Effect Of Weight Changes On Serum Insulin Response In Subjects With Normal Oral Glucose Tolerance.

ABSTRACT Serum insulin responses during 100-g oral glucose tolerance test were studied at 3–4-month intervals in subjects with normal glucose tolerance. Obese people had higher insulin levels than non-obese people both at fasting and after glucose load. Insulin responses were similar between the two tests when the bw did not change, whether the subjects were obese or non-obese. Hyper-response of insulin in obese people decreased significantly after wt losses of 5–10 kg. Significant elevation of insulin response was observed in patients with mild tuberculosis who gained 3.5–7.0 kg bw, but still remained within the normal wt range. The degree of obesity does not seem to be the sole factor causing insulin hyper-response in these patients.