← Back to Search
Chitosan–Sodium Lauryl Sulfate Nanoparticles As A Carrier System For The In Vivo Delivery Of Oral Insulin
A. Elsayed, M. Al-Remawi, N. Qinna, A. Farouk, K. Al-Sou’od, A. Badwan
Published 2011 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability.
This paper references
Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats.
Zengshuan Ma (2005)
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin
YH Lin (2007)
Insulin-loaded nanoparticles are prepared by alginate ionotropic pre-gelation followed by chitosan polyelectrolyte complexation.
B. Sarmento (2007)
[Analysis of issues of insulin self-injection in elderly].
K. Yamauchi (2009)
Human Insulin: Basic Sciences to Therapeutic Uses
Y. Chien (1996)
Formulation pH modulates the interaction of insulin with chitosan nanoparticles.
Zengshuan Ma (2002)
Novel B melatonin-loaded chitosan microcapsules: in vitro characterization and antiapoptosis efficacy for aflatoxin B1-induced apoptosis in rat liver.
I. El-Gibaly (2003)
Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications.
J. Berger (2004)
Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery
Takahiro Nagamoto (2004)
Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs
A. Berthold (1996)
Oral insulin delivery.
Quantitative determination of insulin entrapment efficiency in triblock copolymeric nanoparticles by high-performance liquid chromatography.
Xiongliang Xu (2006)
Formulation and characterization of an oily-based system for oral delivery of insulin.
A. Elsayed (2009)
Barriers to insulin injection therapy: patient and health care provider perspectives
R Rubin (2009)
Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods.
A. Sadeghi (2008)
High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation.
M. Lavertu (2006)
Characterization of physiochemical and biological properties of an insulin/lauryl sulfate complex formed by hydrophobic ion pairing.
Wei-guo Dai (2007)
Alternative routes of insulin
R Krishnankutty (2009)
Oral delivery of protein drug using microemulsion. International patent (WO2007/068311) date of publication 21
Oral peptide delivery using nanoparticles composed of novel graft copolymers having hydrophobic backbone and hydrophilic branches
Shinji Sakuma (1997)
Alternative routes of insulin delivery
D. Owens (2003)
Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption.
M. Rekha (2009)
Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin.
S. Mao (2006)
Controlled release of Bordetella bronchiseptica dermonecrotoxin (BBD) vaccine from BBD-loaded chitosan microspheres in vitro
HL Jiang (2004)
Investigation of the Interactions in Complexes of Low Molecular Weight Chitosan with Ibuprofen
A. Qandil (2009)
Inhaled insulin: overview of a novel route of insulin administration
L. Mastrandrea (2010)
Synthesis and characterization of PEG modified N-trimethylaminoethylmethacrylate chitosan nanoparticles
Siyu Zhu (2007)
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery.
Yu-Hsin Lin (2007)
Nanoparticles for protein drug delivery. US patent. Publication number
Alternative routes of insulin delivery. Zhong Nan Da Xue Xue Bao Yi Xue Ban
R Krishnankutty (2009)
Cyclodextrin-insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery.
S. Sajeesh (2006)
The physiological rationale for oral insulin administration.
E. Arbit (2004)
Enhancement of oral bioavailability of insulin in humans.
A. Badwan (2009)
Insulin therapy: current alternatives.
F. Gómez-Pérez (2005)
Why is Exubera being withdrawn?
C. Bailey (2007)
Oral delivery of protein drug using microemulsion
A. Badwan (2007)
Polysaccharide colloidal particles as delivery systems for macromolecules.
K. Janes (2001)
Nanoparticles for protein drug delivery. US patent
Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition.
Y. Ohya (1993)
This paper is referenced by
Synthesis and Characterization of Polymeric Nanoparticles Formed from Cowry Shells and Acacia Gum Extracts
Kunle Akinluwade (2017)
Polymeric hydrogels for oral insulin delivery.
K. Chaturvedi (2013)
Evidence of oral translocation of anionic G6.5 dendrimers in mice.
G. Thiagarajan (2013)
Chitin and Chitosan as Direct Compression Excipients in Pharmaceutical Applications
A. Badwan (2015)
Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers
Kurt Ristroph (2019)
Preparation, characterization, and evaluation of corrosion inhibition efficiency of sodium lauryl sulfate modified chitosan for mild steel in the acid pickling process
S. Jessima (2020)
An application of nanotechnology and its risk in developing countries.
Tekalign Kasa (2016)
Polymers in oral insulin delivery
T. A. Sonia (2014)
Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound
Gisela N. Piccirilli (2014)
Synthesis of Bioactive Chemicals Cross-linked Sodium Tripolyphosphate(TPP) - Chitosan Nanoparticles for Enhanced Cytotoxic Activity againstHuman Ovarian Cancer cell Line (PA-1)
A. Sujimaanbu (2016)
Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier
R. Upadhyay (2014)
Oral delivery of diabetes peptides - Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context.
H. R. Lakkireddy (2016)
Drug Design, Development and Therapy Dovepress Impact of Streptozotocin on Altering Normal Glucose Homeostasis during Insulin Testing in Diabetic Rats Compared to Normoglycemic Rats Nidal a Qinna
Adnan Ali H Badwan ()
Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats
N. Qinna (2015)
Co-assembly in chitosan-surfactant mixtures: thermodynamics, structures, interfacial properties and applications.
Leonardo Chiappisi (2015)
New Curcumin-Loaded Chitosan Nanocapsules: In Vivo Evaluation.
E. Marín (2017)
Low Molecular Weight Chitosan-Insulin Complexes Solubilized in a Mixture of Self-Assembled Labrosol and Plurol Oleaque and Their Glucose Reduction Activity in Rats
Amani M. Elsayed (2018)
Insulin administration: present strategies and future directions for a noninvasive (possibly more physiological) delivery
E. Matteucci (2015)
Nanotechnology based approaches for anti-diabetic drugs delivery.
P. Kesharwani (2018)
Oral Delivery of Insulin : Novel Approaches Amani
M. Elsayed (2018)
Investigation of novel supersaturating drug delivery systems of chlorthalidone: The use of polymer‐surfactant complex as an effective carrier in solid dispersions
Maria Terezinha França (2018)
Albendazole Microcrystal Formulations Based on Chitosan and Cellulose Derivatives: Physicochemical Characterization and In Vitro Parasiticidal Activity in Trichinella spiralis Adult Worms
J. Priotti (2016)
Materials for oral delivery of proteins and peptides
Tyler D. Brown (2019)
Polymer-based nanoparticles for oral insulin delivery: Revisited approaches.
P. Fonte (2015)
Green Formulation of Triglyceride/Phospholipid-Based Nanocarriers as a Novel Vehicle for Oral Coenzyme Q10 Delivery.
Sonia Alavi (2019)
Properties of Chitosan Nanoparticles Formed Using Sulfate Anions as Crosslinking Bridges
M. Al-Remawi (2012)
Effects of Kudingcha Nanoparticles in Hyperlipidaemic Rats Induced by a High Fat Diet
H. Zhang (2018)
Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles.
B. Cheng (2019)
Development and evaluation of viscosity-enhanced nanocarrier (VEN) for oral insulin delivery.
Mariam Boushra (2016)
Chitosan nanoparticles: a survey of preparation methods
A. Grenha (2012)
Effect of surface charge and other critical parameters on the adsorption of dyes on SLS coated ZnO nanoparticles and optimization using response surface methodology
Dephan Pinheiro (2020)
An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers
Suha M. Dadou (2018)See more