Online citations, reference lists, and bibliographies.
← Back to Search

The Association Of Vitamin D With Femoral Neck Strength: An Additional Evidence Of Vitamin D On Bone Health.

H. Kim, S. Lee, J. Kim, Kyeong-Hye Lim, S. H. Ahn, B. Kim, Jung-Min Koh
Published 2015 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
CONTEXT Although bone mineral density (BMD) is a strong predictor of fracture risk, additional parameters, such as bone strength, are needed to predict future fracture risk because of the low sensitivity of BMD for predicting fracture risk. OBJECTIVE The objective was to study the association of vitamin D with femoral neck (FN) strength. DESIGN AND SETTING This was a population-based, cross-sectional study from Korea National Health and Nutrition Examination Surveys. PARTICIPANTS A total of 1209 Koreans (586 men and 623 women) aged ≥50 years participated. MAIN OUTCOME MEASURES We calculated composite indices of FN strength, such as the compression strength index, bending strength index (BSI), and impact strength index, by combining BMD, body weight, and height with the femoral axis length and width, which were measured by dual-energy x-ray absorptiometry. RESULTS Multiple regression analysis demonstrated that serum 25-hydroxyvitamin D [25(OH)D] levels were associated with compression strength index, BSI, and impact strength index in both genders. When women were categorized into four quartiles of 25(OH)D, FN BMD and composite indices (except for BSI) significantly increased from the lowest (Q1) to the highest quartile (Q4) (P for trend = .001-.004). In contrast, there is no significant association of quartiles with composite indices in men. When women were divided into two groups according to their serum 25(OH)D levels, the composite indices as well as the FN BMD were markedly higher in subjects with higher 25(OH)D levels (≥51.5 nmol/L). CONCLUSION These findings provide the first clinical evidence that high serum 25(OH)D levels exhibit higher composite indices of FN strength in a dose-dependent manner, especially in women.
This paper references
Femoral Volumetric Bone Density, Geometry, and Strength in Relation to 25‐Hydroxy Vitamin D in Older Men
Elizabeth Martin (2015)
Vitamin D status predicts physical performance and its decline in older persons.
I. Wicherts (2007)
Prevalence of osteoporosis and reference data for lumbar spine and hip bone mineral density in a Korean population
L. Cui (2007)
The combination of vitamin D deficiency and mild to moderate chronic kidney disease is associated with low bone mineral density and deteriorated femoral microarchitecture: results from the KNHANES 2008-2011.
Y. Lee (2014)
Diagnosis and Classification of Diabetes Mellitus
Vittorio Basevi (2011)
Serum 25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures
B. Clarke (2009)
Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT.
M. Ito (2011)
Diabetes and Femoral Neck Strength: Findings from The Hip Strength Across the Menopausal Transition Study
B. Morrey (2012)
Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES
T. Kelly (2009)
Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2011
E. Park (2014)
Relative contributions of aging and estrogen deficiency to postmenopausal bone loss.
L. S. Richelson (1984)
Bone dimensional change with age: Interactions of genetic, hormonal, and body size variables
R. Heaney (2006)
Osteoporosis: a still increasing prevalence.
J. Reginster (2006)
Sex steroids and the construction and conservation of the adult skeleton.
B. Riggs (2002)
The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D From the Institute of Medicine: What Clinicians Need to Know
A. Ross (2011)
Dietary Calcium and Serum 25‐Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults
H. Bischoff-Ferrari (2009)
Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y.
H. Bischoff-Ferrari (2004)
Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial.
M. Ooms (1995)
Associations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans: the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2009
S. Hwang (2014)
Hip fracture risk assessment using composite indices of femoral neck strength: the Rancho Bernardo study
A. Karlamangla (2004)
H. Peretz (1966)
Effects of a Short‐Term Vitamin D and Calcium Supplementation on Body Sway and Secondary Hyperparathyroidism in Elderly Women
M. Pfeifer (2000)
Structural patterns of the proximal femur in relation to age and hip fracture risk in women.
J. Carballido-Gamio (2013)
Does Obesity Really Make the Femur Stronger? BMD, Geometry, and Fracture Incidence in the Women's Health Initiative‐Observational Study
T. Beck (2009)
Relation between age, femoral neck cortical stability, and hip fracture risk
Paul M. Mayhew (2005)
Androgens and the ageing male.
A. Juul (2002)
Bone mineral density thresholds for pharmacological intervention to prevent fractures.
E. Siris (2004)
Diagnosis and Classification of Diabetes Mellitus The information that follows is based largely on the reports of the Expert Committee on the Diagnosis and Classification of Diabetes (Diabetes Care 20:1183–1197, 1997, and Diabetes Care 26:3160–3167, 2003).
G. Rossi (2008)
The diagnosis of osteoporosis
J. Kanis (1992)
3 rd , Christiansen C , Johnston CC , Khaltaev N . The diagnosis of osteoporosis
JA Kanis (2010)
Dose-related effect of urinary cotinine levels on bone mineral density among Korean females
J.-P. Myong (2012)
Age-related bone mineral density patterns in Koreans (KNHANES IV).
E. Lee (2012)
The modification of diet in renal disease study.
S. Klahr (1989)
The incidence and residual lifetime risk of osteoporosis-related fractures in Korea
C. Park (2011)
Calcium Plus Vitamin D Supplementation Has Limited Effects on Femoral Geometric Strength in Older Postmenopausal Women: The Women’s Health Initiative
Rebecca D. Jackson (2010)
Fracture risk assessment without race/ethnicity information.
S. Ishii (2012)
Evaluation of Compressive Strength Index of the Femoral Neck in Caucasians and Chinese
N. Yu (2010)
Structural Trends in the Aging Femoral Neck and Proximal Shaft: Analysis of the Third National Health and Nutrition Examination Survey Dual‐Energy X‐Ray Absorptiometry Data
T. J. Beck (2000)
Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis
P. Vestergaard (2006)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar