreatic Tumor Formation
A. Rhim (2012)
Transforming Growth Factor-β1 Induces Desmoplasia in an Experimental Model of Human Pancreatic Carcinoma
M. Löhr (2001)
10.1200/JCO.2005.03.4082
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.
D. Reardon (2006)
10.1038/ng.3818
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Huipeng Li (2017)
10.1016/j.semcancer.2013.12.005
Regulation of the anti-tumour immune response by cancer-associated fibroblasts.
James Harper (2014)
10.1158/0008-5472.CAN-14-3041
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.
A. Lo (2015)
CD10GPR77 Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
Shicheng Su (2018)
10.1038/s41591-018-0096-5
Phenotype molding of stromal cells in the lung tumor microenvironment
D. Lambrechts (2018)
10.1016/j.immuni.2019.03.024
Transforming Growth Factor-β Signaling in Immunity and Cancer.
E. Batlle (2019)
10.1038/sj.bjc.6602141
Overexpression of TGF-β by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer
Y. Aoyagi (2004)
10.1038/nrclinonc.2018.8
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
D. Johnson (2018)
10.1126/science.aaa6204
T cell exclusion, immune privilege, and the tumor microenvironment
J. Joyce (2015)
Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma.
M. Löhr (2001)
10.1158/1078-0432.CCR-15-2851
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen
H. Brechbuhl (2016)
10.3390/ijms19051532
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Twana Alkasalias (2018)
10.1084/jem.20030152
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
W. Chen (2003)
Bonneau C , et al : miR 200 - regulated CXCL 12 beta promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
AM Givel (2018)
10.1038/s41568-018-0006-7
A history of exploring cancer in context
Shelly Maman (2018)
10.1158/0008-5472.CAN-12-3022
Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens.
J. Zhang (2013)
10.1038/nri2852
The impact of the extracellular matrix on inflammation
L. Sorokin (2010)
10.1038/onc.2014.410
Osteopontin Mediates an MZF1-TGF-β1-Dependent Transformation of Mesenchymal Stem Cells into Cancer Associated Fibroblasts in Breast Cancer
Cynthia E. Weber (2014)
10.1016/j.cell.2018.01.009
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
Shicheng Su (2018)
10.4049/jimmunol.174.9.5215
TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T Cells
M. Ahmadzadeh (2005)
10.1016/j.coph.2016.04.001
Immunosuppressive activities of adenosine in cancer.
B. Allard (2016)
10.1002/ijc.27550
Smooth muscle actin‐expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin‐1 and induction of poor prognosis factors
J. Valach (2012)
10.1038/s41388-019-0688-7
Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
G. Comito (2019)
10.1016/j.cell.2014.08.007
Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy
M. Sherman (2014)
10.1172/JCI30082
The pancreatic stellate cell: a star on the rise in pancreatic diseases.
M. Omary (2007)
10.1038/nature25501
TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
S. Mariathasan (2018)
10.1158/0008-5472.CAN-12-1097
Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo.
S. Vicent (2012)
10.1158/2326-6066.CIR-13-0027
Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
L. Wang (2013)
10.1053/j.gastro.2013.07.025
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma.
Abasi E Ene-Obong (2013)
10.1038/s41419-019-1435-2
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer
Rongsheng Zhang (2019)
10.1172/JCI94624
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
Y. Wei (2017)
10.1038/nri3902
Immunological hallmarks of stromal cells in the tumour microenvironment
S. Turley (2015)
10.1038/nri2808
The polarization of immune cells in the tumour environment by TGFβ
R. Flavell (2010)
10.1038/nri.2017.49
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy
Nisha Nagarsheth (2017)
10.1038/cr.2015.51
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment
P. Li (2015)
10.1053/j.gastro.2008.07.016
PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.
I. Pinchuk (2008)
and cancer
SS Donatelli (2019)
10.4161/cbt.5.12.3354
Identification of fibroblast heterogeneity in the tumor microenvironment
H. Sugimoto (2006)
10.1053/j.gastro.2011.06.047
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.
Fieke E. M. Froeling (2011)
10.1158/0008-5472.CAN-12-4601
Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.
T. Mace (2013)
10.1016/j.ccr.2014.04.021
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma.
Andrew D. Rhim (2014)
Cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer
S Su (2018)
10.1073/pnas.1319269111
TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells
Sarah S. Donatelli (2014)
10.1038/onc.2017.65
Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
N. Cohen (2017)
10.1172/JCI15518
Evidence that fibroblasts derive from epithelium during tissue fibrosis.
M. Iwano (2002)
TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells.
M. Ahmadzadeh (2005)
10.1038/s41467-018-06654-8
TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
A. Chakravarthy (2018)
10.4049/jimmunol.174.1.215
Differential Roles of Vascular Endothelial Growth Factor Receptors 1 and 2 in Dendritic Cell Differentiation1
M. Dikov (2005)
10.1038/nm.2848
Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
S. Dulauroy (2012)
10.1158/2326-6066.CIR-18-0098
FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors
V. Cremasco (2018)
10.1002/ijc.32278
Cancer‐associated fibroblasts promote PD‐L1 expression in mice cancer cells via secreting CXCL5
Ziqian Li (2019)
phase II study results
DA Reardon (2019)
10.1016/S1084-8045(02)00061-9
Publisher's Note
H. V. D. Togt (2003)
TGF-beta-inducible microRNA-183 silences tumor-associated natural killer cells
SS Donatelli (2014)
10.1038/s41568-018-0081-9
The lung microenvironment: an important regulator of tumour growth and metastasis
N. Altorki (2018)
10.1371/journal.pone.0211117
Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
Andrew J. Gunderson (2019)
10.1371/journal.pone.0055146
Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
Y. Ino (2013)
10.1007/s004280100530
CD34+ fibrocytes in invasive ductal carcinoma, ductal carcinoma in situ, and benign breast lesions
P. Barth (2001)
10.1172/JCI66369
Hepatic stellate cells in liver development, regeneration, and cancer.
C. Yin (2013)
10.1038/s41467-018-03347-0
Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
M. Lakins (2018)
10.1016/j.ccell.2018.01.011
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.
Ana Costa (2018)
10.1158/0008-5472.CAN-10-0673
Breast carcinoma-associated fibroblasts rarely contain p53 mutations or chromosomal aberrations.
A. N. Hosein (2010)
10.1038/ncomms10204
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
Jean Albrengues (2015)
10.1101/gad.279737.116
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy.
Philippe Gascard (2016)
10.1038/s41573-018-0004-1
Turning foes to friends: targeting cancer-associated fibroblasts
Xueman Chen (2018)
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.
H. Kitamura (2005)
10.1016/j.ccr.2009.12.041
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.
Neta Erez (2010)
10.1158/1078-0432.CCR-17-2033
Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice
Elizabeth K Duperret (2018)
10.1126/science.1171362
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
K. Olive (2009)
10.1158/2326-6066.CIR-13-0150
Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-α and Heme Oxygenase-1
J. N. Arnold (2013)
10.1038/s41419-018-0458-4
Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma
Yusheng Cheng (2018)
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
F Calvo (2013)
10.1152/ajprenal.00260.2018
Macrophage-secreted TGF-β1 contributes to fibroblast activation and ureteral stricture after ablation injury.
E. Ueshima (2019)
10.1111/cas.13332
Interleukin‐6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy
H. Kitamura (2017)
10.1038/ncb3478
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
A. Labernadie (2017)
10.1038/s41467-018-03348-z
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
Anne-Marie Givel (2018)
10.1016/J.CCR.2005.10.012
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
D. A. Thomas (2005)
10.1038/ncomms2766
Recruitment of Mesenchymal Stem Cells Into Prostate Tumors Promotes Metastasis
Y. Jung (2013)
10.1038/s41467-018-07582-3
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
M. Bartoschek (2018)
10.1038/nri2536
Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation
G. Rabinovich (2009)
Macrophage secreted TGF-beta1 contributes to fibroblast activation and ureteral stricture following ablation injury
E Ueshima (2019)
10.1016/S0140-6736(15)01238-6
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
G. Zalcman (2016)
10.1084/jem.20122344
Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
E. W. Roberts (2013)
10.1158/0008-5472.CAN-09-4687
Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization.
N. Kobayashi (2010)
10.1158/0008-5472.CAN-17-0569
Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells.
Seiichiro Ishihara (2017)
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
10.1002/ijc.23925
Stromal myofibroblasts are drivers of invasive cancer growth
O. De Wever (2008)
10.1038/s41467-018-04492-2
Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
Cheng Wang (2018)
10.1038/nm.3394
Microenvironmental regulation of tumor progression and metastasis
Daniela F. Quail (2013)
10.1038/nm1096-1096
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
D. Gabrilovich (1996)
10.1186/s40425-019-0505-4
Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager
Jana de Sostoa (2019)
10.1073/pnas.1308887110
Modulation of macrophage phenotype by cell shape
Frances Y. McWhorter (2013)
10.1158/0008-5472.CAN-14-1317
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression.
Y. Yamamura (2015)
10.3389/fimmu.2017.00424
Are Mast Cells MASTers in Cancer?
G. Varricchi (2017)
tissue is related to poor outcome in prostate cancer patients
M Iwano (2009)
10.1158/0008-5472.CAN-12-4479
Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer.
Y. Ma (2013)
10.1166/jbn.2018.2616
Fusion of Dendritic Cells and Cancer-Associated Fibroblasts for Activation of Anti-Tumor Cytotoxic T Lymphocytes.
Liwen Qian (2018)
10.1111/cas.12584
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine
Y. Ohshio (2015)
10.18632/oncotarget.14374
Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
Hideyuki Takahashi (2017)
10.1084/jem.20101876
Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer
L. De Monte (2011)
10.1038/nature15748
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Kari R. Fischer (2015)
10.1136/gutjnl-2015-310977
Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer
Gemma Ferrer-Mayorga (2016)
10.1038/s41374-018-0185-6
Fibroblast activation protein-positive fibroblasts promote tumor progression through secretion of CCL2 and interleukin-6 in esophageal squamous cell carcinoma
Nobuhide Higashino (2019)
10.1182/BLOOD-2003-11-3909
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation.
R. Meisel (2004)
10.1038/nrc.2016.73
The biology and function of fibroblasts in cancer
R. Kalluri (2016)
10.1111/j.1600-0714.2012.01127.x
Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance.
Nobuyuki Fujii (2012)
10.1016/j.lungcan.2018.10.021
Link between tumor-promoting fibrous microenvironment and an immunosuppressive microenvironment in stage I lung adenocarcinoma.
T. Sakai (2018)
10.1111/cas.12096
Cancer‐associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
M. Herrera (2013)
10.1038/sj.bjc.6604662
The role of endothelial-to-mesenchymal transition in cancer progression
S. Potenta (2008)
10.1073/pnas.1320318110
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
Christine Feig (2013)
10.1158/0008-5472.CAN-07-3127
Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts.
E. Zeisberg (2007)
10.1016/j.ccell.2015.11.002
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
B. Özdemir (2015)
10.1084/jem.20162024
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
D. Öhlund (2017)
10.1084/jem.20140692
Fibroblast heterogeneity in the cancer wound
D. Öhlund (2014)
10.4049/jimmunol.179.2.733
Response to Comment on “Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells”
M. Nazareth (2007)
10.1038/NM1196-1267
Erratum: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells (Nature Medicine 2, 1096-1103 (1996))
D. Gabrilovich (1996)
10.1039/c5ib00040h
Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.
I. Acerbi (2015)
10.1038/mt.2013.110
Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma.
Sunitha Kakarla (2013)
10.1158/0008-5472.CAN-13-2740
Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties.
Martin Augsten (2014)
10.1158/0008-5472.CAN-15-2973
FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling.
Xuguang Yang (2016)
10.1093/carcin/bgv146
Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts
M. Vizoso (2015)
10.1073/pnas.1013805107
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Yasushi Kojima (2010)
10.1172/JCI26532
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake.
M. Loeffler (2006)
10.1002/pros.20927
Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients
P. Wikström (2009)
10.1016/j.ajpath.2010.11.017
FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation.
J. Zhang (2011)
10.1080/2162402X.2018.1440167
Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation
J. Jacobs (2018)
10.1038/cddis.2014.263
The IL-6–STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression
Q. Zhu (2014)
10.1038/s41575-019-0115-0
Cancer-associated fibroblasts in gastrointestinal cancer
H. Kobayashi (2019)
10.1007/s13402-011-0012-1
Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors
Constantin Jotzu (2011)
10.1016/J.IMMUNI.2005.09.010
IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells
H. Kitamura (2005)
10.1007/s12032-013-0663-z
Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity
T. Li (2013)
A history of exploring cancer
S Maman (2018)
10.3389/fonc.2014.00062
Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment
M. Augsten (2014)
10.1172/JCI93555
Fibroblast heterogeneity: implications for human disease
M. Lynch (2018)
10.1158/1078-0432.CCR-12-1632
Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
J. Khalili (2012)
10.3389/fimmu.2018.00414
Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
Linda Ziani (2018)
10.1111/cas.12099
Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma
Tomonari Kinoshita (2013)
10.1016/j.immuni.2011.03.005
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.
I. Gutcher (2011)
10.1016/j.tips.2019.04.005
Cancer and Microenvironment Plasticity: Double-Edged Swords in Metastasis.
Xueqian Zhuang (2019)
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of Liu et al
AJ CJWE-OA. (2019)



This paper is referenced by
10.3779/j.issn.1009-3419.2020.102.16
[Research Progress of Cancer-associated Fibroblasts in Lung Cancer].
Chongbiao Huang (2020)
10.3390/cancers12061365
Emerging Therapeutic RNAs for the Targeting of Cancer Associated Fibroblasts
Laura Santana-Viera (2020)
10.21873/anticanres.14434
Borderline Microenvironment Fibrosis Is a Novel Poor Prognostic Marker of Oral Squamous Cell Carcinoma
Kei Tsuchihashi (2020)
10.1186/s40364-019-0174-y
Epigenetic heterogeneity in cancer
Mingzhou Guo (2019)
10.3390/ijms21010169
Endoplasmic Reticulum Stress Pathway, the Unfolded Protein Response, Modulates Immune Function in the Tumor Microenvironment to Impact Tumor Progression and Therapeutic Response
M. U. Ramirez (2019)
10.3390/cells9091988
The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells
Leslimar Rios-Colon (2020)
10.1186/s12964-020-0530-4
Tumor microenvironment complexity and therapeutic implications at a glance
Roghayyeh Baghban (2020)
10.3390/antib8040051
Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors
Nicholas Gravbrot (2019)
10.1016/j.phymed.2020.153227
Breast Tumor Microenvironment: Emerging target of therapeutic phytochemicals.
Rama Rao Malla (2020)
10.3390/cancers12092687
Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities
Patrick Freeman (2020)
10.1007/s00432-019-03068-x
Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia
D. Nalini (2019)
10.1002/mc.23205
The interplay between cancer associated fibroblasts and immune cells in the context of radiation therapy
Miles Piper (2020)
10.3390/cancers12051307
Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer
A. Sebastian (2020)
10.1111/cpr.12865
Modifying the tumour microenvironment and reverting tumour cells: New strategies for treating malignant tumours
Y. Cheng (2020)
10.2147/CMAR.S229395
Effects of Nicotinamide on Cervical Cancer-Derived Fibroblasts: Evidence for Therapeutic Potential
Reem N Hassan (2020)
10.3389/fcell.2020.00377
Label-Free Infrared Spectral Histology of Skin Tissue Part II: Impact of a Lumican-Derived Peptide on Melanoma Growth
S. Brézillon (2020)
10.1007/s13206-020-4201-8
Recent Advances in 3D Bioprinted Tumor Microenvironment
Jinseung Bae (2020)
10.1007/s13206-020-4108-4
3D Pancreatic Tissue Modeling in vitro: Advances and Prospects
M. Kim (2020)
10.3390/cancers12051347
Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment
J. Norton (2020)
10.1016/j.cyto.2020.155205
An overview of the role of interleukin-8 in colorectal cancer.
Soroush Najdaghi (2020)
10.3390/cells9061539
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