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Relationship Of Androgenic Activity To Body Fat Topography, Fat Cell Morphology, And Metabolic Aberrations In Premenopausal Women.
D. Evans, R. Hoffmann, R. Kalkhoff, A. Kissebah
Published 1983 · Medicine
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A possible role for increased androgenic/estrogenic activity in the pathogenesis of upper body fat localization and its accompanying cellular and metabolic characteristics was examined. Eighty healthy, nonhirsute, premenopausal, caucasian women with a wide range of body fat topography [waist to hips girth ratio (WHR), 0.64 to 1.02] and obesity level (percentage of ideal body weight, 92-251%) were studied. Increasing androgenicity, as reflected by a decrease in plasma sex hormone-binding globulin capacity and an increase in the percentage of free testosterone, was accompanied by 1) increasing WHR, this relationship being independent of and additive to that of obesity level; 2) increasing size of abdominal, but not femoral, adipocytes; 3) increasing plasma glucose and insulin levels, both basally and in response to oral glucose loading; and 4) diminished in vivo insulin sensitivity, as revealed by increasing steady state plasma glucose levels at comparable plasma insulin levels, attained by the infusion of somatostatin, insulin, and glucose. No association was found between total plasma testosterone, androstenedione, dehydroepiandrosterone sulfate, or estradiol concentrations and WHR, fat cell size, or metabolic profiles. We, therefore, propose that in premenopausal women, a relative increase in tissue exposure to unbound androgens may be responsible in part for localization of fat in the upper body, enlargement of abdominal adipocytes, and the accompanying imbalance in glucose-insulin homeostasis.
This paper references
Contraceptive steroids: modifications of carbohydrate and lipid metabolism.
P. Beck (1973)
An inverse relation between body weight and the activity of the steroid binding -globulin in human plasma.
P. Demoor (1970)
Increased estrogen production in obese men.
G. Schneider (1979)
A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties.
J. Albano (1972)
Fat weight and fat placement in the female.
S. Garn (1957)
Statistical Package for the Social Sciences
S. Edition (1970)
Low serum testosterone and sex-hormone-binding-globulin in massively obese men.
A. Glass (1977)
A simple and rapid method to measure non-protein-bound fractions of cortisol, testosterone and oestradiol by equilibrium dialysis: comparison with centrifugal filtration.
H. Kley (1977)
Relation of Body Fat Distribution to Metabolic Complications of Obesity
A. Kissebah (1982)
Obesity and oligomenorrhea are associated with hyperandrogenism independent of hirsutism.
A. Hosseinian (1976)
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.
C. Kahn (1976)
THE EFFECT OF WEIGHT LOSS ON SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMEN
P. Kopelman (1981)
The influence of age, alcohol consumption, and body build on gonadal function in men.
D. Sparrow (1980)
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
P. Randle (1963)
Female fat distribution--a photographic and cellularity study.
M. Ashwell (1978)
Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective
J. Olefsky (1981)
THE EFFECT OF ANABOLIC STEROIDS ON BLOOD SUGAR AND PLASMA INSULIN LEVELS IN MAN.
J. Landon (1963)
Use of anthropometric measures to assess weight loss.
G. Bray (1978)
INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY IN MODERATELY OBESE MEN AFTER WEIGHT REDUCTION
R. Schwartz (1978)
Radioimmunoassay of Plasma Dehydroepiandrosterone Sulfate
J. Buster (1972)
Increased adipose tissue lipoprotein lipase activity during the development of the genetically obese rat (fa/fa).
R. Gruen (1978)
Radioimmunoassay of plasma estrogens.
C. H. Wu (1971)
REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROME
S. Yen (1980)
A radioimmunoassay for plasma testosterone.
S. Furuyama (1970)
The antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation.
P. Arner (1981)
Capacity of the Testosterone-Binding Globulin in Human Plasma and Influence of Specific Binding of Testosterone on Its Metabolic Clearance Rate
A. Vermeulen (1969)
Depressed plasma testosterone and fractional binding of testosterone in obese males.
J. Amatruda (1978)
Mild Hypogonadotropic hypogonadism in obese men.
G. Strain (1982)
Studies of the relation of plasma androgen levels to androgen action in women.
R. Rosenfield (1975)
Relationship of plasma sex hormones to different parameters of obesity in male subjects.
H. Kley (1980)
17beta-ol androgens and free index in hirsute and hirsute obese women.
E. Zorn (1976)
Obesity and Its Role in Poly cystic Ovary Syndrome
S. Plymate (1981)
Effects of castration and testosterone substitution on body composition and muscle metabolism in rats.
M. Krotkiewski (1980)
Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease.
G. Burghen (1980)
The effect of weight loss on reproductive hormones in obese men.
S. Stanik (1981)
Effects of testosterone on body weight and adipose tissue: Role of aromatization
J. M. Gray (1979)
New automated method for measuring glucose by glucose oxidase
D. Cramp (1967)
Relationship of body fat topography to insulin sensitivity and metabolic profiles in premenopausal women.
D. Evans (1984)
Studies on the binding of testosterone to human plasma.
A. Vermeulen (1968)
Induction of Insulin-dependent Diabetes by Streptozotocin Inhibition by Estrogens and Potentiation by Androgens
S. Paik (1982)
The effect of a very-low-calorie diet with and without chronic exercise on thyroid and sex hormones, plasma proteins, oxygen uptake, insulin and c peptide concentrations in obese women.
M. Krotkiewski (1981)
A simplified method for the quantitative determination of testosterone-estradiol-binding globulin activity in human plasma.
W. Rosner (1972)
ABNORMAL SEX STEROID SECRETION AND BINDING IN MASSIVELY OBESE WOMEN
P. Kopelman (1980)
D. Anderson (1974)
A Simplified Method Using Somatostatin to Assess In Vivo Insulin Resistance over a Range of Obesity
M. Nagulesparan (1979)
Hormonal modulation of adipose tissue lipoprotein lipase may alter food intake in rats.
L. Steingrimsdottir (1980)
A direct radio-immunoassay for plasma Δ4-androstenedione. Application to children
C. Lejeune-Lenain (1979)
This paper is referenced by
Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio
K. Landin (1990)
Risk factors for breast carcinoma in Singaporean Chinese women
E. Ng (1997)
Studies in the distribution of body fat. III. Effects of cigarette smoking.
H. Shimokata (1989)
Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus.
A. Kissebah (1989)
Androgen-estrogen metabolism in women with upper body versus lower body obesity.
M. Kirschner (1990)
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture.
C. Sztalryd (1991)
7 Diabetes and adrenal disease
J. Nestler (1992)
[Sex differences in interrelationships between percent body fat (%fat) and waist-to-hip ratio (WHR) in healthy male and female adults].
Y. Tahara (1994)
Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome.
C. Buffington (1994)
Indications of Low Sex Hormone Binding Globulin (SHBG) in Young Females with Type 1 Diabetes, and an Independent Association to Microalbuminuria
S. Rudberg (1995)
Contribution of body fatness and adipose tissue distribution to the age variation in plasma steroid hormone concentrations in men: the HERITAGE Family Study.
C. Couillard (2000)
The effect of tibolone on fat mass, fat-free mass, and total body water in postmenopausal women.
I. Meeuwsen (2001)
Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome.
L. Morin-Papunen (2003)
Sex-specific fat distribution is not linear across pubertal groups in a multiethnic study.
Q. He (2004)
The link between polycystic ovary syndrome and Type 2 diabetes: what do we know today?
T. Sathyapalan (2011)
Effects of elevated testosterone levels on reproductive neuroendocrine function and behavior in female rheus macaques (macaca mulatta)
W. K. McGee (2012)
31 Aus der Praxis für die Praxis
Hanne Marquardt (2019)
Gender differences in the relation of insulin‐like growth factor binding protein‐1 to cardiovascular risk factors: a population‐based study
A. Undén (2005)
Mechanisms explaining effects of pubertal timing on adulthood cardio-metabolic health.
M. Bleil (2016)
Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk
L. Torchen (2019)
Fettsuchtformen und Stoffwechselstörungen
J. Vague (1987)
Associations of dietary fat, regional adiposity, and blood pressure in men.
P. Williams (1987)
Increased free testosterone but normal 5α‐reduced testosterone metabolites in obese premenopausal women
V. A. Glagulll (1992)
7 Dyslipidaemia and obesity
J. Després (1994)
Interaction between sex hormone levels and body dimensions in postmenopausal women.
S. Kirchengast (1994)
Disturbances in insulin secretion and sensitivity in women with the polycystic ovary syndrome.
J. Holte (1996)
Insulin Sensitivity and Abdominal Obesity in African-American, Hispanic, and Non-Hispanic White Men and Women: The Insulin Resistance and Atherosclerosis Study
A. Karter (1996)
Hormonal and Biochemical Parameters and Osteoporotic Fractures in Elderly Men
J. Center (2000)
Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats.
C. Nilsson (1998)
The association between dyslipidaemia and obesity in Chinese men after adjustment for insulin resistance.
G. Ko (1998)
Medical Consequences of Obesity
F. Pi-Sunyer (1999)
Diagnosis of polycystic ovary syndrome.
R. Chang (1999)See more