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Differences In Insulin Resistance Do Not Predict Weight Loss In Response To Hypocaloric Diets In Healthy Obese Women.

T. McLaughlin, F. Abbasi, M. Carantoni, P. Schaaf, G. Reaven
Published 1999 · Medicine

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The current study was initiated to determine whether insulin resistance and/or hyperinsulinemia affected the ability of obese individuals to lose weight in response to hypocaloric diets. Thirty-one obese, nondiabetic women, with values for body mass index ranging from 28.0-35.0 kg/m2, volunteered for this program. Resistance to insulin-mediated glucose disposal was assessed by determining their steady state plasma insulin and glucose concentration during the last 30 min of a 180-min infusion of somatostatin, insulin, and glucose. The total integrated insulin response to breakfast and lunch was also determined. After the baseline measurements, volunteers were placed on a hypocaloric diet calculated to lead to a minimum weekly loss of 1% of ideal body weight. Individuals who met the criteria after 30 days of dieting were defined as weight loss successes (n = 20) and continued on the diet for another 30 days. Individuals not meeting the criteria were designated as weight loss failures (n = 12) and were discharged from the study. There was a mean (+/-SEM) weight loss at 60 days of 9.2 +/- 0.4 kg in the 20 individuals defined as weight loss successes, but there was no correlation between weight loss and either steady state plasma glucose or the total integrated insulin response (r < 0.1; P > 0.83). Furthermore, using the same criteria to define insulin sensitivity and insulin resistance as those for therapeutic successes, the therapeutic failures comprised six insulin-sensitive and five insulin-resistant subjects. In summary, insulin-mediated glucose disposal varied widely in nondiabetic, obese women, and there was no relationship between baseline insulin resistance or total integrated insulin response and weight loss. It is concluded that the ability to lose weight on a calorie-restricted diet over a short time period does not vary in obese, healthy women as a function of insulin resistance or hyperinsulinemia.
This paper references
10.1210/JCEM.80.5.7745002
Reduced insulin secretion: an independent predictor of body weight gain.
M. Schwartz (1995)
10.1055/S-2007-1013559
Estimates of in vivo insulin action in humans: comparison of the insulin clamp and the minimal model techniques.
J. Foley (1985)
High fasting insulin levels associated with lower rates of weight gain in persons with normal glucose tolerance: the San Luis Valley Diabetes Study.
S. Hoag (1995)
10.1172/JCI106433
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes.
S. W. Shen (1970)
10.2337/diab.30.5.387
Assessment of Insulin Resistance with the Insulin Suppression Test and the Euglycemic Clamp
M. Greenfield (1981)
10.1210/JCEM-60-4-723
Presentation of a new method for specific measurement of in vivo insulin-stimulated glucose disposal in humans: comparison of this approach with the insulin clamp and minimal model techniques.
C. Donner (1985)
10.1210/EDRV-6-1-45
Assessment of insulin sensitivity in vivo.
R. Bergman (1985)
10.1210/JCEM-64-6-1169
Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance.
C. Hollenbeck (1987)
10.1172/JCI115274
Insulin resistance associated with lower rates of weight gain in Pima Indians.
B. Swinburn (1991)
10.1172/JCI112886
Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.
R. Bergman (1987)
10.1210/JCEM-45-5-1124
Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity.
Y. Harano (1977)
10.2337/diab.42.9.1324
Insulin Resistance and Insulin Secretion Are Determinants of Oral Glucose Tolerance in Normal Individuals
G. Reaven (1993)
10.1172/JCI119628
Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR).
E. Ferrannini (1997)
Predictors of weight change in a bi-ethnic population. The San Antonio Heart Study.
R. Valdez (1994)
10.2337/diab.46.8.1341
Fasting Hyperinsulinemia Is a Predictor of Increased Body Weight Gain and Obesity in Pima Indian Children
O. E. Odeleye (1997)
10.1042/BJ0880137
Immunoassay of insulin with insulin antibody preciptate.
C. N. Hales (1963)
10.1210/JCEM-71-6-1508
Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects.
S. Welch (1990)
10.2337/diab.46.6.1025
Acute Postchallenge Hyperinsulinemia Predicts Weight Gain: A Prospective Study
R. Sigal (1997)



This paper is referenced by
10.2337/DIACARE.28.12.2939
A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial.
A. Pittas (2005)
Czy nadciśnienie tętnicze wpływa na skuteczność terapii odchudzającej u osób z otyłością prostą? Does hypertension influence effectiveness of weight reduction therapy in patients with
Danuta Pupek-Musialik (2010)
10.5455/IJMSPH.2013.2.413-416
A STUDY OF Hs-CRP AND LIPID PROFILE IN OVERWEIGHT INDIVIDUALS
H. K. Reddy (2013)
10.1017/S1368980009991881
Effectiveness of energy-restricted diets with different protein:carbohydrate ratios: the relationship to insulin sensitivity.
M. Ballesteros-Pomar (2010)
Alternate Day Fasting Versus Calorie Restriction for Weight Loss and Cardio-Protection
J. Trepanowski (2015)
10.2337/dc09-zb09
The 6th Annual World Congress on the Insulin Resistance Syndrome
Z. Bloomgarden (2009)
10.1016/J.AMJCARD.2004.12.013
Relation of serum uric acid with metabolic risk factors in asymptomatic middle-aged Brazilian men.
M. Desai (2005)
Endocrine-related factors and risk of venous thromboembolism
G. Lerstad (2017)
10.1007/978-0-387-69737-6
Pharmacotherapy of Diabetes: New Developments
C. Mogensen (2007)
10.1157/13106848
Identificación de individuos con resistencia a la insulina mediante mediciones clínicas y marcadores bioquímicos de rutina. Construcción de un índice de riesgo individual
L. D. González (2007)
PREVALENCE AND RISK FACTORS OF CHILDHOOD OVERWEIGHT AND OBESITY
Manasi Behera (2015)
10.7326/0003-4819-138-5-200303040-00012
Importance of Identifying the Overweight Patient Who Will Benefit the Most by Losing Weight
G. Reaven (2003)
10.31590/EJOSAT.563713
Akkermansia muciniphila: Obezite ve Diyabetten Korunmada Yeni Bir Alternatif Olabilir mi?
Lütfiye Ekici (2019)
10.1080/1464727022000198952
Polycystic ovary syndrome and fat distribution: The central issue?
J. Lord (2002)
10.1093/AJE/KWG022
Metabolic predictors of 5-year change in weight and waist circumference in a triethnic population: the insulin resistance atherosclerosis study.
E. Mayer-Davis (2003)
The influence of insulin, insulin resistance, and leptin on the effectiveness of weight reduction therapy in simple obesity
M. Kujawska-Łuczak (2006)
10.1146/ANNUREV.NUTR.24.012003.132155
The insulin resistance syndrome: definition and dietary approaches to treatment.
G. Reaven (2005)
10.1159/000343507
Insulin Resistance Predicts the Effectiveness of Different Glycemic Index Diets on Weight Loss in Non-Obese Women
Mauro Felippe Felix Mediano (2012)
Différentes répercussions métaboliques d'un régime hypocalorique selon le degré d'insulino-résistance chez les patients obèses
Jeanne Caroline Jimenez-Thomet (2003)
10.1016/j.jadohealth.2008.03.002
Insulin resistance and parental obesity as predictors to response to therapeutic life style change in obese children and adolescents 10-18 years old.
O. Pinhas-Hamiel (2008)
10.1093/JN/136.10.2580
Longitudinal changes in food patterns predict changes in weight and body mass index and the effects are greatest in obese women.
P. Newby (2006)
10.1016/j.diabres.2011.02.031
Insulin resistance influences weight loss in non-obese women who followed a home-based exercise program and slight caloric restriction.
M. Mediano (2011)
10.1016/J.METABOL.2003.10.004
Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women.
F. Abbasi (2004)
10.2337/DIASPECT.16.4.261
Body Weight Issues in Preventing and Treating Type 2 Diabetes
Christine Beebe (2003)
10.1038/OBY.2001.113
Popular diets: a scientific review.
M. Freedman (2001)
10.4158/EP.9.S2.58
Insulin resistance syndrome and obesity.
T. McLaughlin (2003)
10.1016/J.CLNU.2005.09.009
Differences in glycaemic status do not predict weight loss in response to hypocaloric diets in obese patients.
D. de Luis (2006)
10.1001/JAMA.297.5.509
A 27-year-old woman with a diagnosis of polycystic ovary syndrome.
R. Legro (2007)
10.1111/j.1467-789X.2006.00225.x
Glycaemic index effects on fuel partitioning in humans
E. Díaz (2006)
10.3945/ajcn.113.058099
Insulin resistance and inflammation predict kinetic body weight changes in response to dietary weight loss and maintenance in overweight and obese subjects by using a Bayesian network approach.
L. C. Kong (2013)
10.1016/J.BPG.2004.06.024
Is there an optimal macronutrient mix for weight loss and weight maintenance?
Dana Lee Wilkinson (2004)
Síndrome metabólico (Segunda Parte)
R. IsaacCrespo (2006)
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