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Updates On Phase1b/2 Trial Of The Indoleamine 2,3-dioxygenase Pathway (IDO) Inhibitor Indoximod Plus Checkpoint Inhibitors For The Treatment Of Unresectable Stage 3 Or 4 Melanoma.

Y. Zakharia, J. Drabick, S. Khleif, R. McWilliams, D. Munn, C. Link, N. Vahanian, E. Kennedy, M. Shaheen, O. Rixe, M. Milhem
Published 2016 · Medicine

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3075Background: IDO is an enzyme that catalyzes tryptophan to kynurenine. Tryptophan depletion enhances the function of the suppressive Treg and inhibits the effector T cells. Kynurenine metabolite...

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