Efficacy Of Citalopram In The Prevention Of Recurrent Depression In Elderly Patients: Placebo-controlled Study Of Maintenance Therapy
The highly recurrent nature of major depression in the young and the elderly warrants long-term antidepressant treatment.
To compare the prophylactic efficacy of citalopram and placebo in elderly patients; to evaluate long-term tolerability of citalopram.
Out-patients, ⩾65 years, with unipolar major depression (DSM – IV: 296.2 x or 296.3 x) and Montgomery – Åsberg Depression Rating Scale score ⩾22 were treated with citalopram 20–40 mg for 8 weeks. Responders continued on their final fixed dose of citalopram for 16 weeks before randomisation to double-blind treatment with citalopram or placebo for at least 48 weeks.
Nineteen of the 60 patients using citalopram
Long-term treatment with citalopram is effective in preventing recurrence of depression in the elderly and is well tolerated.