Online citations, reference lists, and bibliographies.
← Back to Search

Intracellular Calcium Accumulation In Duchenne Dystrophy And Other Myopathies

J. Bodensteiner, A. Engel
Published 1978 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Ultrastructural studies have shown plasmalemmal defects in a proportion of non-necrotic muscle fibers in Duchenne dystrophy, suggesting that intracellular calcium overloading may be an important mechanism of muscle fiber degeneration. To investigate this assumption, we studied the localization of calcium with the von Kössa method, with alizarin red, and with glyoxalbis-(O-hydroxyanil) in serial, fresh-frozen sections of 114 biopsy specimens. The biopsy material included Duchenne dystrophy (24 cases), other dystrophies (27 cases), inflammatory myopathies (47 cases), and normal controls (11 cases). Counted in each specimen were every muscle fiber, the so-called large-dark fibers, and all calcium-positive fibers. Separate counts were made of the large-dark, necrotic, and other types of calcium-positive fibers. In Duchenne dystrophy, non-necrotic calcium-positive fibers occurred with a mean frequency of 4.83 percent. For all other groups, the corresponding value was 0.57 percent, with a range of 0.21 percent (normals) to 1.76 percent (scleroderma), p < 0.001. Large-dark fibers were 12 times more common in Duchenne dystrophy than in all other cases. Forty-three percent of the fibers were calcium-positive in Duchenne dystrophy, whereas calcium-positive large-dark fibers were extremely rare in the other cases.
This paper references



This paper is referenced by
Erythrocyte membrane studies in human muscular dystrophy
S. Lloyd (1980)
Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture
E. Rybalka (2007)
10.1016/B978-0-12-417044-5.00030-5
Chapter 30 – Dystrophinopathies
B. Darras (2015)
10.1113/jphysiol.1990.sp018210
Resting calcium concentrations in isolated skeletal muscle fibres of dystrophic mice.
D. Williams (1990)
10.1007/978-1-4684-5598-4_54
Pathogenetic Roles of Intracellular Calcium and Magnesium in Membrane-Mediated Progressive Muscle Degeneration in Duchenne Muscular Dystrophy
S. K. Bhattacharya (1989)
Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.
D. Law (1994)
10.1002/MUS.880100106
Clinical investigation in duchenne dystrophy. VI. Double‐blind controlled trial of nifedipine
R. Moxley (1987)
10.2490/JJRM1963.24.325
The study of propagation velocity of motor unit action potential in Duchenne muscular dystrophy
T. Konishi (1987)
10.1016/S0304-3940(02)00148-9
Hypotonic medium increases calcium permeant channels activity in human normal and dystrophic myotubes
C. Vandebrouck (2002)
10.1016/0304-4165(95)00180-8
The sarcoplasmic reticulum calcium pump is functionally altered in dystrophic muscle.
M. Kargacin (1996)
10.1016/J.CCR.2005.10.004
Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.
Swarnali Acharyya (2005)
10.1016/0009-8981(85)90202-5
Measurements of calcium and other elements in muscle biopsy samples from patients with Duchenne muscular dystrophy.
M. Jackson (1985)
10.4236/OJAPPS.2014.46030
Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy
Sanjeev Kumar (2014)
10.1093/jnen/nly106
Sarcolemmal Complement Membrane Attack Complex Deposits During Acute Rejection of Myofibers in Nonhuman Primates
D. Skuk (2019)
10.1016/0009-8981(79)90432-7
Duchenne muscular dystrophy: 45Ca exchange in cultured skin fibroblasts and the effect of calcium ionophore A23187.
H. Statham (1979)
10.1152/PHYSREV.2000.80.3.1215
Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease.
M. Berchtold (2000)
10.1093/hmg/ddp383
Stra13 regulates oxidative stress mediated skeletal muscle degeneration.
C. Vercherat (2009)
10.1002/MUS.880050802
Inflammatory myopathy: A review of etiologic and pathogenetic factors
J. Whitaker (1982)
10.1093/HMG/11.21.2645
Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology.
M. Spencer (2002)
10.1007/BF01833324
Deterioration induced by physiological concentration of calcium ions in skinned muscle fibres
N. Kasuga (2005)
10.1002/JCP.1041370308
Ca‐dependent slow action potentials in human skeletal muscle
L. Siri (1988)
10.1248/BPB1978.9.672
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
M. Tamai (1986)
10.1007/978-3-642-81553-9_87
Morphometric comparison of Duchenne's muscular dystrophy and experimental bupivacaine myopathy.
W. J. Cumming (1981)
10.1016/S0140-6736(80)92121-2
CALCIUM-POSITIVE MUSCLE FIBRES IN FETUSES AT RISK FOR DUCHENNE MUSCULAR DYSTROPHY
B. Brambati (1980)
10.1093/JB/118.5.959
Visualization of dystrophic muscle fibers in mdx mouse by vital staining with Evans blue: evidence of apoptosis in dystrophin-deficient muscle.
R. Matsuda (1995)
10.1212/WNL.32.10.1088
Muscle calcium and magnesium content in Duchenne muscular dystrophy
T. Bertorini (1982)
10.1002/med.21279
Cardiac and Respiratory Dysfunction in Duchenne Muscular Dystrophy and the Role of Second Messengers
Matías Mosqueira (2013)
10.1007/s00415-012-6512-8
Permanent muscular sodium overload and persistent muscle edema in Duchenne muscular dystrophy: a possible contributor of progressive muscle degeneration
M. Weber (2012)
Investigating the Potential Effectiveness of Two Therapeutic Targets, Utrophin and HSP70, in the Treatment of Duchenne Muscular Dystrophy
Daniel Spensieri (2014)
10.1016/S0960-8966(01)00279-6
Normal calcium homeostasis in dystrophin-expressing facioscapulohumeral muscular dystrophy myotubes
C. Vandebrouck (2002)
10.1590/S0004-282X1995000200001
Enzimas séricas e eletromiografia em doenças Neuromusculares: estudo comparativo de 817 casos
L. C. Werneck (1995)
10.1038/nrd1085
Pharmacological strategies for muscular dystrophy
T. Khurana (2003)
See more
Semantic Scholar Logo Some data provided by SemanticScholar