Online citations, reference lists, and bibliographies.
← Back to Search

Chitosan-Modified PLGA Nanoparticles With Versatile Surface For Improved Drug Delivery

Y. Wang, P. Li, L. Kong
Published 2013 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Shortage of functional groups on surface of poly(lactide-co-glycolide) (PLGA)-based drug delivery carriers always hampers its wide applications such as passive targeting and conjugation with targeting molecules. In this research, PLGA nanoparticles were modified with chitosan through physical adsorption and chemical binding methods. The surface charges were regulated by altering pH value in chitosan solutions. After the introduction of chitosan, zeta potential of the PLGA nanoparticle surface changed from negative charge to positive one, making the drug carriers more affinity to cancer cells. Functional groups were compared between PLGA nanoparticles and chitosan-modified PLGA nanoparticles. Amine groups were exhibited on PLGA nanoparticle surface after the chitosan modification as confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The modified nanoparticles showed an initial burst release followed by a moderate and sustained release profile. Higher percentage of drugs from cumulative release can be achieved in the same prolonged time range. Therefore, PLGA nanoparticles modified by chitosan showed versatility of surface and a possible improvement in the efficacy of current PLGA-based drug delivery system.
This paper references
10.2217/nnm.11.92
Nanocarriers for vascular delivery of antioxidants.
Elizabeth D Hood (2011)
10.1016/j.ejpb.2008.06.008
Understanding the adsorption mechanism of chitosan onto poly(lactide-co-glycolide) particles.
Chunqiang Guo (2008)
10.1080/10611860701794353
Polymeric nanoparticles for cancer therapy
S. Parveen (2008)
10.2174/1389201033489748
Application of chitin and chitosan derivatives in the pharmaceutical field.
Y. Kato (2003)
10.1002/PAT.141
Metal complexes with linear and crosslinked polysaccharides as mediators of angiogenesis
R. Barbucci (2001)
10.1016/S0168-3659(02)00025-1
Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol).
L. Mu (2002)
10.1016/j.jconrel.2008.02.002
Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid.
G. Pasut (2008)
10.1080/10611860802088630
Folate-receptor-targeted delivery of docetaxel nanoparticles prepared by PLGA-PEG-folate conjugate.
Farnaz Esmaeili (2008)
10.1016/J.IJPHARM.2007.07.040
Selectivity of folate conjugated polymer micelles against different tumor cells.
H. Zhao (2008)
10.1016/j.biomaterials.2008.02.008
The immobilization of basic fibroblast growth factor on plasma-treated poly(lactide-co-glycolide).
H. Shen (2008)
10.1016/j.biomaterials.2009.09.104
Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain.
Z. Wang (2010)
10.1080/10611860601143479
Poly(l-lactide-co-glycolide) nanospheres conjugated with a nuclear localization signal for delivery of plasmid DNA
O. Jeon (2007)
10.3109/08982100009029385
Receptor-Specific Delivery of Liposomes Via Folate-Peg-Chol
W. Guo (2000)
10.1016/S0378-5173(02)00040-6
Buparvaquone mucoadhesive nanosuspension: preparation, optimisation and long-term stability.
R. Mueller (2002)
10.1016/J.BIOMATERIALS.2007.06.004
Combining oxygen plasma treatment with anchorage of cationized gelatin for enhancing cell affinity of poly(lactide-co-glycolide).
H. Shen (2007)
10.1016/J.CARBPOL.2009.12.040
Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications
Ashish Dev (2010)
10.1002/(SICI)1097-4628(20000328)75:13<1615::AID-APP7>3.0.CO;2-L
Stereocomplex formation between enantiomeric PLA–PEG–PLA triblock copolymers: Characterization and use as protein‐delivery microparticulate carriers
D. W. Lim (1999)
10.1002/JBM.A.10034
Plasma-treated, collagen-anchored polylactone: Its cell affinity evaluation under shear or shear-free conditions.
J. Yang (2003)
Understanding the adsorptionmechanism of chitosan onto poly ( lactidecoglycolide ) particles
GemeinhartRA GuoCQ (2008)
Influence of molecular weight and pH on adsorption of chitosan at the surface of large and giant vesicles. Biomacromolecules
F Quemeneur (2007)
10.1106/088532802024246
Changes in Cisplatin Delivery Due to Surface-Coated Poly (Lactic Acid)–Poly(∊-Caprolactone)Microspheres
T. Chandy (2002)
10.1007/s00216-012-6113-5
Influence of secondary preparative parameters and aging effects on PLGA particle size distribution: a sedimentation field flow fractionation investigation
C. Contado (2012)
10.1021/BM700943J
Influence of molecular weight and pH on adsorption of chitosan at the surface of large and giant vesicles.
F. Quemeneur (2008)
Cumulative drug release from PLGA nanoparticles, PLGA- CS nanoparticles by physical adsorption and PLGA-CS nanoparticles by chemical binding method
10.1016/J.EJPB.2007.08.001
Nanoparticles for drug delivery: the need for precision in reporting particle size parameters.
M. Gaumet (2008)
10.1016/J.EJPB.2007.06.007
Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa.
M. Simonoska Crcarevska (2008)
10.1016/S0168-3659(98)00070-4
Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties.
M. Morlock (1998)
10.1016/J.IJPHARM.2006.06.023
PLA/PLGA nanoparticles for sustained release of docetaxel.
T. Musumeci (2006)
10.1002/JBM.A.31036
Surface modification and characterization of chitosan or PLGA membrane with laminin by chemical and oxygen plasma treatment for neural regeneration.
Yi-Cheng Huang (2007)
10.1016/J.CARBPOL.2011.03.045
Development of chitosan nanoparticles as drug delivery systems for 5-fluorouracil and leucovorin blends
P. Li (2011)
10.1002/SIA.2923
Surface modification of polyester by oxygen‐ and nitrogen‐plasma treatment
A. Vesel (2008)
10.1002/jbm.a.31846
Chitosan/poly(L-lactic acid) multilayered membrane for guided tissue regeneration.
Y. Ku (2009)
10.1016/j.carres.2011.01.027
Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells.
P. Li (2011)



This paper is referenced by
10.24377/LJMU.T.00004499
PULMONARY DELIVERY OF PNEUMOCCOCAL VACCINE USING NANOCOMPOSITE MICROPARTICLE CARRIERS VIA DRY POWDER INHALATION
Iman M. Alfagih (2015)
10.1016/j.ijbiomac.2019.08.101
Injectable PNIPAM/Hyaluronic acid hydrogels containing multipurpose modified particles for cartilage tissue engineering: Synthesis, characterization, drug release and cell culture study.
Zhaleh Atoufi (2019)
10.1016/j.ijbiomac.2019.07.168
Cellular uptake and transport characteristics of chitosan modified nanoparticles in Caco-2 cell monolayers.
T. Dou (2019)
10.1021/acs.molpharmaceut.6b00335
PLGA Microparticles Entrapping Chitosan-Based Nanoparticles for the Ocular Delivery of Ranibizumab.
N. Elsaid (2016)
10.1080/10667857.2016.1258517
Surface modification of Poly Hydroxybutyrate (PHB) nanofibrous mat by collagen protein and its cellular study
S. Heidari-keshel (2016)
10.2147/IJN.S241448
Lipoprotein-Inspired Nanocarrier Composed of Folic Acid-Modified Protein and Lipids: Preparation and Evaluation of Tumor-Targeting Effect
Mengmeng Han (2020)
10.1016/j.biopha.2018.07.102
Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability.
Mohamed M. Badran (2018)
10.3390/pharmaceutics12030203
Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy
N. Ahmad (2020)
10.1080/21691401.2018.1477788
Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid
Isabela Angeli de Lima (2018)
10.1038/s41598-017-15012-5
Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy
A. Babu (2017)
10.1111/jcmm.13110
Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles
S. Salatin (2017)
10.1080/21691401.2018.1561458
Brain-targeted glycyrrhizic-acid-loaded surface decorated nanoparticles for treatment of cerebral ischaemia and its toxicity assessment
N. Ahmad (2019)
10.3390/ph6111361
Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes
Mónica Rivera Díaz (2013)
10.1080/21691401.2016.1243545
Chitosan-coated PLGA nanoparticles of bevacizumab as novel drug delivery to target retina: optimization, characterization, and in vitro toxicity evaluation
J. Pandit (2017)
10.2217/nnm-2018-0038
Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis.
Iqra Afzal (2019)
Polymeric Nanoparticles - the new face in Drug Delivery and Cancer Therapy
Meshak Dhanashekaran Cecileya Jasmine (2014)
10.1016/j.ijpharm.2017.08.084
Engineering PLGA nano-based systems through understanding the influence of nanoparticle properties and cell-penetrating peptides for cochlear drug delivery.
H. Cai (2017)
10.3390/ma13051090
Effect of UV and Gamma Irradiation Sterilization Processes in the Properties of Different Polymeric Nanoparticles for Biomedical Applications
Y. Tapia-Guerrero (2020)
10.1016/j.jddst.2020.101585
Comparative Study of PLGA in-situ Implant and Nanoparticle Formulations of Entecavir; in-vitro and in-vivo evaluation
Margrit M. Ayoub (2020)
10.1016/j.msec.2016.04.073
Surface modification of electrospun PLGA scaffold with collagen for bioengineered skin substitutes.
A. R. Sadeghi (2016)
10.13023/ETD.2017.273
HALO- AND SOLVATO-FLUOROCHROMIC POLYMER NANOASSEMBLIES FOR CANCER THERANOSTICS
Derek Reichel (2017)
10.1016/j.ijbiomac.2017.12.104
Chitosan-stablized bovine serum albumin nanoparticles having ability to control the release of NELL-1 protein.
Yourui Li (2018)
10.1016/j.actbio.2017.08.009
Elastin-PLGA hybrid electrospun nanofiber scaffolds for salivary epithelial cell self-organization and polarization.
Zahraa I. Foraida (2017)
10.1016/J.FOODHYD.2017.03.016
Pectin and polygalacturonic acid-coated liposomes as novel delivery system for nisin: Preparation, characterization and release behavior
Nathalie Almeida Lopes (2017)
10.1055/a-0596-7288
Quantification and Brain Targeting of Eugenol-Loaded Surface Modified Nanoparticles Through Intranasal Route in the Treatment of Cerebral Ischemia.
N. Ahmad (2018)
10.1016/J.CPLETT.2018.06.053
Hollow chitosan nanocomposite as drug carrier system for controlled delivery of ramipril
Tanushree Basu (2018)
10.1016/J.JDDST.2019.04.010
Chondroitin sulfate modification enhances the targeting and therapeutic effect of nanomedicine on AOM/DSS-induced mouse colon cancer
Z. Liu (2019)
10.1016/j.ijpharm.2019.03.011
Natural biodegradable polymers based nano‐formulations for drug delivery: A review
Archana George (2019)
10.3390/polym11101632
Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects
A. A. Öztürk (2019)
10.1016/j.colsurfb.2018.12.006
A novel MUC1 aptamer-modified PLGA-epirubicin-PβAE-antimir-21 nanocomplex platform for targeted co-delivery of anticancer agents in vitro and in vivo.
Amirhossein Bahreyni (2019)
10.3390/nano6020026
Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer
Yichao Wang (2016)
10.1016/j.ijbiomac.2016.11.098
Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer.
Mohamed M. Badran (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar