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A Corepressor And Chicken Ovalbumin Upstream Promoter Transcriptional Factor Proteins Modulate Peroxisome Proliferator-Activated Receptor-γ2/Retinoid X Receptor α-Activated Transcription From The Murine Lipoprotein Lipase Promoter.
C. E. Robinson, X. Wu, Z. Nawaz, Sergio A Ona Te, J. Gimble
Published 1999 · Medicine, Biology
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Complex physiological stimuli differentially regulate the tissue-specific transcription of the lipoprotein lipase (LPL) gene. A conserved DNA recognition element (−171 to −149 bp) within the promoter functions as a transcriptional enhancer when bound by the peroxisome proliferator-activated receptor-γ2 (PPARγ2)/retinoid X receptor α (RXRα) heterodimer, but serves as a transcriptional silencer in the presence of unidentified double and single stranded DNA-binding proteins. To address this apparent paradox, the current study examined the effect of two classes of candidate comodulatory proteins, COUP-TF (chicken ovalbumin upstream promoter transcriptional factor) and the corepressor SMRT (silencing mediator of retinoic acid receptor and thyroid receptor). The expression of COUP-TF was detected by Western and Northern blots in a preadipocyte 3T3-L1 cell model during periods corresponding to increased LPL transcription. Cotransfection of COUP-TF expression constructs in the renal epithelial 293T cell line sign...
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