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The Regulation By Growth Hormone Of Lipoprotein Lipase Gene Expression Is Mediated By C-fos Protooncogene.

S. Barcellini-Couget, A. Pradines-Figuères, P. Roux, C. Dani, G. Ailhaud
Published 1993 · Biology, Medicine

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GH has been previously shown in Ob1771 adipose cells to activate transiently the expression of c-fos gene by a protein kinase-C-dependent pathway and to modulate, at last in part by a protein kinase-C-dependent pathway, the expression of the lipoprotein lipase (LPL) gene. In Ob1771 cells exposed to GH, under conditions where protein synthesis is inhibited by cycloheximide, the modulation of LPL gene expression is prevented, suggesting that synthesis of trans-acting factor(s) is required to modulate LPL gene expression. The present results indicate the involvement of c-Fos protein in this modulation; this involvement is supported by various lines of evidence: 1) upon GH stimulation, the increase in c-fos mRNA content is followed by the emergence of c-Fos protein within the nucleus, and this emergence precedes the increase in LPL mRNA content; 2) in GH-treated Ob1771 cells, exposure to antisense sof oligonucleotides abolishes the synthesis of c-Fos protein; and 3) at the same time, the increase in LPL mRNA content and LPL activity does not occur, whereas sense fos oligonucleotides show no effect. It is concluded that c-Fos protein plays an intermediary role in the modulation of LPL gene expression by GH.
This paper references
10.1016/0167-4781(90)90203-E
Structural organization of the human CaMIII calmodulin gene.
M. Koller (1990)
Behind the Fos and Jun leucine zipper.
T. Kouzarides (1989)
10.1016/0092-8674(88)90024-4
Fos and jun: The AP-1 connection
Tom Curran (1988)
10.1073/PNAS.75.12.6054
Establishment of preadipocyte clonal line from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones.
R. Négrel (1978)
10.1016/0735-0651(89)90007-1
Antisense RNA: effect of ribosome binding sites, target location, size, and concentration on the translation of specific mRNA molecules.
B. Daugherty (1989)
10.1038/312711A0
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
W. Kruijer (1984)
10.1016/0888-7543(91)90102-K
The structure of the mouse lipoprotein lipase gene: a B1 repetitive element is inserted into the 3' untranslated region of the mRNA.
R. Zechner (1991)
10.1016/0006-291X(86)91165-4
Coupling of growth arrest and expression of early markers during adipose conversion of preadipocyte cell lines.
E. Amri (1986)
10.1016/0092-8674(90)90807-Q
TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence
L. Kerr (1990)
10.1016/0092-8674(87)90621-0
Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos
R. Distel (1987)
10.1210/ENDO-127-6-3187
Rapid events in growth hormone action. Induction of c-fos and c-jun transcription in 3T3-F442A preadipocytes.
G. Gurland (1990)
Cloning and regulation of a mRNA specifically expressed in the preadipose state.
C. Dani (1989)
Maturation and secretion of lipoprotein lipase in cultured adipose cells. I. Intracellular activation of the enzyme.
C. Vannier (1985)
10.1289/EHP.898017
Coupling growth arrest and adipocyte differentiation.
G. Ailhaud (1989)
10.1016/0092-8674(88)90195-X
Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters
A. Schönthal (1988)
10.1128/MCB.10.8.4284
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.
S. McDonnell (1990)
10.1073/PNAS.76.9.4350
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
H. Towbin (1979)
10.1038/312716A0
Induction of c-fos gene and protein by growth factors precedes activation of c-myc
R. Müller (1984)
10.1038/311433A0
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
M. Greenberg (1984)
10.1016/0092-8674(90)90167-D
Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals
P. Roux (1990)
10.1021/BI00510A024
Biochemical and biological effects of nonionic nucleic acid methylphosphonates.
P. Miller (1981)
10.1126/SCIENCE.2462278
Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways.
L. Kerr (1988)
10.1042/BJ2380123
Growth hormone regulation of the expression of differentiation-dependent genes in preadipocyte Ob1771 cells.
A. Doglio (1986)
10.1016/S0006-291X(05)80863-0
Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown.
R. M. Catalioto (1990)
10.1016/0962-8924(92)90100-2
Cellular uptake and intracellular fate of antisense oligonucleotides.
S. Akhtar (1992)
10.1016/0003-2697(87)90021-2
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
P. Chomczyński (1987)
10.1101/GAD.4.4.477
Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos.
E. Gizang-Ginsberg (1990)
10.1038/334314a0
Transcriptional autoregulation of the proto-oncogene fos
P. Sassone‐Corsi (1988)
10.1073/PNAS.85.4.1028
Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.
E. Wickstrom (1988)



This paper is referenced by
10.1210/JCEM.80.11.7593431
Effects of acromegaly treatment and growth hormone on adipose tissue lipoprotein lipase.
R. Simsolo (1995)
10.1210/MEND.9.11.8584020
Heat shock protein-70 induction mediates luteal regression in the rat.
A. Khanna (1995)
10.1016/0005-2760(93)90196-G
Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level.
S. Enerbäck (1993)
10.1016/S0197-0186(96)00112-X
On the role of c-fos expression in striatal transmission. The antisense oligonucleotide approach
W. Sommer (1997)
10.1007/978-3-319-12108-6_11
Hormonal Regulation of Liver Cytochrome P450 Enzymes
D. Waxman (2015)
10.1007/s00109-002-0384-9
Lipoprotein lipase: structure, function, regulation, and role in disease
J. R. Mead (2002)
10.1111/J.1432-1033.1993.TB18433.X
The biochemistry of white and brown adipocytes analysed from a selection of proteins.
D. Ricquier (1993)
Tumor Necrosis Factor-a Eliminates Binding of NF-Y and an Octamer-binding Protein to the Lipoprotein Lipase Promoter in 3 T 3L 1 Adipocytes
Cathérine (2013)
10.1146/ANNUREV.PH.58.030196.001155
Molecular mechanism of growth hormone action.
C. Carter-Su (1996)
10.1210/ENDO.132.4.8462486
Regulation of c-fos proto-oncogene expression by growth hormone: protein synthesis is not required for down-regulation.
S. Barcellini-Couget (1993)
10.1515/JPEM.2002.15.6.771
Growth Hormone Signal Transduction
G. Piwien-Pilipuk (2002)
10.1152/AJPCELL.00331.2001
Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways.
F. Machinal-Quélin (2002)
10.1007/978-3-642-58785-6
Antisense Research and Application
T. Akiyama (1998)
10.14288/1.0089351
Regulation of cardiac lipoprotein lipase during hypertension and diabetes
N. Sambandam (1999)
10.1210/endo.141.8.7610
Estradiol Stimulation of c-fos and c-jun Expressions and Activator Protein-1 Deoxyribonucleic Acid Binding Activity in Rat White Adipocyte.
Esther Sanz i García (2000)
10.1083/JCB.135.2.457
Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma
R. Jotte (1996)
10.1111/J.1439-0531.1993.TB00109.X
THE GROWTH HORMONE RECEPTOR DURING DEVELOPMENT
G. Norstedt (1993)
10.1007/978-3-642-58785-6_13
Antisense oligonucleotides and their anticancer activities
D. Fabbro (1998)
10.1016/0303-7207(93)90238-F
Terminal differentiation of mouse preadipocyte cells: adipogenic and antimitogenic role of triiodothyronine
C. Darimont (1993)
10.1677/JOE.0.1460131
Effects of growth hormone antagonists on 3T3-F442A preadipocyte differentiation.
B. Xu (1995)
10.1210/ENDO.136.11.7588201
Rapid changes in gene expression after in vivo growth hormone treatment.
A. Gronowski (1995)
10.2337/DIABETES.50.3.660
Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs.
S. E. Michaud (2001)
Effects of growth hormone antagonists on 3 T 3F 442 A preadipocyte differentiation
B. Xu (1997)
10.1016/S1096-6374(98)80316-X
The molecular basis of growthhormone action
M. Thomas (1998)
10.1002/CPHY.CP070514
Molecular Events in Growth Hormone–Receptor Interaction and Signaling
L. S. Smit (2011)
10.1016/0163-7258(94)90018-3
Molecular events in adipocyte development.
S. Butterwith (1994)
10.1210/MEND.7.8.8232317
A novel in vitro model for studying signal transduction and gene regulation via the growth hormone receptor.
S. Francis (1993)
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