Meta-analysis Of Randomised Controlled Trials Of Fluoxetine V. Placebo And Tricyclic Antidepressants In The Short-term Treatment Of Major Depression
Previous meta-analyses of fluoxetine as an antidepressant have many methodological problems, including diagnosis of major depression, validity of outcome measures and lack of intention-to-treat analyses.
To provide an estimate of the effect of fluoxetine compared with placebo and tricyclic antidepressants (TCAs), and to investigate reasons for early discontinuation from acute treatment.
Randomised trials were analysed using both intention-to-treat, efficacy and end-point.
Fluoxetine was superior to placebo but effect size was low. In trials comparing fluoxetine
Fluoxetine is superior to placebo, irrespective of the analytical approach use, whereas the results obtained