Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Vitamin D Status Predicts Physical Performance And Its Decline In Older Persons.

I. Wicherts, N. V. van Schoor, A. Boeke, M. Visser, D. Deeg, J. Smit, D. Knol, P. Lips
Published 2007 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
CONTEXT Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness. OBJECTIVE The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25-OHD) concentration with current physical performance and its decline over 3 yr among elderly. DESIGN The study consisted of a cross-sectional and longitudinal design (3-yr follow-up) within the Longitudinal Aging Study Amsterdam. SETTING An age- and sex-stratified random sample of the Dutch older population was used. OTHER PARTICIPANTS Subjects included 1234 men and women (aged 65 yr and older) for cross-sectional analysis and 979 (79%) persons for longitudinal analysis. MAIN OUTCOME MEASURE(S) Physical performance (sum score of the walking test, chair stands, and tandem stand) and decline in physical performance were measured. RESULTS Serum 25-OHD was associated with physical performance after adjustment for age, gender, chronic diseases, degree of urbanization, body mass index, and alcohol consumption. Compared with individuals with serum 25-OHD levels above 30 ng/ml, physical performance was poorer in participants with serum 25-OHD less than 10 ng/ml [regression coefficient (B) = -1.69; 95% confidence interval (CI) = -2.28; -1.10], and with serum 25-OHD of 10-20 ng/ml (B = -0.46; 95% CI = -0.90; -0.03). After adjustment for confounding variables, participants with 25-OHD less than 10 ng/ml and 25-OHD between 10 and 20 ng/ml had significantly higher odds ratios (OR) for 3-yr decline in physical performance (OR = 2.21; 95% CI = 1.00-4.87; and OR = 2.01; 95% CI = 1.06-3.81), compared with participants with 25-OHD of at least 30 ng/ml. The results were consistent for each individual performance test. CONCLUSIONS Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.
This paper references
10.1007/s00198-005-1860-1
Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women
P. Gerdhem (2005)
10.1056/NEJM199212033272305
Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women
M. Chapuy (1992)
10.1046/j.1532-5415.2003.51561.x
Effects of Vitamin D Supplementation on Strength, Physical Function, and Health Perception in Older, Community‐Dwelling Men
A. Kenny (2003)
10.1007/s001980050030
Prevalence of Vitamin D Insufficiency in an Adult Normal Population
M. -C. Chapuy (1997)
10.1093/GERONJ/49.2.M85
A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission.
J. Guralnik (1994)
10.1093/AJCN/46.6.1005
Determinants of vitamin D status in patients with hip fracture and in elderly control subjects.
P. Lips (1987)
10.1016/S0895-4356(01)00475-9
Attrition in the Longitudinal Aging Study Amsterdam. The effect of differential inclusion in side studies.
D. Deeg (2002)
10.1093/GERONA/55.4.M221
Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery.
J. Guralnik (2000)
10.1016/S0895-4356(96)00274-0
Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients' self-reports and on determinants of inaccuracy.
D. Kriegsman (1996)
10.1016/S0140-6736(89)91124-0
AGE, VITAMIN D, AND SOLAR ULTRAVIOLET
MichaelF. Holick (1989)
10.1056/NEJM199503023320902
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability.
J. Guralnik (1995)
10.1007/s00198-004-1604-7
Functional limitations and poor physical performance as independent risk factors for self-reported fractures in older persons
V. Stel (2004)
10.1046/j.1532-5415.2002.50219.x
Low Serum Vitamin D Does Not Predict New Disability or Loss of Muscle Strength in Older Women
R. Verreault (2002)
10.1007/BF03324497
Income differentials in functional disability in old age: Relative risks of onset, recovery, decline, attrition and mortality
M. B. V. Groenou (2003)
10.1016/S0895-4356(03)00082-9
Balance and mobility performance as treatable risk factors for recurrent falling in older persons.
V. Stel (2003)
10.1056/NEJM199803193381201
Hypovitaminosis D in medical inpatients.
M. Thomas (1998)
10.1007/PL00022726
Prevalence of Subclinical Vitamin D Deficiency in Different European Countries
S. Scharla (1998)
10.1093/GERONJ/38.1.19
Age-related changes in parathyroid hormone and 25 hydroxycholecalciferol levels.
M. Chapuy (1983)
10.1007/s00198-005-1867-7
Estimates of optimal vitamin D status
B. Dawson-Hughes (2005)
10.1093/GERONA/57.1.M7
Relation between vitamin D, physical performance, and disability in elderly persons.
M. Zamboni (2002)
10.1210/JC.2006-0510
Vitamin D status in relation to one-year risk of recurrent falling in older men and women.
M. Snijder (2006)
10.1080/00401706.1991.10484817
Categorical Data Analysis
A. Agresti (1991)
10.1016/J.JCLINEPI.2005.03.008
Static and dynamic measures of frailty predicted decline in performance-based and self-reported physical functioning.
M. Puts (2005)
10.1111/j.1532-5415.1999.tb04581.x
Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function
M. Mowé (1999)
10.1210/JCEM-57-1-204
Seasonal variation in serum concentrations of parathyroid hormone in elderly people.
P. Lips (1983)
10.1007/s00223-005-0009-8
Addressing the Musculoskeletal Components of Fracture Risk with Calcium and Vitamin D: A Review of the Evidence
S. Boonen (2005)
10.1359/JBMR.040504
Different Aspects of Visual Impairment as Risk Factors for Falls and Fractures in Older Men and Women
M. D. de Boer (2004)
10.1210/JCEM-67-2-373
Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin.
A. R. Webb (1988)
10.1093/AJCN/80.3.752
Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y.
H. Bischoff-Ferrari (2004)
10.1016/J.JCLINEPI.2003.07.008
Comparison of the LASA Physical Activity Questionnaire with a 7-day diary and pedometer.
V. Stel (2004)
10.1677/JOE.0.1490013
Age-related endocrine deficiencies and fractures of the proximal femur. II implications of vitamin D deficiency in the elderly.
S. Boonen (1996)
10.1359/jbmr.2002.17.5.891
Neuromuscular and Psychomotor Function in Elderly Subjects Who Fall and the Relationship With Vitamin D Status
J. Dhesi (2002)
10.1677/JOE.0.1490007
Age-related endocrine deficiencies and fractures of the proximal femur. I implications of growth hormone deficiency in the elderly.
S. Boonen (1996)
10.1093/AJCN/56.3.537
Serum 25-hydroxyvitamin D: distribution and determinants in the Swiss population.
B. Burnand (1992)
10.1037//0022-006X.60.3.402
Clinically significant change: Jacobson and Truax (1991) revisited.
D. Speer (1992)
10.1210/EDRV.22.4.0437
Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications.
P. Lips (2001)
10.1055/S-2001-14831
Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis.
M. Pfeifer (2001)
10.1016/S0895-4356(02)00438-9
Different cognitive functions in relation to falls among older persons. Immediate memory as an independent risk factor for falls.
N. V. van Schoor (2002)
10.1111/J.2517-6161.1980.TB01109.X
Regression Models for Ordinal Data
P. McCullagh (1980)



This paper is referenced by
10.1007/s40137-017-0193-2
Frailty in Trauma Patients: An Emerging Geriatric Syndrome
M. Khan (2017)
10.5694/mja16.00568
Osteoporosis treatment: a missed opportunity
F. Milat (2016)
10.1007/s10522-010-9297-0
Frailty and muscle metabolism dysregulation in the elderly
W. Evans (2010)
10.4172/2165-7939.1000E107
The Inconsistent Data On The Effect Of Vitamin D On Muscle Function
Giulio Pioli (2012)
Calcium and vitamin D Nutrition and Bone Disease of the Elderly
S. Bahlas (2014)
10.1016/j.clnu.2017.08.016
Does nutrition play a role in the prevention and management of sarcopenia?
S. Robinson (2018)
10.17179/excli2019-1386
The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
R. Tabrizi (2019)
10.1016/j.clinthera.2013.12.007
Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture.
H. Ohta (2014)
10.1017/S0007114515005383
Serum concentrations of 25-hydroxyvitamin D and its association with bone mineral density and serum parathyroid hormone levels during winter in urban males from Guiyang, Southwest China.
Q. Zhang (2016)
10.1111/j.1532-5415.2012.04114.x
Do Depressive Symptoms and Gait Speed Impairment Predict Each Other's Incidence? A 16‐Year Prospective Study in the Community
J. Sanders (2012)
10.1155/2015/953241
Vitamin D: A Review on Its Effects on Muscle Strength, the Risk of Fall, and Frailty
M. Halfon (2015)
10.1111/j.1365-2265.2010.03926.x
Serum 25‐hydroxyvitamin D concentration and physical function in adult men
L. Ceglia (2011)
10.1007/s00223-010-9449-x
Calcium Plus Vitamin D Supplementation Has Limited Effects on Femoral Geometric Strength in Older Postmenopausal Women: The Women’s Health Initiative
Rebecca D. Jackson (2010)
10.1530/EJE-11-0430
Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals.
R. D. de Jongh (2011)
10.1016/J.RBO.2014.05.010
Associação da deficiência de vitamina D com mortalidade e marcha pós-operatória em paciente com fratura de fêmur proximal
D. N. Gumieiro (2015)
10.1093/jn/nxy024
Cholecalciferol or 25-Hydroxycholecalciferol Supplementation Does Not Affect Muscle Strength and Physical Performance in Prefrail and Frail Older Adults.
A. Vaes (2018)
10.1007/s11695-019-03963-9
Prevalence of Vitamin D Depletion, and Associated Factors, among Patients Undergoing Bariatric Surgery in Southern Brazil
M. A. Vivan (2019)
10.1007/978-1-4614-7836-2_108
Diet and Nutrition in Orthopedics
S. Everett (2015)
10.1056/JW200706140000002
Vitamin D and Physical Performance in Older Adults
A. S. Brett (2007)
10.1002/9781118951026.CH19
Balance Disorders and Falls in Epilepsy
S. Petty (2015)
10.3390/nu10081103
Muscle and Bone Health in Postmenopausal Women: Role of Protein and Vitamin D Supplementation Combined with Exercise Training
D. Agostini (2018)
10.1007/s00129-015-3723-y
Vitamin D und postmenopausale Knochengesundheit
H. Bischoff-Ferrari (2015)
10.14283/jfa.2019.15
Frailty and the Metabolic Syndrome — Results of the Berlin Aging Study II (Base-II)
N. Buchmann (2019)
10.1007/s11914-011-0059-y
The Role of Falls in Fracture Prediction
H. Bischoff-Ferrari (2011)
10.1093/GERONA/GLW037
Cystatin C and Objectively Measured Mobility 10 Years Later in Older Women.
K. Ensrud (2016)
10.1007/s00198-016-3877-z
Vitamin D deficiency is associated with functional decline and falls in frail elderly women despite supplementation
M. Kotlarczyk (2016)
10.1359/jbmr.081209
Vitamin D Status, Parathyroid Function, Bone Turnover, and BMD in Postmenopausal Women With Osteoporosis: Global Perspective
Natalia O Kuchuk (2009)
10.1111/j.1532-5415.2010.03142.x
A Randomized Controlled Trial of the Effects of Vitamin D on Muscle Strength and Mobility in Older Women with Vitamin D Insufficiency
K. Zhu (2010)
Falls prevention for older people: vitamin D, calcium or both?
J. Kotecha (2011)
10.1016/B978-0-12-386960-9.00017-4
Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle.
W. Janssens (2011)
10.1093/aje/kwn163
Frequency of leisure-time physical activity and serum 25-hydroxyvitamin D levels in the US population: results from the Third National Health and Nutrition Examination Survey.
R. Scragg (2008)
10.1007/S12603-009-0207-6
Validated treatments and therapeutic perspectives regarding nutritherapy
H. Bischoff-Ferrari (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar